• At the end of each exposure period, fishes were sacrificed and tissues were removed and analysed for enzyme activity. (pharmaresearchlibrary.com)
  • A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
  • To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. (cranberryinstitute.org)
  • Fetal brain regions and peripheral tissues were examined for nAChR subtypes, other neurotransmitter receptors, and indices of cell signaling and cell damage. (nature.com)
  • Some tissues and organs, such as the brain, spermatazoa, and salivary glands, contain a large amount of zinc ions. (dojindo.com)
  • However, prior studies have primarily focused on biological tissues outside of the basal ganglia, despite the known relevancy of this brain region in motor and cognitive dysfunction associated with PD and LBD. (mdpi.com)
  • On day 4 post- challenge, three ferrets from each group were euthanized and organs (lung, trachea, nasal turbinates, olfactory bulbs, and brain tissues pooled from anterior and posterior brain sections) were collected for virus titration. (cdc.gov)
  • Gamma glutamyl transferase (GGT) is an enzyme found in cell membranes of many tissues mainly in the liver, kidney, and pancreas. (medscape.com)
  • The drug increased enzyme levels in many tissues, including the brain, suggesting that it might be helpful in treating PDHC deficiency in humans. (medscape.com)
  • An endogenous inhibitor of AChE in neurons is Mir-132 microRNA, which may limit inflammation in the brain by silencing the expression of this protein and allowing ACh to act in an anti-inflammatory capacity. (wikipedia.org)
  • In an upcoming issue of Science , the investigators report that, in cellular and animal models, blocking the action of the enzyme, SIRT2, can protect the neurons damaged in Parkinson's disease from the toxic effects of alpha-synuclein, a protein that accumulates in the brains of patients. (genengnews.com)
  • They then injected a drug to block a specific protein into the taste cortex - an area of the brain associated with taste memory. (jpost.com)
  • They hypothesized, on the basis of earlier research by Sacktor, that this protein (an enzyme called PKMzeta) acts as a miniature memory machine that keeps memory up and running. (jpost.com)
  • Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)
  • We have recently demonstrated that a prominent pool of enzymatically inactive AChE protein exists in the AD brain. (nih.gov)
  • The latter but not the former activity was inhibited in a concentration-dependent manner by phosphoramidon (approximate IC50, 1 microM) and converted bET-1 to ET-1 at a rate of 0.6 nmol/hr/mg of protein. (aspetjournals.org)
  • Here we report that nonglycosylated full-length and C-terminal truncated amyloid precursor protein (APP) accumulates exclusively in the protein import channels of mitochondria of human AD brains but not in age-matched controls. (jneurosci.org)
  • The discovery of an abnormal protein that likely spurs cancer growth in children with the brain tumor ependymoma. (stjude.org)
  • Individuals with Alzheimer's disease develop plaques in their brains made of abnormal clumps of protein. (stjude.org)
  • A new study by Michael R. Kreutz's group at the Leibniz Institute of Neurobiology Magdeburg (LIN) reveals a mechanism by which the activity of synapses controls the protein levels of a de novo DNA methylating enzyme. (bionity.com)
  • In order to degrade the enzyme in a targeted manner, it interacts with a protein that is biochemically tagged with a modification called neddylation. (bionity.com)
  • Alzheimer's disease (AD) is characterized by a decrease in the enzymatic activity of the enzyme acetylcholinesterase (AChE). (nih.gov)
  • For the first time, scientists have found a connection between abnormalities in how the brain breaks down glucose and the severity of the signature amyloid plaques and tangles in the brain, as well as the onset of eventual outward symptoms, of Alzheimer's disease. (nih.gov)
  • Researchers measured glucose levels in different brain regions, some vulnerable to Alzheimer's disease pathology, such as the frontal and temporal cortex, and some that are resistant, like the cerebellum. (nih.gov)
  • and individuals without symptoms during life but with significant levels of Alzheimer's pathology found in the brain post-mortem. (nih.gov)
  • They found distinct abnormalities in glycolysis, the main process by which the brain breaks down glucose, with evidence linking the severity of the abnormalities to the severity of Alzheimer's pathology. (nih.gov)
