Endothelial myocardial reperfusion injury myocardial ischemia reperfusion injury ischemia reperfusion. Medical search. Frequent questions

On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
GRh2 reduced the area of myocardial infarction and the histological changes in the myocardium and improved cardiac functions. (spandidos-publications.com)
Following myocardial infarction (MI), elderly patients have a poorer prognosis than younger patients, which may be linked to increased coronary microvessel susceptibility to injury. (jci.org)
Only patients with ST-segment elevation myocardial infarction (STEMI) receiving successful primary percutaneous coronary intervention (pPCI) and defined Δapelin-12 with apelin-12 elevation per cent 72 hours after pPCI compared with apelin-12 level immediately prior to pPCI were enrolled. (bmj.com)
ST-elevation myocardial infarction (STEMI) following successful primary percutaneous coronary intervention (pPCI) is the leading cause of mortality and morbidity worldwide in major adverse coronary events (MACEs) due to mechanical complications, acute heart failure and cardiac shock after successful procedure. (bmj.com)
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. (nature.com)
Hypoxia/reoxygenation (H/R)-induced cardiomyocyte cell apoptosis is critical in developing myocardial infarction. (biomedcentral.com)
Since reperfusion (RP)-induced EC injury following myocardial infarction is known to occur due to oxidative stress, we simulated RP as flow of oxygenated media over ischemic ECs and showed that RP leads to excessive levels of mitochondrial ROS, mitochondrial fragmentation/fission, and EC inflammation/dysfunction (our work set the standard for how to simulate in vitro ischemia/RP and quantify mitochondrial dynamics). (drexel.edu)
When ischemia is severe and prolonged, it causes myocyte death and results in loss of contractile function and tissue infarction. (medscape.com)
Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
Under pathological conditions, such as myocardial infarction, humoral factors released by these cells may induce tissue damage or protection, depending on the type and concentration of molecules secreted. (unab.cl)
We also discuss pre-clinical molecules proposed as treatments for myocardial infarction and provide a clinical perspective on these potential therapeutic agents. (unab.cl)
[ 2 ] In 1958, streptokinase was first used in patients with acute myocardial infarction (AMI), and this changed the focus of treatment. (medscape.com)
Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. (cdc.gov)

Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as aggravates ischemia/reperfusion (I/R)-induced myocardial injury. (nih.gov)
Picking up on the original 1998 Nobel-winning work of Drs. Louis Ignarro and Ferid Murad, Dr. Bryan has focused on identifying specific changes in NO-related signaling pathways associated with endothelial dysfunction, ischemia and other disease states, and testing botanical interventions that improve NO signaling and vascular function. (holisticprimarycare.net)
In many people with endothelial dysfunction and NO deficiency, the arginine pathway itself is dysfunctional. (holisticprimarycare.net)
Pretreating the rats with simvastatin 18 hour prior to the induction of ischemiareperfusion has been shown to reduce cardiac dysfunction and improve coronary flow [ 7 ]. (ac.ir)
In addition to protective "immune response", sepsis is characterized by destructive "endothelial response" of the host, leading to endotheliopathy and its molecular dysfunction. (biomedcentral.com)
There is substantial evidence that endothelial injury during organ procurement and preservation, caused by ischemia and subsequent reperfusion, results in endothelial dysfunction. (frontierspartnerships.org)
Besides endothelial dysfunction, the progression of interstitial and perivascular fibrosis consecutively leads to impaired diastolic and systolic graft function, thus preservation of endothelial and vascular function is certainly a clinically desirable goal. (frontierspartnerships.org)
Endothelial cell (EC) dysfunction is the hallmark of cardiovascular diseases and most of them are associ-ated with altered hemodynamics. (drexel.edu)
Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. (eurekaselect.com)
Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
Finding all 3 entities in the same patient with chronic myocardial dysfunction is not uncommon (see the image above). (medscape.com)
All of these factors affect the way in which the immature heart handles calcium, which, in turn, contributes to the myocardial dysfunction observed after CPB. (medscape.com)

