Endothelial cells bone marrow hematopoietic myeloid cells. Medical search. Frequent questions

LMO2 plays a role in angiogenesis and hematopoesis, and its expression has been detected in erythroid and myeloid precursors, megakaryocytes, and also in lymphoblastic and acute myeloid leukemias. (genomeme.ca)
In acute myeloid leukemia (AML), initiation of tumorigenesis via multiple oncogenic mutations occurs throughout various stages of hematopoiesis that disrupt the corresponding transcriptomic and epigenetic profiles. (uni-heidelberg.de)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. (haematologica.org)
Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication ( ITD )-mutated FMS - like Tyrosine Kinase - 3 ( FLT3 ) have a dismal outcome. (biomedcentral.com)
Acute myeloid leukemia (AML) is mainly a fatal disease. (biomedcentral.com)
Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. (drugbank.com)
Gilteritinib is indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia with an FLT3 mutation detected by an FDA-approved test. (drugbank.com)
Acute myeloid leukemia is cancer that impacts the blood and bone marrow with a rapid progression. (drugbank.com)
As well, data showed a gilteritinib-driven inhibition of the receptor tyrosine kinase AXL which is known to modulate the activity of FLT3 in acute myeloid leukemia. (drugbank.com)
The interest in FLT3 transmembrane tyrosine kinases was raised when studies reported that approximately 30% of the patients with acute myeloid leukemia presented a mutationally activated isoform. (drugbank.com)
As people age, their HSCs age as well, leading to greater numbers of poorly-functioning blood cells, a decline in the ability to fight infections, and a predisposition to blood cancers like acute myeloid leukemia (AML), which is characterized by an excess of immature blood cells. (cornell.edu)
The myelodysplastic syndromes (MDS) include a heterogeneous group of clonal bone marrow failure syndromes characterized by cytopenias, clonally restricted hematopoiesis (associated with an abnormal G-banded metaphase karyotype in about 50% of cases), genomic instability, and a risk of progression to acute myeloid leukemia (AML). (dermatologyadvisor.com)
10% of cells), or acute myeloid leukemia. (dermatologyadvisor.com)

Hematopoietic stem cells are key players in hematopoiesis as the body maintains a physiologic steady state, and the signaling pathways and control mechanisms of these dynamic cells are implicated in processes from inflammation to cancer. (bvsalud.org)
Although the bone marrow is commonly regarded as the site of hematopoiesis and hematopoietic stem cell residence, these cells also circulate in the blood and reside in extramedullary tissues, including the lungs. (bvsalud.org)
Hematopoiesis in the lungs is a new and emerging concept, and discovering ways in which the study of lung-resident hematopoietic stem cells can be translated from murine models to patients will impact clinical treatment. (bvsalud.org)
The results agreed with differential gene expression highlighting many TFs that play a critical role in hematopoiesis, endothelial-to-hematopoietic transition, or leukemic stem cell activation. (uni-heidelberg.de)
Age-related clonal hematopoiesis and monoclonal B-cell lymphocytosis/chronic lymphocytic leukemia: a new association? (haematologica.org)
The first wave, defined as primitive hematopoiesis, takes place in the extraembryonic yolk sac and generates transitory hematopoietic cell populations consisting of primitive erythrocytes. (amegroups.org)
The second wave, referred to as definitive hematopoiesis, temporarily occurs in the fetal liver and transitions to the bone marrow and thymus, where multipotent hematopoietic stem cells (HSCs) contribute to the generation of all blood lineages ( 1 - 3 ). (amegroups.org)
In zebrafish, primitive hematopoiesis occurs at early somite stages in the intermediate cell mass (ICM) and the rostral blood island (RBI). (amegroups.org)
Despite these apparent differences in definitive hematopoiesis between fish and mammals, the definitive HSC niche functions to actively recruit stem cells and maintain their plasticity throughout adulthood ( 2 , 4 , 5 ). (amegroups.org)
Figure 1 VCAM-1 + macrophages guide hematopoietic stem/progenitor cell to sites of definitive hematopoiesis. (amegroups.org)
Subset of macrophages expressing ICAM-1 migrate to the sites of definitive hematopoiesis in AGM and CHT to recruit hematopoietic stem cells and initiate neonatal hematopoiesis and guide them further to sites of adult and definitive hematopoiesis in kidneys and thymus. (amegroups.org)
Mouse hematopoiesis was thought to develop initially in the yolk sac, where primitive hematopoietic development occurs [ 4 ]. (biomedcentral.com)
The bone marrow is the main site for hematopoiesis , the process of new blood cells forming via the hematopoietic stem cells (HSC) dividing and differentiating. (medicalnewstoday.com)
The hematopoiesis process in adults takes place in the red bone marrow. (differencebetween.com)

