Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. (qub.ac.uk)
For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
Our aim was to study the influence of acute graft-versus-host disease (a-GVHD) on primary engraftment times after allogeneic transplantation. (unict.it)
Although allogeneic hematopoietic cell transplantation (alloHCT) is the treatment of choice, patient eligibility criteria and optimal conditioning regimen remain under study. (confex.com)
Here we describe the initial results of allogeneic bone marrow transplantation in three children with osteogenesis imperfecta, a genetic disorder in which osteoblasts produce defective type I collagen, leading to osteopenia, multiple fractures, severe bony deformities and considerably shortened stature. (nih.gov)
Thus, allogeneic bone marrow transplantation can lead to engraftment of functional mesenchymal progenitor cells, indicating the feasibility of this strategy in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well. (nih.gov)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
Identifying and understanding acute complications after allogeneic haematopoietic cell transplantation (alloHCT). (ebmt.org)
In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)
As stated above, the fine tuning of the allogeneic immune response by T-cell depletion or pharmacological means represents the second important pillar in the development of optimized transplantation protocols. (haematologica.org)
This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
The primary endpoint of the study was time to neutrophil engraftment, or the time it took for the white blood cells to recover following transplantation. (seekingalpha.com)
We developed a protocol for EHM production under GLP conditions and completed the transplantation of EHM patches prepared from allogeneic and autologous non-human primate (NHP) cell lines. (ca.gov)
We also completed the transplantation of an allogeneic human size relevant patch format that did not cause any adverse effect on the recipient animals and had evidence of engraftment even afer six months. (ca.gov)
Data obtained from the allogeneic and autologous transplantation models helped us identify a suitable immunosuppression regimen that allows cell survival and engraftment for up to the total duration of the studies (6 months). (ca.gov)
Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
Currently, my work aims to establish strategies to reduce the risk of relapse after allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease or interfering with donor stem cell engraftment. (stanford.edu)
Dr. Flake was the first to investigate the therapeutic potential of in utero stem cell transplantation (IUSCT) for treating hematopoietic and other genetic disorders by demonstrating that transplanting allogeneic hematopoietic cells early in gestation achieve clinically significant levels of hematopoietic chimerism. (chop.edu)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Sana's hypoimmune platform has shown the potential to evade both allogeneic and autoimmune rejection in preclinical models, and we look forward to seeing if these insights translate into patients, providing a path to cell transplantation without immunosuppression," said Steve Harr, Sana's President and CEO. (pipelinereview.com)
Combining Sana's hypoimmune technology with primary islet cell transplantation therapy can generate important first-in-human data that may be a step to removing immunosuppression from allogeneic cell transplant in the type 1 diabetes setting. (pipelinereview.com)
Primary islet cell transplantation is an established procedure in type 1 diabetes, where allogeneic islet cells are isolated from a cadaver and transplanted into a patient with a goal of blood glucose control without the need for insulin. (pipelinereview.com)
If UP421 successfully overcomes immunologic rejection, it may result in engraftment, survival, and C-peptide production in patients with type 1 diabetes following transplantation without immune suppression. (pipelinereview.com)
Prospective Clinical Trial of BUSULFEX: The prospective trial was a single-arm, open-label study in 61 patients who received BUSULFEX as part of a conditioning regimen for allogeneic hematopoietic stem cell transplantation. (clustermed.info)
To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
Real-World Data Showing Trends and Outcomes by Race and Ethnicity in Allogeneic Hematopoietic Cell Transplantation: A Report from the Center for International Blood and Marrow Transplant Research. (mcw.edu)
Infection and graft-versus-host disease are major complications of allogeneic HSCT. (wikipedia.org)
For other cancers such as acute myeloid leukemia, though, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, so the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
Ganciclovir is drug of choice for prevention of CMV following autologous or allogeneic HSCT in adults, adolescents, and children. (drugs.com)
This group etic stem cell transplant (HSCT) (8 allogeneic) and in 15 of patients has also been disproportionately represented patients with malignancy treated at 6 Australian tertiary cen- among those with severe infections from infl uenza A pan- ters during winter 2009. (cdc.gov)
Serum citrulline was quantified by liquid chromatography in blood samples collected from consecutive patients who received an allogeneic HSCT in our institution between July 2014 and November 2019. (confex.com)
CONCLUSION: These data demonstrate the feasibility of allogeneic orautologous HSCT in heavily pretreated lymphoma patients who also receivedtositumomab/iodine-131 tositumomab. (cancernetwork.com)
