• Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
  • We showed that a small molecule Wnt inhibitor developed in my laboratory that targets the Dvl PDZ domain blocks the oxidative stress-induced neovascularization in human retinal vascular endothelial cells. (uclahealth.org)
  • Fluorescein angiography enhance the identification of the microvascular abnormalities, such as microaneurysms, IRMA's, ischemic areas and several neovascularizations. (zeiss.com)
  • Carnosine supplementation enhanced the bioavailability of carnosine in the ischemic limb, which was accompanied by increased expression of proton-coupled oligopeptide transporters. (frontiersin.org)
  • Similarly pretreatment of WT C57/Bl6 mice with carnosine showed enhanced blood flow in the ischemic limb following HLI surgery. (frontiersin.org)
  • Even though the exact mechanisms underlying ischemic injury in the muscle are not completely understood, hypoxia-inducible factor-1 alpha (HIF-1α) has emerged as an attractive target to enhance post ischemic angiogenesis. (frontiersin.org)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
  • Contrast-enhanced ultrasound (CEUS) detects carotid intraplaque neovascularization (IPN). (elsevierpure.com)
  • Assessment of subclinical atherosclerosis and intraplaque neovascularization using quantitative contrast-enhanced ultrasound in patients with familial hypercholesterolemia. (cdc.gov)
  • After intravitreal injection, rEXS-cL-aV exploited the ability of rEXS to localize in neovascularization lesions and, upon MMP-mediated cleavage, released rEXS and aV to suppress inflammation and VEGF activity, respectively," said Prof. WEI Wei from IPE. (exosome-rna.com)
  • Amniotic membrane has several antimicrobial and biological properties in corneal surgery, as it enhances epithelialization, reinforces adhesion of basal epithelial cells, maintains epithelial phenotype, and modulates the proliferation of normal corneal, conjunctival, and limbal fibroblast. (researchandmarkets.com)
  • LRG1 promotes endothelial cell proliferation and migration by binding directly to transforming growth factor- β (TGF- β ) accessory receptor endoglin, which, in the presence of TGF- β , enhances the activation of the proangiogenic Smad1/5/8 signaling pathway. (medscape.com)
  • One may speculate that, early after the development of RVO, systemic ET-1 level may increase, then decrease later till the onset of retinal neovascularisation, which might induce an increase again possibly via an increased expression of vascular endothelial growth factor (VEGF), since VEGF can cause an increased expression of endothelin converting enzyme. (bmj.com)
  • Insight into pathways that regulate endogenous vascular repair, drawing on comparisons with development, may reveal novel targets for therapeutically enhancing neovascularization. (jci.org)
  • Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy. (exosome-rna.com)
  • Decreased vision with choroidal neovascularization is caused in part by the accumulation of subretinal fluid secondary to increased vascular permeability. (medscape.com)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • The diameters of the choroidal lesions then were plotted to determine the degree of neovascularization. (ophthalmologytimes.com)
  • Accordingly, they illuminated new uses for IDO1 inhibitors to enhance the antitumor efficacy of hypoxia/metabolic stress-inducing drugs in cancer and other diseases. (mainlinehealth.org)
  • Combination drug studies using IDO inhibitors to safely enhance the efficacy of cancer cell-targeted therapeutics, including RAS/RAF pathway inhibitors, PI3K/mTOR pathway inhibitors and hypoxia-inducing agents. (mainlinehealth.org)
  • Pretreatment of murine myoblast (C2C12) cells with octyl-D-carnosine or carnosine enhanced HIF-1α protein expression, VEGF mRNA levels and VEGF release under hypoxic conditions. (frontiersin.org)
  • Anti-VEGF agents arrest the neovascularization and reduce vision loss. (medscape.com)
  • Cold laser therapy consists of low-intensity lasers or light-emitting diodes (LEDs) that help stimulate and enhance cell function, alleviate pain, and improve healing. (lhah.com)
