OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
CatecholsCatechol 2,3-DioxygenaseDioxygenasesCatechol 1,2-DioxygenaseOxygenasesEstrogens, Catechol4-Hydroxyphenylpyruvate DioxygenaseProtocatechuate-3,4-DioxygenaseCysteine DioxygenaseTryptophan OxygenaseCatechol O-MethyltransferaseHomogentisate 1,2-Dioxygenase3-Hydroxyanthranilate 3,4-DioxygenasePseudomonasBiodegradation, EnvironmentalKynureninePseudomonas putidaHydroxybenzoatesRhodococcusPhenolChlorobenzenesSorbic AcidCatechol OxidaseTryptophanChlorobenzoatesTolueneBenzoatesMixed Function OxygenasesSphingomonasBurkholderiaSubstrate SpecificityMolecular Sequence DataBenzoic AcidGentisatesAlcaligenesBenzeneAdipatesEquileninComamonasGenes, BacterialHomogentisic AcidOxidation-ReductionAcinetobacterPyrogallolBrevibacteriumHydrocarbons, AromaticPhenolsRalstoniaHydroquinonesAmino Acid SequencePlanococcus BacteriaIronHydroxylationCloning, MolecularParabensPolychlorinated BiphenylsGram-Negative Aerobic Rods and CocciFerredoxinsKineticsCresolsBurkholderiaceae3-Hydroxyanthranilic Acidgamma-Butyrobetaine DioxygenaseArthrobacterAlkaptonuriaXylenesKetoglutaric AcidsBiphenyl CompoundsSalicylatesEscherichia coliIntramolecular LyasesFerrous CompoundsToluidinesEnzyme Inductionortho-AminobenzoatesVanillic AcidBiotransformationBacterial ProteinsSulfanilic AcidsPhenanthrenesBase SequenceIron-Sulfur ProteinsSequence Homology, Amino AcidNaphthalenesBenzene DerivativesHydroxyestronesQuinolinic AcidSpectrophotometryPseudomonas stutzeriDelftia acidovoransElectron Spin Resonance SpectroscopyChlorophenolsAcinetobacter calcoaceticusChromatography, High Pressure LiquidOxidoreductases3,4-Dihydroxyphenylacetic AcidSequence Analysis, DNAMultigene FamilyBurkholderia cepaciaOxygen
CatabolicGeneAromaticSubstrates2021Inhibitors2019PurificationPseudomonasRecombinantEndogenousSubstrateImmunosorbentKEGGOxidoreductaseProteinSynthesisAminoReactionDegradationSilkwormBioremediationMetabolicWastewaterCDNAProteinsInhibitsAcetylOxygenCompoundsPyrene2022BiologyFormulaRegulationAcidReductionContaminantsTemperatureMicrobiologyHazardousBiosynthesisPathway
Catabolic4
  • The second ben/cat operon was located in a 92-kb scaffold along with (i) an operon ( opp ) comprising genes for the transformation of OPP to BA and 2-hydroxypenta-2,4-dienoate (and genes for its transformation) and (ii) an incomplete biphenyl catabolic operon ( bph ). (nature.com)
  • Proteomics identified 13 up-regulated catabolic proteins when S. haloaromaticamans was growing on OPP and/or BA. (nature.com)
  • The existence of catabolic and surfactant genes namely catechol dioxygenase ( C23O ), rhamnolipid enzyme ( rhlB ) and surfactin /lichenysin enzyme ( SrfA3 /LicA3 ) genes were detected in only four (4) out of the nine (9) marine aromatic degrading bacteria with 881 base pairs sizes. (journalarrb.com)
  • An analysis of the genome and its transcriptome revealed enzymes with biotechnological potential, such as two extracellular tannases (Atan1p and Atan2p) of the tannic-acid catabolic route, and a new pathway for the assimilation of n-butanol via butyric aldehyde and butyric acid. (biomedcentral.com)
Gene7
  • Moreover, a dioxygenase gene, nidA3B3, was detected in Mycobacterium vanbaalenii PYR-1 as an alternate degradation pathway which could catalyze both the initial dihydroxylation of pyrene [ 11 ] to be pyrene cis-4,5-dihydrodiol, and an alternate detoxification pyrene pathway to be pyrene cis-1,2-dihydrodiol [ 12 ]. (omicsonline.org)
  • 6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
  • Each enzyme entry contains its common name and synonym, reaction in which enzyme is involved, family and subfamily, structure and gene link and literature citation. (biomedcentral.com)
  • Complementation of the E. coli phr-1 mutation was observed, strongly suggesting that the yeast PHR1 gene encodes a. (shengsci.com)
  • Catechol 2,3-dioxygenase (C23O) gene was found andamplified with the designed primers from the total DNA of C-14-1. (researchgate.net)
  • The result of Southern blot indicated that there isonly one C23O gene in the genome of C-14-1. (researchgate.net)
  • The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)
Aromatic6
  • Polycyclic aromatic hydrocarbons (PAHs) are one class of organic pollutants that are considered the most hazardous due to their toxic, mutagenic, and carcinogenic properties [ 1 ]. (omicsonline.org)
  • PAHs could be degraded by bacteria under aerobic conditions through the initial oxidation of the aromatic ring, which is catalyzed by the dioxygenase enzyme. (omicsonline.org)
  • A number of bacteria that can degrade a variety of aromatic compounds have been identified and the pathways involved in the degradation have been extensively characterized [ 3 , 4 ]. (biomedcentral.com)