To determine the mechanism(s) responsible for decreased coronary flow after global cardiac ischemia and reperfusion, we studied 40 isolated rabbit hearts before and after 30 minutes of normothermic ischemic arrest and reperfusion. (elsevierpure.com)
Numerous apoptotic cardiomyocytes were found in ischemic fields in ischemia-reperfusion groups and werent observed in the sham-operated group. (ac.ir)
Both ischemic and reperfused rat myocardium can undergo apoptotic cell death, however the myocardium, which is subjected to ischemia followed by reperfusion, undergoes accelerated apoptosis [ 3 ]. (ac.ir)
These pleiotropic effects thus have a major role in protecting the myocardium against ischemic injury. (ac.ir)
Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
Endothelial ischemia-reperfusion (I/R) injury importantly contributes to the poor prognosis during ischemic (myocardial) events. (artinis.com)
Protection of the ischemic myocardium is known to occur as a result of ischemic preconditioning (PC), in which repetitive brief periods of ischemia protect the heart from a subsequent prolong ischemic insult. (eurekaselect.com)
Systolic wall thickening after coronary artery occlusion and subsequent reperfusion in normal and ischemic zones. (medscape.com)
Because of the increased ability of the immature myocardium to rely on anaerobic glycolysis, it can withstand ischemic injury better than adult myocardium can. (medscape.com)
The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)

In vivo rat hearts or isolated Langendorff-perfused mouse hearts were subjected to ischemia followed by reperfusion with intralipid (0.5%, 1% and 2% ex-vivo, and 20% in vivo), cyclosporine-A (0.2 μM, 0.8 μM, and 1.5 μM ex- vivo and 10 mg/kg in vivo), or vehicle. (silverchair.com)

Evidence has been provided that activation of the vascular endothelial cells in the presence of the risk factors promotes oxidative stress and vascular inflammatory responses, leading to acceleration of atherosclerotic vascular disease. (frontiersin.org)
Hypoxic vascular endothelial cells activate white blood cells, which bind to the endothelium and release directly damaging substances (eg, reactive oxygen species, proteolytic enzymes) and inflammatory mediators (eg, cytokines, leukotrienes, tumor necrosis factor). (msdmanuals.com)

In lpr mice, a naturally occurring mutant deficient in Fas, there is marked reduction in infarct size and abundance of apoptotic cardiac myocytes following ischemia and reperfusion that also signifies the importance of Fas pathway in ischemia-reperfusion injury [ 5 ]. (ac.ir)
Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. (nature.com)

Upregulation of Fas expression in myocardial ischemia-reperfusion can induce cardiomyocyte apoptosis, and atorvastatin can significantly inhibit cardiomyocyte apoptosis by inhibiting Fas expression. (ac.ir)
METHODS By means of network pharmacology, the active components of PLR and PTR against cardiomyocyte OGD/R injury were identified. (magtechjournal.com)
Cells were pretreated with STA (50 µM) 2 h before H/R. Cardiomyocyte injury was evaluated by CCK-8 assay and lactate dehydrogenase (LDH) release. (biomedcentral.com)
To investigate this hypothesis, the H9c2 cardiomyocyte cell line was used to establish an in vitro myocardial H/R injury model to explore the roles and potential mechanisms of STA in myocardial H/R injury. (biomedcentral.com)
This review provides a current summary of the principal molecules, pathways, and mechanisms underlying cardiomyocyte and cardiac fibroblast crosstalk during ischemia/reperfusion injury. (unab.cl)

However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)
Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
Immature calcium handling in immature myocardium raises intracellular calcium concentrations after ischemia and reperfusion. (medscape.com)

The nitric oxide donor S-nitroso-human-serum-albumin (S-NO-HSA) is known to attenuate myocardial ischemia-reperfusion (I/R)-injury. (frontierspartnerships.org)
In this study, we hypothesized that STA could attenuate myocardial H/R injury. (biomedcentral.com)
However, clinical and preclinical results using various cardioprotective strategies to attenuate reperfusion injury have generally not been applicable for every day clinical practice. (eurekaselect.com)

