Enter a state of cellular senescence. Medical search. Frequent questions

Senescent cells cause harm through what is known as the senescence-associated secretory phenotype (SASP) , the secretion of signals that spur inflammation, tissue modeling, and alterations in cellular behavior. (fightaging.org)
Senescent cells are characterized by an irreversible growth arrest and formation of a senescence-associated secretory phenotype (SASP), a proinflammatory secretome that modifies the cellular microenvironment and contributes to tissue deterioration. (bvsalud.org)
Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
And lung biopsies taken from people with mild to moderate COPD also show signs of senescent cells, suggesting that these cells could be a cause, rather than a consequence, of COPD.Left unchecked, the cells will secrete molecules that promote inflammation and bring about degradation of extracellular matrices - behaviour that is referred to as the senescence-associated secretory phenotype, or SASP. (howhelp.org)
The program aims to catalyze the development of a framework for mapping cellular senescence and its associated secretory phenotype at high resolution, and to provide atlases of cellular senescence in multiple tissues across various states of human health, and across the lifespan. (friendsofnia.org)
Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)

Specifically, oxidative stress by reactive oxygen species (ROS) is the main extrinsic factor that induces senescence [ 12 ]. (hindawi.com)
Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS. (bvsalud.org)

Using multiple senescence markers, we found that exposure to 15 nM, but not 5 nM of tau increased levels of cell cycle arrest and a DNA damage marker, induced loss of the nuclear envelope protein lamin B1 and the histone marker H3K9me3, impaired tau clearance and migration, altered the cell morphology and resulted in formation of a SASP. (bvsalud.org)
Increasing evidence indicates that senescent cells could be a promising new target for therapeutic intervention known as senotherapy, which includes depleting senescent cells, modulating SASP and restoration of senescence inhibitors. (frontiersin.org)
As we reported earlier , at the ARDD 2023 conference in Copenhagen, João Passos of Mayo Clinic presented results from a new study elucidating a previously unknown aspect of cellular senescence: the role of leaked mitochondrial DNA (mtDNA), which appears to contribute to SASP secretion. (lifespan.io)
The researchers suspected that this mechanism, which resembles a weaker version of apoptosis, is essential for continuous SASP production, which is probably the most deleterious aspect of senescence. (lifespan.io)
However, it did not alter the levels of senescence markers, suggesting that BAX and BAK regulate the SASP but not the senescence-associated cell cycle arrest. (lifespan.io)

Cellular senescence, a permanent state of cell cycle arrest accompanied by a complex phenotype that affects the microenvironment, is an essential mechanism that limits tumorigenesis and tissue damage. (longevitynation.org)

Unlike apoptosis, senescence is a state of which cells are still alive and metabolically active. (frontiersin.org)
However, mitochondria are also well-known triggers of apoptosis, a widespread type of programmed cellular death [3]. (lifespan.io)
In a new study, fisetin was shown to prevent immune cells from becoming senescent, allowing them to enter into a state of apoptosis or cellular suicide, a normal process at the end of a cell's life cycle. (longevityclips.com)
A major theory of aging involves cellular senescence or apoptosis resulting from oxidative damage as the skin's antioxidant system tends to weaken with age. (encyclopedia.pub)
In the later generations, when telomeres are short, cells die via apoptosis or senescence. (hopkinsmedicine.org)
Cada célula está programada para realizar determinado número de divisiones celulares y, al finalizar dicho tiempo, la proliferación se interrumpe y la célula entra en un estado de inactividad tras el cual se produce la MUERTE CELULAR a través del proceso de APOPTOSIS. (bvsalud.org)
When telomeres become critically short, the cell enters a state of senescence or apoptosis (cell death), leading to a decline in tissue function. (khaledlotfy.com)

