Loading...
  • vasodilation
  • The few points of consensus among the researchers may be summarized as follows: (1) NO, probably produced in the endothelium, plays an important role in the maintenance of the basal cerebral blood flow, (2) NO is not directly involved in hypoxic vasodilation, and (3) NO mediates a functional coupling of metabolism and cerebral blood flow in certain types of neural activation. (nii.ac.jp)
  • 1996. l-Arginine Induces Nitric Oxide-Dependent Vasodilation in Patients With Critical Limb Ischemia A Randomized, Controlled Study. (ac.ir)
  • BACKGROUND Estrogen replacement therapy reduces the risk of coronary heart disease in postmenopausal women, and estrogen treatment modulates endothelium-dependent vasodilation in ovariectomized, atherosclerotic monkeys. (ahajournals.org)
  • This, together with the wide separation between the nerve and endothelium in the vessel wall, suggests that ACh is not involved in TNS-induced vasodilation. (ahajournals.org)
  • Blockade of the TNS-induced vasodilation by tetrodotoxin (TTX) or cold storage denervation did not prevent the arteries from relaxing in response to ACh or methacholine (MCh). (ahajournals.org)
  • Although these data in adults suggest that the endothelium, parenchymal neurons, and perivascular nerves are not important during hypercapnia-induced cerebral vasodilation, it is also possible that these cells produce overlapping vasodilator messengers, and removal of an individual messenger is not sufficient to alter the response. (asahq.org)
  • The mechanism by which urocortin relaxes blood vessels appears to be complex, eg, vasodilation has been reported to be both endothelium dependent and independent. (ahajournals.org)
  • 3,4,9,10 The endothelium-independent vasodilation was suggested to be mediated by activation of the cAMP/protein kinase A (PKA) signaling cascade, 2,11 which is in line with the observation that activation of CRF-2R increases cAMP levels in Ltk cells. (ahajournals.org)
  • In arterioles from the pial circulation, increases in flow stimulate endothelium-dependent vasodilation at low transmural pressures. (asahq.org)
  • vascular endothelium
  • The vascular endothelium plays an important functional role in maintaining homeostasis in normal vessels by releasing vasoactive substances such as NO 7 and ET-1 8 that modulate smooth muscle tone and proliferation. (ahajournals.org)
  • The vascular endothelium is now known to be more than a pure anatomical entity, which smoothly contacts the blood and forms a passive barrier against plasma lipids. (spotidoc.com)
  • Surgical or chemical denervation of arteries, pretreatment with blockers of excitatory neurotransmission, application of tetrodotoxin (TTX), or removal of vascular endothelium did not attenuate vasomotion, indicating its myogenic origin. (ahajournals.org)
  • small arteries
  • 1 2 It also is well established that sustained hypertension is associated with morphological alterations, such as eutrophic and hypertrophic remodeling in small arteries to adapt to elevated wall stress, and thereby may protect the microcirculation. (ahajournals.org)
  • 10 Spontaneous rhythmic variation in the diameter of small arteries has been observed through closed cranial windows in the pial microcirculation in vivo. (ahajournals.org)
  • agonist
  • Because, in our previously study with the NO-cGMP pathway in rat resistance coronary arteries, halothane had no effect distal to the agonist receptor whereas isoflurane did, we hypothesized that isoflurane may have an attenuating effect on FID but halothane may not. (asahq.org)
  • Specifically, we sought to determine the effects of adventitial expression of eNOS on the response to a contractile agonist, phenylephrine, and vascular relaxations to calcium ionophore, a known stimulant of eNOS, in rabbit carotid arteries. (ahajournals.org)
  • Methods
  • METHODS AND RESULTS The present study was designed to test whether the sensitivity and specificity of the relaxing response of coronary vascular smooth muscle to exogenous estradiol-17 beta is dependent on the sex hormone status of the animal. (ahajournals.org)
  • Methods- Changes in basilar artery diameter were measured with the use of a cranial window preparation in anesthetized Sprague-Dawley rats. (ahajournals.org)
  • Methods- Mice exhibiting a 2-fold increase in vascular EC-SOD and wild-type (WT) littermates were subjected to sham surgery or SAH by perforation of the right anterior cerebral artery. (ahajournals.org)
  • vasorelaxation
  • These results suggest that in chronic hypertension, vasorelaxation to an ATP-sensitive K+ channel opener is augmented and that hydrogen peroxide produced in smooth muscle cells may partly contribute to these relaxations. (semanticscholar.org)
