• Few mechanistic studies, however, have examined the vascular effects of androgens in humans, although we have recently demonstrated an association between androgen deprivation and enhanced endothelial function in older men consistent with a deleterious effect of androgens on vascular reactivity. (ahajournals.org)
  • Although anti-VEGF agents are widely used for cancer treatment, their use can also lead to vascular damage such as arterial thromboembolism and re-occlusion of new vessels. (nature.com)
  • Comparable results were obtained in arterial endothelial cells and in endothelium stimulated with the cytokine tumor necrosis factor-α. (ahajournals.org)
  • Arterial endothelium-derived hyperpolarization: potential role in pregnancy adaptations and complications. (semanticscholar.org)
  • The vascular endothelium releases nitric oxide (NO) and von Willebrand Factor (VWF) in accord with autonomic balance to regulate the capillary gate mechanism that governs hemodynamic physiology and determines cardiac output, cardiac efficiency, tissue perfusion, tissue oxygenation, organ function, organ protection, and arterial patency. (stressmechanism.com)
  • Orienta pelos Programas de P s-Gradua o em Nefrologia e em Medicina Translacional (UNIFESP-EPM), desenvolvendo estudos cl nicos e experimentais que abordam os seguintes temas: Programa o Fetal, Repercuss es Tardias do Baixo Peso ao Nascer: Aspectos Vasculares e Renais, Modelos Experimentais de Desnutri o Intra-Uterina, Marcadores Epigen ticos, Hipertens o Arterial e Disfun o Endotelial. (cnpq.br)
  • A) Aortic wall (confocal microscopy, top 2 panels), and aortic endothelium () from wild type ( Mgp +/+ ) and Mgp − / − mice. (nih.gov)
  • Endothelium-dependent vasorelaxation was impaired, and the concentration of bioavailable NO decreased in the aortic ring in IDH2 knockout mice. (ovid.com)
  • The anticoagulantly active HSPG were concentrated immediately beneath the aortic and vasa vasorum endothelium with only a very small extent of labeling noted on the luminal surface of the endothelial cells. (rupress.org)
  • Cumulative addition of atropine to the organ bath containing endothelium-intact (+E) rat aorta, which was precontracted with phenylephrine (PE, 1 microM) and subsequently relaxed with carbachol (1 microM), caused biphasic changes in the vascular contractility of +E rat aortic rings. (scienceopen.com)
  • Atropine-induced aortic relaxation was significantly inhibited upon endothelium removal by either rubbing or saponin treatment, but considerable relaxation still persisted in the range of 30-100 microM atropine. (scienceopen.com)
  • 5 In vascular cells, this oxidative reaction is mediated by two distinct classes of NOS. (ahajournals.org)
  • There are some evidence linking excess vascular oxidative stress to the impairment of EDRF action associated with hypercholesterolemia. (springer.com)
  • It is concluded that antibody JC70 is of value for studying benign and malignant human vascular disorders in routinely processed tissue. (bmj.com)
  • In addition, DHE and DCF fluorescence staining demonstrated that IL-4 increases ROS production in human vascular endothelial cells. (vt.edu)
  • We have also provided the first novel evidence that 5-LOX, one of the enzymes associated with arachidonic acid metabolism, is responsible for the IL-4-induced ROS generation and MCP-1 expression in human vascular endothelial cells. (vt.edu)
  • These data indicate a novel human-specific mechanism in which Neu5Gc-rich foods deliver immunogenic Neu5Gc to the endothelium, giving anti-Neu5Gc antibody- and complement-dependent activation, and potentially contributing to human vascular pathologies. (ashpublications.org)
  • These findings demonstrate that nanomolar concentrations of phenylephrine, which are devoid of any contractile effect, induced a slight endothelium-dependent vasorelaxation in the rat MVB through the stimulation of α 1D -adrenoceptors, located on endothelial cells, which act through phospholipase C stimulation, followed by IP 1 generation, and nitric-oxide synthase activation. (aspetjournals.org)