A diet high in processed food and sedentary lifestyle choices lead to inflammation, shortened telomeres, and cellular damage. (giasahammed.com)
Our current understanding of cellular aging rests upon the uncapping of the repetitive, non-protein-coding extremities of our linear chromosomes called telomeres. (genengnews.com)
A team of cancer scientists led by Francis Rodier, PhD, a professor at the University of Montréal, has updated the current model of cellular senescence by providing evidence that the aging-related arrest of DNA replication is caused by irreversible damage to the genome rather than simply by an erosion of telomeres. (genengnews.com)
It cannot help in determining the cellular threshold for the number of dysfunctional telomeres that causes cells to stop dividing due to persistent DNA damage response signaling. (genengnews.com)
Genetically, we were able to reproduce the phenomenon of cellular aging in the laboratory and ensured that all the telomeres of a population of cells became dysfunctional," said PhD student Marc-Alexandre Olivier, co-first author of the study with former colleague Sabrina Ghadaouia, PhD, currently pursuing postdoctoral studies in England. (genengnews.com)
This shortening of our telomeres appears to be the cellular clock that determines the number of times our cells divide which, in turn, appears to control the aging of our cells. (virtualbeauty.co.nz)
For it is the progressive shortening of our telomeres that may be a cause (or the cause) of cellular aging, and which weakens our chromosomes to the point where cell division is no longer possible! (virtualbeauty.co.nz)
With cell division, telomeres are degraded and get shorter, inducing cellular aging and deterioration (aka, senescence) - specifically immunosenescence, the age-related dysregulation and decline of the immune system, which results in susceptibility to infections, cancers, and other diseases associated with aging. (purformwellness.com)
The shortening of telomeres and resulting cellular senescence have been very well documented as two crucial molecular characteristics of aging. (purformwellness.com)
When the telomeres reach a critical length, it leads the cell to enter a deteriorating state. (purformwellness.com)
During cell division, telomeres shorten and signal a stop in cellular growth called cellular senescence, which can lead to aging and illness. (wakeup-world.com)
Cellular aging is closely linked to telomeres, the protective caps at the ends of chromosomes. (cnnn.com)
Telomeres naturally shorten with each cell division, eventually leading to cell senescence or death. (cnnn.com)
Once telomeres reach a critically short length, the cell ceases to divide and enters cellular senescence, ready to be disposed of by the immune system. (mediluxegulf.com)

Here we show that a combination of oncogenes that is characteristic of liver cancer (CTNNB1, TERT, MYC) induces senescence in human fibroblasts and primary hepatocytes. (biorxiv.org)

We demonstrate that PLL provides favourable microenvironment for MSC culture by reversing the replicative senescence. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
Moreover, replicative senescence of MSCs exhibits reduced functionality, and cellular senescence might impair the regenerative potential of MSCs [ 10 ]. (hindawi.com)
Studies show that replicative senescence or cellular senescence is induced by intrinsic or extrinsic environmental factors [ 11 ]. (hindawi.com)
We demonstrate that replicative senescence, a tumor suppressor mechanism and guardian of genome stability, sometimes requires genomic instability to initiate its own action," the authors said. (genengnews.com)
One of them is the replicative aging of cells (senescence), which consists in the irreversible stopping of cell division at the G1 stage of the cell cycle. (vechnayamolodost.ru)

The research results linked below fall into the latter category: the researchers improve the understanding of the way in which diabetes produces blindness by showing that cellular senescence is a bridging mechanism in the retina . (fightaging.org)
The arrest of cell division related to cellular aging prevents cells with unstable genomes from multiplying and is a key mechanism in suppressing cancer. (genengnews.com)
Damaged cells often enter senescence-cellular old age-as a protective mechanism that allows them to expend less energy," the article states. (cancerwellness.com)
In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. (frontiersin.org)
In this review, we summarize the evidence linking cellular senescence to the pathogenesis of CKD and discuss current understanding of the mechanism and regulators controlling senescence. (frontiersin.org)
That is the mechanism that puts them into senescence," says Peter Barnes, a respiratory scientist at the National Heart and Lung Institute in London. (howhelp.org)
To investigate this mechanism further in vivo, the researchers created genetically engineered BAK- and BAX-deficient mice and irradiated them with a small dose of radiation known to induce cellular senescence in the liver. (lifespan.io)
In addition cellular senescence constitutes a tumor suppressor mechanism [1] , [2] . (plos.org)
A novel study has shown that Senolytics, a new class of drugs, have the potential to prevent the transfer of senescence, a key mechanism of ageing, and the associated physical and cognitive impairments in recipients of older donor organs. (press-news.org)
Press-News.org) (18 September 2023, Athens, Greece) A novel study has shown that Senolytics, a new class of drugs, have the potential to prevent the transfer of senescence*, a key mechanism of ageing, and the associated physical and cognitive impairments in recipients of older donor organs. (press-news.org)
By transplanting older donor organs into younger recipients, researchers from Harvard Medical School and the Mayo Clinic investigated the role of transplantation in inducing senescence, a biological mechanism linked to ageing and age-related diseases. (press-news.org)

Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)
Cellular senescence is defined as a state in which normal somatic cells lose their ability to divide, due to either prolonged cell division in culture or exposure to subcytotoxic stressors, thereby entering irreversible growth arrest [ 1 ]. (koreamed.org)

In addition, GSK3 inhibition was sufficient to induce senescence in Chang cells. (koreamed.org)
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. (rndsystems.com)

Increased mitochondrial mass has also been reported in stress-induced senescence systems [ 7 , 8 ]. (koreamed.org)
Mitochondrial dysfunction is a hallmark of cellular senescence [2]. (lifespan.io)
Interestingly, cell death regulators also regulate many other cellular processes prior to a death stimulus, including neuronal activity, mitochondrial dynamics and energetics. (hopkinsmedicine.org)
Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)

It was also shown that inhibition of the p16 tumour suppressor gene delays growth arrest and therefore senescence of MSC [ 16 ]. (hindawi.com)
Cellular senescence is a phenomenon where cells stop dividing and enter a state of permanent growth arrest. (newos.me)
Francis Rodier, PhD, and Marc-Alexandre Olivier [Source: CRCHUM] These findings improve upon the widely accepted scientific model of cellular aging that holds, telomeric ends erode with each cell division and trigger an arrest of cell division once they get too short, preventing further damage of the DNA code. (genengnews.com)
Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Cellular senescence is characterized by an irreversible and permanent cell cycle arrest coupled with altered transcriptome and secretome. (frontiersin.org)
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. (bvsalud.org)

The technique was used to measure senescence over time in tumour-bearing mice injected with the nanoparticles. (gowinglife.com)

By the time that the SENS rejuvenation research proposals were first formalized, more than three decades later, a little after the turn of the century, the research community had a much better understanding of cellular senescence as a phenomenon, as well as a good deal of indirect evidence to show that (a) senescent cells accumulated with age, and (b) their presence contributed to age-related disease and dysfunction. (fightaging.org)
Aging-causing cells enter a state called cellular senescence, where it's no longer able to divide, leading to tissue and organ dysfunction. (giasahammed.com)

94: 690-694, 1997), that cellular anti-death genes can alter the pathogenesis of virus infections (Nature Med. (hopkinsmedicine.org)
Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (oaepublish.com)

December 2, 2022 -- Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. (scienceboard.net)
Our study clearly demonstrates that these non-replicating cells are going through the deterioration process of senescence and that it is directly related to neuroinflammation and Alzheimer's disease," Rusty Gage, PhD, president of the Salk Institute and co-corresponding author of the paper, said in a statement . (scienceboard.net)

The new multistep model for entry into telomere-mediated senescence presented in the current study reconciles observations of senescence-associated genomic instability with observations that telomere breaks are largely irreparable and that cells can tolerate telomere-induced DNA damage foci (TIF) during an unstable "pre-senescent" state. (genengnews.com)
Accumulation of DNA damage over time can lead to mutations and genomic instability, which can have detrimental effects on cellular function and increase the risk of age-related diseases. (khaledlotfy.com)

In many aspects, CKD can be viewed as a state of accelerated and premature aging. (frontiersin.org)
In the absence of Bmi1, M33, or Phc2, primary embryonic fibroblasts (MEFs) are unable to progress into S phase, undergo premature senescence after only a few passages in culture and show an increased accumulation of the tumor suppressors p16 INK4a , p19 ARF and p15 INK4b [4] , [10] . (plos.org)
Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)

