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  • middle cerebral artery
  • Previously, we have demonstrated that transgenic mice (GET-1 mice) that over-express endothelin-1 (ET-1) specifically in the astrocytes are more susceptible to brain damage, including increased infarct volume, hemispheric swelling as well as cerebral water content, upon transient focal ischemia induced by middle cerebral artery occlusion (MCAO). (biomedcentral.com)
  • In this video, we show our optimized system for cerebral perfusion monitoring during transient middle cerebral artery occlusion by intraluminal filament in the rat. (jove.com)
  • To mimic ischemic stroke in patients, in whom approximately 80% thrombotic or embolic strokes occur in the territory of the middle cerebral artery (MCA), the intraluminal middle cerebral artery occlusion (MCAO) model is quite relevant for stroke studies. (jove.com)
  • constriction
  • In contrast, concentration of any magnitude (10(-6) to 3 x 10(-3) M) induced constriction exclusively in arteries without endothelium. (ahajournals.org)
  • These data showing a strong expression of the P2Y 2 purinoceptor in the neointima of injured arteries suggest that extracellular nucleotides may be involved, via this receptor, in the intimal hyperplasia and/or chronic constriction observed at the lesion site, and consequently in the restenotic process. (ahajournals.org)
  • endothelin
  • Publications] Tadayoshi NAKAGOMI: 'Pharmacological effect of Endothelin,an Endothelium-derived vasoconstrictive peptide,on canine basilar arteries' Neurologia Medico-Chirurgica. (nii.ac.jp)
  • It has been shown that NO (catalyzed by eNOs, nNos, and iNOs), an endothelium-derived relaxing factor (EDRF), augments with endothelin-1 and inhibits activation of rhoA/ROCK in rat thoracic aorta [ 8 ]. (hindawi.com)
  • agonist
  • Because, in our previously study with the NO-cGMP pathway in rat resistance coronary arteries, halothane had no effect distal to the agonist receptor whereas isoflurane did, we hypothesized that isoflurane may have an attenuating effect on FID but halothane may not. (asahq.org)
  • Methods
  • Methods- Changes in basilar artery diameter were measured with the use of a cranial window preparation in anesthetized Sprague-Dawley rats. (ahajournals.org)
  • METHODS AND RESULTS The present study was designed to test whether the sensitivity and specificity of the relaxing response of coronary vascular smooth muscle to exogenous estradiol-17 beta is dependent on the sex hormone status of the animal. (ahajournals.org)
  • Methods- Mice exhibiting a 2-fold increase in vascular EC-SOD and wild-type (WT) littermates were subjected to sham surgery or SAH by perforation of the right anterior cerebral artery. (ahajournals.org)
  • In humans, the middle cerebral artery (MCA) is most commonly affected in stroke syndromes and multiple methods of MCA occlusion (MCAO) have been described to mimic this clinical syndrome in animal models. (jove.com)
  • small arteries
  • 1 2 It also is well established that sustained hypertension is associated with morphological alterations, such as eutrophic and hypertrophic remodeling in small arteries to adapt to elevated wall stress, and thereby may protect the microcirculation. (ahajournals.org)
  • vertebral
  • Several studies have attempted to link chiropractic manipulation to adverse events, the most serious and widely studied being strokes following dissections of the vertebral artery. (chiro.org)
  • The vertebral artery (VA) itself, emerges from the subclavian artery, passes through the transverse foramina of C6 C1 to become the atlantal segment as it exits through the transverse foramen of C1. (chiro.org)
  • Mechanisms of dissection: As the layer which makes up the vessel lining, the tunica intima is more susceptible to tearing [ 32 ] and as such is the typical site of the initial defect which initiates a vertebral artery dissection (VAD). (chiro.org)
  • augments
  • 3-6 However, it is still unclear whether thromboxane A 2 augments this enzymatic activity in the intact artery. (asahq.org)