Endothelial cells gpi linked proteins. Medical search. Frequent questions

CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. (biolegend.com)
CD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins. (bioworlde.com)
Testisin (PRSS21) is a membrane anchored serine protease, which is tethered to the cell surface via a glycosylphosphatidylinositol (GPI)-anchor. (umaryland.edu)
FcRIIIB is a glycosylphosphatidylinositol (GPI)-linked receptor that has no cytoplasmic domain. (pepas.org)

We found that Gas1 deficiency mainly phenocopies Dhh deficiency especially by inducing VCAM-1 (vascular cell adhesion molecule 1) and ICAM-1 (intercellular adhesion molecule 1) overexpression while Cdon deficiency has opposite effects by promoting endothelial junction integrity. (oskar-bordeaux.fr)
bFGF is a more potent angiogenic factor than VEGF ( vascular endothelial growth factor ) or PDGF ( platelet-derived growth factor ). (beauty104.com.tw)
Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct and distinguished by the lack of expression of fibroblast/mesenchymal genes, and by the high expression of a 13-gene profile (that is, the 'vascular endothelial growth factor (VEGF) profile') that included VEGF, ANGPTL4, ADM and the monocarboxylic acid transporter SLC16A3 . (biomedcentral.com)
Ali MA, Choy H, Habib AA, Saha D. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. (famri.org)
Decreased expression of VE-cadherin in the neovasculature of Prss21-/- ovaries was also observed without marked differences in endothelial cell content, vascular claudin-5 expression or pericyte recruitment. (umaryland.edu)
As part of the tangled web of host defense systems that respond to vascular injury, the blood coagulation factors act in concert with the endothelium and blood cells, especially platelets, to generate a protective fibrin-platelet clot, forming a hemostatic plug. (mhmedical.com)
For normal hemostasis, both procoagulant and anticoagulant factors must interact with the vascular components and cell surfaces, including the vessel wall and platelets. (mhmedical.com)

Gas1 inhibits cell proliferation, protects endothelial cells from apoptosis, and promotes excitotoxic neuronal death. (bio-techne.com)
VEGF signals promote endothelial cell motility, filopodial extension and proliferation, and together with Notch signaling controls whether specific endothelial cells (ECs) become pioneering 'EC-tip' cells (non-proliferating) or trailing 'EC-stalk' cells (proliferating). (aopwiki.org)
Knockdown of Cripto-1 inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells. (cusabio.com)
and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES . (nih.gov)
Epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF-2) induce the proliferation of neural precursor cells isolated from specific regions of the embryonic and adult brain. (beauty104.com.tw)
Not long after FGF1 and FGF2 were isolated, another group isolated a pair of heparin -binding growth factors which they named HBGF-1 and HBGF-2, whilst a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells which they called ECGF-1 and ECGF-2. (beauty104.com.tw)
One of the most important functions of bFGF is the promotion of endothelial cell proliferation and the physical organization of endothelial cells into tube-like structures. (beauty104.com.tw)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)
Furthermore to adding to the pathogenesis of many diseases, cholesterol can be exploited by pathogens because of their proliferation and entrance within web host cells. (cancercurehere.com)

Gas1 is a GPI-linked membrane glycoprotein that blocks entry to S phase cell cycle. (bio-techne.com)
thus, PIGA mutations lead to a deficiency of GPI-anchored proteins, such as complement decay-accelerating factor (also known as CD55) and CD59 glycoprotein (CD59), which are both complement inhibitors. (medscape.com)
Among aPL, anti-beta2-glycoprotein I antibodies (anti-beta2-GPI) have been shown to induce NF-kappaB nuclear translocation leading to a pro-inflammatory endothelial cell phenotype and thereby inducing acute phase proteins, such as serum amyloid A (SAA). (europa.eu)
Description: The 61D3 monoclonal antibody reacts with human CD14, a 53-55 kDa GPI-linked glycoprotein. (thermofisher.com)
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. (thermofisher.com)
ii) Elucidating the CD1d-restricted protective immune response that arises in mice that are vaccinated against the GPI anchor of the trypanosome variant surface glycoprotein, or infected with phospholipase C knock-out trypanosomes. (umass.edu)