It is an interesting point to consider that a range of diseases, age-related and otherwise, may provoke greater cellular senescence as a part of the progression of pathology, even though cellular senescence is not one of the main root causes of these condition. (fightaging.org)
While the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. (bvsalud.org)
This decline is influenced by both genetic and environmental factors, and can lead to a reduced ability to repair cellular damage, decreased immune function, and increased susceptibility to diseases such as cancer, heart disease, and neurodegenerative disorders. (khaledlotfy.com)

Finally, blocking lipogenesis with fatty acid synthase inhibitors (cerulenin and C75) and siRNA-mediated silencing of SREBP1 and ATP citrate lyase (ACL) significantly attenuated GSK3 inhibition-induced senescence. (koreamed.org)

Many physiological decrements underlying aging are linked to cellular senescence. (bvsalud.org)
Cellular communication is essential for coordinating and regulating physiological processes throughout the body. (khaledlotfy.com)
Prof. Valery Krizhanovsky's research is focused on understanding of the role of cellular senescence in physiological and pathophysiological conditions. (longevitynation.org)

A 2018 paper published in the journal Molecular and Cellular Pediatrics shares a disturbingly long list of adverse neurological effects of chemotherapy on children, including effects to memory, intellect, academic achievement and emotional health. (cancerwellness.com)

Now, interest in the role of senescence in chronic lung disease is growing, potentially leading to new treatments.Biological linksThe hallmarks of COPD are emphysema and inflammation - a process involved in the hardening or fibrosis of the airways, causing them to become obstructed. (howhelp.org)
As we age, our immune system undergoes changes that can lead to a persistent, low-level state of inflammation. (cnnn.com)

Conversely, activation of p16 through reactive oxygen species, DNA damage, or senescence leads to the buildup of p16 in tissues and is implicated in the aging of cells. (wikipedia.org)
Aged, nondividing cells however continue to play an array of biological roles and their accumulation in tissues over time compromises tissue functions, linking cellular aging to organismal aging and cancer. (genengnews.com)
Maintaining optimal cellular function is vital for our overall health, as disruptions at the cellular level can lead to a cascade of negative effects on tissues, organs, and ultimately, the entire organism. (khaledlotfy.com)

Alzheimer's "patient-derived directly induced neurons exhibit strong transcriptomic, epigenetic, and molecular biomarker signatures, indicating a specific human neuronal senescence-like state," according to the researchers. (scienceboard.net)

The understanding that senescent cells existed and were important in human health and aging started sometime around the discovery and subsequent exploration of the Hayflick limit to cellular replication, in the 1960s. (fightaging.org)
Cellular senescence, which is morphologically characterized by an enlarged and flattened cell shape, was first described by Hayflick [ 9 ]. (hindawi.com)
When a cell reaches this "Hayflick Limit" it enters into a twilight state called cellular senescence. (virtualbeauty.co.nz)

These pathways are activated in the cellular response to reduce senescence. (wikipedia.org)
The tumor suppressor pathways, ARF/MDM2/p53 and p16 INK4a /Rb, have been shown to play critical roles in the induction of cellular senescence [3] . (plos.org)
Dr. Lee's lab is studying how alterations in cellular protein homeostasis contribute to neurodegeneration and targeting these pathways for novel therapies that can stop disease progression. (michaeljfox.org)

As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
What's most surprising is that, before really entering senescence, the cells divide one last time," said Rodier. (genengnews.com)
Cellular senescence refers to the process where cells lose their ability to divide and function optimally over time. (doctorleta.com)
The potential cancer cell is lulled into a zombie-like state in which it cannot divide, and therefore cannot be cancerous. (howhelp.org)

This damage accumulates over time and can impair cellular function and contribute to aging. (khaledlotfy.com)

In order to protect against itself, special cellular mechanisms of tumor suppression have formed in the body. (vechnayamolodost.ru)

These results show that tumorigenesis is triggered by a combination of three elements: the set of driver mutations, the cellular lineage, and the state of differentiation of the cells along the lineage. (biorxiv.org)