  • More severe reductions in brain glycolysis were also related to the expression of symptoms of Alzheimer's disease during life, such as problems with memory. (nih.gov)
  • For some time, researchers have thought about the possible links between how the brain processes glucose and Alzheimer's," said NIA Director Richard J. Hodes, M.D. "Research such as this involves new thinking about how to investigate these connections in the intensifying search for better and more effective ways to treat or prevent Alzheimer's disease. (nih.gov)
  • While similarities between diabetes and Alzheimer's have long been suspected, they have been difficult to evaluate, since insulin is not needed for glucose to enter the brain or to get into neurons. (nih.gov)
  • They found that the activities of enzymes controlling these key glycolysis steps were lower in Alzheimer's cases compared to normal brain tissue samples. (nih.gov)
  • Furthermore, lower enzyme activity was associated with more severe Alzheimer's pathology in the brain and the development of symptoms. (nih.gov)
  • They found that GLUT3 levels were lower in brains with Alzheimer's pathology compared to normal brains, and that these levels were also connected to the severity of tangles and plaques. (nih.gov)
  • These findings point to a novel mechanism that could be targeted in the development of new treatments to help the brain overcome glycolysis defects in Alzheimer's disease," said Thambisetty. (nih.gov)
  • The researchers cautioned that it is not yet completely clear whether abnormalities in brain glucose metabolism are definitively linked to the severity of Alzheimer's disease symptoms or the speed of disease progression. (nih.gov)
  • The next steps for Thambisetty and his team include studying abnormalities in other metabolic pathways linked to glycolysis to determine how they may relate to Alzheimer's pathology in the brain. (nih.gov)
  • A recent study suggests the enzyme might also play a role in Alzheimer's disease. (stjude.org)
  • This is the first time this enzyme has been linked to Alzheimer's disease. (stjude.org)
  • The Alzheimer's Society states that "wet brain" may afflict about two per cent of the general population. (dualdiagnosis.org)
  • The current study has examined the effects of moderate maternal exposure to EtOH (10 % v/v in the drinking water) throughout gestation, or gestation and lactation, on crucial 21-day-old offspring Wistar rat brain parameters, such as the activities of acetylcholinesterase (AChE) and two adenosine triphosphatases (Na(+),K(+)-ATPase and Mg(2+)-ATPase), in major offspring CNS regions (frontal cortex, hippocampus, hypothalamus, cerebellum and pons). (gla.ac.uk)
  • Acetylcholinesterase (AChE) activity levels can be used as an indicator for AChE inhibition due to pesticide poisoning in bird species. (scielo.br)
  • Roberson said researchers saw a reduction in activity by the enzyme acetylcholinesterase, a key to controlling electrical impulses in the brain. (veteransforcommonsense.org)
  • In addition, glutathione peroxidase activity was significantly elevated in Epo-treated animals compared to saline-treated animals and the control group. (deu.edu.tr)
  • Modulation of tight junction structure in blood-brain barrier endothelial cells. (worthington-biochem.com)
  • Characterization of endothelin-converting enzyme from endothelial cells and rat brain: detection of the formation of biologically active endothelin-1 by rapid bioassay. (aspetjournals.org)
  • Using the endothelin-1 (ET-1)-stimulated elevation in cGMP in LLC-PK1 cells as a biological detector system for the conversion of big ET-1 (bET-1) to ET-1, we detected bET-1-converting activities in subcellular fractions from bovine aortic cultured endothelial cells (BAE) and rat brain. (aspetjournals.org)
  • These results show the presence of at least two different endothelin-converting enzyme activities in endothelial cells and a third within the rat brain. (aspetjournals.org)
  • It also reflects changes in brain neurotransmitter. (ijpsonline.com)
  • Magnesium is involved in over 300 biochemical reactions in the body, including neurotransmitter, enzyme and hormonal activity. (davidwolfe.com)
  • To address this issue, we evaluated behavioral responses, assessed neuronal function and integrity, and conducted a comprehensive analysis of mitochondria-related parameters in selected brain regions of aged (24 months old) male rats supplemented with testosterone propionate (TP). (aging-us.com)
  • Hence, a need was felt to investigate a effect of sublethal exposure of Organ chlorine pesticide Lindane to enzyme content of GOT, GPT, ALP, ACP and LDH in the liver, muscle and brain of freshwater fish Cyprinus carpio . (pharmaresearchlibrary.com)
