Enhanced trail induced apoptosis. Medical search. Frequent questions

RGD-avidin-biotin pretargeting to a (v) b (3) integrin enhances the proapototic activity of TNF a related apoptosis inducing ligand (TRAIL). (rug.nl)
Involvement of Up-regulation of Death Receptors and Bim in Hispolon-mediated TNF-related Apoptosis-inducing Ligand Sensitization in Human Renal Carcinoma. (greenmedinfo.com)
In this study, we evaluated the sensitizing effect of hispolon on TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human renal carcinoma cells. (greenmedinfo.com)
In a second project we are investigating the induction of apoptosis by activation of death receptors for the ligand TRAIL in breast and ovarian cancer cells. (cancer.gov)
We have shown that most breast and ovarian cancer cell lines are resistant to the induction of apoptosis by TRAIL, the ligand for the death receptors DR4 and DR5. (cancer.gov)
Our current work utilizes biochemical and genetic approaches to identify mechanisms that regulate the induction of death by TRAIL ligand in breast and ovarian cancer cells. (cancer.gov)
Impeded apoptosis was overcome in combinations with agonistic CD95 antibody or TNF-related apoptosis-inducing ligand (TRAIL), resulting in up to 60% apoptosis and almost complete loss of cell viability. (fu-berlin.de)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer that is expressed in natural killer cells, whose cytotoxicity is activated by interferon (IFN). (oncotarget.com)
The apoptotic response of cells can be induced by the intrinsic and the extrinsic pathway, the former being mediated by the mitochondria and the latter activated by ligand stimulation of death receptors at the cell surface [ 1 ]. (biomedcentral.com)
Aims: The aim of this study was to sensitize the resistant breast adenocarcinoma cells towards Tumour Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced apoptosis. (eurekaselect.com)
Death receptor DR5 (DR5/TRAIL-R2) is an apoptosis-inducing membrane receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (dsmc.or.kr)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for the design of bifunctional antibodies. (biomedcentral.com)
Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. (uni-muenster.de)
Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. (uni-muenster.de)
Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. (uni-muenster.de)
Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. (uni-muenster.de)
Hence, the present study investigated the effect of combined DG/TNF-related apoptosis-inducing ligand (TRAIL) on gastric cancer cell lines (BGC-823) in vitro. (scienceasia.org)
One such therapy, which Institute researchers have studied and are developing, centers on a protein called TRAIL (tumor necrosis factor related apoptosis inducing ligand). (cedars-sinai.org)
Once ceramide-enriched microdomains are formed, Fas/FasL and DR5/TRAIL as well as other signaling mediators become clustered and can be activated in either a ligand-dependent or -independent manner [ 4 - 6 ]. (biomedcentral.com)
ISSN= ------>authors_c= ------>score=113 ------>journal_name=J Intern Med Taiwan ------>paper_name=Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL)-Mediated Apoptosis in Human Hepatocellular Carcinoma Cells ------>confirm_date=None ------>tch_id=097069 ------>pmid=19497411 ------>page1=271 ------>fullAbstract=The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in some carcinoma cancer cells. (tmu.edu.tw)
TRAIL, a natural ligand for death receptors that can induce the apoptosis of malignancy cells, continues to be explored being a healing agent for malignancies, but it continues to be reported that lots of cancer tumor cells are resistant to Path, limiting the clinical usage of Path being a cancers therapy. (phytid.org)

