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  • protein
  • While chemical methylation of an amide bond uses a strong base to generate the imidate, OphA, the precursor protein of the fungal peptide macrocycle omphalotin A, self-hypermethylates amides at pH 7 using S -adenosyl methionine (SAM) as cofactor. (sciencemag.org)
  • AJOU Open Repository: Enzymatic methylation of recombinant TIS21 protein-arginine residues. (ajou.ac.kr)
  • This is only one factor in the very high FDRs for methylated peptides reported in the MCP paper 'Large Scale Mass Spectrometry-based Identifications of Enzyme-mediated Protein Methylation Are Subject to High False Discovery Rates' , in which a match to the correct peptide with the correct modification but on the wrong site was counted as false. (matrixscience.com)
  • In the present study, we synthesized DNA duplexes containing MeC analogues with modified C-5 side chains and examined their ability to guide cytosine methylation by the human DNMT1 protein. (rsc.org)
  • Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs]. (univ-mrs.fr)
  • methyl
  • We will use a novel enzymatic approach, to detect 5-methyl cytosines (5mC's), that results in longer reads and higher coverage of genomic features at lower minimum coverage thresholds when compared to Illumina bisulfite libraries. (embl.de)
  • These enzymes catalyze the methylation of a single outer hydroxyl group in substrates possessing a 1,2,3-trihydroxybenzene moiety, such as methyl gallate and myricetin. (deepdyve.com)
  • Methyl-tetrahydrofolate reductase (MTHFR), is an enzyme that is responsible for methylation in every single cell in your body. (drlam.com)
  • Methylation is the process of adding a methyl group, one carbon and three hydrogens, to a compound. (drlam.com)
  • 1997). There is an endogenous pathway for the de novo biosynthesis of the choline moiety via the sequential methylation of phosphatidylethanolamine using S -adenosylmethionine as the methyl donor (Bremer and Greenberg, 1961) (see Figure 12-1 ). (nap.edu)