Endothelial progenitors should be devoid of hematopoietic markers and able to form vessels both in vitro and in vivo . (hindawi.com)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
Recently, controversy has developed over the definition of true endothelial progenitors. (wikipedia.org)
Molecular genetic analysis of early outgrowth putative EPC populations suggests they do indeed have monocyte-like expression patterns, and support the existence of a separate population of progenitors, the late outgrowth, or endothelial colony forming cell (ECFC). (wikipedia.org)
Unfortunately, there are no unique markers for endothelial progenitors that are not shared with other endothelial or hematopoietic cells, which has contributed to the historical controversy surrounding the field. (wikipedia.org)
Certain developmental cells may be similar to or the same as other endothelial progenitors, though not typically referred to as EPCs. (wikipedia.org)
The proliferation and differentiation of pluripotent stem cells give rise to progeny that can populate the entire immunologic and hematopoietic systems through committed progenitors of both the lymphoid and myeloid lineages. (medscape.com)
Analyses of CD34+ cell lines representing early myeloid, multipotential, and pre-pre-B-lymphoid progenitors indicate that precursors of both myeloid and B-lymphoid cells express PECAM-1 at high levels. (ox.ac.uk)
The composition of cell types was generally more skewed to early progenitors at the point of diagnosis when compared to their matching relapse sample. (uni-heidelberg.de)
In this assay hematopoietic cells are cultured in MyeloCult™ medium with supportive human or mouse stromal cell layers and tested for their ability to generate myeloid clonogenic progenitors for several weeks as assayed by replating the cells in a colony-forming unit (CFU) assay using MethoCult™ medium. (stemcell.com)
Establish stromal cell layers and culture hematopoietic progenitors in "Dexter-type" long-term bone marrow cultures. (stemcell.com)
Early in murine embryonic development, hematopoietic progenitors can be found in the para-aortic splanchnopleura region on embryonic day 7 (as depicted in Figure 1 A), but these progenitors are not LT reconstituting although they do possess lymphoid potential [ 11 - 13 ]. (biomedcentral.com)
These more advanced hematopoietic progenitors isolated from the aorta-gonad-mesonephros (AGM) region at embryonic day 9.5 to 10 can give rise to lymphoid lineages and are LT reconstituting definitive HSCs, but since this time point is after the establishment of the circulatory system in the embryo their source was difficult to determine [ 13 ]. (biomedcentral.com)
Cumano and colleagues' approach was to culture explants containing hematopoietic progenitors isolated from the yolk sac and the embryo proper before the onset of circulation, and to determine their LT reconstitution potential [ 10 ]. (biomedcentral.com)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
Adenoviral mediated overexpression of HOXB4 in human primitive hematopoietic cells in vitro generates very high levels of HOXB4 within 24 hours of transduction, leading to an increased differentiation towards myeloid lineages, and to a reduction of primitive hematopoietic progenitors, suggesting that the level of HOXB4 expression may determine the fate options following gene transfer. (dissertations.se)

However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
These original, early outgrowth, CFU-Hill or CACs are also shown to express CD14, a lipopolysaccharide receptor expressed by monocytes but not endothelial cells. (wikipedia.org)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
MLL fusions, except for MLL-EDC4, generally conferred a more differentiated phenotype predominantly consisting of monocytes/macrophage CD14-like and promonocyte-like cells. (uni-heidelberg.de)
During this first wave, small number of myeloid cells (e.g., primitive monocytes/macrophages and megakaryocytes) are also generated. (amegroups.org)
The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. (stemcell.com)
These fractions consisted of either mononuclear cells (MO-MDSCs), resembling inflammatory monocytes, or low-density polymorphonuclear cells (PMN-MDSCs), akin to immature neutrophils. (ashpublications.org)
In that purpose, CD14 + monocytes/macrophages from human NHO were isolated using immunomagnetic cell separation and cultured with or without LPS (100 ng/ml) for 3 days. (jci.org)