Through membrane-binding proteins and secreted ions, individual sponge cells are able to coordinate aggregation while preventing fusion between different species or even different individuals. (wikipedia.org)
This is likely due to distinct cadherins, a calcium-binding membrane protein, expressed by different sponge species and individuals. (wikipedia.org)
Selectin is a receptor protein found on the membranes of leukocytes, platelet cells, and endothelial cells that binds membrane-bound glycans. (wikipedia.org)
One type of PRR is a group of integral membrane glycoproteins called toll-like receptors (TLRs), which can recognize certain lipoproteins, peptidoglycan, CpG-rich DNA, and flagellar components in bacterial cells, as well as glycoproteins and phospholipids from protozoan parasites and conidia (fungal spores). (wikipedia.org)
Caveolins can serve as protein markers of caveolae ('little caves'), invaginations in the plasma membrane 50-100 nanometers in diameter. (biomedcentral.com)
Interestingly, VIP21 was isolated as an integral membrane protein component of transport vesicles derived from the trans-Golgi network in Madin-Darby canine kidney (MDCK) cells, suggesting that Cav-1/VTP21 may have a role in molecular trafficking as well as oncogenesis. (biomedcentral.com)
Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack complex. (sdbonline.org)
Important biological events associated with plasma membranes, such as signal transduction, cell adhesion, and protein trafficking, are mediated through the membrane microdomains. (mdpi.com)
Semaphorin-5A, also known as Semaphorin-F, Sema F, SEMA5A and SEMAF, is a single-pass type I membrane protein which belongs to thesemaphorin family. (betalifesci.com)
Whereas the trisaccharidic head group of Gb 3 defines the specificity of Shiga toxin binding, the lipophilic part composed of sphingosine and different fatty acids is suggested to determine its localization within membranes impacting membrane organisation and protein binding eventually leading to protein internalisation. (springer.com)
Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
It is known that GSLs interact with both intracellular as well as exogenous proteins and are critical for membrane organisation, signalling, and recognition events. (springer.com)
GPI-anchored cell membrane protein involved in Nodal signaling. (cusabio.com)
This classification was abandoned because of the observation that surface proteins were missing not only in the RBC membrane but also in all blood cells, including the platelet and white cells. (medscape.com)
In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)
Cholesterol can 16-Dehydroprogesterone be an important lipid in mammalian cell membranes assisting varied functions, one of the most fundamental which are membrane integrity and fluidity (Maxfield and Tabas, 2005). (cancercurehere.com)
Other MMPs, known as membrane-type MMPs (MT-MMP), are linked to the plasma membrane either by a transmembrane domain or by a glycosyl-phosphatidyl inositol linkage, attached to the hemopexin domain. (periobasics.com)
Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)
Two other members of the MT-MMP subfamily, MMP-17 (MT4-MMP) and MMP-25 (MT6-MMP) are anchored to the plasma membrane via a glycosyl-phosphatidyl inositol (GPI) anchor. (periobasics.com)
HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
GAGs bound into PGs are located to the extracellular matrix, basal membrane, and cell surface [ 7 ]. (hindawi.com)
PGs, molecules which consist of a protein core that is covalently modified with GAG chains, are distributed both to the ECM "proper" associated with the cell membrane as well as located to intracellular compartment. (hindawi.com)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)

It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. (biolegend.com)
CD14 is expressed on monocytes, interfollicular macrophages and some dendritic cells. (thermofisher.com)
The innate immune system includes macrophages, dendritic cells (DC), and natural killer (NK) cells, which respond quickly to an immunological threat. (nature.com)

The common denominator in the disease, a biochemical defect, appears to be a genetic mutation leading to the inability to synthesize the glycosyl-phosphatidylinositol (GPI) anchor that binds these proteins to cell membranes. (medscape.com)
Most ZP domain proteins are synthesized as precursors with carboxy-terminal transmembrane domains or glycosyl phosphatidylinositol (GPI) anchors [ 2 ]. (expasy.org)

It was isolated as one of several proteins that became phosphorylated on tyrosine residues in chicken embryo fibroblasts transformed with the v-Src oncogene [ 4 ]. (biomedcentral.com)
MMPs are secreted by a variety of connective tissue and pro-inflammatory cells including fibroblasts, osteoblasts, endothelial cells, macrophages, neutrophils, and lymphocytes. (periobasics.com)

CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. (bioworlde.com)

This down-regulates VEGFR-2 expression in prospective EC-stalk cells but promotes VEGFR2 expression in EC-tip cells, enabling them to extend filopodial processes along VEGF-A rich paths thus orienting the angiogenic sprout [Williams et al. (aopwiki.org)

Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes). (oskar-bordeaux.fr)
The objective of t his proposal is to understand the role of anti-beta2-GPI antibodies and SAA in activating pro-thrombotic inflammatory responses in the endothelium and to determine the inhibitory effects by which LXA4 could counteract these molecular signaling pathways. (europa.eu)

A receptor on one cell surface binds to its specific ligand on a nearby cell, initiating a cascade of events which regulate cell behaviors ranging from simple adhesion to complex cellular differentiation. (wikipedia.org)
In response to an injury, endothelial cells will express selectin, which binds to glycans present on the leukocyte cell surface. (wikipedia.org)
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN . (nih.gov)
CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. (thermofisher.com)
ZP3 first binds to specific sperm proteins, thus mediating sperm contacts with the oocyte. (expasy.org)
This protein is a proteoglycan that binds to TGF-β and could be involved in capturing and retaining TGF-β for presentation to the signalling receptors. (expasy.org)

CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. (biolegend.com)
It is well established that inflammatory cytokines such as interleukin-1β (IL-1β) play a major regulatory role in the selective destruction of insulin-producing β-cells, resulting in the onset of type 1 diabetes ( 1 - 3 ). (diabetesjournals.org)
The interaction between pathogen-bound IgG and activating FcRs directly mediates pathogen clearance by antibody-dependent cell-mediated cytotoxicity (ADCC), degranulation of cytotoxic cells and phagocytosis, and indirectly through the release of cytokines and other inflammatory mediators1. (pepas.org)

Studies suggest glycan-glycan interactions, observed to be approximately 200-300pN, also may play a role in cell-cell recognition. (wikipedia.org)
These interactions, although observed to be weak, have been studied in a variety of test subjects including, but not limited to, mouse embryonal cells, corneal epithelial cells, and human embryonal carcinoma cells. (wikipedia.org)
This can either occur by cell surface receptor interactions, as in the case with peptide growth factors, or by interactions with intracellular molecules, as in the case with steroid hormones. (beauty104.com.tw)
The FGFs are heparin -binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans has been shown to be essential for FGF signal transduction. (beauty104.com.tw)
SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation. (uchicago.edu)
Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. (uchicago.edu)
Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. (uchicago.edu)
2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. (uchicago.edu)
The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)

功能： Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis (The amount of the reagent is suggested to be used ≤ 0.25 µg /10^6 cells in 100 µl). (sungenebiotech.com)
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). (elabscience.com)
therefore, antibody preparations containing this preservative agent must not be used in cell cultures nor injected into animals. (bdbiosciences.com)
Sodium azide may be removed by washing stained cells or plate-bound antibody or dialyzing soluble antibody in sodium azide-free buffer. (bdbiosciences.com)
The TEA 2/16 monoclonal antibody specifically recognizes CD109 which is also known as C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7 (CPAMD7), Gov platelet alloantigens, or 150 kDa TGF-beta-1-binding protein. (bdbiosciences.com)
Immunoprecipitation (IP) refers to methods of affinity chromatography that enrich and/or purify a specific protein from a complex mixture using a specific antibody immobilized on a solid support. (bvsalud.org)
Applications Tested: This 61D3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)

Cells with immune system recognition abilities include macrophages, dentritic cells, T cells, and B cells. (wikipedia.org)

In an investigation of testisin's function in endothelial cells we identified testisin as a novel regulator of physiological hormone-induced angiogenesis and microvascular endothelial permeability. (umaryland.edu)
Gelatinases degrade molecules in the basal lamina around capillaries, facilitate angiogenesis and neurogenesis, and contribute to instigating cell death. (periobasics.com)