  • In the convergent mode, structurally diverse aromatic compounds are converted to one of a few aromatic ring cleavage substrates such as catechol, gent sate, protocatechuate and their derivatives [ 5 ]. (biomedcentral.com)
  • Peripheral enzymes, particularly oxygenases and dehydrogenases, were found to transform structurally diverse substrates into one of these central intermediates by bringing about the hydroxylation of the aromatic nucleus (Fig. 2A ), and hence it is thought that bacteria have developed these enzymes to extend their substrate range [ 5 ]. (biomedcentral.com)
  • Some of the enzymes which generate aromatic radicals that break down most prominent bacterial strains found were isolated and tax- the complex linkages present in lignin to compounds of lower onomically identified using 16S ribosomal RNA (rRNA) se- molecular weight. (lu.se)
Substrates2
20211
Inhibitors1
  • In vitro production of enzymatically active O. volvulus prolyl 4-hydroxylase should facilitate identification of specific inhibitors of the parasite enzyme. (embl.de)
20191
  • The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). (bvsalud.org)
Purification3
Pseudomonas2
Recombinant1
  • An A. salmonicida genomic DNA library was constructed by using lambda GEM-11 and recombinant phage carrying both genes ompAI and ompAII) selected by immunoscreening. (shengsci.com)
Endogenous2
  • Particularly, a Western blot of normal ws-PrP (ws-PrPC) and disease-associated ws-PrP (ws-PrPSc) [3] displayed a glycotyping that was different from that of the classical PrPC and PrPSc, showing a slightly faster migration mobility and a diglycoslated band with higher propensity to degradation by endogenous enzymes. (tam-receptor.com)
  • Cell culture and in vitro studies show that fenretinide binds and inhibits the activity of ß-carotene oxygenase 1 (BCO1), the enzyme responsible for endogenous vitamin A formation. (bvsalud.org)
Substrate3
  • Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. (lookformedical.com)
  • The substrate specificity of catechol oxidase from Lycopus europaeus towards phenols is examined. (lookformedical.com)
  • this file supplies the natural data of preliminary experiments performed using 2 enzyme dilutions in order to discover out the dilution that greatest fitted with requirements 1 and 2 described in the outcomes portion of the manuscript (automated sugars releasing assay: substrate focus). (tam-receptor.com)
Immunosorbent4
  • This competitive enzyme-linked immunosorbent assay-like method, used competitive binding of free hyaluronan in the sample and biotin-labeled standard hyaluronan to hyaluronan binding protein in solid phase. (go.jp)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
  • The detection and quantitation method consists of an enzyme-linked immunosorbent assay ( ELISA ). (kits-elisa.com)
KEGG1
  • The entries are also linked to several external database including BRENDA, KEGG, ENZYME and UM-BBD providing wide background information. (biomedcentral.com)
Oxidoreductase1
  • An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. (lookformedical.com)
Protein6
  • The enzyme contained 2 g-atoms of iron per mol of protein. (shengsci.com)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)
  • Mouse monoclonal to NCOR1 water-soluble form of the prion protein (ws-PrP) in blood plasma and brain of Syrian hamster [3]. (tam-receptor.com)
  • A correlation network between DFS-SEs of splicing factors and non-splicing factors was constructed to determine the potential mechanisms in PRAD, which included the potential regulatory interaction between the splicing event of splicing factor RNA binding motif protein 5-alternate terminator (AT)-64957 and the splicing event of non-splicing factor heterochromatin protein 1 binding protein 3-AT-939. (spandidos-publications.com)
  • Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)
Synthesis2
  • Further, the centralized degradation pathways mean synthesis of fewer degradative enzymes requiring less metabolic energy. (biomedcentral.com)
  • Because levodopa bypasses the enzyme tyrosine hydroxylase , the rate-limiting step in dopamine synthesis, it is much more readily converted to dopamine than tyrosine, which is normally the natural precursor for dopamine production. (cloudfront.net)
Amino3
  • The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)
  • The present invention is extra directed to a package deal and a means for detecting the presence and determining focus of an antibody that inhibits HIV-1 fusion-associated epitope, a peptide on gp41 with the amino acid sequence represented by GCSGKLIC. (kits-elisa.com)
  • l -3,4-dihydroxyphenylalanine , is an amino acid that is made and used as part of the normal biology of some plants [3] and animals, including humans. (cloudfront.net)
Reaction2