While bone-marrow transplantation might mitigate hematopoietic syndrome, currently there are no approved medical countermeasures to alleviate radiation-induced gastrointestinal syndrome (RIGS), resulting from direct cytocidal effects on intestinal stem cells (ISC) and crypt stromal cells. (elsevierpure.com)
We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. (elsevierpure.com)
Methodology/Principal Findings: Autologous bone marrow was cultured in mesenchymal basal medium and adherent cells were harvested for transplantation to C57Bl6 mice, 24 and 72 hours after lethal whole body irradiation (10.4 Gy) or abdominal irradiation (16-20 Gy) in a single fraction. (elsevierpure.com)
Transplantation of enriched myeloid and non-myeloid fractions failed to improve survival. (elsevierpure.com)
Conclusion/Significance: Mitigation of lethal intestinal injury, following high doses of irradiation, can be achieved by intravenous transplantation of marrow-derived stromal cells, including mesenchymal, endothelial and macrophage cell population. (elsevierpure.com)
Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
Allogeneic hematopoietic stem cell transplantation is curative but it requires a histocompatible donor and is associated with significant morbidity and mortality, so it is reserved for severe cases of PNH with aplastic anemia or transformation to leukemia. (medscape.com)
New research from my institute, Weill Cornell Medical College, suggests that transplantation of young blood vessel cells rejuvenates aged stem cells in mice, boosting older blood system function. (cheapgenericsonline.com)
Despite improved therapeutic approaches, allogeneic hematopoietic stem cell transplantation remains the only curative treatment option. (ovgu.de)
Enforced expression of HOXB4 dramatically increases the regeneration of murine HSC following transplantation, and enhances the repopulating ability of human SCID repopulating cells. (dissertations.se)
Collectively, these findings indicate that correct expression levels of HOXB4 improve proliferative recruitment of HSC in settings demanding high proliferation, for example after bone marrow transplantation. (dissertations.se)
Both cells have common applications in various cell-based therapies such as tissue regeneration and transplantation. (differencebetween.com)
Transplantation of young blood vessel cells into older mice makes their aged stem cells take on the characteristics of young stem cells. (cornell.edu)
This approach is appealing because endothelial cell infusions can potentially supplement a number of currently available bone marrow transplantation therapies to improve the overall clinical outcomes in both young and aged patients. (cornell.edu)

The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Specific niches within the bone marrow are discussed, as are metabolic processes that contribute to stem cell self-renewal and differentiation, as well as the role of hematopoietic stem cells outside of the bone marrow at physiologic steady state. (bvsalud.org)
The cancer cells that emerge are referred to as blasts and share biological features from these disease-specific alterations and patterns associated with differentiation and the tumor cell of origin. (uni-heidelberg.de)
Both tumor entities harboring FLT3-ITDs or IDH1 mutations showed a more complex composition of cell types along the myeloid differentiation trajectory than MLL fusions. (uni-heidelberg.de)
This indicates a partial differentiation of AML cells that treatment might induce. (uni-heidelberg.de)
Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. (stemcell.com)
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of self-renewal and exhibit multilineage differentiation properties. (techscience.com)
Enhanced expression of IL-6, IGF-1, TGF-β, and VEGF has also been observed in LC treated BMSCc+ groups, suggested the cardiac differentiation of BMSCc+, and can be utilized in tissue engineering for cardiac cell therapy. (techscience.com)
We show that marrow from human NHOs contains hematopoietic stem cell (HSC) niches, in which mesenchymal stromal cells (MSCs) and endothelial cells provide an environment supporting HSC maintenance, proliferation, and differentiation. (jci.org)
We demonstrate that oncostatin M (OSM) produced by activated macrophages promotes osteoblastic differentiation and mineralization of human muscle-derived stromal cells surrounding NHOs. (jci.org)
Several HOX transcription factors, including HOXB4, are highly expressed in hematopoietic stem cells (HSCs) but are downregulated upon differentiation towards more mature progeny cells. (dissertations.se)
The production of terminally differentiated cells from such cells, therefore, requires successive changes of cell fates, meaning that genes relevant for the next stage of differentiation must be switched on and genes not relevant anymore must be switched off. (amegroups.org)
The development of the hematopoietic system has long served as model to understand how changes in gene regulatory networks drive the differentiation of the various blood cell types. (amegroups.org)
These cells evolve from the differentiation of neural progenitor cells (NPCs). (differencebetween.com)
They play a role in cell development and differentiation. (differencebetween.com)
Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. (umbc.edu)