  • It was found that GOT, GPT and LDH increased to the maximum level (after Lindane exposure) when compared to the controls (100%) and ACP,ALP were decreased from the control at 10, 20 and 30 days in the liver, muscle and brain, respectively at LC 50 exposure. (pharmaresearchlibrary.com)
  • Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations. (greenmedinfo.com)
  • However, related studies are absent on which link in the acupuncture will motivate the regulation of the synthesis and release of NO. In this study, we try to observe the influence of electroacupuncture (EA) on the NO concentration and BP in the liver tissue of the mice through inhibiting the activity of eNOS and discuss the relationships between NO levels and hepatic blood perfusion (HBP) regulation by EA. (hindawi.com)
  • We aimed to examine whether ROT-induced oxidative stress could be counteracted by cranberry juice not only in the brain but also in the liver and kidney. (cranberryinstitute.org)
  • The highest concentration is in the kidney, but the liver is considered the source of normal enzyme activity. (medscape.com)
  • Although biopsy is unnecessary, Gaucher cells-lipid-laden tissue macrophages in the liver, spleen, lymph nodes, bone marrow, or brain that have a wrinkled tissue-paper appearance-are diagnostic. (msdmanuals.com)
  • A closer look revealed a reduction in the ability of the enzyme eNOS to produce nitric oxide (NO), a potent signal for blood vessels to dilate. (nih.gov)
  • When the amino acid L-arginine, which can increase eNOS activity and NO production, was added, the blood vessels responded normally. (nih.gov)
  • IL-17 suppressed eNOS activity and reduced NO production to restrict blood flow. (nih.gov)
  • These findings together show that a high-salt diet affects the activity of the eNOS enzyme, which in turn leads to problems with blood flow and cognition," Iadecola says. (nih.gov)
  • The study also suggests that inhibiting this pathway could help in the treatment of other conditions in which abnormal proteins accumulate in the brain. (genengnews.com)
  • This should help us to understand how abnormal NF-κB activity drives cancer. (stjude.org)
  • Defects in one of many of the mitochondrial enzymes involved in energy metabolism may demonstrate similar brain pathology. (medscape.com)
  • Mutations in genes encoding any of the 3 pyruvate dehydrogenase complex (PDHC) enzymes are inborn errors of mitochondrial energy metabolism. (medscape.com)
  • Recent studies at CDC, using a more sensitive enzyme-linked assay, have detected HHV-6 antibodies in more than 95% of healthy persons. (cdc.gov)
  • Method of measurement: Enzyme-linked immunosorbent assay (ELISA) kits. (who.int)
  • AChE activity levels ranged from 56.3 to 85.9 µmol/min/g of brain tissue of birds representing DVNP. (scielo.br)
  • Second, the larger amounts of tissue available from fetal monkey brain enables determinations to be carried out more readily in specified regions and subregions. (nature.com)
  • Led by Madhav Thambisetty, M.D., Ph.D., investigator and chief of the Unit of Clinical and Translational Neuroscience in the NIA's Laboratory of Behavioral Neuroscience, researchers looked at brain tissue samples at autopsy from participants in the Baltimore Longitudinal Study of Aging (BLSA), one of the world's longest-running scientific studies of human aging. (nih.gov)
  • Genetic defects of the enzyme cause glucocerebroside accumulation in tissue macrophages through phagocytosis, forming Gaucher cells. (msdmanuals.com)
  • Additionally, CJ decreased the activity of serum hepatic enzymes. (cranberryinstitute.org)
  • Our data showed a significant increase in GPx activity and decrease in serum level of MDA in Down syndrome individuals after treadmill exercise for 3 months. (who.int)
  • It has a very high catalytic activity-each molecule of AChE degrades about 25,000 molecules of acetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. (wikipedia.org)
  • The structure and mechanism of action of AChE have been elucidated from the crystal structure of the enzyme. (wikipedia.org)
  • The activity of AChE is higher in motor neurons than in sensory neurons. (wikipedia.org)
  • In accordance with a subset of AChE-R monomers that display amphiphilic properties that are upregulated in the AD brain, we demonstrate that the increase of N-AChE species is due, at least in part, to N-AChE-R variants. (nih.gov)
  • In conclusion, we demonstrate selective alterations in specific AChE variants in AD cortex, with no correlation in enzymatic activity. (nih.gov)
