We previously showed that expression and activity of eEF2K are increased in isolated mesenteric arteries from spontaneously hypertensive rats (SHR) contributing to development of essential hypertension. (bvsalud.org)
In order to test the hypothesis that inhibition of eEF2K activity induces vasodilatation by suppressing sympathetic nerve activity, we examined the effects of A484954 on perivascular sympathetic nerve stimulation-induced contraction in isolated renal artery from normotensive and hypertensive rats. (bvsalud.org)
In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)
When compared with WKY control rats, 12-week-old vehicle-treated SHRs were hypertensive, overweight, and insulin resistant, with elevated fasting levels of insulin and ET-1 and reduced serum adiponectin levels. (diabetesjournals.org)
Cardiovascular2
The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Vascular endothelium contributes importantly to regulation of cardiovascular and metabolic homeostasis ( 1 , 2 ). (diabetesjournals.org)
Treatment1
ACh-induced vasorelaxation in aortic rings was also superior with both of the combinations compared to individual treatment. (biomedcentral.com)
Effects2
Our results show that chronic nicotine inhalation led to impaired acetylcholine-mediated vasodilatory response in both thoracic aortas and pulmonary arteries, and these effects were accompanied by altered endothelial nitric oxide synthasephosphorylation (enhanced inhibitory phosphorylation at threonine 495) and reduced plasma nitrite levels in WT but not α7-nAChR-/- mice. (bvsalud.org)
By restoring phosphatidylinositol 3-kinase-dependent effects, rosiglitazone and/or enalapril therapy of SHRs also significantly improved vasodilator responses to insulin in MVB preconstricted with NE ex vivo. (diabetesjournals.org)
Essential1
In addition to its essential metabolic actions, insulin also has important endothelial-dependent vasodilator actions mediated by nitric oxide (NO) via phosphatidylinositol 3-kinase (PI 3-kinase)-dependent activation of endothelial NO synthase ( 5 - 9 ). (diabetesjournals.org)