Cell-cell recognition occurs when two molecules restricted to the plasma membranes of different cells bind to each other, triggering a response for communication, cooperation, transport, defense, and/or growth. (wikipedia.org)
In mouse embryos, E-cadherin on cell membranes is responsible for the adhesion of cells needed for embryonic compaction. (wikipedia.org)
Glycosphingolipids (GSLs) are a subclass of glycolipids that are found in cell membranes of various organisms ranging from bacteria to humans. (springer.com)
In fundamental cell biological processes such as signal transduction, enzymatic activity or intracellular fusion during vesicular transport, a large number of proteins are recruited to and released from the cytoplasmic surface of intracellular membranes (Casey et al. (biologists.com)
Lipids are recognized to carry out different features within cells, including being truly a major element of cell membranes, so that as signaling messengers. (cancercurehere.com)

Extracellular Vesicles (EVs) are membranous vesicles produced by all cells under physiological and pathological conditions. (nature.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Specifically, these extracellular matrix (ECM) components critically modulate the tumor cell "motile phenotype" affecting their adhesive/migratory abilities which are directly correlated to the metastatic cascade [ 5 , 6 ]. (hindawi.com)
The digital laminae are composed of extracellular matrix and link the coffin bone of the foot to the hoof wall, thus suspending the horse's weight within the hoof. (umass.edu)
The ZP domain is a conserved module for polymerization of extracellular proteins. (expasy.org)

The recombinant proteins are stable for up to 1 year from date of receipt at -70°C. (betalifesci.com)

Its large sample-handling capacity, broad applicability (particularly to proteins and enzymes), moderate cost, powerful resolving ability, ability to perform simultaneous quantitation, and ease of scale-up and automation have led to it becoming one of the most versatile and widely used of all liquid chromatography (LC) techniques. (bvsalud.org)
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on a conserved mechanism involving activation of an active site-bound water molecule by a Zn 2+ ion. (evelinvahter.com)

Semaphorins, a family of about 20 secreted, transmembrane and GPI-linked glycoproteins, and their cognate receptors (plexins and neuropilins) play a pivotal role in the crosstalk between cancer and stromal cells present in the tumor microenvironment. (biomedcentral.com)
Moreover, semaphorins and their cognate receptors are involved in controlling cancer stem cell phenotype, contributing to tumor progression, resistance to therapies, and metastasis initiation [ 18 ]. (biomedcentral.com)
Conversely, web host cells want lipids for mounting a solid immune system response to infections through conserved design identification receptors (Castrillo et al. (cancercurehere.com)
Activated protein C exerts multiple protective homeostatic actions, including proteolytic inactivation of factors Va and VIIIa, as well as direct cell-signaling activities involving protease-activated receptors 1 and 3, endothelial cell protein C receptor, integrin CD11b/CD18, and apolipoprotein E receptor 2. (mhmedical.com)
The receptors for the Fc region of IgG (FcRs) are expressed by many immune cells (FIG. 1) and are important in both promoting and regulating the immune and inflammatory response to immune complexes. (pepas.org)
In such cells, immune complex-mediated activation of these receptors is negatively regulated by FcRIIB. (pepas.org)
These results suggest that the fast glycinergic spIPSCs in AII cells are probably mediated by 1 heteromeric receptors with a contribution from 1 homomeric receptors. (gasyblog.com)
Indeed, it has been suggested that amacrine cells only express glycine receptors with sluggish kinetic properties (Frech 2001). (gasyblog.com)
In this study, we have investigated the functional characteristics of glycine receptors in the narrow-field AII amacrine cell. (gasyblog.com)

aPL activate endothelial cells (ECs) by up-regulating adhesion molecules, IL-6 production and modulating prostaglandin metabolism. (europa.eu)

Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
Results: No difference in antigen expression between normal and malignant endothelial cells (ECs) was found for CD54, CD109, CD137, CD141, CD144 and CXCR7. (researchgate.net)
FcRIIB is the only FcR expressed by B cells and negatively regulates B cell receptor activation by immune-complexed antigen. (pepas.org)

Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. (elabscience.com)
Most work on FcRIIB and infection has involved the study of is through capsular polysaccharide- and cell wall phosphocholine-specific antibodies, which bind pneumococci and mediate FcR-dependent phagocytosis by neutrophils and macrophages123. (pepas.org)