  • We assessed the comparative brain cholinesterase (AChE) activity level of five bird species inhabiting pesticide exposed croplands and Protected Area i.e. (scielo.br)
  • The magnitude of the energy deficit depends on the residual activity of the enzyme. (medscape.com)
  • Residual enzyme activity is highest. (msdmanuals.com)
  • Type II (acute neuronopathic) is rarest, and residual enzyme activity in this type is lowest. (msdmanuals.com)
  • The DDC gene provides instructions for making the AADC enzyme, which is important in the nervous system. (medlineplus.gov)
  • both in the brain and spinal cord (central nervous system) and in other parts of the body (peripheral nervous system). (medlineplus.gov)
  • Dudai notes that the question of how memories are retained over long periods is still unresolved: Most studies on the biological bases of long-term memory storage focused till now mostly either on simple preparations, such as the nervous systems of invertebrates, or on slices taken from a particular brain region called the hippocampus. (jpost.com)
  • It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: acetylcholine + H2O = choline + acetate It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. (wikipedia.org)
  • The hydrolysis reaction of the carboxyl ester leads to the formation of an acyl-enzyme and free choline. (wikipedia.org)
  • Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
  • These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
  • Brain mitochondrial dysfunction and reduced testosterone levels are common features of aging in men. (aging-us.com)
  • The brain cholinesterase inhibition levels under-protected ecosystems (DVNP, Bhimber) and agricultural landscape suggest insecticidal contamination and its impact on avifauna diversity. (scielo.br)
  • Lower rates of glycolysis and higher brain glucose levels correlated to more severe plaques and tangles found in the brains of people with the disease. (nih.gov)
  • Finally, the team checked blood glucose levels in study participants years before they died, finding that greater increases in blood glucose levels correlated with greater brain glucose levels at death. (nih.gov)
  • Low magnesium levels can have a huge negative impact on your mood and brain function. (davidwolfe.com)
  • Accumulation of APP across mitochondrial import channels, which varied with the severity of AD, inhibited the entry of nuclear-encoded cytochrome c oxidase subunits IV and Vb proteins, which was associated with decreased cytochrome c oxidase activity and increased levels of H 2 O 2 . (jneurosci.org)
  • Regional distribution of mitochondrial APP showed higher levels in AD-vulnerable brain regions, such as the frontal cortex, hippocampus, and amygdala. (jneurosci.org)
  • Drinking more than these levels may result in binge drinking, and if this goes on for an extensive period of time, it may lead to substance abuse, alcohol addiction or wet brain. (dualdiagnosis.org)
  • Under experimental stress, there is increased masseter activity, which returns to baseline levels upon relaxation ( 12 ). (spandidos-publications.com)
  • Chronically high cortisol levels, which are associated with stress, have been shown to kill brain cells, cause premature aging in the brain, and decrease the rate at which new brain cells are made. (chriskresser.com)
  • My question relates to cortisol levels in general, and in particular, as they relate to fatigue and brain fog. (chriskresser.com)
  • Moreover, in a zebrafish model of PDHC deficiency, the drug restored enzyme levels and alleviated symptoms of lethargy and hyperpigmentation. (medscape.com)
  • Ongoing elevated activity is due to influenza B/Victoria viruses, increasing circulation of influenza A(H1N1)pdm09 viruses, and low levels of influenza B/Yamagata and influenza A(H3N2) viruses. (cdc.gov)
  • As is true with EBV and other viruses, levels of HHV-6 antibodies do not correlate with clinical activity of the virus and may be nonspecific immune responses to a variety of stimuli. (cdc.gov)
  • The nitrate reduction activity of the microbiota in toombak is suspected to be a contributing factor to its high levels of TSNAs. (cdc.gov)
  • When APP is catabolized by other enzymatic activities (α- and Z-secretase complexes), Aβ is not produced. (frontiersin.org)
  • These effects were consistent with improved mitochondrial function, reflected by testosterone-induced increases in mitochondrial membrane potential (MMP), antioxidant enzyme (GSH-PX, catalase, and Mn-SOD) expression/activity, and mitochondrial respiratory complex activities in both brain regions. (aging-us.com)