  • Cold laser therapy uses a low-intensity laser or light-emitting diodes (LEDs) to help relieve pain, stimulate and enhance cell function, and improve healing. (mahopacvet.com)
  • Dynamic, contrast-enhanced MR imaging has allowed quantitative assessment of cerebral blood volume (CBV) in brain tumors. (ajnr.org)
  • These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three-dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength. (iubmb.org)
  • The role of adult bone marrow-derived stem cells in choroidal neovascularization. (medscape.com)
  • Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
  • Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes). (oskar-bordeaux.fr)
  • The enhanced antitumor efficacy and reduced toxic effect of ethaselen-loaded polymeric micelle when compared with ethaselen-HP-β-CD inclusion were observed at the same dose in H 22 human liver cancer cell bearing mouse models. (springer.com)
  • IDO inhibitors offer broad interest for cancer treatment, with preclinical and emerging clinical evidence that they can safely enhance the efficacy of chemotherapy, radiotherapy, radio-chemotherapy and immunotherapy. (mainlinehealth.org)
  • We found that wild type (WT) C57BL/6 mice, subjected to hind limb ischemia (HLI) and supplemented with carnosine (1g/L) in drinking water, had improved blood flow recovery and limb function, enhanced revascularization and regeneration of myocytes compared with HLI mice placed on water alone. (frontiersin.org)
  • Fluorescent dye patent: Akorn has received a U.S. patent for fluorescent dye angiography and dye-enhanced photocoagulation for the diagnosis and treatment of abnormal vasculature. (ophthalmologytimes.com)
  • In addition, we plan to carry out additional cellular assays to examine the role of abnormal Wnt signaling in neovascularization further. (uclahealth.org)
  • Dynamic, contrast-enhanced MR imaging is a valuable adjunct to conventional imaging in assessing tumor activity during antiangiogenic therapy, and correlates better than conventional studies with clinical status and response to therapy. (ajnr.org)
  • nAMD is characterized by choroidal neovascularization (CNV), which is the formation of a choroidal neovascular membrane fibrovascular complex that emanates from the choriocapillaris through a defective Bruch's membrane. (molvis.org)
  • Effect can be enhanced by use of liposomal formulation. (medscape.com)
  • Consistent with these data, blocking miR-92a by systemic infusion of antagomirs enhances neovascularization and functional recovery after ischemia in vivo. (uni-frankfurt.de)
  • Dishevelled (Dvl), a vital component of the Wnt pathways, plays a significant role in initiating neovascularization in ROP as demonstrated in a mouse model, oxygen-induced retinopathy (OIR). (uclahealth.org)
  • Finally, we have started to evaluate the effects of our small molecules in reducing neovascularization in ROP using the OIR mouse model. (uclahealth.org)
  • Lesion leakage and lesion diameter were both significantly reduced following administration of NPD1 in a mouse model of laser-induced choroidal neovascularization. (ophthalmologytimes.com)
  • The purpose of our study was to compare postcontrast T1-weighted imaging with dynamic, contrast-enhanced T2*-weighted echo-planar imaging in the evaluation of the response of recurrent malignant gliomas to thalidomide and carboplatin. (ajnr.org)
  • D Dioptres, AL Axial length, FA Fluorescein angiography, OCTA Optical coherence tomography angiography, SD-OCT Spectral domain optical coherence tomography, mCNV Myopic choroidal neovascularisation. (medscape.org)
  • Nicotine-containing products are sometimes used for the performance-enhancing effects of nicotine on cognition. (wikipedia.org)
  • en-INT_31_173_0128I This is a code assigned to all external communications materials, to assist in tracking and monitoring during the internal approval process. (zeiss.com)
  • The adult heart reverts to its former hypertrabeculated state and repeats the process of compaction, which may facilitate endocardium-derived neovascularization. (jci.org)
  • Animal research suggests that monoamine oxidase inhibitors present in tobacco smoke may enhance nicotine's addictive properties. (wikipedia.org)