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  • EDHF
  • Early studies indicated that the EETs produce important biological effects, particularly in the vascular and renal systems ( 52 , 68 , 103 ), but there was only limited interest in these compounds until the middle 1990s, when they were shown to be synthesized in the endothelium and to function as an endothelium-dependent hyperpolarizing factor (EDHF) under certain conditions in the coronary circulation ( 7 , 51 ). (physiology.org)
  • arterial
  • Interest was further heightened by the observations that EETs have anti-inflammatory effects in the endothelium ( 120 ), stimulate angiogenesis ( 105 , 115 ), and prevent arterial smooth muscle migration ( 151 ). (physiology.org)
  • reactive
  • Plasma nitrotyrosine, an in vivo marker of NO-dependent damage induced by reactive nitrogen intermediates derived from NO, will be measured by ELISA. (clinicaltrials.gov)
  • induction
  • As an alternative to myocyte-driven hypertrophy in response to hemodynamic stress we recently reported a cross-talk loop induction of myocardial hypertrophy by expanding vascular endothelium in the absence of traditional hypertrophy stimuli. (yale.edu)
  • Studies
  • Besides ensuring appropriate experimental protocols, future studies require the precise monitoring of the degree and cellular specificity (endothelium, perivascular nerve fibers, neurons, etc.) of NOS inhibition in order to obtain concrete and reliable experimental data. (nii.ac.jp)
  • dose
  • An intravenous bolus injection of incremental doses of big ET-1 (0.3, 1.0, and 3.0 nmol/kg) produced a significant hypertensive effect that was dose dependent and prolonged (from 113±7 mm Hg to a maximum of 148±6 mm Hg). (ahajournals.org)
  • increase
  • These factors might be a compensatory mechanism to the increase in SBP. (nih.gov)
  • Our hypothesis is that an increase in vascular endothelium in the adult heart results in increased nitric oxide (NO) production that in turn drives the growth of cardiomyocytes by sustained ubiquitination of the negative regulator of G protein signaling subtype 4 (RGS4) and derepression of the hypertrophic program via heterotrimeric G protein signaling. (yale.edu)
  • activity
  • L rum, O. D. Purification and properties of a 155 kDa bone marrow-derived glycoprotein enhancing the activity of granulocyte-macrophage colony stimulating factor (GM-CSF). (uib.no)