These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
Inhibition of renal Rho kinase attenuates ischemia/reperfusion-induced injury. (rug.nl)
Proapoptotic caspase cascades were activated, and apoptosis was suppressed by caspase inhibition. (fu-berlin.de)
Combined treatment with SP600125 further enhances tumor inhibition of C-2 associated with enhanced activation of caspase3 and reduction of autophagy. (biomedcentral.com)
It reveals a series of molecular mechanisms about SP600125 potentiate the cytotoxicity and tumor inhibition of C-2 in bladder cancer cells through promoting C-2-induced apoptosis, expecting it provides research basis and theoretical support for new drugs development. (biomedcentral.com)
Anti-apoptotic strategies include inhibition of caspase, poly [ADP-ribose] polymerase (PARP), and Bcl-2 proteins as well as induction of the PKB/Akt pathway and inhibitors of apoptosis (IAP) family of proteins. (biomedcentral.com)
Consistently, caspase-8 inhibition blocked the effects of TFP/TMX on TRA-8-induced apoptosis. (oncotarget.com)
Apis mellifera propolis enhances apoptosis and invasion inhibition in head and neck cancer cells. (sorentt.ir)
SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells. (tmu.edu.tw)
Publisher Correction: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer. (medscape.com)

Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
Hispolon induced up-regulation of Bim and death receptors expression at the post-translational level. (greenmedinfo.com)
We investigated the effect of suppressor of cytokine signaling (SOCS) 3 on the expression of TRAIL receptors (DR4) and on TRAIL sensitivity in renal cell carcinoma (RCC) cells. (oncotarget.com)
Similar trend was observed in MCF-7 whereby TZT treatment down-regulated the anti-apoptotic catalase and PON2, increased the proapoptotic, B cell lymphoma 2 (Bcl-2)-associated agonist of cell death (Bad) and Bcl-2-associated X (Bax), second mitochondria-derived activator of caspase (SMAC) and HtrA serine peptidase 2 (HTRA2) as well as TRAIL receptors (TRAIL R1 and TRAIL R2). (eurekaselect.com)
T umor Necrosis Factor-α R elated A poptosis I nducing L igand (TRAIL) is a member of the Tumor Necrosis Factor (TNF) super-family of cytokines that engages the cellular apoptotic mechanism upon specific binding to death receptors (DRs) 4 and 5 on the cell surface [ 1 ]. (biomedcentral.com)
Although TRAIL and agonistic antibodies to death receptors 4 and 5 are promising candidates for cancer therapy, many tumor cells are inherently resistant or acquire resistance to TRAIL-mediated apoptosis. (biomedcentral.com)
Binding of the trimeric TRAIL to its receptors TRAIL-R1 and TRAIL-R2 induces caspase activation and apoptosis [ 4 ], either through the extrinsic pathway alone or recruiting the intrinsic apoptotic pathway [ 5 ]. (biomedcentral.com)
α-TEA induces apoptosis via activation of extrinsic death receptors Fas (CD95) and DR5, JNK/p73/Noxa pathways, and suppression of anti-apoptotic mediators Akt, ERK, c-FLIP and survivin in breast, ovarian and prostate cancer cells. (biomedcentral.com)
The exact mechanism of fen-retinide-induced cell death is not fully understood, although it is reported to induce apoptosis indepen-dently of retinoic acid receptor expression [6-9], lacking the carboxyl group required for binding to these receptors [10]. (lsd1receptor.com)

2) We investigate induction of apoptosis in breast cancer cells by TRAIL receptor agonists. (cancer.gov)
ROS production alone was not sufficient for apoptosis induction but may play a critical role in sensitizing cancer cells for apoptosis and therapy. (fu-berlin.de)
c A dose-dependent induction of apoptosis by C-2 was demonstrated through flow cytometric analysis of Annexin V/PI stain assay. (biomedcentral.com)
Notably, this enhanced cytotoxicity is not mediated by the induction of apoptosis, but is accompanied by the pronounced induction of autophagy. (spandidos-publications.com)
However, suppression of CHOP expression by small interfering RNA did not abrogate the curcumin-mediated induction of DR5 and the cell death induced by curcumin plus TRAIL, demonstrating that CHOP is not involved in curcumin-induced DR5 upregulation. (dsmc.or.kr)
TRAIL-R1 and TRAIL-R2 have distinct crosslinking requirements for apoptosis induction [ 6 ]. (biomedcentral.com)
Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. (uni-muenster.de)
Now we have a drug that appears to lower thresholds for induction of apoptosis," said Yu, senior author of a paper describing the study in the Journal of Biological Chemistry, published online Nov. 30, 2005. (cedars-sinai.org)
These indicators of apoptosis were correlated with the induction of caspase activity that resulted in the cleavage of poly(ADP-ribose) polymerase (PARP). (tmu.edu.tw)

