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  • disease
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • epidemiology
  • Salient organizing principles for understanding the epidemiology of enterovirus infection and disease include evolutionary and adaptational strategies, the interaction of the virus with its human host and the environment, and characteristic modes of transmission. (asmscience.org)
  • Molecular epidemiology promises new insights into the origin, evolution, and prevention of human enteroviruses. (asmscience.org)
  • Knowledge of the epidemiology of human enterovirus 71 transmission will allow public health personnel to predict when outbreaks might occur and to plan interventions in an effective manner in order to reduce the burden of disease. (beds.ac.uk)
  • clinical
  • The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. (mdpi.com)
  • Molecular studies have confirmed the silent circulation of enterovirus (EntV) and hepatitis A virus in the environment, even in the absence of clinical manifestation. (aaem.pl)
  • poliovirus
  • The results indicate that mildly to moderately symptomatic HIV-infected children retain the ability to clear enteroviruses, including vaccine-related poliovirus. (biomedcentral.com)
  • Chronic VDPV persistence has been documented for persons with certain defects of antibody production [ 1 , 2 , 8 ], but little is known about poliovirus persistence among human immunodeficiency virus (HIV)-infected persons. (biomedcentral.com)
  • viral agents
  • The spectrum of enteroviral infection and disease can be better understood and categorized according to epidemiologic features that include modes of transmission as well as evolutionary-adaptational aspects of the relationships between the viral agents, their human hosts, and the environment. (asmscience.org)
  • severe
  • In the past 2 years, CDC has learned of several clusters of respiratory illness associated with human enterovirus 68 (HEV68), including severe disease. (cdc.gov)
  • Human Enterovirus D68 (EV-D68) is a non-polio enterovirus that can cause mild to severe respiratory illness, especially in infants and children with asthma. (nih.gov)
  • mice
  • We describe a model of Enterovirus 71 encephalomyelitis in 2-week-old mice that shares many features with the human central nervous system (CNS) disease. (ovid.com)
  • antibody
  • Human enterovirus 71 complexed with antibody D5. (sciencephoto.com)
  • Mouse monoclonal antibody prepared against a recombinant form of the human interferon beta protein was purified from clone A7 hybridoma supernatant by protein G affinity chromatography. (atcc.org)
  • results
  • RESULTS The frequency of human enterovirus RNA in stool samples from case subjects before seroconversion (43 of 339, 12.7%) did not differ from the frequency in control subjects (94 of 692, 13.6%) ( P = 0.97). (diabetesjournals.org)
  • chronic
  • Enteroviruses have also been implicated in the etiology of chronic diseases such as inflammatory myositis, diabetes mellitus, dilated cardiomyopathy, amyotrophic lateral sclerosis, chronic fatigue syndrome, and post-poliomyelitis muscular atrophy. (asmscience.org)
  • proteins
  • Western blotting, two-dimensional gel electrophoresis, and mass spectrometry were used to identify human islet proteins bound by the clone 5-D8/1. (diva-portal.org)
  • samples collected
  • OBJECTIVE To test whether the frequency of human enterovirus RNA in fecal samples collected monthly from early infancy was associated with development of multiple islet autoantibodies in children with the highest risk HLA genotype. (diabetesjournals.org)
  • mitochondrial
  • Tamura K, Nei M. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.Mol Biol Evol. (aaem.pl)
  • specific
  • In each cluster, HEV68 was diagnosed by reverse transcription--polymerase chain reaction (RT-PCR) testing targeting the 5'-nontranslated region, followed by partial sequencing of the structural protein genes, VP4-VP2, VP1, or both, to give definitive, enterovirus type-specific information. (cdc.gov)
  • Human enterovirus 71 has emerged as an important pathogen in the Asia Pacific region and it is important to be able to make a rapid and specific diagnosis for outbreak control. (biomedcentral.com)
  • There are at least 66 human enteroviruses known and the cost and labour involved in making a specific identification is high for a syndrome which is generally very mild. (biomedcentral.com)
  • Primary
  • Primary infection with an enterovirus leads to viral replication in the tissue around the gastrointestinal tract, followed by a transient viremia and sometimes migration into other tissues ( 2 , 34 ). (asm.org)