Enzymatic methylation of arsenic compounds. Medical search. Frequent questions

Aposhian HV (1997) Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. (springer.com)

1999. Arsenic: health effects, mechanisms of actions, and research issues. (cdc.gov)

1997. Effect of arsenic (V)-chromium (III) interaction on plasma glucose and cholesterol levels in growing rats. (cdc.gov)

Chen CJ, Chen CW, Wu MM, Kuo TL (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. (springer.com)

Resveratrol is a well-known polyphenolic compound that is reported to reduce As 2 O 3 -induced cardiotoxicity. (springer.com)
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)

In mammalian cells, histone H3 Lys 9 (H3K9) methylation and histone hypoacetylation are usually associated with methylated DNA, heterochromatin, and gene silencing. (aacrjournals.org)

Arsenite methyltransferase (EC 2.1.1.137, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, methylarsonite methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:arsenite As-methyltransferase. (wikipedia.org)
Chen B, Arnold LL, Cohen SM, Thomas DJ, Le XC (2011) Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. (springer.com)

Cadmium, lead, mercury and arsenic in animal feed and feed materials-trend analysis of monitoring results. (sciendo.com)

In contrast, some studies have reported that EPA and DHA can make cell membranes more susceptible to non-enzymatic oxidation mediated by reactive oxygen species, leading to the formation of potentially toxic oxidation products and increasing the oxidative stress. (nutrition-evidence.com)

1976. Intracellular effects of chronic arsenic administration on renal proximal tubule cells. (cdc.gov)
Exposure to arsenic causes renal cancer. (springer.com)
On the sixth day, the cats were killed to determine the histological renal damage, renal function, the accumulation of arsenic, and antioxidant activities in the kidney. (springer.com)
The concentrations of renal malondialdehyde, reactive oxygen species, 8-hydroxydeoxyguanosine, serum creatinine, blood urea nitrogen, and renal arsenic accumulation were significantly decreased and reduced renal morphologic injury was observed compared with the As 2 O 3 -treated group. (springer.com)
These results demonstrate that resveratrol could significantly scavenge reactive oxygen species, inhibit As 2 O 3 -induced oxidative damage, and significantly attenuate the accumulation of arsenic in renal tissues by facilitating As 2 O 3 metabolism. (springer.com)

Arsenic trioxide (As 2 O 3 ) is an environmental toxicant and a potent antineoplastic agent. (springer.com)
Recent advances in understanding the role that epigenetics plays in cancer pathogenesis and understanding the mechanisms through which these processes regulate gene expression have stimulated considerable interest in developing clinically viable antineoplastic agents that target enzymatic components of transcriptional regulatory complexes responsible for the establishment of pathologic epigenetic modifications that lead to deregulated gene expression in cancer. (aacrjournals.org)

This means that oxide levels increase, such as hydrogen peroxide, putting toxic stress on your other enzymatic pathways, including the methylation cycle, liver detox phases, and in the mitochondria (energy production). (ourkidsasd.com)
Some elements and compounds used in industry cause local damage in the digestive system affecting, for example, the mouth and neighbouring area, stomach, intestine, liver or pancreas. (cloudaccess.net)
Severe gastro-intestinal syndromes, such as those due to phosphorus, mercury or arsenic are manifested by vomiting, colic, and bloody mucus and stools and may be accompanied by liver damage (hepatomegalia, jaundice). (cloudaccess.net)

The universal soldier: enzymatic and non-enzymatic antioxidant functions of serum albumin. (sciendo.com)

Enzymatic colorimetric method for the determination of inorganic phosphorus in serum and urine. (sciendo.com)

In the resveratrol + As 2 O 3 -treated group, activities of glutathione peroxidase, catalase, and superoxide dismutase, the ratio of reduced glutathione to oxidized glutathione, the total arsenic concentrations, and the percentage of methylated arsenic in urine were significantly increased. (springer.com)
Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization, and the promotion percentage under non-flooded conditions were significantly higher than that under flooded conditions. (bvsalud.org)

Histone hyperacetylation and H3K4 methylation are associated with unmethylated DNA, euchromatin, and gene expression ( Fig. 2 ). (aacrjournals.org)