We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. (medchemexpress.com)
Utilization of JNK inhibitor SP600125 or knockdown of JNK by siRNA potentiate the cytotoxicity of C-2 through down-regulation of p62 and LC3II proteins and up-regulation of active-Caspase3 proteins, enhance the cell death effect, facilitating the switch from autophagy to apoptosis. (biomedcentral.com)
And in that article, another compound 7 g (Fig. 1 a, Fig. 2 ) also has significant cytotoxicity and could induce cell autophagy, due to the efficiency of Jaspine B derivatives was investigated in bladder cancer cells rarely, and the specific autophagy effect of compound 7f in PC3 cells had not been investigated deeply. (biomedcentral.com)
C-2 induced autophagy of bladder cancer cells. (biomedcentral.com)
a The expression levels of C-2-induced autophagy related protein Beclin-1, LC3, p62, ATG3, ATG5 and ATG7 were detected by western blotting in BIU87 and EJ cells at the indicated concentrations or treated with 4 μM of C-2 at the indicated time points. (biomedcentral.com)
b The expression levels of C-2-induced autophagy related protein Beclin-1, p62 and LC3 were detected by western blotting in EJ cells at the indicated concentrations. (biomedcentral.com)
In contrast to necrosis (murdered cells), in apoptosis (commit suicide) and autophagy process, cytoplasmic membranes are maintained and cell body is completely removed without any inflammation. (biomedcentral.com)

Pretreatment with SB203580 resulted in significantly increased sub-G1 population and loss of mitochondrial membrane potential (MMP) in TRAIL-induced apoptosis. (tmu.edu.tw)

Co-Treatment of Prostate Cancer Cells with Mscs Expressing Trail and Iap Inhibitors Reduce Trail Resistance and Production of Trail-Induced Cytokines. (essex.ac.uk)
We have demonstrated that resistance to TRAIL-induced apoptosis can be overcome by co-incubation of the cells with chemotherapeutic agents, semi-synthetic retinoids (such as 4HPR), or molecularly targeted agents (such as anti-ErbB-2 antibodies). (cancer.gov)
Resistance to apoptosis may unmask TRAIL signaling cascades favoring tumor biology. (elsevierpure.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. (uni-muenster.de)
TRAIL-activating therapy has been promising, however, clinical trials have shown resistance and limited responses of pancreatic cancers. (oncotarget.com)
Dysregulation of apoptosis of tumor cells plays an important role in the pathogenesis of pancreatic cancer and their resistance to therapies [ 5 ]. (oncotarget.com)

In the current work, we screened a small library of fifty-five FDA and foreign-approved anti-neoplastic drugs in order to identify candidates that sensitized resistant prostate and pancreatic cancer cells to TRAIL-induced apoptosis. (biomedcentral.com)

The knockdown of L-type amino acid transporter 1 (LAT-1) by siRNA also enhanced GEF-induced cytotoxicity. (spandidos-publications.com)
T umor Necrosis Factor-α R elated A poptosis I nducing L igand (TRAIL) and agonistic antibodies to death receptor 4 and 5 are promising candidates for cancer therapy due to their ability to induce apoptosis selectively in a variety of human cancer cells, while demonstrating little cytotoxicity in normal cells. (biomedcentral.com)
TRAIL has attracted significant attention in recent years due to its ability to selectively induce apoptosis in transformed (malignant) cells while demonstrating little cytotoxicity in normal cells [ 2 - 7 ]. (biomedcentral.com)

