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  • DPDPE
  • 250 µCi quantities of [Tyrosyl-2, 6-3H(N)]-Enkephalin (2-D-Penicillamine, 5-D-Penicillamine), (DPDPE) are available for your research. (perkinelmer.com)
  • In C57BL/6J mice, we evaluated the local antinociceptive effects of a DOR agonist, [D-Pen2,5]-enkephalin (DPDPE) and a nitric oxide donor, DETA NONOate DETA/NO 2,2'-(hydroxynitrosohydrazino) Bis-Ethanamine (NOC-18) alone or combined (DPDPE plus NOC-18) at 1, 4, 7, and 10 days after CFA injection. (nih.gov)
  • The purpose of this study was to examine the properties of TIPP at selected points of the signal transduction pathway (i.e., receptor binding, G-protein activation, and effector regulation) in GH 3 DORT cells (GH 3 cells expressing δ-opioid receptors) and compare them with that of an established δ-opioid agonist, [ d -Pen 2 , d -Pen 5 ]-enkephalin (DPDPE). (aspetjournals.org)
  • receptor
  • As part of a continuing investigation of the role of spinal delta opioid receptors in antinociception, this study characterized the ability of 7- benzylidenenaltrexone (BNTX), a selective delta-1 opioid receptor antagonist, to antagonize the antinociception produced in the rat by intrathecal (i.t.) administration of the respective delta-1 and delta-2 opioid receptor agonists, DPDPE and [D-Ala2, Glueltorphin (DELT), or the mu receptor agonist DAMGO. (pcom.edu)
  • We used the spinal nerve ligation (SNL) and gp120 models of experimental neuropathic pain to evaluate compound 2-261, a nonbenzodiazepine site positive allosteric modulator of α4β3δ GABAARs optimized to be nonsedative by selective activation of β2/3-subunit-containing GABAARs over receptor subtypes incorporating β1 subunits. (arizona.edu)
  • adenosine
  • Agonist-stimulated [ 35 S]GTPγS autoradiography also examined other G-protein-coupled receptors, including δ opioid, ORL-1, GABA B , adenosine A 1 , cannabinoid, and 5-HT 1A . (jneurosci.org)
  • Adenosine diphosphate ribosylation of histone and nonhistone chromosomal proteins with oxidized nicotinamide adenine dinucleotide and 2'-deoxynicotinamide adenine dinucleotide using nuclei isolated from rat liver and HeLa cells. (docphin.com)
  • The protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases. (docphin.com)
  • gene
  • The proopiomelanocortin gene (POMC) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into enkephalin. (meddic.jp)
  • Products
  • Two lines of research involving acetaldehyde are reviewed: (1) implications of the formation of acetaldehyde in brain areas such as the NArc, with high expression of ethanol metabolizing enzymes and presence of cell bodies of endorphinic neurons and (2) the formation of condensation products between DA and acetaldehyde such as salsolinol, which exerts its actions via OR. (frontiersin.org)
  • Clinical
  • Phase I clinical investigation and preliminary pharmacokinetics of 9-10 anthracenedicarboxaldehyde bis (4,5-dihydro-1H-imidazole-2-yL) (hydrazone) dihydrochloride (bisantrene) with correlative in vitro human tumor clonogenic assay. (arizona.edu)
  • brain
  • Similar levels of 2-261 were detected in the brain and plasma after intraperitoneal administration. (arizona.edu)