As more cells enter a senescent state, tissue functionality declines, leading to the classic signs of aging. (doctorleta.com)
Scientists have a variety of methods for detecting senescent cells, but most of these work only in cell cultures or tissue samples, meaning that an animal has to be sacrificed in order to measure senescence within its organs. (gowinglife.com)
Prof. Krizhanovsky was one of the pioneers to study the role of cellular senescence in tissue damage and repair and the interaction of senescent cells with the immune system. (longevitynation.org)

In some cases, the decline in proliferation reaches an irreversible state called cellular senescence, which is characterized by a total lack of cell divisions and altered cellular morphology, gene expression profile, and chromatin organization ( 3 ). (diabetesjournals.org)
Second, the team looked at senescence markers and gene expression in post-mortem brains of 20 people with Alzheimer's and matched healthy controls. (scienceboard.net)
Cellular senescence, telomere shortening, and changes in gene expression have been well documented to contribute to the aging process. (jonsabes.com)

The study is reported in an article in the journal Nucleic Acids Research, titled, " Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence . (genengnews.com)

Thus, lysosomes play important roles in cellular activity. (biomedcentral.com)
Emerging evidence suggests that lysosomes may also be the cellular center for intracellular transport (Fig. 1 ), signaling (Fig. 2 ), and metabolism. (biomedcentral.com)

Although the current model accepts that telomeric uncapping triggers a telomeric DNA damage response that leads to senescence, the authors showed entry into senescence involves DNA repair mechanisms and a multistep relationship between irreversible telomeric and non-telomeric DNA damage, which control a transient unstable state and a stable state where cell division is arrested. (genengnews.com)

As serum markers did not reflect the corresponding CSF protein levels, our data highlight the need to interpret serum inflammatory markers depending on the respective protein's specific biology and cellular origin. (bvsalud.org)
In the treated mice, levels of several pro-inflammatory factors were much lower than in controls, but senescence markers were not. (lifespan.io)
Through the analyses, the researchers showed that the brains of Alzheimer's patients have significantly higher proportions of neurons that express senescence markers, and that their distribution indicates bystander effects. (scienceboard.net)

Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an increase in organellar mass, one of the indicators of senescence. (koreamed.org)
While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)
Senescence plays a necessary protective role against the development of cancer by preventing cell division. (gowinglife.com)
thus providing, together with other laboratories, the first evidence that senescence can play a role in embryonic development. (longevitynation.org)
Moving forward, we will delve deeper into the mechanisms underpinning our current findings, with a particular focus on the potential role of Senolytics in preventing the transfer of senescence in humans. (press-news.org)

However, the discovery of senescence-like features in terminally differentiated cells, including neurons, has challenged the assumption that the phenomenon only applies to proliferating cells. (scienceboard.net)

Free radicals are highly reactive molecules that can damage cells and cellular components. (doctorleta.com)
The production of reactive oxygen species (ROS) during normal cellular metabolism can damage cellular components, including proteins, lipids, and DNA. (khaledlotfy.com)

Microglia, the innate immune cells in the brain, can enter a senescent state during aging. (bvsalud.org)

This method will significantly contribute to effective preparation of MSCs for cellular therapy. (hindawi.com)
When old donors were treated with Senolytics (Dasatinib and Quercetin) prior to organ procurement, the transfer of senescence was significantly reduced through a diminished accumulation of senescent cells and mt-DNA. (press-news.org)

Cellular senescence is a complex process, and its molecular mechanisms are unknown. (hindawi.com)
Understanding the various cellular and molecular mechanisms that lead to aging is crucial to improving human lifespan. (giasahammed.com)
We investigated the molecular mechanisms by which signaling molecules control SREBP1-mediated lipogenesis and senescence. (koreamed.org)

If aging is not a stochastic process of attrition but is centrally orchestrated, it is reasonable to suspect that the timing of senescence is also influenced by one or more biological clocks. (karger.com)

Studies investigating MSC senescence are therefore crucial for successful therapeutic application of MSCs. (hindawi.com)
Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. (plos.org)