We performed a review chart audit of 12 children who experienced allogeneic HSCT for WAS to report our involvement. (alliedacademies.org)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
Transplants6
Identical twin allogeneic transplants are called syngeneic transplants. (ucsfhealth.org)
Primary engraftment and frequency of marrow granulocyte-macrophage colony-forming units and erythroid burstforming units, at day +18, were studied in 126 allogeneic transplants. (unict.it)
Among seven allogeneic transplants,three received matched related peripheral blood stem cells and four receivedmatched unrelated marrow (n = 3) or peripheral blood (n = 1) stem cells.Allogeneic recipients received tacrolimus and methotrexate for graft-vs-hostdisease prophylaxis. (cancernetwork.com)
Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
We have performed approximately 165 allogeneic, primary islet cell transplants and have seen the benefits for patients, but the complications of immunosuppression inhibit broader use of this procedure. (pipelinereview.com)
Early reports indicated cell engraftment from bone marrow transplants into non- hematopoietic tissues in mouse to mouse and in human allogeneic bone marrow transplants. (ucl.ac.uk)
Graft5
Finally, NK cells have low risk of eliciting graft versus host disease, making them attractive for allogeneic cell therapy. (biospace.com)
As such, they are considered an allogeneic graft, which typically requires immunosuppression in order for the recipient to tolerate the implant. (biospace.com)
The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)
All patients except two who received reduced intensity had severe mucositis.Reversible veno-occlusive disease of the liver also developed in two patients.There was one death from graft-vs-host disease and no regimen-related mortality.Engraftment was prompt, with a median recovery of absolute neutrophil count to ³ 500/µL of 12 days (range: 11-18 days). (cancernetwork.com)
The other three allogeneic recipients died from either graft-vs-hostdisease, relapse, or acetaminophen-induced hepatic necrosis. (cancernetwork.com)
Myeloid4
In conclusion, a-GVHD may influence early marrow reconstitution and is a relevant factor for primary myeloid and platelet engraftment. (unict.it)
Criteria for discharge were presence of myeloid engraftment and absence of severe concomitant problems. (nature.com)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Measurable Residual IDH1 before Allogeneic Transplant for Acute Myeloid Leukemia. (mcw.edu)
Transplant5
Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients. (uchicago.edu)
Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
The company highlighted positive data, productive regulatory interactions and progress on commercial readiness activities supporting its lead product candidate, omidubicel, an advanced cell therapy candidate for allogeneic stem cell transplant, as it advances toward its May 1, 2023 target Prescription Drug User Fee Act (PDUFA) action date. (advfn.com)
Recently presented data continue to support the clinical benefits and safety of omidubicel, which, if approved, may be a valuable new donor source for patients in need of allogeneic stem cell transplant. (advfn.com)
Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients. (mcw.edu)
Enhance engraftment2
Strikingly, the depletion of CD8 + cells did not further enhance engraftment in anti-CD154 mAb-treated recipients in a model in which rejection is mediated by both CD4 + and CD8 + T cells. (umn.edu)
iMC signaling combined with autocrine IL-15 may enhance engraftment and survival of CAR-NK cells. (biospace.com)
Platelet3
When factors important for engraftment were studied in a multivariate analysis, postengraftment a-GVHD was a significant factor in delayed neutrophil and platelet engraftment. (unict.it)
The middle times to neutrophil and platelet engraftment were 19 days (run, 13 to 27) and 18.5 days (extend, 12 to 31), separately. (alliedacademies.org)
The efficacy parameters in this study were myeloablation (defined as one or more of the following: absolute neutrophil count [ANC] less than 0.5x109/L, absolute lymphocyte count [ALC] less than 0.1x109/L, thrombocytopenia defined as a platelet count less than 20,000/mm³ or a platelet transfusion requirement) and engraftment (ANC greater than or equal to 0.5x109/L). All patients (61/61) experienced myeloablation. (clustermed.info)
Recipients4
In contrast, pan-T-cell depletion resulted in only transient engraftment in 200 cGy-irradiated recipients. (umn.edu)
Host CD4 + cells were essential for alloengraftment as depletion of CD4 + cells abrogated engraftment in anti-CD154-treated recipients. (umn.edu)
Additionally, the administration of either anti-CD28 mAb or anti-CD152 (anti-CTLA-4) mAb or the use of CD28 deletional recipients abrogated engraftment in anti-CD154 mAb-treated mice suggesting that balanced CD28/CD152:B7 interactions are required for the engraftment-promoting capacity of anti-CD154 mAb. (umn.edu)
Six patients relapsed, includingall five autologous and one allogeneic recipients. (cancernetwork.com)
Cells15
Engraftment is the term used to describe when your new marrow begins to function and produce blood cells. (ucsfhealth.org)
While awaiting engraftment, no mature cells leave the marrow and enter the blood stream. (ucsfhealth.org)
However, anti-CD154 mAb did facilitate engraftment in a model in which only CD8 + T cells mediate rejection. (umn.edu)
It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
These results support our enthusiasm for the application of the GoCAR platform to allogeneic natural killer cells. (biospace.com)
Allogeneic GoCAR-NK cells may improve the durability of clinical responses while offering the anticipated advantages that an off-the-shelf product may provide, including faster and more certain time to treatment, greater scalability and convenience, and potentially lower cost. (biospace.com)
Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
However, the Encaptra device is designed to prevent the patient's immune system from accessing the implanted cells, thereby facilitating successful engraftment and subsequent maturation to islets. (biospace.com)
Three months after osteoblast engraftment (1.5-2.0% donor cells), representative specimens of trabecular bone showed histologic changes indicative of new dense bone formation. (nih.gov)
Current CLL xenograft models are hampered by inefficient engraftment of good prognostic CLLs, overgrowth with co-transplanted T cells, and the need for allogeneic humanization or irradiation. (uzh.ch)
While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Sana's hypoimmune technology seeks to overcome the immunologic rejection of allogeneic cells via disruption of human leukocyte antigen (HLA) class I and class II expression to allow cells to evade the adaptive immune system, including antibody and T cell responses, as well as overexpression of CD47 to allow cells to evade the innate immune cell system, in particular macrophages and natural killer (NK) cells. (pipelinereview.com)
Sana's prior presentations across multiple preclinical models have highlighted the potential of this platform to enable allogeneic cells to evade immune recognition and the potential of hypoimmune-modified cells as a therapeutic for patients. (pipelinereview.com)
After one rest day, allogeneic hematopoietic progenitor cells were infused. (clustermed.info)
Regimen1
We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. (qub.ac.uk)
Immunosuppression1
In addition to complications from this immune suppression, inadequate immunosuppression has limited uptake and durability of effect, as most patients eventually reject the transplanted islets over months to years, lose glucose control, and become insulin-dependent again, primarily due to immune rejection of the allogeneic islets from inadequate immunosuppression. (pipelinereview.com)
Chimerism2
In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
Chimerism analysis - testing of short tandem repeat regions to assess donor bone marrow engraftment. (ouh.nhs.uk)
Transplantations1
What's the difference between allogeneic and autologous stem cell transplantations? (clevelandclinic.org)
GVHD2
All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. (qub.ac.uk)
and the postengraftment a-GVHD group are those who were not on corticosteroid treatment at the time of engraftment but needed it after day +19. (unict.it)
Grafts1
Furthermore, CD154 deletional mice irradiated with 200 cGy irradiation were not tolerant of grafts, suggesting that engraftment promotion by anti-CD154 mAb may not simply be the result of CD154:CD40 blockade. (umn.edu)
Toxicities1
We conclude that in spite of rapid engraftment, non-hematological toxicities and infections remain important limitations for further reduction of the length of patient hospitalization in a significant number of patients after PBSCT. (nature.com)
Reconstitution1
Rethymic ( allogeneic processed thymus tissue-agdc) is processed thymus tissue indicated for immune reconstitution in pediatric patients with congenital athymia. (rxlist.com)
Irradiation2
Therefore, we aimed to establish an effective and reproducible xenograft protocol which allows engraftment of all CLL subtypes without the need of humanization or irradiation. (uzh.ch)
In conclusion, we developed an easy-to-use CLL xenograft protocol which allows reliable engraftment for all CLL subgroups without humanization or irradiation of mice. (uzh.ch)
Severe1
Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)
Complications1
The aim of this study is thus to define group-based trajectory modeling, to identify clusters of individual serum citrulline kinetics in the early phase of allogeneic HCST, and to test whether these unsupervised trajectories were correlated with these early complications. (confex.com)
Feasibility1
3 After a wave of fascinating reports on the feasibility and efficacy of this "revolutionary" approach, some studies revealed that patients with a high risk of either disease recurrence or non-engraftment did not fare too well with this strategy. (haematologica.org)
Nonmyeloablative1
More specifically, the development of minimal intensity or so called "nonmyeloablative" conditioning regimens paved the way towards the application of allogeneic HCT in older patients and all of those who probably would not tolerate classical intensity conditioning. (haematologica.org)
Treatment1
He continues to study the requirements to engraftment and developed a pre-clinical canine model of IUSCT in which he has achieved clinically relevant levels of donor engraftment with a goal of prenatal treatment of hemoglobinopathies. (chop.edu)
Tissue2
Our Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
RETHYMIC consists of yellow to brown slices of allogeneic processed thymus tissue for administration by surgical implantation. (rxlist.com)
Approaches1
Bellicum's GoCAR-NK platform is designed to address several of the current challenges of allogeneic cell therapy approaches. (biospace.com)
Decrease1
5 Along these lines, Monaca and co-workers, 6 again from Seattle, have convincingly demonstrated in this issue of Haematologica that subtle dose increases of unfractionated TBI can significantly decrease the failure rate after allogeneic HCT. (haematologica.org)
Dose1
9 While this trial tested a dose of 60 mg/kg ATG (day -3 to -1), a similar finding was made after allogeneic HCT from matched siblings applying 30 mg/kg again within intensive conditioning. (haematologica.org)