  • by 1 hr after the injection, the activity of tryptophan hydroxylase had significantly declined in the neostriatum, hippocampus and hypothalamus as well. (erowid.org)
  • Although extensive recovery had occurred by 2 weeks, the activity of the enzyme remained significantly depressed in most regions. (erowid.org)
  • For example, 100 days after exposure, animals in the 40 percent dose group spent significantly more time in the center of their activity chambers and traveled greater distances in the chambers, McDonough said. (veteransforcommonsense.org)
  • UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer. (nih.gov)
  • The high polyphenols content of cranberry accounts for its strong antioxidant activity underlying the beneficial health effects of this fruit. (cranberryinstitute.org)
  • Substantial studies indicate that icariin may be beneficial to AD by reducing the production of extracellular amyloid plaques and intracellular neurofibrillary tangles and inhibiting phosphodiesterase-5 activity. (frontiersin.org)
  • Mutations in the DDC gene result in reduced activity of the AADC enzyme. (medlineplus.gov)
  • This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. (cancerindex.org)
  • It is generally believed that rapid and reversible DNA methylation in the brain is essential for the stability of long-term memory , but very little is known about how synaptic signals can control DNA methylation to induce permanent changes in plasticity-related gene expression. (bionity.com)
  • Research has shown that DNA methylation affects the fine-tuning of gene expression in response to neuronal activity in the brain. (bionity.com)
  • PMID 17460369 ] Angiotensin-converting enzyme gene 2350 G/A polymorphism is associated with left ventricular hypertrophy but not essential hypertension. (snpedia.com)
  • PMID 23065222 ] Association of angiotensin-converting enzyme gene 2350 G/A polymorphism with diabetic retinopathy in Chinese Han population. (snpedia.com)
  • The effect of single and repeated doses of acrylamide (a neurotoxin) and N,N'-methylene-bis- acrylamide (a non-neurotoxic analogue of acrylamide ) on glutathione (GSH), glutathione-S-transferase (GST) and dopamine receptors has been studied in rat brain. (cdc.gov)
  • Single or repeated injections of acrylamide but not of bis- acrylamide increased brain dopamine receptors (3H spiroperidol binding) in a concentration-dependent manner. (cdc.gov)
  • This enzyme helps produce dopamine and serotonin from other molecules. (medlineplus.gov)
  • Without enough of this enzyme, nerve cells produce less dopamine and serotonin. (medlineplus.gov)
  • An enzyme causes structural and functional changes in other proteins: PKMzeta, located in the synapses (the functional contact points between nerve cells) changes some facets of the structure of synaptic contacts. (jpost.com)
  • Essentially, by providing excessive cholinergic stimulation throughout fetal life, nicotine discoordinates the numerous events in cell replication, differentiation and synaptic development that are necessary to the proper assembly of the mammalian brain. (nature.com)
  • How is this enzyme regulated by synaptic activity in order to set precisely fitting epigenetic signatures in the DNA? (bionity.com)
  • In laboratory studies, St. Jude researchers found that increasing enzyme activity may reduce the number of plaques in the brain. (stjude.org)
  • The researchers found that phenylbutyrate increased PDHC enzyme activity in fibroblasts from patients with PDHC deficiency. (medscape.com)
  • The separation and identification of enolase isozymes of brain and sciatic nerve by high-pressure liquid anion-exchange chromatography. (cdc.gov)
  • The time course of these neurochemical changes was examined in several serotonergic nerve terminal regions of the brain. (erowid.org)
  • New research led by St. Jude scientists indicates that the academic struggles of some brain tumor survivors may be due to damaged "insulation" covering nerve cells in the brain. (stjude.org)
  • The connection is an enzyme that nerve cells use to recycle or dispose of unneeded proteins. (stjude.org)
  • Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. (acs.org)
  • We will illustrate by using zinc, but every nutrient is similar in that it is necessary for multiple body activities. (glutenfreeworks.com)
  • Zinc is a mineral that is involved in numerous aspects of cellular metabolism, being essential for activation of almost 200 enzymes that have vital roles in the body. (glutenfreeworks.com)
  • Zinc ion regulates the activities of several enzymes. (dojindo.com)
