Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and of degradation products produced during bone resorption. (medscape.com)
Alkaline phosphatase has been clinically available for several years as a marker for bone metabolism. (medscape.com)
Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
Experimental silicon deprivation in rats [ 14 - 16 ] and chicks [ 17 , 18 ] demonstrated marked effects on growth and bone metabolism which in some studies resulted in aberrant connective tissue and bone mineralization (thinner cortex, less calcified bone matrix) and bone defects. (biomedcentral.com)
The major advantages of using osteocalcin as a clinical index of bone turnover are its tissue specificity, its wide availability, and its relatively low within-person variation. (medscape.com)
The calcium ion is essential to any physiologic phenomena, including preservation of the integrity of cellular membranes, neuromuscular activity, regulation of endocrine and exocrine secretory activities, blood coagulation, activation of the complement system, and bone metabolism. (abdominalkey.com)
To investigate whether oral protein supplements benefit bone metabolism in patients with recent hip fracture. (acpjournals.org)
Protein1
Osteocalcin is a small protein (49 amino acids) synthesized by mature osteoblasts, odontoblasts, and hypertrophic chondrocytes. (medscape.com)
Serum4
Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
The resulting heterogeneity of the osteocalcin fragments in the serum leads to limitations with the use of this marker. (medscape.com)
Serum osteocalcin levels reportedly vary significantly during the menstrual cycle, with the highest levels observed during the luteal phase. (medscape.com)
Biochemical indicators of bone formation were serum osteocalcin and amino-terminal propeptide of type I procollagen, and a marker for bone resorption was serum type I collagen carboxy-terminal telopeptide (CTx). (nih.gov)
Dual-energy x-ray a2
A DPX (Lunar Radiation Corporation, Madison, Wisconsin) operating on the principle of dual-energy x-ray absorptiometry (DXA) was used for the measurement of the lumbar spine (L2-L4 segment) and proximal femur (neck) bone mineral content. (medscape.com)
A total of 117 female patients were divided according to lumbar spine BMD measurements via dual-energy x-ray absorptiometry in three groups: 47 with osteopenia, 21 with osteoporosis and 49 with normal BMD. (biomedcentral.com)
Released during bone fo1
Biochemical monitoring of bone metabolism depends upon measurement of enzymes and proteins released during bone formation and of degradation products produced during bone resorption. (medscape.com)
Bone turnover1
The major advantages of using osteocalcin as a clinical index of bone turnover are its tissue specificity, its wide availability, and its relatively low within-person variation. (medscape.com)
Osteoblasts2
Osteocalcin is a small protein (49 amino acids) synthesized by mature osteoblasts, odontoblasts, and hypertrophic chondrocytes. (medscape.com)
Osteocalcin is a protein primarily produced by osteoblasts, which are cells responsible for bone formation. (medicallabnotes.com)
Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. (nih.gov)
The resemblance of uranium metabolism to that of calcium in bone enables the effects of uranium on bone. (nih.gov)
Levels1
Osteocalcin levels follow a circadian rhythm characterized by a decline during the morning, a low around noon, and a gradual increase to a peak after midnight. (medscape.com)
Type1
Type I collagen carboxyterminal propeptide (PICP) and type I collagen carboxyterminal cross-linked telopeptide (ICTP) were determined by radioimmunoassay using an Orion Diagnostica analytical kit. (medscape.com)