The microenvironment, consisting of lymphocytes, macrophages, fibroblasts, endothelial elements, and stroma in which hematopoietic cells reside, creates a regulatory niche that determines the local area network. (medscape.com)
and the RBI cells are derived from the lateral mesoderm of the zebrafish head and differentiate into macrophages ( 4 - 8 ). (amegroups.org)
Our results provide strong evidence that macrophages contribute to NHO formation through the osteogenic action of OSM on muscle cells within an inflammatory context and suggest that OSM/OSMR could be a suitable therapeutic target. (jci.org)
A ) CD34 + cells from human neurogenic heterotopic ossification (NHO) were isolated using immunomagnetic cell separation and induced to differentiate into macrophages for 2 weeks in specific medium. (jci.org)
B ) Activated macrophages derived in vitro from NHO CD34 + cells stimulate NHO muscle-derived stromal cells (NHO-MDSCs). (jci.org)
C ) Mononuclear cells from human NHO marrows were analyzed by flow cytometry for mac markers, as in A . ( D ) Medium conditioned by activated macrophages from human NHO stimulate NHO-MDSC mineralization. (jci.org)

FLT3 ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. (biomedcentral.com)
A) The biological activity of Human Recombinant G-CSF, ACF was tested by its ability to promote the proliferation of mouse NFS-60 cells. (stemcell.com)
Cell proliferation was measured using a fluorometric assay method. (stemcell.com)
The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. (stemcell.com)

The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
Stromal cell feeder layers (e.g. (stemcell.com)

I established and adjusted the experimental and bioinformatic procedures to generate reproducible and scalable data by scRNA/ATAC-seq of peripheral blood and bone marrow biopsies from AML patients. (uni-heidelberg.de)
The principal studies used to establish the diagnosis of PNH are flow cytometry of peripheral blood and bone marrow analysis. (medscape.com)
Hematopoietic stem cells (HSCs) are immature cells found in the peripheral blood and bone marrow. (differencebetween.com)

Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
LMO2, also known as LIM-Only Transcription Factor 2, RBTN2, or TTG2, is an oncoprotein that is expressed in normal germinal center B-cells, as well as bone marrow hematopoietic precursors and endothelial cells. (genomeme.ca)
While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)

These HSCs are primarily derived from endothelial cells within the ventral wall of the dorsal aorta. (amegroups.org)
The definitive HSCs in mammals first migrate to and repopulate in the fetal liver and then home to the bone marrow, while the definitive HSCs in zebrafish migrate first to the caudal hematopoietic tissue and then to their definitive anatomical sites in the kidney and thymus ( 5 - 8 ). (amegroups.org)
In adults, HSCs residing in the bone marrow may become activated and mobilize into peripheral blood in response to ischemic injury or infection. (amegroups.org)
Altogether, the evidence of HSCs in ectopic bones growing at the expense of soft tissue in spinal cord/brain-injured patients indicates that inflammation and muscle contribute to HSC regulation by the brain-bone-blood triad. (jci.org)
The aging of hematopoietic stem cells (HSCs) is characterized by the impaired ability of these cells to regenerate and produce blood cells. (medicalnewstoday.com)
Besides producing daughter HSCs after cell division, HSCs also produce different progenitor cell types that, in turn, divide to produce specific types of mature blood cells. (medicalnewstoday.com)
Besides housing hematopoietic stem cells and their progeny, the endosteum and the central marrow also contain distinct cell populations that express molecules or secrete proteins, such as cytokines that regulate the formation, development, and function of HSCs and progenitor cells. (medicalnewstoday.com)
The study found that bone marrow niche cells that support the functioning of HSCs played a key role in blood aging. (medicalnewstoday.com)
The initial HSCs in vertebrates arise from the ventral endothelial wall of the embryonic aorta within the aorta-gonad-mesonephros region. (differencebetween.com)
HSCs develop into different types of blood cells in lines called myeloid and lymphoid , which are involved in dendritic cells formation. (differencebetween.com)
Here, a combination of different cell surface markers is used to separate the rare HSCs. (differencebetween.com)
Blood stem cells, also known as hematopoietic stem cells (HSCs), are located within the bone marrow and give rise to all mature blood cells in the body throughout a person's life. (cornell.edu)
The researchers isolated young and old blood vessel cells from the bone marrow - called bone marrow endothelial cells - and grew them in petri dishes with young or old HSCs. (cornell.edu)
We found that when we culture old HSCs with young endothelial cells, we can rejuvenate the mouse stem cells," Dr. Butler said. (cornell.edu)

leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. (stemcell.com)