Preconditioning, i.e., repeated exposure to short periods of ischemia, effectively reduces endothelial I/R injury. (artinis.com)

Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)

Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
This dual role of the complement must be nature's rule just like normal hemostasis, which protects human lives in external bodily injury, but also may harm human lives in intravascular injury through thrombogenesis. (biomedcentral.com)
Recent studies have demonstrated that supplementation of nitric oxide (NO), or increased expression of endothelial NO-synthase (eNOS) protects against both IR-injury and fibrosis ( 5 , 6 ). (frontierspartnerships.org)
Our data speculated that STA protects H/R injury and inhibits oxidative stress and apoptosis in cardiomyocytes by activation of the SIRT1-Nrf2 pathway. (biomedcentral.com)
We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. (silverchair.com)
Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)

In project no. 81-02 a novel in vitro approach was established by replacing flatbed cultures through cultivation of endothelial cells on microcarrier beads. (forschung3r.ch)
This allows the interaction between blood cells and derived natural factors and interactions with endothelial cells to be studied in vitro . (forschung3r.ch)
The system is based on endothelial cells (as an example, porcine aortic endothelial cells, PAEC) which are previously expanded in vitro in conventional flatbed culture systems. (forschung3r.ch)
Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)

It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
It has been shown that the Fas pathway is functional in cardiac myocytes and plays a critical role in myocardial death due to ischemia-reperfusion in vivo [ 4 ]. (ac.ir)

In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)

Apoptosis of the cardiomyocytes has been demonstrated in animal models with coronary artery occlusion [ 1 ], and experimental evidence suggests that myocardial cells are able to undergo apoptosis during ischemia followed by reperfusion [ 2 ]. (ac.ir)
The results indicated that TFs significantly alleviate H/R injury, which include inhibiting apoptosis and enhancing antioxidant capacity. (hindawi.com)
The myocardial apoptosis and inflammation have been recognized as features of I/R injury. (hindawi.com)
Wogonin could suppress apoptosis in rats experienced myocardial I/R [ 25 ]. (hindawi.com)
In addition, PEMF treatment also reduced the apoptosis of myocardial cells by up-regulating the expression of anti-apoptosis protein B-cell lymphoma 2 (Bcl-2) and down-regulating the expression of pro-apoptosis protein (Bax). (pemfglobal.com)

Another mechanism by which β3-AR agonists exert their relaxative effects on vasculature is by promoting endothelial nitric oxide synthase (eNOS) activity and NO bioavailability. (wikipedia.org)
is the parent ROS molecule produced by the one electron reduction of oxygen catabolized by various enzymes including NADPH oxidase, cyclooxygenase, lipoxygenases, cytochrome P450 enzymes, enzymes in the mitochondrial electron transport chain ( Yang and Lüscher, 2002 ), and also endothelial NO ⋅ Synthase (eNOS, see below). (frontiersin.org)

Atorvastatin has been shown to be cardioprotective in ischemia-reperfusion (I/R) injury. (ac.ir)

Stachydrine (STA), an active constituent of Leonurus heterophyllus sweet, could have a protective effect on myocardial H/R injury, which remains unexplored. (biomedcentral.com)
In our study, we demonstrated for the first time that extracorporeal PEMF has a novel effect on myocardial I/R injury. (pemfglobal.com)

Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure worldwide ( 1 , 2 ). (spandidos-publications.com)
this may be an important mechanism of decreased coronary perfusion and subsequent myocardial injury during reflow. (elsevierpure.com)
Cold ischemia and subsequent reperfusion injury are non-immunologic cornerstones in the development of graft injury after heart transplantation. (frontierspartnerships.org)

leaves alleviate hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes and to explore potential mechanisms. (hindawi.com)
Myocardial ischemia, also called cardiac ischemia or hypoxia/reoxygenation (H/R)-induced heart damage, is caused by decreased blood flow [ 1 ]. (biomedcentral.com)