Our goal is to selectively trigger apoptosis in the cancer cells. (cancer.gov)
Casticin-induced DR5 upregulation and apoptosis potentiation are ROS-dependent in BGC-823 cells We recently demonstrated that 5, 7-dimethoxyflavone selectively enhances TRAIL-induced apoptosis by ROS stimulated ER-stress triggering CHOP-mediated DR5 upregulation in hepatocellular carcinoma cells [15]. (nos-nop.org)

In various other research, CPP was discovered to induce the appearance of DRs and enhance TRAIL-induced apoptosis in hepatocellular carcinoma cells which were resistant to Path, as the system which is unclear as yet [33] still. (phytid.org)

786-O cells were resistant to TRAIL and showed higher SOCS3 expression. (oncotarget.com)
In ACHN cells, DR4 expression was down-regulated by transfection with pCI-SOCS3, and the cells became resistant to TRAIL. (oncotarget.com)
however, many cholangiocarcinoma cells are resistant to TRAIL-mediated apoptosis. (elsevierpure.com)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
Although TRAIL and agonistic antibodies to DR4 and DR5 are considered safe and promising candidates in cancer therapy, many malignant cells are resistant to DR-mediated, TRAIL-induced apoptosis. (biomedcentral.com)
FDA-approved drugs were screened for their ability to sensitize TRAIL resistant prostate cancer cells to TRAIL using an MTT assay for cell viability. (biomedcentral.com)
We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic cancer cells, and underlying mechanisms. (oncotarget.com)
TFP or TMX alone did not induce apoptosis of resistant PANC-1 cells, while they dose-dependently enhanced TRA-8-induced apoptosis. (oncotarget.com)
Altogether, we have demonstrated that CaM antagonists enhance TRA-8-induced apoptosis of TRA-8-resistant pancreatic cancer cells by increasing DR5 expression and enhancing recruitment of apoptotic signal while decreasing survival signals in DR5-associated DISC. (oncotarget.com)
Prevention of raft reorganization into larger platforms by inactivation of acid sphingomyelinase (ASMase), renders cells resistant to Fas clustering and apoptosis [ 9 ], indicating that ASMase/ceramide plays an important role in death receptor-mediated apoptosis. (biomedcentral.com)
However, it was found that treatment with TRAIL in combination with nontoxic concentrations of genistein sensitized TRAIL-resistant human hepatocellular carcinoma Hep3B cells to TRAIL-mediated apoptosis. (tmu.edu.tw)
Our data demonstrated that a lot of of ESCC cells we tested are resistant to TRAIL, but sensitive to CPP. (phytid.org)

Death receptor 5 targeting activity-guided isolation of isoflavones from Millettia brandisiana and Ardisia colorata and evaluation of ability to induce TRAIL-mediated apoptosis. (dharaonline.org)

C-2 significantly reduced the viabilities of human bladder cancer cells and induced apoptosis associated with the mitochondrial pathway. (biomedcentral.com)
These data demonstrate that TRAIL promotes cell migration and invasion via a NF-κB-dependent pathway in human cholangiocarcinoma cell lines, an observation that has a potential negative implication for TRAIL in cancer therapy. (elsevierpure.com)
We have described and are exploiting a biochemical pathway to make brain cancers much more sensitive to common therapeutic agents that cause a natural process of cell death called apoptosis," said John S. Yu, MD , co-director of the Comprehensive Brain Tumor Program at the Institute, adding that the researchers are applying for Food and Drug Administration approval to translate their findings into patient clinical trials as soon as possible. (cedars-sinai.org)
Metformin facilitates TRAIL-induced apoptosis in CRC cells through activation of extrinsic and intrinsic pathway We additional looked into the synergistic connections between metformin and Path. (healthweeks.com)

