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  • artery
  • These experiments have investigated how the endothelium modulates resistance artery contractility in hypertension. (bl.uk)
  • Only ACE inhibitor treatment normalised resistance vessel contractility and endothelium-dependent relaxation suggesting that factors other than blood pressure reduction play an important role in restoring resistance artery endothelial function. (bl.uk)
  • inhibitor
  • In this study, we use 2 mouse models of vascular calcification, mice with gene deletion of matrix Gla protein, a bone morphogenetic protein (BMP)-inhibitor, and Ins2Akita/+ mice, a diabetes model. (nih.gov)
  • Treatment of SHRs with either an ACE inhibitor, a vasodilator or a calcium antagonist prevented the rise in blood pressure and normalised vascular structural alterations. (bl.uk)
  • The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. (wikipedia.org)
  • enzyme
  • Once produced in endothelial cells, NO diffuses across the vascular smooth muscle cell membranes and activates the enzyme soluble guanylate cyclase (sGC), which catalyzes the conversion of guanosine triphosphate into cyclic guanosine monophosphate (cGMP). (wikipedia.org)
  • pressures
  • The technique enables studying vascular adhesion under shear flow with differing intraluminal pressures up to 200 mmHg thus mimic-ing the pathophysiological conditions of high blood pressure. (jove.com)
  • lesions
  • We speculate that large shear stress gradients can induce morphological and functional changes in the endothelium in regions of disturbed flow in vivo and thus may contribute to the formation of atherosclerotic lesions. (ahajournals.org)
  • However, it is not clear whether the vascular endothelium has a role in contributing osteoprogenitor cells to the calcific lesions. (nih.gov)
  • injury
  • Since serum MGO level is increased in diabetic patients, MGO is implicated in diabetic complications related to vascular injury. (nih.gov)
  • cell
  • Here, we show that potassium softens vascular endothelium and increases the release of NO. It is suggested that these changes in stiffness, mediated by potassium and sodium, involve principally a dynamic viscous zone at the periphery of the cell. (pnas.org)
  • Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium. (nih.gov)
  • This will establish involvement of CaMKIIδ in modulation of NF-kB signalling in a vascular endothelial cell line. (bmj.com)
  • brain
  • Additionally, endothelial-specific deletion of Gpr116 resulted in a significant increase of the brain vascular leakage. (diva-portal.org)
  • PKG-II has been detected in renal cells, zona glomerulosa cells of the adrenal cortex, club cells in distal airways, intestinal mucosa, pancreatic ducts, parotid and submandibular glands, chondrocytes, and several brain nuclei, but not in cardiac and vascular myocytes. (wikipedia.org)
  • cells
  • We show that enhanced BMP signaling in both types of mice stimulates the vascular endothelium to contribute osteoprogenitor cells to the vascular calcification. (nih.gov)
  • Chemical (acetylcholine) activation triggered spatiotemporally-complex, propagating IP3-mediated Ca2+ waves that originated in clusters of cells and progressed from there across the endothelium. (strath.ac.uk)
  • Here we (i) characterise NF-kβ signalling in vascular endothelial cells and examine the potential for CaMKII modulation and (ii) determine whether CaMKIIδ expression is altered in ageing. (bmj.com)
  • PKG-I has been detected at high concentrations (above 0.1 µmol/L) in all types of smooth muscle cells (SMCs) including vascular SMCs and in platelets. (wikipedia.org)
  • The vascular endothelium has to continually renew itself, so this killing of cells leads to a breakdown of the lining and to hemorrhage. (wikipedia.org)
  • disease
  • It can be difficult to make a vascular disease diagnosis since there are a variety of symptoms that a person can have, also family history and a physical examination are important. (wikipedia.org)
  • There is research interest in attempting to develop such products to treat conditions including Crohn's disease and a variety of vascular conditions. (wikipedia.org)
  • levels
  • Recent studies showed that high levels of transforming growth factor (TGF)-β1 in the airways reduced airway responsiveness, which was reversed in conditions of basic fibroblast growth factor (FGF2) deficiency, whereas high levels of vascular endothelial growth factor (VEGF) enhanced airway sensitization to allergens and airway hyperresponsiveness (AHR). (ingentaconnect.com)
  • Lower levels are present in vascular endothelium and cardiomyocytes. (wikipedia.org)
  • Small
  • Intercellular clefts are important for allowing the transportation of fluids and small solute matter through the endothelium. (wikipedia.org)