In the host, MAC also may induce channel formation to innocent bystander endothelial cells (ECs) and ECs cannot be protected. (biomedcentral.com)

Now, we know that complement system, protecting the host through innate immune system, could trigger harmful endothelial pathogenesis. (biomedcentral.com)
Although the role of the endothelium in the pathogenesis of sepsis is not clearly established yet, coagulopathy has been proposed to play a key role through crosstalk mechanism between inflammation and coagulation as a result of systemic endothelial injury [ 11 , 12 , 13 ]. (biomedcentral.com)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
The number and function of circulating endothelial progenitor cells (EPCs) were increased in PEMF treating rats. (pemfglobal.com)

PGC‑1α, Nrf2, endothelial nitric oxide synthase and superoxide dismutase levels were significantly decreased, while inducible nitric oxide synthase and malondialdehyde levels were significantly increased by I/R induction. (spandidos-publications.com)
This peripheral vasodilation is mediated by endothelial nitric oxide release following β3-AR agonism, not by adrenergic receptor blockade. (wikipedia.org)

Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Reperfusion treatment has a potential risk of worsening tissue damage after ischemia, which can accelerate the deterioration of cardiac function [ 2 ]. (hindawi.com)
Myocardial ischemia is a clinical syndrome manifesting a variety of tissue effects and global cardiac effects that impair cardiac function. (medscape.com)
In the heart, cardiomyocytes, fibroblasts, and endothelial cells interact to form the cardiac tissue. (unab.cl)
Identifying the molecules and cellular signal pathways implicated in these processes will be crucial for creating effective tissue-preserving treatments during or after reperfusion. (unab.cl)
Numerous therapies to protect cardiac tissue from reperfusion-induced injury have been explored, and ample pre-clinical research has attempted to identify drugs or techniques to mitigate cardiac damage. (unab.cl)
but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Until today the activity of such substances had to be tested in animal models because of complex interactions between endothelial cells, coagulation and innate immunity. (forschung3r.ch)
Accordingly, the interaction between blood cells and derived natural factors and interactions with endothelial cells cannot be studied in conventional cell culture systems. (forschung3r.ch)
However, replacing flatbed cultures through cultivation of endothelial cells on microcarrier beads increases the surface-to-blood volume ratio twenty-fold to reach that of small arteries and veins (16 cm 2 endothelial cell surface per ml of blood). (forschung3r.ch)
In this system potential "endothelial cell protectants", i.e. substances which preserve endothelial integrity and prevent activation of the endothelial cells, can be pre-incubated with the cells in the flask or co-incubated with the whole blood, and their effects assessed. (forschung3r.ch)
Porcine aortic endothelial cells (PAEC, used here as an example of endothelial cells in general) are expanded in conventional flatbed cell culture and then grown to confluence on microcarriers. (forschung3r.ch)
Abstract ： OBJECTIVE To explore the similarities and differences of material basis, action, and mechanism of Puerariae Lobatae Radix(PLR) and Puerariae Thomsonii Radix(PTR) against myocardial cell injury, and compare the differences of relative amount of active ingredients and the effect against H9c2 cells OGD/R injury in different medicated systems. (magtechjournal.com)
The main active components and relative contents in medicated intestinal absorption fluid(IAF) and medicated serum(MS) of PLR and PTR were determined by UPLC-Q-TOF-MS. The OGD/R injury model in H9c2 cells was established and intervened with different drug-containing systems of PLR and PTR. (magtechjournal.com)
The comparison showed that the anti-H9c2 cell injury effect of PLR was superior to that of PTR, and the effect of IAF on each pharmacodynamic index was better than that of MS. CONCLUSION PLR and PTR can protect H9c2 cells against injury induced by OGD/R in different degrees, while PLR playing a stronger role, which might be through the regulation of MAPKp38 and NFκBp65 protein expressions. (magtechjournal.com)
Experimental manipulation of DNA methylation in engineered human umbilical vein endothelial cells indicated that the identified differentially methylated probes located at TRIM6 , TLN2, and FLRT2 genes may play a role in endothelial cell adhesion and atherosclerosis. (biomedcentral.com)
The potential functional role of DMPs was verified in a CRISPR/dCas9-Dnmt3a model in human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)

