Receptors, EndothelinReceptor, Endothelin AReceptors, NicotinicReceptor, Endothelin BEndothelinsEndothelin-1SulfonamidesPhenylpropionatesPeptides, CyclicIndansViper VenomsEndothelin-3Hypertension, PulmonaryAntihypertensive AgentsPyrrolidinesPyridazinesEndothelin-2Eisenmenger ComplexIsoxazolesAzepinesPiperidinesRats, Sprague-DawleyVasoconstrictionOligopeptidesTetrazolesThiophenesPyrimidinesDose-Response Relationship, DrugHemodynamicsRats, WistarDioxanesBlood PressurePyridinesDioxolesInterleukin 1 Receptor Antagonist ProteinPhosphodiesterase 5 InhibitorsVasodilator AgentsPulmonary ArteryNeurokinin-1 Receptor AntagonistsScleroderma, SystemicEpoprostenolRats, Inbred WKYVasoconstrictor AgentsRenal CirculationMuscle, Smooth, VascularAdministration, OralRats, Inbred SHRKidneySulfonesRNA, MessengerEndothelium, VascularVascular ResistanceNitric OxideAngiotensin Receptor AntagonistsDisease Models, AnimalPurinergic P1 Receptor AntagonistsRadioligand AssayAortaPurinesBinding, CompetitiveHistamine H2 AntagonistsHypertensionAspartic Acid EndopeptidasesSerotonin 5-HT3 Receptor AntagonistsTime FactorsIndolesExcitatory Amino Acid AntagonistsDogsDouble-Blind MethodNitric Oxide SynthaseMyocardiumCHO CellsEnzyme InhibitorsDopamine AntagonistsHormone AntagonistsMuscle ContractionSerotonin 5-HT2 Receptor AntagonistsHeart RateAdenosine A2 Receptor AntagonistsCells, CulturedRabbitsInfusions, IntravenousExercise ToleranceTreatment OutcomePhosphodiesterase InhibitorsAdenosine A1 Receptor AntagonistsMetalloendopeptidasesPurinergic P2 Receptor AntagonistsAngiotensin IINarcotic AntagonistsGuinea PigsHeart FailureCalciumDansyl CompoundsHistamine H1 AntagonistsSignal TransductionDrug Therapy, CombinationVasodilationIodine RadioisotopesMuscarinic Antagonists