The gradual decrease in the rate of cell division seen already in early postnatal life, before any evidence of senescence, is even less well-understood. (diabetesjournals.org)

Constant stimulation by toxins from cigarette smoke and pollution accelerates senescence and might exhaust the immune system, resulting in a slowing down of the body's ability to deal with it. (howhelp.org)

By understanding aging research, genetics, key cellular mechanisms, and environmental factors, we can optimize our lifestyle choices and make informed decisions to increase our lifespan. (giasahammed.com)
Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)

This pathway connects the processes of tumor oncogenesis and senescence, fixing them on opposite ends of a spectrum. (wikipedia.org)
Cells convert nutrients from food into energy in the form of adenosine triphosphate (ATP), which is used to fuel cellular processes. (khaledlotfy.com)

When they don't get cleared, then the accumulation of senescent cells can cause harm," he says.Older people seem to be more susceptible to chronic illness caused by cellular senescence. (howhelp.org)

Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. (plos.org)
Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M (2009) Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence. (plos.org)

As we age, our cells undergo a gradual decline in function, a process known as cellular aging. (khaledlotfy.com)

Radiation exposure, too much or not enough oxygen and certain toxins, such as those found in cigarette smoke, can all provide the spark, says James Kirkland at Mayo Clinic in Rochester, Minnesota, who is a leader in the field of cellular senescence.Unlike the zombie armies of Hollywood films, senescent cells can be useful. (howhelp.org)

The other states that the ageing process is dramatically influenced by external factors.The general consensus of opinion is that skin ageing can be dramatically accelerated by extremes in environmental factors (i.e., photoageing of skin and carcinogenic chemicals). (virtualbeauty.co.nz)
Researchers have traditionally viewed senescence, the process by which cells age and stop dividing, in the context of proliferating cells. (scienceboard.net)
The aging process begins at the cellular level within the DNA. (divadeva.com)

A series of recent articles and videos help to chronicle the state of the union in longevity research. (jonsabes.com)

Our genetic makeup influences various aspects of aging, such as the rate of cellular decay and the efficiency of repair mechanisms. (doctorleta.com)

RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)

This updated model offers a new basis for stress- or age-associated genome damage and indicates, cells that escape telomere-mediated senescence harbor irreparable genome damage. (genengnews.com)
We developed cellular models for stress-induced senescence, by exposing Chang cells, which are immortalized human liver cells, to subcytotoxic concentrations (200 µM) of deferoxamine (DFO) and H 2 O 2 . (koreamed.org)
In this model of stress-induced cell senescence using DFO and H 2 O 2 , the phosphorylation profile of glycogen synthase kinase 3α (GSK3α) and β corresponded closely to the expression profile of the mature form of SREBP-1 protein. (koreamed.org)
Senescence is a state of dormancy brought about in response to DNA damage and cellular stress. (gowinglife.com)
Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals. (bvsalud.org)
However, certain lifestyle choices and behaviors, such as a healthy diet , regular exercise, and stress management, can help preserve telomere length and slow down cellular aging. (cnnn.com)

Anatomy31

Organisms8

Diseases15

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes68

Disciplines and Occupations1

Information Science2

Health Care1

Secretory phenotype6

Oxidative stress2

SASP5

Phenotype1

Apoptosis7

Telomeres14

Induces senescence1

Replicative6

Mechanism11

Irreversible growth arrest2

Induce senescence2

Mitochondrial4

Arrest6

Tumour1

Dysfunction2

Pathogenesis2

Deterioration2

Genomic instability2

Premature3

Diseases3

Inhibitors1

Physiological3

20181

Inflammation2

Tissues3

Neuronal1

Hayflick3

Pathways3

Divide4

Damage accumulates over time1

Tumor suppression1

Mutations1

Tissue3

Gene expression3

Underlies1

Lysosomes2

Transient1

Markers3

Role5

Phenomenon1

Reactive2

Senescent state1

Significantly2

Molecular mechanisms3

Biological1

Crucial2

Evidence1

Immune1

Genetics2

Processes2

Chronic1

Replication2

Undergo1

Unlike1

Process3

Longevity1

Repair mechanisms1

Survival1

Stress6