Cross-linked fibrin is deposited in tissues surrounding wounds, inflammatory sites, or tumors and serves not only as a supporting substratum for trafficking cells, but also as a structural barrier to invasion. (silverchair.com)
Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. (thermofisher.com)

In in vitro studies, cultured human lens epithelial cells and bovine retinal pericytes and endothelial cells were exposed to high glucose or palmitate. (johnshopkins.edu)
The 38- to 87-kDa and the 17- to 38-kDa poly(ADP-ribosyl)ated protein expression increased by 74% and 275%, respectively, after 4 weeks of diabetes and by approximately 65% early after exposure of lens epithelial cells to 30 mM glucose. (johnshopkins.edu)
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cells. (famri.org)
2013). Impact of Laminitis on the Canonical Wnt Signaling Pathway in Basal Epithelial Cells of the Equine Digital Laminae . (umass.edu)

An engineered variant, Cartilage Oligomeric Matrix Protein - Angiopoietin-1 (COMP-Ang1), has been demonstrated to overcome the limitations of the native molecule and activate the Tie2 pathway with several fold greater potency than Ang1, both in vitro and in vivo. (bvsalud.org)
In primary cultures of mouse embryonic day 14 (E14) striatum, maintained in vitro for 24 hr, 12% of the cells responded to FGF-2, whereas no response to EGF could be detected. (beauty104.com.tw)
Priming of striatal cells for 24 hr with FGF-2 but not with EGF was sufficient to induce the appearance of EGF- and FGF-2 responsive cells after only 2 d in vitro. (beauty104.com.tw)
Thus, neural precursor cells from the mouse E14 striatum initially responding to FGF-2 only acquire EGF responsiveness later during in vitro development. (beauty104.com.tw)
Live cell imaging of in vitro cultured microvascular endothelial cells depleted of testisin by siRNA knockdown revealed that loss of testisin markedly impaired reorganization and tubule-like formation on Matrigel. (umaryland.edu)

Cross-linking of activating FcRs by immune complexes results in the phosphorylation of immunoreceptor tyrosine-based activating motifs (ITAMs) that are present either Rabbit polyclonal to PHACTR4 in the cytoplasmic domain of the receptor (FcRIIA and FcRIIC), or in the associated FcR common -chain (FcRI and FcRIIIA), resulting in an activating signalling cascade. (pepas.org)
Cross-linking of activating FcRs by immune complexes results in the phosphorylation of immunoreceptor tyrosine-based activating motifs (ITAMs) that are present either in the cytoplasmic domain of the receptor (FcRIIA and FcRIIC) or in the associated FcR common -chain (FcRI and FcRIIIA). (pepas.org)

CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. (thermofisher.com)
Special EV surface protein patterns in serum have the potential as noninvasive biomarker candidates to distinguish several disease-related patterns ex vivo or in vivo. (nature.com)

We will use primary ECs and endothelial cell lines to determine the molecular events by which anti-beta2-GPI antibodies and SAA i n presence and absence of LXA4 affect the transcriptional regulation of target genes (such as IL-6, IL-8, tissue factor). (europa.eu)
Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)

Cells in the monocyte gate were used for analysis. (thermofisher.com)

The biological events that unfold due to cell-cell recognition are important for animal development, microbiomes, and human medicine. (wikipedia.org)
The utility of AOPs for regulatory application is defined, to a large extent, by the confidence and precision with which they facilitate extrapolation of data measured at low levels of biological organisation to predicted outcomes at higher levels of organisation and the extent to which they can link biological effect measurements to their specific causes. (aopwiki.org)
Latin or common names of a species or broader taxonomic grouping (e.g., class, order, family) that help to define the biological applicability domain of the KER.In general, this will be dictated by the more restrictive of the two KEs being linked together by the KER. (aopwiki.org)
Although two substrates of testisin have so far been identified, protease activated receptor 2 (PAR2) and protein inhibitor C (PCI), little is known of the biological, physiological, and pathophysiologic characteristics of testisin. (umaryland.edu)

Our hypothesis states that anti-beta2-GPI antibodies and SAA play relevant roles in the regulation of NF-kappaB, AP-1 and Egr-1. (europa.eu)

