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  • reactivity
  • It is well documented in the medical literature that the major factors in mercury toxicity effects, in addition to dose, are susceptibility factors-immune reactivity degree of other toxic exposures and synergisms, systemic detoxification ability based on blood allele type or metallothionein function, sulfur detoxification deficiencies, or other inhibited enzymatic processes related to detoxification or methylation. (amalgam.org)
  • pathways
  • The sequence of steps in new degradative pathways is dictated by the repertoire of enzymes in exposed microbes and/or microbial communities that can catalyze newly needed reactions. (pnas.org)
  • substrate
  • Enzymes employ many different schemes to use dioxygen, and this largely depends on the substrate and reaction at hand. (wikipedia.org)
  • The majority of dioxygenases fully incorporate dioxygen into a single substrate, and a variety of cofactor schemes are utilized to achieve this. (wikipedia.org)
  • Further classification into mono- and dioxygenases in based on whether the enzyme causes transfer of just one atom to the substrate (S) (eq. 1) or whether the whole molecule is incorporated into a single substrate (eq. 2a) or is shared by a pair of substrates (S, S′) (eq. 2b) ( 1, 2 ) 1 . (springer.com)
  • a non-heme iron dioxygenase with broad substrate tolerance. (cbrc.jp)
  • Using O-18 isotopes, he found that oxygen atoms incorporated in the product came entirely from O 2 and not at all from H 2 O. His discovery and a concurrent independent discovery by Howard Mason at the University of Oregon Medical School of incorporation of an atom of molecular oxygen into a substrate by mushroom phenolase were milestones in the understanding of how oxygen is utilized in biological systems. (asbmb.org)
  • selective
  • Examples of recent gene duplication events in signaling as well as dioxygenase clusters are present, indicating selective gene family expansion as a relatively recent event in D. aromatica 's evolutionary history. (biomedcentral.com)
  • Pathway
  • It follows the above pathway through 2-hydroxybenzimidazole. (ethz.ch)
  • The pathway followed is the same as for the above two organisms, through 2-hydroxybenzimidazole. (ethz.ch)
  • When grown on salicylate, P. cepacia induces only the catechol ortho pathway by its induction of catechol 1,2-dioxygenase. (springer.com)
  • 2-Naphthoate catabolic pathway in Burkholderia strain JT 1500. (genome.jp)
  • Molecular Oxygen
  • Turro, N. J., V. Ramamurthy, K.-C. Liu, A. Krebs and R. Kemper: Reaction of Strained Acetylenes with Molecular Oxygen. (springer.com)
  • Schmitt, R. J., V. M. Bierbaum, and C. H. Depuy: Gas-Phase Reactions of Carbanions with Triplet and Singlet Molecular Oxygen. (springer.com)
  • metalloenzymes
  • Blomberg, M.R.A., Siegbahn, P.E.M.: A quantum chemical approach to the study of reaction mechanisms of redox-active metalloenzymes. (springer.com)
  • A class of natural metalloproteins called metalloenzymes is able to carry out extremely specific reactions under physiological conditions (between 10 and 40 °C for most of them). (rsc.org)
  • detoxification
  • The principal physiological function of glyoxalase I is the detoxification of methylglyoxal, a reactive 2-oxoaldehyde that is cytostatic at low concentrations and cytotoxic at millimolar concentrations. (wikipedia.org)
  • molecule
  • OTA is composed of a 7-carboxy-5-chloro-8-hydroxy-3,4-dihydro-3- R -methylisocoumarin (ochratoxin α) moiety and a L- β -phenylalanine molecule, which are linked through the 7‑carboxy group by an amide bond. (mdpi.com)
  • There are two chiral centers on the molecule on carbons 2 and 3. (wikipedia.org)
  • tetralin
  • The Sphingomonas macrogolitabida strain TFA is a gram-negative bacterium that is able to grow on tetralin (1,2,3,4-tetrahydronaphthalene) as the only carbon and energy source ( 14 ). (pubmedcentralcanada.ca)
  • structural
  • This widespread structural motif is called the 2-His-1-carboxylate facial triad, and is found in many metalloproteins. (rsc.org)
  • sole carbon and energy
  • strain Rue61a is an isolate from sewage sludge able to utilize quinaldine (2-methylquinoline) as sole carbon and energy source. (biomedcentral.com)
  • SG-4G is capable of using carbendazim, 2-aminobenzimidazole, and 2-hydroxybenzimidazole as sole carbon and energy sources for growth. (ethz.ch)
  • proteins
  • Many of the biosynthetic reactions of carotenoids involve diiron proteins (common in fatty acid desaturases) and cytochrome p450 (common in sterol biosyntheis). (bris.ac.uk)