• Primary ESFT from four patients containing CD133 + CSC subpopulations ranging from 3-17% of total tumor cells were subjected to treatment with enoxacin, doxorubicin or both drugs. (stemcellsciencenews.com)
  • Second-generation quinolones have a fluorine substituent in the main quinolone ring that significantly increases antibacterial activity. (aafp.org)
  • The present invention relates to a family of S-substituted quinazoline derivatives that have selective or specific inhibitory activity of the enzyme phosphodiesterase 7 (PDE7), without significantly inhibiting other phosphodiesterases such as the enzyme phosphodiesterase 4 (PDE4). (justia.com)
  • The inventors of the present patent, after extensive and exhaustive research, have surprisingly discovered a family of S-substituted quinazoline derivatives that have selective or specific inhibitory activity of the enzyme phosphodiesterase 7 (PDE7), without significantly inhibiting other phosphodiesterases such as the enzyme phosphodiesterase 4 (PDE4). (justia.com)
  • In another small study of male smokers, researchers found that green tea significantly reduced blood levels of harmful LDL (bad) cholesterol. (mountsinai.org)
  • Roflumilast has been shown to significantly reduce sputum neutrophils and eosinophils in COPD patients. (medscape.com)
  • Duloxetine undergoes extensive metabolism, but the major circulating metabolites have not been shown to contribute significantly to the pharmacologic activity of duloxetine. (medlink.com)