TRAIL receptor (DR5) and proapoptotic Bcl-2 proteins (Puma and Bad) were upregulated, while anti-apoptotic factors (survivin, XIAP, cFLIP, Mcl-1, and Bcl-w) were downregulated. (fu-berlin.de)
For E-MDA-MB- 231, down-regulation of catalase, paraoxonase-2 (PON2), clusterin, an inhibitor of apoptosis proteins (IAPs) and cell stress proteins validated the notion that E-cadherin re-expression enhances TZT anti-cancer efficacy. (eurekaselect.com)
The Cedars-Sinai researchers theorized that a diabetes drug called troglitazone would limit the effects of the overexpressed proteins, reinstating the caspase activity and the process of apoptosis. (cedars-sinai.org)

MUC16 decreases TRAIL receptor R2 (DR5) expression and inhibits pro-caspase-8 activation at the death-inducing signaling complex (DISC). (biomedcentral.com)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis. (dharaonline.org)

Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by CHOP-independent upregulation of DR5. (dsmc.or.kr)

In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, is a potent enhancer of TRAIL-induced apoptosis through upregulation of DR5 expression. (dsmc.or.kr)

Down-regulation of cFLIP following treatment of MUC16-expressing OVCAR3 cells with cFLIP siRNA also increases TRAIL-induced apoptosis. (biomedcentral.com)
Both treatment with DR5/Fc chimeric protein and silencing of DR5 expression using small interfering RNA (siRNA) attenuated curcumin plus TRAIL-induced apoptosis, showing that the critical role of DR5 in this cell death. (dsmc.or.kr)
Functional knockdown of ASMase with either the chemical inhibitor, desipramine, or siRNA markedly reduces α-TEA-induced cell surface membrane accumulation of ceramide and its co-localization with Fas, DR5, and FADD, cleavage of caspases-8 and -9 and apoptosis, suggesting an early and critical role for ASMase in α-TEA-induced apoptosis. (biomedcentral.com)

Fourteen drugs were identified as having synergy with TRAIL, including those whose TRAIL sensitization activities were previously unknown in either prostate or pancreatic cancer cells or both. (biomedcentral.com)

Methods: The breast adenocarcinoma cells, MDA-MB-231, MCF-7 and E-MDA-MB-231 (E-cadherin re-expressed MDA-MB-231) were treated with TSA, Zeb, TZ, TRAIL and TZT. (eurekaselect.com)

Consequently, cFLIP isoforms are potent negative regulators of the TRAIL signaling cascade. (biomedcentral.com)
Alpha-tocopherol ether-linked acetic acid (α-TEA), an analog of vitamin E (RRR-alpha-tocopherol), is a potent and selective apoptosis-inducing agent for human cancer cells in vivo and in vitro . (biomedcentral.com)

TMX treatment enhanced efficacy of TRA-8 therapy on tumorigenesis in vivo . (oncotarget.com)
Taken together, these studies demonstrate that ASMase activation and membrane ceramide accumulation are early events contributing to α-TEA-induced apoptosis in vitro and perhaps in vivo . (biomedcentral.com)

Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
TRAIL is a potential anticancer candidate for targeted treatment due to its selective killing effects on neoplastic cells. (eurekaselect.com)

MUC16 knockdown decreases caspase-8 inhibitor cFLIP mRNA levels, increases cFLIP degradation, and consequently increases TRAIL-induced apoptosis. (biomedcentral.com)
NF-jB knockdown did not induce death under normal growth conditions, but did reduce TNFa-dependent cell survival. (lsd1receptor.com)

Pyocyanin-induced cells incubated with ROS Inhibitor (N-acetyl-L-cysteine) demonstrate minimal green or orange fluorescence signal comparable to control values. (enzolifesciences.com)

Cancer cells avoid apoptosis by a variety of genetic and epigenetic mechanisms. (cancer.gov)
In the present study, we investigated the mechanisms by which MUC16 attenuates TRAIL-induced apoptosis. (biomedcentral.com)
These findings indicate that MUC16 protects EOC cells against TRAIL-induced apoptosis through multiple mechanisms including the blockade of TRAIL R2 expression and the regulation of cFLIP expression at both the transcriptional and the protein level. (biomedcentral.com)
However, mechanisms involved in α-TEA induced Fas- and DR5-dependent apoptotic signaling are not fully understood. (biomedcentral.com)

