• CuL also mimics the action of other copper enzymes, being capable of catalyzing the peroxidative oxidation of cyclohexane, under in mild conditions and in several media. (uea.ac.uk)
  • A recent experiment has looked at the motion of benzene and cyclohexane on a nickel catalyst using neutron scattering and computational modeling. (databasefootball.com)
  • Other information on identity and properties Physical state: White crystalline solid (pure) Amber waxy solid (technical) Melting point: 40 C (pure) Solubility: Water - about 4 g/ml Benzene, toluene, methyl ethyl ketone, ethyl acetate, acetonitrile, methylene chloride, anisole, cyclohexanone, chloroform - 1 g/ml [xylene - 0.125 g/ml petroleum ether, cyclohexane - insoluble Volatility: Very low. (inchem.org)
  • This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. (wikipedia.org)
  • Cyclohexane is an alicyclic alkane that contains six carbon atoms in its structure. (laballey.com)
  • Rhea has been designed for the functional annotation of enzymes and the description of genome-scale metabolic networks, providing stoichiometrically balanced enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list and additional reactions), transport reactions and spontaneously occurring reactions. (hes-so.ch)
  • In enzymology, a cyclohexane-1,2-diol dehydrogenase (EC 1.1.1.174) is an enzyme that catalyzes the chemical reaction trans-cyclohexane-1,2-diol + NAD+ ⇌ {\displaystyle \rightleftharpoons } 2-hydroxycyclohexan-1-one + NADH + H+ Thus, the two substrates of this enzyme are trans-cyclohexane-1,2-diol and NAD+, whereas its 3 products are 2-hydroxycyclohexan-1-one, NADH, and H+. (wikipedia.org)
  • The first and rate-limiting step of cholesterol synthesis is the conversion of acetyl-CoA to mevalonate by the enzyme HMG-CoA reductase (HMGCR) . (biochemden.com)
  • The next step of cholesterol synthesis occurs in the endoplasmic reticulum (ER), where HMG-CoA is converted into mevalonate by the enzyme HMG-CoA reductase (HMGCR) . (biochemden.com)
  • A concentration of 40 mg/l caused 50% inhibition of enzyme activity of plasma. (inchem.org)
  • Four hours after guinea-pigs had received 40 mg vamidothion/kg orally, 81% inhibition of plasma and 20% inhibition of cellular enzyme occurred. (inchem.org)
  • We describe an alternative method using unnatural L-enantiomer nucleosides (L-adenosine and L-2-deoxyadenosine) which eliminates the need for enzyme inhibition. (cdc.gov)
  • Rings A, B, and C are cyclohexane rings, while ring D is a cyclopentane ring. (biochemden.com)
  • This article will explain the step-by-step mechanism of cholesterol synthesis , its key enzymes and genes, and the feedback mechanisms that control its production and transport. (biochemden.com)
  • 1961). Effects on enzymes Vamidothion inhibits cholinesterase in vitro and in vivo . (inchem.org)
  • Nitisinone is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme upstream of fumarylacetoacetate hydrolyase (FAH) in the tyrosine catabolic pathway. (lgmpharma.com)
  • Hereditary tyrosinemia type 1 occurs due to a deficiency in fumarylacetoacetase (FAH), the final enzyme in the tyrosine catabolic pathway. (lgmpharma.com)
  • Rhea reactions are extensively curated with links to source literature and are mapped to other publicly available enzyme and pathway databases such as Reactome, BioCyc, KEGG and UniPathway, through manual curation and computational methods. (hes-so.ch)
  • An enzyme that catalyzes the conversion of prephenate to p-hydroxyphenylpyruvate in the presence of NAD . (nih.gov)
  • Nature also has its own form of catalysts in enzymes, which control the chemical reactions necessary for life. (databasefootball.com)
  • Lab Alley's premium quality Cyclohexane is certified as an ACS (American Chemical Society) reagent due to its high purity. (laballey.com)
  • Knowledge about the central steps of diterpene formation in coffee provides a foundation for future characterization of the subsequent enzymes involved in CAF and KAH biosynthesis. (bvsalud.org)