  • In view of the participation of vascular endothelial cells (EC) in a wide range of normal and pathological conditions, phenotypic heterogeneity of EC is an important concept for consideration: different sub-populations of EC may play differing biological roles in normal and patho-physiological states. (springer.com)
  • Small physiological changes in extracellular sodium concentration directly stiffen vascular endothelium ( 16 ). (pnas.org)
  • Despite its known expression in both the vascular endothelium and the lung epithelium, until recently the physiological role of the adhesion receptor Gpr116/ADGRF5 has remained elusive. (diva-portal.org)
  • Vascular theory of the glaucomatous optic neuropathy pathogenesis: physiological and pathophysiological rationale: Part 2. (ssmj.ru)
  • It is involved in the regulation of vascular tone, local hemostasis, proliferation. (ssmj.ru)
  • These Nrp-plexin and semaphorin complexes initiate cascades that regulate diverse processes such as axon pruning and repulsion, dendritic attraction and branching, regulation of cell migration, vascular remodeling, and growth cone collapse. (wikipedia.org)
  • Vascular cell adhesion molecule-1 (VCAM-1) is induced on endothelial cells by inflammatory cytokines, and binds mononuclear leukocytes through the integrin very late antigen-4 (VLA-4) (alpha 4 beta 1). (rupress.org)
  • A constitutively active Ca 2+ -calmodulin-dependent isoform of the enzyme predominates in endothelial cells, whereas a Ca 2 -insensitive isoform is induced by inflammatory cytokines in vascular smooth muscle. (ahajournals.org)
  • The vascular endothelium comprises a dynamic interface with the blood and acts as an integrator and transducer of both biochemical (e.g. inflammatory cytokines) and biomechanical (e.g. laminar shear stress) stimuli. (grantome.com)
  • During inflammatory conditions, however, the endomucin on the endothelial cell surface is dramatically reduced and the levels of pro-adhesives molecules (such as ICAM) on the endothelium increase, resulting in neutrophil accumulation. (scienmag.com)
  • The researchers showed both in tissue culture and animal models that the adherence and infiltration of inflammatory cells could be blocked by experimentally expressing excess endomucin in the vascular endothelium. (scienmag.com)
  • Breakdown of the inner blood-retinal barrier and the blood-brain barrier is associated with changes in tight and adherens junction-associated proteins that link vascular endothelial cells. (open.ac.uk)
  • Barrier function - the endothelium acts as a semi-selective barrier between the vessel lumen and surrounding tissue, controlling the passage of materials and the transit of white blood cells into and out of the bloodstream. (wikipedia.org)
  • Recent studies have shown the restoration of endothelial function before significant reduction of serum cholesterol levels effect of statins on the endothelium were first defined by their ability to enhance endothelial NO production, upregulating endothelial nitric oxide synthase (eNOS) PI3 kinase/Akt signaling, which is a crucial regulator of cell metabolism and apoptosis, appears to mediate statin-induced eNOS upregulation. (pharmaceuticalintelligence.com)
  • The vasodilator activity of α 1 -adrenoceptor agonists was tested in the rat mesenteric vascular bed (MVB), and the mechanism involved was investigated in cultured endothelial cells isolated from the bovine coronary vascular bed. (aspetjournals.org)
  • Experimental approach: The rat mesenteric vascular bed was perfused with Krebs solution. (elsevier.com)
  • Here, we show that the vascular endothelial growth factor receptor 3 (VEGFR-3)/p110 alpha PI3-kinase signaling pathway is selectively required for the formation of mesenteric lymphatic vasculature. (diva-portal.org)
  • Systemic anthrax disease is characterized by vascular leakage pathologies. (mdpi.com)
  • Experimental observation of Chuanxiong and Chishao on reducing blood lipoid of hyperglycemia rats, anti-oxidation and vascular endothelium function. (springer.com)
  • We investigated the effects of acute administration of a high concentration of lead acetate (100 µÌ) on the pressor response to phenylephrine (PHE) in the tail vascular bed of male Wistar rats . (bvsalud.org)