Chen SC, Chen CC, Kuo CY, Huang CH, Lin CH, Lu ZY, Chen YY, Lee HS, Wong RH (2012) Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes. (springer.com)
The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
Herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with straw-derived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440 (GE P. putida). (bvsalud.org)

Arsenic methylation contributes to the formation and diversity of environmental organoarsenicals, an important process in the arsenic biogeochemical cycle. (bvsalud.org)
Cobalamin synthesis is an extremely complex process which involves over 30 enzymatic steps and scientists still don't understand many details associated with it. (healthaid.co.uk)

Cobalamin is such a unique and complex compound that no scientist in the lab is able to make it and for this reason it is often referred to as "the Mount Everest of biosynthetic problems. (healthaid.co.uk)

The present study aimed to investigate the effect of resveratrol on As 2 O 3 -induced nephrotoxicity and arsenic metabolism. (springer.com)

Examination of aminophenol-containing compounds designed as antiproliferative agents and potential atypical retinoids. (yale.edu)
Arsenic (As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under flooded conditions. (bvsalud.org)
Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-flooded conditions. (bvsalud.org)

Deletion of the additional 37 residues restored As(III) methylation activity. (bvsalud.org)

1992. Arsenic induced and enhances rat hepatic metallothionein production in vivo. (cdc.gov)

In that same article, I discuss that beyond the chemical toxins mold produces (mycotoxins) to lay claim on that piece of decaying matter, there are a whole host of other inflammagens that mold and bacteria emit that make a person with CIRS sick - Beta Glucans, Volatile Organic Compounds (VOC), Lipopolysaccharides (LPS), etc. (biotoxinjourney.com)
Endocrine-disrupting chemicals (EDCs) comprise a diverse group of naturally occurring and synthetic compounds that mimic and interfere with the endogenous chemical hormones. (intechopen.com)

In acute promyelocytic leukemia (APL), "differentiation therapy" using all-trans retinoic acid and arsenic trioxide releases the differentiation block and is curative in most patients, but treatments to promote differentiation have not emerged clinically in most other leukemia subtypes 11 . (nature.com)
We recently demonstrated that human primary macrophages constituted a critical target for arsenic trioxide (As 2 O 3 ), an inorganic trivalent form. (aai.org)
arsenic trioxide 07. (tendersinkarnataka.com)

Arsenite methyltransferase (EC 2.1.1.137, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, methylarsonite methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:arsenite As-methyltransferase. (wikipedia.org)
Using highly purified arsenic methyltransferase from rabbit liver and the partially purified enzyme from Chang human liver hepatocytes, the activity of methylarsonic acid (MMAV) and methylarsonous acid (MMAIII) as a substrate has been characterized by Michaelis-Menten kinetics. (nih.gov)
Although investigators have been unable to detect the arsenic methyltransferase in surgically removed human liver, its presence in Chang human hepatocytes now has been established. (nih.gov)
While limitations in the supply of methyl groups appear to be a common mechanism, available data suggest that other factors determining DNA methylation, including DNA methyltransferase (Dnmt), may be influenced by bioactive food components. (nih.gov)

Alternatively, the S21 phosphorylated EZH2 may impact the assembly mechanics of other epigenetic regulatory complexes, such TC-E 5001 as those involved in methylation and demethylation on the lysine 4, lysine 9 or lysine 36 of the histone H3 proteins. (mdm2-inhibitors.com)

The process of biotransformation, i.e., the enzymatic alteration of foreign or xenobiotic compounds, is conventionally divided into two phases. (cdc.gov)

The approach is to encourage collaboration between nutrition and epigenetic /DNA methylation experts to study bioactive food components with cancer preventative properties, and to examine key epigenetic events in cancer processes (i.e., carcinogen metabolism, cell division, differentiation, apoptosis) so that investigators can begin to establish linkages between epigenetics, methylation pattern, and tumor incidence/behavior. (nih.gov)
Preclinical and clinical studies provide intriguing evidence that part of the anticancer properties attributed to several bioactive food components, encompassing both essential and non-essential nutrients, may relate to DNA methylation patterns. (nih.gov)