  • The identified inhibitor 16 displays high target affinity on tankyrase 1 and 2 with a biochemical and cellular IC50 values of 29 nM, 6.3 nM and 19 nM, respectively, and high selectivity towards other Poly(ADP-ribose) polymerase enzymes. (diamond.ac.uk)
  • The outstanding panel of contributors in "Directed Enzyme Evolution: Advances and Applications" has ensured the compilation of some remarkable examples of enzymes improved by evolution in just a single volume, as well as providing an interesting collection of the cutting-edge approaches and methods currently available or soon to be added to the directed evolution tool-box. (miguelalcaldelab.eu)
  • We describe a novel method to measure petroleum distillates in BAL fluid using gas chromatography-mass spectrometry (GC/MS). METHODS: n-Hexane, n-heptane, n-octane, methylcyclopentane, and cyclohexane were measured in BAL fluid specimens by headspace solid-phase microextraction/gas chromatography/mass spectrometry. (cdc.gov)
  • The next step of cholesterol synthesis involves condensing six isoprene units (three IPP and three DMAPP) to form a 30-carbon molecule called squalene, which is catalyzed by the enzyme squalene synthase . (biochemden.com)
  • With higher dosage levels the plasma cholinesterase level remained stationary but cellular enzyme activity decreased (Dubost et al. (inchem.org)
  • In the enteric bacteria, this enzyme also possesses chorismate mutase activity, thereby catalyzing the first two steps in the biosynthesis of tyrosine. (nih.gov)
  • Adding an inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA), has been previously reported to minimize enzyme activity, although this adds additional cost and complexity. (cdc.gov)
  • Efficient base-catalyzed Kemp elimination in na engineered ancestral enzyme. (miguelalcaldelab.eu)
  • Halophilic microorganisms are source of potential hydrolytic enzymes to be used in industrial and/or biotechnological processes. (scielo.org)
  • Cholesterol synthesis starts in the cell's cytosol with the conversion of two molecules of acetyl-CoA into a four-carbon molecule called acetoacetyl-CoA, which is then converted into 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) by the enzyme HMG-CoA synthase . (biochemden.com)
  • The following steps involve the conversion of mevalonate-5-phosphate into 3-isopentenyl pyrophosphate (IPP) and its isomer dimethylallyl pyrophosphate (DMAPP) by the enzymes phosphomevalonate kinase , mevalonate pyrophosphate decarboxylase , and isopentenyl pyrophosphate isomerase . (biochemden.com)
  • We describe a novel method to measure petroleum distillates in BAL fluid using gas chromatography-mass spectrometry (GC/MS). METHODS: n-Hexane, n-heptane, n-octane, methylcyclopentane, and cyclohexane were measured in BAL fluid specimens by headspace solid-phase microextraction/gas chromatography/mass spectrometry. (cdc.gov)
  • A novel chemiluminescence enzyme immunoassay using bacterial magnetic particles (BMPs) has been developed for highly sensitive and rapid detection of immunoglobulin G. Antibody was immobilized onto BMPs using the heterobifunctional reagents sulfosuccinimidyl 6-[3'-(2-pyridyldithio)propionamido]hexanoate (sulfo-LC-SPDP) and sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1 -carboxylate (sulfo-SMCC). (elsevierpure.com)
  • Furthermore, in order to reduce assay time and to simplify operations, a rapid chemiluminescence enzyme immunoassay method has been developed. (elsevierpure.com)
  • Enzyme immunoassay with captured hapten. (docksci.com)
  • Key terms: Biotinyl-gastrin, streptavidin biotinyl-hapten complex, enzyme immunoassay. (docksci.com)
  • The final chapter has the objective to develop new plasmono-resonance NPs of noble metals (gold and its alloy with silver) stabilized and functionalized with a MA copolymer, as well as to study a possibility of application of obtained organo-mineral colloids containing or containing no specific enzyme in catalysis for the selective aerobic oxidation of glucose to gluconic acid. (novapublishers.com)