  • However, these changes are superimposed in individuals with reduced brain volume, especially in the hippocampus, and other developmental abnormalities, such as reduced dendritic arborizations, decreased number of spines, spine atrophy, and abnormalities of spine orientation in pyramidal neurons. (medscape.com)
  • It may be more common than appreciated, because this condition is potentially responsible for unexplained seizures, acidosis, and developmental delays in cases in which enzyme testing is not done, as well as unexplained Leigh syndrome with demonstrable CNS pathology. (medscape.com)
  • Clinical studies show that depressed patients had elevated antioxidant enzyme activity. (ijpsonline.com)
  • Type III (subacute neuronopathic) falls between types I and II in incidence, enzyme activity, and clinical severity. (msdmanuals.com)
  • Clinical examination, anthropometric measurements and determination of GPx activity and MDA before and after exercise were done. (who.int)
  • It receives blood from a vein in the nasal cavity, runs backwards, and gradually increases in size as blood drains from veins of the brain and the DURA MATER. (bvsalud.org)
  • Although testosterone supplementation in male patients was shown to improve cognitive function in AD [ 12 , 13 ], and to relieve motor and nonmotor symptoms in PD [ 14 , 15 ], it remains unclear whether testosterone beneficially influences mitochondrial function in the aging brain. (aging-us.com)
  • PMID 21258267 ] Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage. (snpedia.com)
  • Because influenza activity is elevated and both influenza A and B virus infections can cause severe disease and death, this health advisory also serves as a reminder that early treatment with antiviral medications improves outcomes in patients with influenza. (cdc.gov)
  • CFS may vary widely in severity, but many patients have become severely disabled and are unable to work or even to participate in many routine activities of daily living for prolonged periods. (cdc.gov)
  • Studies in developing rodents indicate that nicotine is a neuroteratogen that disrupts brain development by stimulating nicotinic acetylcholine receptors (nAChRs) that control neural cell replication and differentiation. (nature.com)
  • In addition to these symptoms, it is important to emphasize that persons who suffer from Wet brain due to prolonged alcohol consumption also experience alcohol withdrawal symptoms, including tremors, sweating, and other unpleasant effects caused by brain damage. (dualdiagnosis.org)
  • Exposure to ethanol during neurodevelopment modifies crucial offspring rat brain enzyme activities in a region-specific manner. (gla.ac.uk)
  • In separate Army-sponsored studies, scientists observed behavioral problems, brain changes and immune system suppression in the animals many days after exposure to doses that caused no immediate effects, such as convulsions or pupil constriction. (veteransforcommonsense.org)
  • Dr. Robert Haley, an epidemiologist at University of Texas Southwestern Medical Center at Dallas, has published almost two dozen studies suggesting that some Gulf War veterans' illnesses are linked to brain damage resulting from exposure to toxins such as sarin. (veteransforcommonsense.org)
  • Despite this increase in occurrences, our understanding of the effects of blast and the mechanisms behind subsequent brain injury remains limited ( 3 , 4 ). (frontiersin.org)
  • Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. (inchem.org)
  • Studies have also linked salt intake with brain health, but the mechanisms involved are poorly understood. (nih.gov)
  • Conclusions: These results suggest that Epo exerts neuroprotective effects against hypoxic-ischemic brain injury at least partially via the modulation of antioxidant enzyme activity. (deu.edu.tr)
  • Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. (cancerindex.org)
  • The enzyme catalyzes the transfer of the gamma-glutamyl group from gamma-glutamyl peptides, such as glutathione to an acceptor such as peptides and L-amino acids. (medscape.com)
  • Yan W , Zhang T , Kang Y , Zhang G , Ji X , Feng X , Shi G , . Testosterone ameliorates age-related brain mitochondrial dysfunction. (aging-us.com)
  • Although evidence suggests that the two phenomena are interrelated, it is unclear whether testosterone supplementation ameliorates mitochondrial dysfunction in the aging male brain. (aging-us.com)
  • These findings suggest that testosterone supplementation may be a viable approach to ameliorating brain mitochondrial dysfunction and thus prevent or treat cognitive-behavioral deficits and neurodegenerative conditions associated with aging. (aging-us.com)