  • Expressed sequence tag (EST) analysis and developmental polymerase chain reaction (PCR) studies demonstrated that Ov-phy-1 was expressed in L3 and adult parasites. (embl.de)
  • In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone. (qmul.ac.uk)
Degradation1
  • Based on the complexity of the degradation pathways, the phenomenon of biodegradation is categorized into two types: convergent and divergent modes of degradation (Fig. 1 ). (biomedcentral.com)
Silkworm2
  • Prophenoloxidase-activating enzyme of the silkworm, Bombyx mori. (lookformedical.com)
  • Prophenoloxidase-activating enzyme (PPAE) was purified to homogeneity as judged by SDS-polyacrylamide gel electrophoresis from larval cuticles of the silkworm, Bombyx mori. (lookformedical.com)
Bioremediation1
Metabolic1
  • Here, we focus on the recently obtained knowledge considering structural genes as well as transcriptional and post-translational regulators involved in the metabolic pathways underlying both appearance and internal quality such as those involved in chlorophyll, carotenoid, cell wall, central and secondary metabolism (Table 1 , Figure 1 ). (biomedcentral.com)
Wastewater2
  • Its application results in the production of large wastewater volumes which require treatment on site 2 . (nature.com)
  • An aerobic bacterial strain C-14-1 was isolated from an acrylic fiber wastewater. (researchgate.net)
CDNA1
  • A full-length cDNA (Ov-phy-1) encoding a catalytically active alpha-subunit of Onchocerca volvulus prolyl 4-hydroxylase was isolated and characterized. (embl.de)
Proteins1
Inhibits1
  • Coumaran (2,3-dihydrobenzofuran), a secondary metabolite of Cyperus nipponicus , inhibits the feeding of polyphagous insects. (go.jp)
Acetyl1
  • The 2,3-dihydrobenzofuran derivative, 7-acetyl-4,6-dimethoxy-2-isopropenyl-2,3-dihydrobenzofuran, had an ED 50 value of 1.3 μg (5.4×10 -9 mol)/cm 2 against the common cutworm. (go.jp)
Oxygen1
Compounds3
  • low-molecular-weight (LMW) compounds consist of two or three rings, and high-molecular-weight (HMW) compounds, more than three rings [ 3 ]. (omicsonline.org)
  • Many of these compounds have been reported to be toxic to the living organisms [ 3 ]. (biomedcentral.com)
  • A survey of agricultural technologies influencing the biosynthesis and accumulation of phenolic compounds in crop plants is presented, including observations on the effects of light, temperature, mineral nutrition, water management, grafting, elevated atmospheric CO 2 , growth and differentiation of the plant and application of elicitors, stimulating agents and plant activators. (mdpi.com)
Pyrene1
  • Three of the set ups were supplemented each with 1 mg /L of xylene, anthracene and pyrene. (journalarrb.com)
20221
Biology2
Formula1
  • A group of 1,2-benzenediols that contain the general formula R-C6H5O2. (lookformedical.com)
Regulation1
  • Alternative sites for cell density regulation of the enzyme could rely on its sensitivity to sulfhydryl groups. (embl.de)
Acid1
  • However, further conversion of these intermediates into tricarboxylic acid (TCA) cycle intermediates was found to be highly diverged (divergent mode) (Fig. 1 ). (biomedcentral.com)
Reduction2
  • this has seen reduction in SO 2 emissions across Europe by more than 60% between 1990 and 2004 (Vestreng et al. (springer.com)
  • reproductive enthusiastic feed 's the Common reduction of 1,3-diaminobenzenes from entirely gradual risks. (xn--drpverein-rahe-vpb.de)
Contaminants1
  • Consequently, the World Health Organisation (WHO) and other environmental agencies have established guidelines for air pollution for a range of contaminants (Table 1 ). (springer.com)
Temperature2
  • Specific activities of Catechol-2,3-dioxygenase and effects of temperature and pH and their stabilities on the enzyme relative activities were observed. (openmicrobiologyjournal.com)
  • METHODS: Seawater samples were collected from Labrador Sea Water (LSW, ~ 2000 m depth) in the North Atlantic and incubated in the dark at in situ temperature unamended, amended with 1 µM thiosulfate, or with 1 µM thiosulfate plus 10 µM glucose and 10 µM acetate (thiosulfate plus dissolved organic matter, DOM). (bvsalud.org)
Microbiology2
Hazardous2
Biosynthesis1
  • The enzyme responsible for collagen maturation is prolyl 4-hydroxylase, making this enzyme a central activity in cuticle biosynthesis and a potentially important chemotherapeutic target. (embl.de)
Pathway2
  • The pcaH was significant in the β-ketoadipate pathway [9] where the pathway as it conserves biochemically, and is a major class of non-heme-iron containing dioxygenase [ 10 ]. (omicsonline.org)
  • In this divergent mode, a metal-dependent dioxygenase channels these dihydroxylated intermediates into one of the two possible pathways: the meta -cleavage pathway or the ortho -cleavage pathway [ 7 - 9 ] (Fig. 1 ). (biomedcentral.com)