Risk-adapted therapies for AML, ALL, and CLL patients consist of chemotherapy with/without stem cell transplantation (SCT), but the rate of early failures and relapses is still unsatisfying. (nature.com)

It is interesting to study the initiation and regulation of differentiation in cells having no G1 phase, Mouse monoclonal to Ractopamine as typically, cell differentiation occurs from your G1 phase of the cell cycle. (globaltechbiz.com)

9] All of these proteins interact with complement proteins, particularly C3b and C4b, dissociate the convertase complexes of the classic and alternative pathways, and halt the amplification of the activation process. (medscape.com)

Cell-cell recognition is especially important in the innate immune system, which identifies pathogens very generally. (wikipedia.org)
EVs were characterized by transmission electron microscopy and fluorescence nanoparticle tracking analysis, and EV surface protein profiles were analyzed by multiplex bead-based flow cytometry to identify tumor- or immune system-related EVs of AML, ALL, CLL, and healthy samples. (nature.com)
Furthermore, other cells at the interface of the innate and the adaptive immune system (e.g cytokine-induced killer cells (CIK) or invariant natural killer T-cells (iNKT)) are important mediators in antitumor-, autoimmune-, and antimicrobial responses and tumor surveillance. (nature.com)
Regularly, anergy of T cells or other immune cells can be regularly reverted to anti-leukemic functionality. (nature.com)
FcRIIB cross-linking by immune complexes results in ITIM phosphorylation and inhibition of the activating signalling cascade. (pepas.org)

Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand. (expasy.org)

Many studies reported that some semaphorins are involved in the development of a permissive tumor niche, guiding cell-cell communication and, consequently, the development and progression, as well as the response to therapy, of different cancer histotypes, including melanoma. (biomedcentral.com)
Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. (betalifesci.com)
Semaphorins have been implicated in diverse developmental processes such as axon guidance during nervous system development and regulation of cell migration. (betalifesci.com)

This relatively simple principle has contributed significantly to our understanding of proteins and their behaviors and has become increasingly fundamental to most protein characterization studies today. (bvsalud.org)

Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)

Like other cellular functions, cell-cell recognition is impacted by detrimental mutations in the genes and proteins involved and is subject to error. (wikipedia.org)
When a large multi-cellular organism sustains an injury, cell-cell recognition is often involved in bringing certain types of cells to the site of an injury. (wikipedia.org)
Moreover, variations in application of the IP principle are discussed, and the adaptability of the techniques based on such is highlighted in the provision of two IP workflows to purify a particular protein from an entire cellular proteosome. (bvsalud.org)
These workflows cover the preparation and fractionation of crude cellular lysate into individual subcellular fractions, through to both "batch" and "column"-based extractions of the target protein of interest. (bvsalud.org)
Cell Cycle The cell cycle is an integral part of cellular processes. (globaltechbiz.com)
Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)

2013) exhibited the elevated expression of cysteine protease (cathepsin B alone or with uPAR) in glioblastomas, which in turn was responsible of self-renewal of malignant glioblastoma stem cells. (globaltechbiz.com)

Gas6 is a vitamin K-dependent protein with a gamma-carboxylated amino terminus (Gla domain), four EGF-like repeats, and C-terminal globulin-like domains. (bio-techne.com)
These proteins had a high degree of amino acid identity but were determined to be distinct mitogens. (beauty104.com.tw)

Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in β-cells briefly (for 15 min) exposed to IL-1β that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation. (diabetesjournals.org)

Similarly, the expression of other proteins such as the protein disulphide isomerase and cytoskeletal proteins (tubulin, myosin, actin, extendin, and ubiquitin) also remain constant [37,38]. (globaltechbiz.com)
Seventy-five percent of these FGF-2-responsive cells were beta tubulin III (TuJ1)-positive neurons, and 25% expressed nestin, a marker for neuroepithelial precursors. (beauty104.com.tw)

Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
Cell-associated and tumor microenvironment GAG content and distribution is markedly altered during tumor pathogenesis and progression [ 11 , 12 ]. (hindawi.com)

