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  • endothelium
  • ESCs will eventually produce endothelial cells (ECs), which create the thin-walled endothelium that lines the inner surface of blood vessels and lymphatic vessels. (wikipedia.org)
  • Boisset J-C, van Cappellen W, Andrieu-Soler C, Galjart N, Dzierzak E, Robin C (2010) In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. (springer.com)
  • Kissa K, Herbomel P (2010) Blood stem cells emerge from aortic endothelium by a novel type of cell transition. (springer.com)
  • Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DYR, Traver D (2010) Haematopoietic stem cells derive directly from aortic endothelium during development. (springer.com)
  • Although it has been particularly challenging to study the genetic determinants that predispose to abnormal function of the endothelium in insulin-resistant states, the possibility of deriving endothelial cells from induced pluripotent stem cells generated from individuals with detailed clinical phenotyping, including accurate measurements of insulin resistance accompanied by multilevel omic data (eg, genetic and genomic characterization), has opened new avenues to study this relationship. (ahajournals.org)
  • Unfractionated WJ cells directly cultured in endothelial cell medium upon enzymatic dissociation express, five passages later, endothelium-related genes and proteins and form vascular networks in vitro . (biomedcentral.com)
  • In the present study, we investigated pulmonary endothelial chimerism using the ABH histo-blood group Keywords Chronic graft-versus-host disease · antigen as an identifying marker in cases of ABO-incom- Chimerism · Lung · Endothelium · Hematopoietic stem cell patible hematopoietic stem cell transplantation. (deepdyve.com)
  • Immunohistology of aorta-gonads-mesonephros (AGM) regions show that GFP(+) cells are specifically localized to the endothelial layer lining the wall of the dorsal aorta but not to the mesenchyme, strongly suggesting that HSC activity arises within a few cells within the endothelium of the major vasculature. (nih.gov)
  • Nichi-In Centre for Regenerative Medicine (NCRM) hopes to make corneal endothelium (inside cell layer) available on a commercial scale. (ncrm.org)
  • The project is based on the findings of Japanese doctor Shiro Amano of the Tokyo University School of Medicine, who in 2002 found that the endothelium of the cornea contains stem cells (cells in initial stages of development) that can be multiplied several times in the laboratory. (ncrm.org)
  • somatic
  • Develop a precise and efficient non-nuclease genome editing technology for editing somatic stem cells in vivo. (ca.gov)
  • Identification of optimal genome editing vector for editing the FVIII gene in human endothelial cells, somatic stem cells and immortalized cells derived from hemophilia A patient. (ca.gov)
  • Comparison of purified, homogeneous populations of somatic cells derived from multiple independent human iPS and ES lines will be required to address this critical question. (ca.gov)
  • Demonstrate
  • Demonstrate genome editing of the FVIII gene in human stem cells and their progeny, to provide proof of concept of the gene editing strategy for therapeutic correction of the mutation. (ca.gov)
  • Vascular endothelial cells demonstrate remarkable plasticity and differentiate into other cell types during embryonic development and disease progression. (springer.com)
  • Interactions
  • It can be used in a variety of applications and can assess important interactions between the different cell types. (unipd.it)
  • HUVECs
  • The monitoring and quantification of MSC sprouting toward HUVECs revealed different distance related response between the different cell sources. (unipd.it)
  • hMSCs
  • We find that iPS-ECs alone have a muted tubulogenic response within GelMA, but that their tubulogenic response is enhanced when they are co-cultured with a small fraction of hMSCs (2% of total cells). (rsc.org)
  • marker
  • Fetal liver kinase-1 (Flk-1) is a cell surface receptor protein that is commonly used as a marker for ESCs and EPCs. (wikipedia.org)
  • Differentiation of USCs in endothelial medium generated EC-like cells by day 14 that displayed endothelial characteristics at the morphological, ultrastructural (tight junction formation), and functional marker expression levels (e.g. (stemcellsportal.com)
  • RT-qPCR of cells derived from co-cultures in fibrin was performed to evaluate changes in the expression of EC marker genes during the first week of culture. (technologynetworks.com)
  • novel
  • The presented system is a novel approach that provides a simple and robust model of cell-cell communication based on varying distances without using complicated and expensive equipment. (unipd.it)
  • Urine-derived stem cells: A novel and versatile progenitor source for cell-based therapy and regenerative medicine. (stemcellsportal.com)
  • Adult
  • Samokhvalov IM, Samokhvalova NI, Nishikawa S-I (2007) Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. (springer.com)
  • Cellular
  • The further specialized a cell is, the more differentiated it is and as a result it is considered to be more committed to a certain cellular lineage. (wikipedia.org)
  • CD134 (OX40), which is a cellular receptor for human herpesvirus-6B (HHV-6B) and expresses on activated T cells, may play a key role for HHV-6B replication after allogeneic hematopoietic stem cell tra. (bioportfolio.com)
  • blood vessels
  • In 1917, Florence Sabin first observer of blood vessels and red blood cells in the yolk sac of chick embryos occur in close proximity and time. (wikipedia.org)
  • Dr. Mariana Kaplan and her team at the University of Michigan Health Systems in Ann Arbor studied the abnormal function of stem cells that repair damaged blood vessels, an important factor implicated in heart disease in lupus. (youtube.com)
  • Here, we report an experimental protocol based on embryonic development that produces large numbers of endothelial cells-the cells that line the interior surface of blood vessels-derived from multiple human ES cells or iPS cells. (ca.gov)
  • Given the limited variability, endothelial cells derived from patient-specific iPS cells may prove useful in modeling diseases of the blood vessels or in testing potential new drugs to treat these diseases. (ca.gov)
  • abnormalities
  • It is important to explore the differences between these two cell types to pinpoint genetic abnormalities or discover if they have a tendency to differentiate toward a particular cell type. (ca.gov)
  • tissues
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)