  • Restoration of vasorelaxation with PEG-SOD or allopurinol suggests that the mechanism(s) by which IL-10 preserves endothelium-dependent vasorelaxation involves O 2 − , perhaps by reducing production of O 2 − by xanthine oxidase. (diabetesjournals.org)
  • Endothelium-dependent vasorelaxation is impaired by proinflammatory cytokines during inflammation ( 1 , 2 ). (diabetesjournals.org)
  • subarachnoid
  • Human basilar arteries were obtained from subjects who died within 1 day after subarachnoid hemorrhage and control subjects who died from causes other than brain involvement. (ahajournals.org)
  • However, the endothelium-independent response to sodium nitroprusside of the subarachnoid hemorrhage group did not differ from that of the control group. (ahajournals.org)
  • Although the decreased relaxation was observed within 1 day after subarachnoid hemorrhage, a period in which delayed spasm does not occur, this time difference may be dependent on the severity of bleeding after rupture of an aneurysm. (ahajournals.org)
  • Soluble guanylyl cyclases (sGCs) and Ras homolog gene family, member A (rhoA)/Ras homolog gene family kinase(rho-kinase) plays a role in vascular smooth muscle relaxation in subarachnoid hemorrhage (SAH). (hindawi.com)
  • inhibits
  • It has been shown that NO (catalyzed by eNOs, nNos, and iNOs), an endothelium-derived relaxing factor (EDRF), augments with endothelin-1 and inhibits activation of rhoA/ROCK in rat thoracic aorta [ 8 ]. (hindawi.com)
  • augments
  • 3-6 However, it is still unclear whether thromboxane A 2 augments this enzymatic activity in the intact artery. (asahq.org)
  • resistance
  • We studied changes in pressure gradient across isolated coronary resistance arteries while keeping the intravascular pressure constant to remove any myogenic effects. (asahq.org)
  • Dietary supplementation with L-arginine fails to restore endothelial function in forearm resistance arteries of patients with severe heart failure. (ac.ir)
  • There is strong evidence suggesting that endothelin is involved in hypertrophic remodeling (increased CSA) of resistance arteries. (ahajournals.org)
  • Bosentan administration did not modify the structural alteration of the resistance vessels induced by L-NAME, nor did it improve endothelium-dependent relaxation of resistance vessels or the aorta. (ahajournals.org)
  • pH, 7.4) at 4°C. An unbranched arteriolar segment at least 1 mm in length from the territory of the posterior cerebellar artery was dissected free, cleared from the adhering tissue, and transferred to a plexiglas vessel chamber (Living Systems, Burlington, VT) containing PSS and mounted on inflow and outflow micropipettes matched for resistance to flow. (asahq.org)
  • Blood circulation depends on the myogenic tone of small, resistance-size arteries ( Meininger and Davis, 1992 ). (rupress.org)
  • mechanism
  • 20 21 In the vessel wall, NO and prostacyclin inhibit ET-1 production via a cGMP-dependent mechanism. (ahajournals.org)
  • Cholinergic mechanism in the large cat cerebral artery. (ahajournals.org)
  • 15 16 The data to be presented demonstrate that oxygen-derived free radicals enhance adenylyl cyclase activation probably via sensitization of the catalytic moiety of adenylyl cyclase and that this effect is mediated in part by hydroxyl radicals and acts via a tyrosine kinase-dependent mechanism. (ahajournals.org)
  • Through activating sGC/cGMP/PKG pathway and partially by inactivating rho-kinase in a NO-dependent mechanism, MLB shows promise to be an effective strategy for the treatment of this disease entity. (hindawi.com)
  • Here, we used high-resolution electron-spray ionization mass spectrometry (ESI-MS), Carr-Purcell-Meiboom-Gill relaxation dispersion (CPMG-RD), and affinity measurements of cTnC for the thin filament in reconstituted papillary muscles to provide evidence of an allosteric mechanism in mutant cTnC that may play a role to the HCM phenotype. (fsu.edu)
  • aorta
  • The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats. (semanticscholar.org)
  • The present study was designed to determine whether relaxations to an ATP-sensitive K+ channel opener, levcromakalim, are increased in the aorta from spontaneously hypertensive rats (SHR) and whether free radical scavengers reduce these relaxations. (semanticscholar.org)
  • Relaxations to levcromakalim (10(-8) to 10(-5) M), which are abolished by glibenclamide (10(-5) M), were augmented in the aorta from SHR, compared to those in the aorta from WKY. (semanticscholar.org)
  • In the aorta from SHR, catalase (1200 U/ml), but neither superoxide dismutase (150 U/ml) nor deferoxamine (10(-4) M), reduced relaxations to levcromakalim, whereas in the aorta from WKY, the free radical scavengers did not affect these relaxations. (semanticscholar.org)
  • In isolated rat aorta, exogenously administered tetrahydrobiopterin causes relaxations. (ahajournals.org)