The binding of PAMPs to TLR proteins generally results in an internal signaling cascade including a number of phosphorylations, the adding of a phosphate group, and ubiquitinations, the adding of a small protein that marks molecules for degradation, that eventually leads to the transcription of genes related to inflammation. (wikipedia.org)
Although these systems aren't known completely, research survey that appearance of cyst encoding protein and genes is normally upregulated, like the Wnt/-catenin pathway functionally. (globaltechbiz.com)

myeloid cells express FcRI, FcRIIA and FcRIIIA, whereas granulocytes express FcRI, FcRIIA and FcRIIIB. (pepas.org)

2016). Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells . (umass.edu)
2016. Overexpression of specific CD44 isoforms is associated with aggressive cell features in acquired endocrine resistance . (cardiff.ac.uk)

Most hematopoietic cells express one or more members of Ly-6 family. (elabscience.com)
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell (HSC) disease. (medscape.com)
Allogeneic hematopoietic stem cell transplantation is curative but it requires a histocompatible donor and is associated with significant morbidity and mortality, so it is reserved for severe cases of PNH with aplastic anemia or transformation to leukemia. (medscape.com)
Paroxysmal nocturnal hemoglobinuria (PNH) was previously classified as purely an acquired hemolytic anemia due to a hematopoietic stem cell mutation defect. (medscape.com)
Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)

Testisin expression has been documented in eosinophiles, ovarian cancers, endothelial cells, and spermatozoa where its expression is highest. (umaryland.edu)

This signature suggests that the response to hypoxia includes the ability to promote new blood and lymphatic vessel formation, and that the dual targeting of multiple cell types and pathways will be needed to prevent metastatic spread. (biomedcentral.com)
These pathways are responsible for downregulation of blood coagulation reactions and contain the plasma proteins that inhibit blood coagulation. (mhmedical.com)

Overexpression of an inactive mutant of Cav-1 lacking the tyrosine phosphorylation site (Y14F) or an siRNA-mediated Cav-1 knock down also resulted in marked attenuation of IL-1β-induced iNOS gene expression and NO release from these cells, thus further implicating Cav-1 in this signaling cascade. (diabetesjournals.org)

2010) The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. (sdbonline.org)
The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. (sdbonline.org)

Extraction procedures are optimized to precipitate and remove proteins and nucleic acids while maximizing solubilization of GSLs along with other lipids. (springer.com)

Results identified elevated CR-1 expression in esophageal squamous cell carcinoma (ESCC) specimens which correlated to poor prognosis of the patients. (cusabio.com)
Due to its location on the X chromosome, and due to X inactivation in female somatic cells, only one mutation is required in either males or females to abolish the expression of GPI-linked proteins. (medscape.com)
PDF) Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer SEndothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. (researchgate.net)
Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1β−induced gene expression of inducible NO synthase (iNOS) and NO release from β-cells. (diabetesjournals.org)
Moreover, testisin siRNA knockdown increased the paracellular permeability to FITC-albumin across endothelial cell monolayers, which was associated with decreased expression of the adherens junction protein VE-cadherin and increased levels of phospho-(Tyr658)-VE-cadherin, without affecting the levels of the tight junction proteins occludin, claudin-5, or ZO-1. (umaryland.edu)

Anatomy50

Organisms11

Diseases11

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes46

Disciplines and Occupations1

Information Science3

Glycosylphosphatidylinositol4

Vascular7

Proliferation9

Glycoprotein6

Membrane24

Dendritic cells3

Glycosyl-phosphatidylinositol2

Fibroblasts2

Mesenchymal Stem1

VEGF1

Endothelium2

Binds6

Cytokines3

Interactions10

Antibody8

Macrophages1

Angiogenesis2

Membranes5

Extracellular5

Recombinant Proteins1

Enzymes2

Receptors9

Adhesion Molecules1

Antigen3

Neutrophils2

Inflammatory2

Epithelial cells4

Vitro5

Cytoplasmic2

Serum2

Molecular3

Monocyte1

Biological4

Antibodies1

Consist1

Monoclonal1

Complement proteins1

Immune5

Ligand1

Semaphorins3

Behaviors1

PIGA1

Cellular6

Malignant1

Amino2

Inhibitors1

Tubulin2

Tumor microenvironment2

Genes2

Myeloid1

20162

Hematopoietic5

Cancers1

Pathways2

Overexpression1

Blood-Brain B2

Lipids1

Expression5