α -TOS is highly selective for malignant cells, inducing them into apoptotic death largely via the mitochondrial route. (nature.com)

The effect of TRAIL on tumor cell migration, invasion, and proliferation was examined in three human cholangiocarcinoma cell lines. (elsevierpure.com)
TRAIL promoted tumor cell migration and invasion but did not induce cell proliferation. (elsevierpure.com)
Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest. (sorentt.ir)
Outcomes In our research, we discovered that CPP by itself or in conjunction with Path could inhibit the proliferation of ESCC cells and induce apoptosis, and we certificated that mix of two realtors exert synergized features. (phytid.org)
Recent research show that CPP can inhibit the proliferation and promote the apoptosis in a number of cancer tumor cells [29C31]. (phytid.org)
A synergistic anti-proliferation activity and anti-tumor activity was observed when ESCC cells or xenografted tumors were treated by TRAIL and CPP. (phytid.org)

TRAIL is normally present as a membrane protein (memTRAIL) on immune effector cells, like natural killer cells. (biomedcentral.com)
In this study, we demonstrate that α-TEA induces the accumulation of cell surface membrane ceramide, leading to co-localization with Fas, DR5, and FADD, followed by activation of caspases-8 and -9 and apoptosis in human MDA-MB-231 breast cancer cells. (biomedcentral.com)

We show that MUC16 attenuates apoptosis, activation of caspase-8 and mitochondria activation in EOC cells in response to TRAIL. (biomedcentral.com)
Pro-caspase-8 activation can directly result in cleavage of caspase-3 to execute apoptosis (type I cells) or cleave Bid to produce a truncated form (tBid), which induces the release of cytochrome c from the mitochondria leading to caspase-9 and subsequent caspase-3 activation (type II cells) as it is the case for EOC cells. (biomedcentral.com)
The proteolytic activation of initiator caspases leads to the subsequent activation of executioner caspases (e.g. caspase-3), which ultimately results in apoptosis in Type I Cells. (biomedcentral.com)
Activation of caspase-8 engages the mitochondria-amplified apoptosis machinery in Type II cells [ 7 ]. (biomedcentral.com)
In contrast, TMX/TFP increased TRA-8-induced DISC recruitment/activation of caspase-8. (oncotarget.com)
With caspase-3 activation blocked, apoptosis is halted and cancer cells grow uncontrolled. (cedars-sinai.org)

By contrast, overexpression of p38 MAPK protected apoptosis by co-treatment with genistein and TRAIL, suggesting that the p38 MAPK act as key regulators of apoptosis in response to treatment with a combination of genistein and TRAIL in human hepatocellular carcinoma Hep3B cells. (tmu.edu.tw)

Thus, understanding the mechanism of apoptosis gives detailed insights of anti-apoptotic molecular targets. (biomedcentral.com)
Although most types of cells can be dismantled and cleared by apoptosis - a "programmed" and necessary cell death mechanism - gliomas and other cancer cells have genes that enable them to thwart apoptosis and continue to grow unchecked even when subjected to therapies that are designed to initiate or enhance apoptosis. (cedars-sinai.org)
BAY 11-7082-induced cell death through an NF-jB-independent mechanism and enhanced cell death when combined with fenretinide. (lsd1receptor.com)

Both cell viability and the cleavage of PARP induced by combined treatment were significantly inhibited by caspase-3, -8 and -9 inhibitors, which demonstrates the important roles of caspases in the observed cytotoxic effects. (tmu.edu.tw)

Cell death occurs under physiological and pathological conditions and mediates through three pathways as follows: apoptosis, autophagic cell death, and necrosis. (biomedcentral.com)
However, if phagocytosis of the cell does not occur at the final stage of apoptosis or autophagic process, the cells are removed through secondary necrosis [ 12 ]. (biomedcentral.com)