An intravital model for imaging the adult and aged IR-injured beating heart in real time in vivo was used to demonstrate heightened basal and injury-induced neutrophil recruitment, and poorer blood flow, in the aged coronary microcirculation when compared with adult hearts. (jci.org)
The in vivo results showed that per-treatment of PEMF could significantly improve the cardiac function in I/R injury group. (pemfglobal.com)
Murine models of Matrigel plug and hindlimb ischemia were employed as in vivo angiogenic assays. (biomedcentral.com)

The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
these socalled pleiotropic properties include anti-inflammatory effects, plaque stabilization, improved endothelial function and inhibition of vascular smooth muscle cell proliferation. (ac.ir)
One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)

Therefore, our aim was to develop a medium throughput comorbidity cell-based test system of myocardial I/R injury, hypercholesterolemia and hyperglycemia that mimics comorbidity conditions. (nih.gov)

in general, understanding the molecular basis of cardiovascular diseases (atherosclerosis, ischemia/reperfusion injury, diabetes). (drexel.edu)
Under normal conditions, a thrombus is confined to the immediate area of injury and does not obstruct flow to critical areas, unless the blood vessel lumen is already diminished, as it is in atherosclerosis . (medscape.com)

As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)

The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. (spandidos-publications.com)
However, despite numerous studies on myocardial I/R injury, deeper insight into the underlying mechanisms of myocardial I/R injury is needed. (spandidos-publications.com)
However, few studies have focused on the role of miR-132 in myocardial I/R injury and the underlying mechanisms. (spandidos-publications.com)
In order to fully understand the mechanisms of I/R injury and to find novel therapeutic strategies, further research is stilled urgently needed [ 3 ]. (hindawi.com)
Therefore, the study aimed to investigate the protective effects and mechanisms of STA on H/R injury of cardiomyocytes. (biomedcentral.com)
Therefore, exploring new therapeutic agents and investigating their potential mechanisms underlying myocardial H/R injury is important. (biomedcentral.com)
However, the effects and the detailed mechanisms of STA in myocardial H/R injury are unknown. (biomedcentral.com)
In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms. (pemfglobal.com)

Thirty Wistar rats were selected and divided into three groups (n = 10): acute ischemia-reperfusion (I/R) group, acute ischemia-reperfusion and treated with atorvastatin group and sham-operated group. (ac.ir)

It was shown that functional Fas system contributes to apoptotic myocardial cell death in response to ischemia/reperfusion injury [ 4 , 5 ]. (ac.ir)

Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
Behavioural screening in 24 mouse mutants identified the kinase Fgr as a driver of this pathogenic state, and interference with Fgr protected mice from inflammatory injury. (studylib.net)

Conversely, blocking miR-21 expression with miR-21 inhibitor effectively suppressed the protective effects of TFs against H/R-induced injury. (hindawi.com)

Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)

One is physiologic defensive mechanism through immune system, and the other is pathologic destructive mechanism through endothelial system. (biomedcentral.com)
Despite the recent surge about miRNA discoveries for cardiac I/R injury, there is still very little known about the mechanism details because of the complexity of cellular events and the interference of other risk factors. (hindawi.com)
Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)

miR‑132 was significantly upregulated and SIRT1 was markedly downregulated in I/R myocardial tissues. (spandidos-publications.com)
However, the role of STA on the H/R injury of cardiomyocytes through the SIRT1-Nrf2 pathway remains unexplored. (biomedcentral.com)

The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)
A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)

The myocardial I/R model was established using C57BL/J6 mice. (spandidos-publications.com)
This may be mechanistically explained by attenuated endothelial oxidative damage and VCAM-1 expression in IL-36Ra-treated mice. (jci.org)
Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)

