- Wan M, Cravatt BF, Ring HZ, Zhang X, Francke U: Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation. (t3db.ca)
- A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. (lookformedical.com)
- Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. (t3db.ca)
- Giang DK, Cravatt BF: Molecular characterization of human and mouse fatty acid amide hydrolases. (t3db.ca)
- A saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils. (lookformedical.com)
- Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (lookformedical.com)
- An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. (lookformedical.com)
- An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE , forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. (lookformedical.com)
- Furthermore, the Krebs cycle intermediates are replenished by uptake of glutamine, which leads to increased production of amino acid precursors [ 8 ]. (degruyter.com)
- Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid. (lookformedical.com)
- Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure. (lookformedical.com)
- A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-chain AMINO ACIDS to 2-oxoglutarate. (lookformedical.com)
- An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. (lookformedical.com)
- The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide. (lookformedical.com)
- The enzymes in this section of the database are organized as you would find them in the Enzyme-Nomenclature book. (enzyme-database.org)
- This enzyme is important in the de novo biosynthesis of pyrimidines. (nih.gov)
- Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. (harvard.edu)
- Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups. (bvsalud.org)
- Mechanistically, NRF2 activation in CD8+ T cells conferred by Asn restriction rewired the metabolic program by reducing the overall glucose and glutamine consumption but increasing intracellular nucleotides to promote proliferation. (bvsalud.org)
- Asparagine-derived 13C-carbon was incorporated into nearly all amino acids. (bvsalud.org)
- Both the exometabolome and the 13C-labeling pattern suggest that in addition to aspartate, the amino acids glutamate, glycine, serine, and alanine, but also pyruvate and malate, were most crucially involved in the osmoprotective effect of asparagine, with glutamate being a major hub between the central carbon and amino acid pathways. (bvsalud.org)
- The linkage is in the form of a carbon-nitrogen bond. (harvard.edu)
- Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. (nih.gov)