After viral infection, they stimulate expression of other viral genes and can either enhance or repress expression of cellular genes depending on cellular context and coordination with other viral genes. (wikipedia.org)
The expression of DR4 induced by combination with IFN-α and tocilizumab was also examined by immunohistochemical staining using mice xenograft model. (oncotarget.com)
Suppression of SOCS3 up-regulated DR4 expression and enhanced the TRAIL sensitivity in 786-O cells. (oncotarget.com)
A marked increase in IFN-induced DR4 protein expression after tocilizumab treatment was observed by immunohistochemical staining in the tumor from the mice xenograft model. (oncotarget.com)
MUC16 expression in EOC cells is associated with increased tumorigenesis and inhibiton of genotoxic drug-induced apoptosis. (biomedcentral.com)
MUC16CTD expression is sufficient to attenuate the TRAIL signaling cascade. (biomedcentral.com)
To address this objective, TRAIL expression in human liver specimens was evaluated by immunohistochemistry. (elsevierpure.com)
TRAIL expression was upregulated by cholangiocytes in preneoplastic disease, primary sclerosing cholangitis, and human cholangiocarcinoma specimens. (elsevierpure.com)
Based on the proteome profiling on MDA-MB-231, TRAIL R2 and Fas expression was increased. (eurekaselect.com)
Curcumin also induced the expression of a potential pro-apoptotic gene, C/EBP homologous protein (CHOP), both at its mRNA and protein levels. (dsmc.or.kr)
After sensitization with cytotoxic drugs, scFv62-TRAIL induced apoptosis only in K V 10.1-positive cancer cells, but not in non-tumor cells, nor in tumor cells lacking K V 10.1 expression. (biomedcentral.com)
Moreover, TFP/TMX induced DR5 expression. (oncotarget.com)
Effect of Turkish Propolis on miRNA Expression, Cell Cycle, and Apoptosis in Human Breast Cancer (MCF-7) Cells. (sorentt.ir)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
Shah, K. TRAIL on trial: Preclinical advances in cancer therapy. (eurekaselect.com)
In particular, mitoxantrone and mithramycin demonstrated significant synergy with TRAIL and led to reduction of cancer cell viability at concentrations lower than 1 μM. (biomedcentral.com)
The identification of a number of FDA-approved drugs as TRAIL sensitizers can expand chemotherapeutic options for combination treatments in prostate and pancreatic cancer diseases. (biomedcentral.com)
In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
Our studies support the use of these readily available CaM antagonists combined with TRAIL-activating agents for pancreatic cancer therapy. (oncotarget.com)
Overall, our findings shed light on a novel strategy of TRAIL-induced apoptosis in combination with DG for the treatment of gastric cancer. (scienceasia.org)
Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice. (sorentt.ir)
from South Sulawesi Indonesia induce apoptosis in the human breast cancer MCF-7 cell line. (sorentt.ir)

Hispolon enhanced TRAIL-mediated apoptosis in renal carcinoma cells. (greenmedinfo.com)

The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. (dharaonline.org)

Therapeutic intervention aims to reverse tumor-induced NK cell suppression and sustain NK cells' tumorlytic capacities. (frontiersin.org)

Hagens WI, Beljaars L, Mann DA, Wright MC, Julien B, Lotersztajn S, Reker-Smit C, Poelstra K. Cellular targeting of the apoptosis-inducing compound Gliotoxin to fibrotic rat livers. (rug.nl)
Apoptosis plays a critical role in cellular homeostasis and prevents the development of tumor cells. (biomedcentral.com)

The RhoAGTP mediated repression of mTORC1 signaling occurred independent of leucine or insulin induced stimulation. (nos-nop.org)