  • Enzyme immunoassays with polystyrene-adsorbed low mass peptides have found widespread application for the identification of immunodominant epitopes of proteins or for the quantitative determination of endogenous peptides in physiological fluids or tissue extracts. (docksci.com)
  • Contrary to what may be believed in Biochemistry, as most enzymes evolved and performed their function in aqueous medium, several research studies have found that proteins co-crystallized or soaked in organic solvents preserve the integrity of the protein fold [ 4 ]. (biomedcentral.com)
  • For example, enzymes from thermophilic organisms are inactive at low temperatures due to a shortage of thermal energy, necessary to surmount the excess of rigidity that these proteins show [ 15 ]. (biomedcentral.com)
  • T opics that will be covered in the course  History of biosensor development, applications and requirements of biosensors and classification  Principles of molecular recognition and transduction signal acquisition Sourcesof Biological Recognition elements - enzymes/proteins, ssDNAs, antibody and Others Design considerations for use of recognition elements in biosensors Modeling of reactions for various biosensor applications‐ electrochemical, optical, piezoelectric, colorimetric, fluorometric and others. (slideshare.net)
  • The reason for this is that the amide bond is a foundational building block in the overall structure of proteins, enzymes, and peptide based signaling molecules - more on peptides later. (organicchemexplained.com)
  • This enzyme participates in caprolactam degradation. (wikipedia.org)
  • Comment: In MetaCyc pathway glutaryl-CoA degradation ( link ), glutaryl-CoA is oxidized to (E)-glutaconyl-CoA and oxidatively decarboxylated to crotonyl-CoA (both by the same enzyme), hydrated to 3-hydroxybutanoyl-CoA, oxidized to acetoacetyl-CoA, and cleaved to two acetyl-CoA. (lbl.gov)
  • chemical kits, including molecular biology enzymes/reagents /biochemicals/ immunochemicals: 5. (tendersindelhi.com)
  • As a class of drugs, aromatase inhibitors offer an anti-estrogenic effect by blocking the enzyme responsible for synthesizing estrogens. (roids.review)
  • Other information on identity and properties Physical state: White crystalline solid (pure) Amber waxy solid (technical) Melting point: 40 C (pure) Solubility: Water - about 4 g/ml Benzene, toluene, methyl ethyl ketone, ethyl acetate, acetonitrile, methylene chloride, anisole, cyclohexanone, chloroform - 1 g/ml [xylene - 0.125 g/ml petroleum ether, cyclohexane - insoluble Volatility: Very low. (inchem.org)
  • Particularly, their promotional ability for electron-transfer reactionswith enzymes and other biomolecules has made carbon nanotubes the ideal supporting material for heterogeneous catalysts. (slideshare.net)
  • Plant growth-promoting effects, photosynthetic performance, reactive oxygen species scavenging enzymes, and phytohormones were investigated. (frontiersin.org)
  • Human metabolism was rapid, first to the monoester, cyclohexane-1,2-dicarboxylic monoisononyl ester (MINCH) which undergoes further oxidative modifications. (cdc.gov)
  • 5. Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin-induced diabetic rats. (nih.gov)
  • The more abundant of these metabolites include cyclohexane-1,2-dicarboxylic acid (CHDA), cyclohexane-1,2-dicarboxylic mono hydroxyisononyl ester (MHNCH or OH-MINCH), cyclohexane-1,2-dicarboxylic mono oxoisononyl ester (MONCH or oxo-MINCH), and cyclohexane-1,2-dicarboxylic mono carboxyisononyl ester (MCHOH or cx-MINCH) (Koch et al. (cdc.gov)
  • 7. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. (nih.gov)
  • The cyclohexylpropionate ester is very similar in structure to the cypionate (cyclopentylpropionate) ester, different only by the inclusion of a cyclohexane ring (6 carbon atoms) instead of cyclopentane ring (5 carbon atoms). (roids.review)
  • Figure 2: General process for the chemical synthesis of an Amide (Note: Biologically, peptides are predominantly synthesized in processes that involve enzymes such as Peptidyl Transferases or Peptide Synthetases. (organicchemexplained.com)