In the control group (n = 10) we evaluated the time course of recovery of coronary flow, vascular reactivity, and myocardial function. (elsevierpure.com)
Coronary artery smooth muscle function was comparable in hearts before and after ischemia. (elsevierpure.com)
In 17 healthy young subjects, we examined changes in brachial artery endothelial function using flow-mediated dilation (FMD) before and after a bout of high-intensity interval exercise, moderate-intensity endurance exercise, or a control intervention. (artinis.com)
In cases of less severe ischemia, some myocytes remain viable but have depressed contractile function. (medscape.com)
Regional myocardial function and electrophysiological alteration after coronary artery occlusion. (medscape.com)
Recovery of myocardial contractile function after spontaneous restoration of flow may be protracted similarly after angioplasty or revascularization surgery. (medscape.com)
When ischemia is prolonged, myocytes have depressed contractile function but remain viable. (medscape.com)
The concomitant presence of myocardial necrosis with myocardial ischemia, stunning, or hibernation may complicate appraisal of left ventricular (LV) function and patient management. (medscape.com)

Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)

In conventional flatbed culture systems, work with whole, non-anticoagulated blood leads to coagulation as the endothelial surface per blood volume does not suffice to ensure that the endogenous anticoagulant state can be maintained. (forschung3r.ch)
Another endogenous form of cardioprotection, similar to PC but applicable at the time of reperfusion, termed postconditioning (PostC), has been recently described. (eurekaselect.com)

Donepezil attenuated cardiac ischemia/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy[J]. Transl Res, 2021,230:82-97. (magtechjournal.com)

Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. (spandidos-publications.com)
Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)

In experimental groups A (n = 10) and B (n = 10), metabolic control of autoregulation was assessed by plots of myocardial oxygen consumption versus coronary flow generated by incremental increases in heart rate. (elsevierpure.com)

Interleukin-36 (IL-36), a newly discovered proinflammatory member of the IL-1 superfamily, may mediate this injury, but its role in the injured heart is currently not known. (jci.org)
In addition, it has been shown that atorvastatin can protect the isolated mouse heart against reperfusion-induced injury [ 6 ]. (ac.ir)
Chronic allograft injury (CAI), consisting of vasculopathy and interstitial fibrosis, affects approximately 50% of patients after 10 years and limits long-term survival following heart transplantation ( 1 ). (frontierspartnerships.org)

Fas expression was significantly higher in the ischemia-reperfusion group as compared to sham-operated group, but was decreased significantly in atorvastatin treated group as compared with I/R group. (ac.ir)

Commercial kits were used to measure the levels of serum myocardial enzymes and inflammatory factors. (spandidos-publications.com)
Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)
The GRh2 pre‑treatment reduced the I/R‑ or H/R‑induced release of myocardial enzymes and the production of IL‑1β, IL‑18 and TNF‑α. (spandidos-publications.com)

Anatomy21

Organisms12

Diseases40

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes32

Disciplines and Occupations1

Information Science1

Health Care5

Infarction14

Dysfunction13

Ischemic13

Subjected to ischemia followed by reperfusion1

Vascular endothelial cells2

Infarct size2

Cardiomyocyte5

Myocardium4

Attenuate3

Periods of ischemia1

Oxidative stress and upregulating1

Protects6

Vitro4

Role in myocardial2

Signalling pathway1

Apoptosis5

ENOS2

Cardioprotective1

Effect on myocardial2

Subsequent3

Hypoxia2

Induce1

Pathogenesis2

Progenitor cells3

Nitric oxide2

Tissue7

Cells11

Vivo3

Inhibition3

Hypercholesterolemia1

Atherosclerosis2

Cardiovascular1

Mechanisms8

Rats1

Contributes1

Inflammatory injury2

Protective effects1

Clinical2

Mechanism3

SIRT12

Renal2

Mice4

Function8

Nrf21

Endogenous2

20211

Tissues2

Metabolic1

Heart3

Significantly higher1

Enzymes3