1997. Effect of arsenic (V)-chromium (III) interaction on plasma glucose and cholesterol levels in growing rats. (cdc.gov)

Inorganic arsenic is an immunotoxic environmental contaminant to which millions of humans are chronically exposed. (aai.org)

1992. Arsenic induced and enhances rat hepatic metallothionein production in vivo. (cdc.gov)
12. Suppression of oxidative stress in aging NZB/NZW mice: effect of fish oil feeding on hepatic antioxidant status and guanidino compounds. (nih.gov)

In the second step, possible RDM patterns on the query compound are selected from the RDM pattern library based on the structurally similar compounds containing the corresponding RDM selleck kinase inhibitor patterns with the use of the SIMCOMP program (Hattori et al. (gabapathway.com)

Although arsenic has been associated epidemiologically with increased lung infections, the identity of the lung cell types targeted by peroral arsenic and the associated immune mechanisms remain poorly defined. (nih.gov)
The molecular mechanisms by which arsenic (As3+) causes human cancers remain to be fully elucidated. (mdm2-inhibitors.com)

1976. Intracellular effects of chronic arsenic administration on renal proximal tubule cells. (cdc.gov)
18. Association of oxidative stress with arsenic methylation in chronic arsenic-exposed children and adults. (nih.gov)

Paradoxically, either deficient or excess dietary arsenic has also been shown to lead to global hypomethylation in rat liver. (nih.gov)

Abnormal DNA methylation patterns are a hallmark of most cancers, including those of high proportion in the United States i.e., colon, lung, prostate, and breast cancer. (nih.gov)

Finally, the DNA methylation patterns may influence the response to a nutrient. (nih.gov)
Global DNA Methylation Patterns Global hypomethylation, accompanied by region-specific hypermethylation, is a common characteristic among tumor cells. (nih.gov)

Thomas, D. J. Metabolism Of Arsenic In Primary Cultures Of Human And Rat Hepatocytes . (ubc.ca)
To specify the effects of arsenic on macrophage phenotype, we investigated in the present study whether As 2 O 3 could regulate the activity of NADPH oxidase, a major superoxide-generating enzymatic system in human phagocytes. (aai.org)
The renin-angiotensin system (RAS), an essential enzymatic cascade involved in maintaining blood pressure and electrolyte balance, is involved in the pathogenicity of COVID-19, since the angiotensin-converting enzyme II (ACE2) acts as the cellular receptor for SARS-CoV-2 in many human tissues and organs. (nutrition-evidence.com)

Second, whether EZH2 S21 phosphorylation reduces the enzymatic activity of EZH2 might be cell context-dependent. (mdm2-inhibitors.com)

10. Lidocaine affects the redox environment and the antioxidant enzymatic system causing oxidative stress in the hippocampus and amygdala of adult rats. (nih.gov)

Thus, evidence exists that variations in the degree or site of DNA methylation can lead to abnormal DNA repair and influence multiple cancer related genes and thereby influence the incidence and behavior of tumors. (nih.gov)

Le, X. C. Evidence Of Hemoglobin Binding To Arsenic As A Basis For The Accumulation Of Arsenic In Rat Blood . (ubc.ca)

Consistent with barrier disruption at the alveolar level, arsenic-exposed mice had evidence for alveolar epithelial type 1 cell injury. (nih.gov)

Arsenic exposure via drinking water impacts millions of people worldwide. (nih.gov)

Anatomy3

Diseases1

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes14

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science2

Health Care3

Geographicals1

Aposhian HV1

19991

19971

Inorganic arsenic1

Polyphenolic compound2

Mammalian1

Arsenite2

CADMIUM1

Oxidation1

Renal5

Antineoplastic2

Liver3

Antioxidant1

Phosphorus1

Percentage2

Gene1

Effects3

Process2

Complex1

Effect1

Potential3

Additional1

Production1

Chemical2

Trioxide3

Methyltransferase4

Demethylation1

Biotransformation1

Bioactive2

CHROMIUM1

Inorganic1

Hepatic2

Selleck1

Mechanisms2

Chronic2

Deficient1

Cancers1

Patterns2

Human3

Activity1

System1

LEAD1

Blood1

Evidence1

Millions1