  • The methanolic extracts were extracted and analyzed for anti-cancer effect through anti-neoplastic enzymes (L-asparaginase and L-glutaminase) screening, while antioxidant capabilities were investigated for fifteen isolates using both radical and non-radical assays. (researchsquare.com)
  • 1. Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract. (nih.gov)
  • 3. Beneficial Effects of Endurance Exercise with Rosmarinus officinalis Labiatae Leaves Extract on Blood Antioxidant Enzyme Activities and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats. (nih.gov)
  • 11. Antidiabetic effect of Phlomis anisodonta: effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. (nih.gov)
  • This review article focuses on the potential applications of lignocellulosic materials in biotechnology, including the production of bio-fuels, enzymes, chemicals, the pulp and paper, animal feed, and composites. (ncsu.edu)
  • Stereochemical aspects of vinylcyclohexene bioactivation in rodent hepatic microsomes and purified human cytochrome P450 enzyme systems. (nih.gov)
  • Physiologically, they produce many of the same proinflammatory responses, including fever, sleep and anorexia, mobilization and activation of polymorphonuclear leukocytes, induction of cyclooxygenase and lipoxygenase enzymes, increase in adhesion molecule expression, activation of B-cells, T-cells and natural killer cells, and stimulation of production of other cytokines. (justia.com)
  • To expand the range of natural bio-resources, significant progress related to the lignocellulose bio-technology has been achieved, and researchers have been re-directing their interests to biomass-based fuels, ligninolytic enzymes, chemicals, and biocompatible materials, which can be obtained from a variety of lignocellulosic waste materials. (ncsu.edu)
  • 2011) (Fig. 1), including bio-fuels, cheap energy sources for microbial fermentation and their enzyme production, chemicals, pulp and paper production, improved animal feedstuffs, and polymer composites for materials science. (ncsu.edu)
  • A rat model of chronic pulmonary infection (CPI) initiated by Pseudomonas aeruginosa embedded in agar beads was used to test the effect of ozone on lysosomal enzyme levels in alveolar macrophages (AM). CPI was induced by intratracheal instillation of a 0.1-ml suspension of infected beads into the left lung. (researchgate.net)
  • Cell size and enzyme content of ozone-exposed animals with CPI were further reduced, suggesting a synergistic effect between ozone exposure and chronic infection. (researchgate.net)
  • The systematic name of this enzyme class is trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase. (wikipedia.org)
  • It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen in the body. (roids.review)
  • Incubations with human CYP2E1 enzyme revealed that (R)-VCH formed significantly more VCH-1,2-epoxide and less VCH-7,8-epoxide than (S)-VCH. (nih.gov)
  • 1961). Effects on enzymes Vamidothion inhibits cholinesterase in vitro and in vivo . (inchem.org)
  • Enzyme levels were measured using a scanning cytospectrophotometer linked to PDP/11 computer. (researchgate.net)
  • These enzyme activities are markers that can be used for studying gene expression in neurons. (nih.gov)
  • Activities of the marker enzymes were assessed in surface cultures of new- born mouse brain cells, and in glial and nonbrain cell lines. (nih.gov)
  • Activities of en- zymes important in neuronal cell metabolism are useful param- eters for following cell maturation and exploring steps in differ- entiation in such cultures. (nih.gov)
  • Researchers have increasingly reported that widespread electrophoresis with three restriction enzymes ( Spe I, Xba I, use of fluoroquinolones in food animals leads to the rapid and Bln I) were performed. (cdc.gov)
  • Measurement of lysozyme in individual rat AM in situ showed a significant decrease in cell size and enzyme content in ozone-exposed uninfected animals. (researchgate.net)