When recruited to the DISC, pro-caspase-8 becomes activated and subsequently activates downstream effectors caspases-3, -6 and -7, leading to apoptosis. (biomedcentral.com)
Analysis of TRA-8-induced death-inducing-signaling-complex (DISC) identified recruitment of survival signals, CaM/Src, into DR5-associated DISC, which was inhibited by TMX/TFP. (oncotarget.com)

The apoptosis rate was assessed by ELISA cell death assay and Caspase 8 activity assays. (scienceasia.org)
TRAIL has been shown to cause cell death in several types of cancers, with negligible damage to normal cells. (cedars-sinai.org)
The new findings should increase the effectiveness of TRAIL and other agents that trigger a "caspase cascade" - a specific biochemical chain reaction resulting in cell death. (cedars-sinai.org)
In the normal process of apoptosis, the enzymes caspase-8 and caspase-9 activate caspase-3, which initiates cell breakdown, leading to cell death. (cedars-sinai.org)
We also employed an Annexin V assay, PARP-1 cleavage assay, and cleavage of caspase 8/9 to clarify whether the effect of metformin on TRAIL-mediated cell death was related to apoptosis. (healthweeks.com)
In this study we have investigated the role of NF-jB in fenretinide-induced cell death and the importance of NF-jB in ESFT. (lsd1receptor.com)

The K V 10.1-specific scFv62 antibody -TRAIL fusion protein was expressed in CHO-K1 cells, purified by chromatography and tested for biological activity. (biomedcentral.com)

Our results demonstrated that DG synergistically enhanced the cytotoxic effects of TRAIL (p (scienceasia.org)

Outcomes Mix of metformin and Kobe2602 Path enhances CRC cell Kobe2602 loss of life, however, not that of regular primary digestive tract cells Metformin continues to be previously reported to stimulate apoptosis in a number of cell types such as for example human cervical cancers, human ovarian, individual leukemia, and individual CRC [39C42]. (healthweeks.com)

Stained HeLa cells induced with L-arginine exhibit bright red fluorescence with a red punctuate cytoplasmic staining pattern. (enzolifesciences.com)

We show here strong anti-proliferative effects of celecoxib in four cSCC cell lines, while apoptosis and cell viability largely remained unaffected. (fu-berlin.de)
Cell viability and IC50 for DG and TRAIL alone or in combination were determined using MTT. (scienceasia.org)

We designed a single-chain antibody against an extracellular region of K V 10.1 (scFv62) and fused it to the human soluble TRAIL. (biomedcentral.com)

RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

TRAIL-mediated cell migration and invasion was NF-κB dependent. (elsevierpure.com)
Fas, DR5 and their adaptor FADD, as an essential early event in α-TEA induced Fas and DR5 dependent apoptosis. (biomedcentral.com)
More recently, fenretinide-induced apoptosis has been reported to be dependent on phosphorylation of nuclear factor-kappa B (NF-jB) in SH-SY5Y neuroblastoma cells [13]. (lsd1receptor.com)

Anatomy30

Organisms9

Diseases14

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes49

Disciplines and Occupations1

Information Science3

Ligand21

Inhibition10

Receptors9

Induction9

Autophagy8

Loss of mitochondrial membrane potential1

Resistance7

Cells to TRAIL-induced apoptosis1

Cytotoxicity3

Selectively2

Hepatocellular carcinoma cells1

Resistant12

Ability to induce1

Pathway4

Proteins3

Receptor3

Curcumin Enhances1

Upregulation1

SiRNA3

Pancreatic cancer cells1

Methods1

Potent2

Vivo2

Anticancer2

Knockdown2

Inhibitor1

Mechanisms4

Malignant cells1

Proliferation6

Membrane2

Activation6

Contrast1

Mechanism3

Inhibitors1

Necrosis2

Expression14

Cancer9

Renal1

Human osteosarcoma1

Therapeutic1

Cellular2

Insulin induced1

DISC2

Death6

Protein1

Synergistically1

Ovarian1

Cytoplasmic1

Cell viability2

Antibody1

Regulates1

Dependent3