• The locus of enterocyte effacement (LEE) is a moderately conserved pathogenicity island consisting of 35,000 base pairs in the bacteria Escherichia coli genome. (wikipedia.org)
  • The locus of enterocyte effacement-encoded regulator (Ler) is a regulatory protein that controls bacterial pathogenicity of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic Escherichia coli (EHEC). (wikipedia.org)
  • A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. (pnas.org)
  • Background: In this study, we present evidence that proteins encoded by the Locus of Enterocyte Effacement (LEE), considered critical for Escherichia coli O157 (O157) adherence to follicle-associated epithelial (FAE) cells at the bovine recto-anal junction (RAJ), do not appear to contribute to O157 adherence to squamous epithelial (RSE) cells also constituting this primary site of O157 colonization in cattle. (harvard.edu)
  • The study of serotypes combined with that of the locus of enterocyte effacement island (LEE) allowed a better appreciation of the heterogeneity of the isolates and helped to determine whether the environment could be one of the main reservoirs in which new clones pathogenic for humans could emerge. (asm.org)
  • To calculate copy numbers of proteins in the enterocytes, [researchers] assumed the volume of these cells to be about 1400µm^3 (primary sources) and the protein content of mammalian cells to be about 20% (BNID 111217 ). (harvard.edu)
  • OBJECTIVES -A physiological adaptation to a sugar-rich meal is achieved by increased sugar uptake to match dietary load, resulting from a rapid transient translocation of the fructose/glucose GLUT2 transporter to the brush border membrane (BBM) of enterocytes. (diabetesjournals.org)
  • Immunolabelling for OB-Rb protein was also found in the brush border of human enterocytes of formol and paraformaldehyde fixed samples. (bmj.com)
  • On the basis that citrulline availability is the rate-limiting factor for renal arginine synthesis, we hypothesized that citrulline synthesis from glutamine was reduced in enterocytes of diabetic rats, which may contribute to the decrease in plasma arginine levels. (tamu.edu)
  • Orexin-A at all concentrations tested (1-100 nM) increased [Ca2+](i) in enterocytes isolated from continuously fed rats, and the OX1R-antagonist SB-334867 (10 nM) attenuated the response. (diva-portal.org)
  • Second, the enterocytes were treated with different concentrations of lysine (0-300 mg/L in media) prior to (pre-treatment), along with (co-treatment) or following (post-treatment) with 6 mg/L of Cu for 24 h. (nih.gov)
  • In adult mammals, enterocytes are the main source of circulating citrulline, which serves as the precursor for arginine synthesis, primarily in the kidney. (tamu.edu)
  • Isenberg JI, Ljungström M, Säfsten B, and Flemström G . Proximal duodenal enterocyte transport: evidence for Na + -H + and Cl - -HC0 3 - exchange and NaHCO 3 cotransport. (springer.com)
  • Our cryopreserved enterocytes maintain their enzyme activity after thawing and have been shown to produce clinically-observed phenomena, such as dose- and time-dependent inhibition of CYP3A4 by grapefruit juice. (invitroadmet.com)