  • Notwithstanding, there is a paucity of research on the effects of testosterone supplementation on age-related mitochondrial dysfunction in the brain. (aging-us.com)
  • Phthalates may affect the activity of aromatase, an enzyme that converts testosterone into estrogen. (sott.net)
  • Assays of the compound's activity against a panel of key enzymes identified only one significant association-a weak but selective inhibition of SIRT2, which is known to regulate the cell cycle and may have a role in aging. (genengnews.com)
  • An experiment using RNAi to suppress SIRT2 and a related enzyme in human cell lines expressing alpha-synuclein confirmed that only the inhibition of SIRT2 reduced alpha-synuclein toxicity. (genengnews.com)
  • Magnetic resonance imaging of the brain performed on the affected twin at 19 months of age showed severely hypoplastic or absent CN IV bilaterally, left CN VI smaller than right, and bilateral hypoplastic CN VII and IX, consistent with a diagnosis of a CCDD, most similar to that of Moebius syndrome. (bvsalud.org)
  • The work of my small laboratory in the national program for prevention of mental retardation by early diagnosis of congenital hypothyroidism, and finally screening of early markers of initial stages of dementia en elderly people. (bvsalud.org)
  • The medium complexity level problem which is the topic of our discussion today, has to do with how to apply the knowledge we have acquired about the brain function through mass intervention diagnosis of cognitive disorders at the community level. (bvsalud.org)
  • Diagnosis is by DNA analysis and/or enzyme analysis of white blood cells. (msdmanuals.com)
  • In vitro, both acrylamide and bis- acrylamide decreased brain GSH content in a concentration-dependent manner. (cdc.gov)
  • A single dose of either acrylamide or bis- acrylamide depleted GSH content of rat brain in a concentration-dependent manner without inhibiting GST activity. (cdc.gov)
  • After eight weeks, the mouse brains showed up to a 30% reduction in blood flow compared to mice that ate a normal diet. (nih.gov)
  • Sphingolipidoses Lysosomal enzymes break down macromolecules, either those from the cell itself (eg, when cellular structural components are being recycled) or those acquired outside the cell. (msdmanuals.com)
  • Severe enzyme deficiencies may lead to congenital brain malformation because of a lack of energy during neural development. (medscape.com)
  • Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics. (worthington-biochem.com)
  • A research team led by Dr. Costantino Iadecola at Weill Cornell Medicine set out to explore the connection between a high-salt diet, TH17 cells, and brain function. (nih.gov)
  • Accumulation of Gaucher cells in the perivascular spaces in the brain causes gliosis in the neuronopathic forms. (msdmanuals.com)
  • Aβ is synthesized in the brain by the cleavage of the transmembrane amyloid precursor proteins (APP). (frontiersin.org)
  • Scientists found that a high-salt diet caused changes in the guts of mice that led to reduced blood flow in the brain and impaired cognition. (nih.gov)
  • When the mice were returned to a normal diet, both brain blood flow and cognition improved, suggesting that the effects of excessive salt consumption could be reversed. (nih.gov)
  • The scientists discovered that blood vessels from the brains of the mice fed a high-salt diet didn't dilate properly when prompted to. (nih.gov)
  • Are memories recorded in our brains as a stable physical change, like an inscription on a clay tablet? (jpost.com)
  • Since ADHD is a brain-based disorder, it makes sense that taking Vitamin B6 would work well. (progressivehealth.com)
  • Young people with the disorder sialidosis have too little enzyme. (stjude.org)
  • This brain disorder suddenly comes on and is often referred to as "alcohol-related dementia," as brain damage can result in challenges with cognition and memory functions. (dualdiagnosis.org)
  • Our previous studies have found that C. chinensis and C. campestris possess anti-inflammatory activities in rodents. (mdpi.com)
  • The problem was found in 70 percent of children with ependymomas in the front part of the brain. (stjude.org)
  • Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. (inchem.org)
  • Isolation of Primary Microglia from the Human Post-Mortem Brain: Effects of Ante- and Post-Mortem Variables. (worthington-biochem.com)
  • Adenosine to inosine editing is common in the human transcriptome and changes of this essential activity is associated with disease. (cancerindex.org)