By method of isolation and cell function, three main populations of putative adult EPCs have been described. (wikipedia.org)
This review outlines current protocols and cell markers used in flow cytometric analysis of hematopoietic stem and progenitor cell populations. (bvsalud.org)
In this report, we show that enriched CD34+ human hematopoietic progenitor cell populations, containing early myeloid, erythroid, and multipotential progenitor cells, are CD31+. (ox.ac.uk)
Cell type prediction revealed extensive malignant cell diversity and a phenotype skewed towards stem- and progenitor-like populations in MLL-EDC4 leukemic cells. (uni-heidelberg.de)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
Research Objective LGR5-antibody drug conjugate to target LIC in B cell tumors that undergo self-renewal Impact LIC were only defined in myeloid leukemia, while LIC populations in B cell tumors remain elusive. (ca.gov)

Sequencing methods that analyze the transcriptome (scRNA-seq) and epigenome (scATAC-seq) are ideally suited to resolve tumor cell heterogeneity as well as non-malignant cell types in the microenvironment. (uni-heidelberg.de)
I could demonstrate that leukemic cells could be successfully distinguished from the microenvironment based on marker gene annotation from the human cell atlas and ploidy inference. (uni-heidelberg.de)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)

These may be classified into those that result in pancytopenia and those limited to failure of 1 or 2 hematopoietic lineages. (medscape.com)
Except for the monocytic cell line, U937, all CD34- cell lines tested, which represent more mature stages of the myeloid, erythroid, and lymphoid lineages, expressed substantially lower or negligible levels of PECAM-1. (ox.ac.uk)
The future direction of the study of hematopoietic stem cells will probably make use of pluripotent stem cells to yield specific immune cell lineages and eventual clinical applications. (biomedcentral.com)

We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)
CD34 + cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. (hindawi.com)
EPCs are enriched in the population coexpressing CD34, CD133, and KDR with a low or absent expression of pan-hematopoietic marker CD45 [ 1 ]. (hindawi.com)
and on a CD34(+)-enriched precursor cell population from normal human bone marrow. (ox.ac.uk)
2.10 5 /well/500 μl) differentiated from NHO CD34 + cells (NHOmac). (jci.org)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
While some other authors have contested these, and maintained that they are true EPCs, many investigators have begun to term these cells colony forming unit-Hill cells (CFU-Hill) or circulating angiogenic cells (CAC) instead (depending on the method of isolation), highlighting their role as hematopoietic myeloid cells involved in promoting new vessel growth. (wikipedia.org)
A large amount of research has been done on CFU-Hill bone marrow-derived putative EPCs. (wikipedia.org)
One particular element that is beginning to garner interest involves the systemic mobilization of endothelial progenitor cells (EPCs). (biomedcentral.com)

Three-color flow-cytometric analyses also show that normal human bone marrow CD31+ CD34+ subsets coexpress myeloid (CD33) or B-lymphoid (CD19, CD10) markers. (ox.ac.uk)
Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)

The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes. (ox.ac.uk)
The high level of expression of PECAM-1 on CD34+ cells suggests that this glycoprotein may function as a heterotypic adhesion molecule, possibly mediating multipotential, myeloid, and early-B-lymphoid precursor cell interactions with stromal cells and extracellular matrix molecules via heparan sulfate proteoglycans. (ox.ac.uk)
Lymphoid cells include T cells, B cells, innate lymphoid cells, and natural killer cells. (differencebetween.com)
These multipotent progenitor cells differentiate into either common myeloid progenitor (CMP) or common lymphoid progenitor cells (CLP). (differencebetween.com)
The common stem cell produces 2 other stem cells, the myeloid stem cell and the lymphoid stem cell. (medscape.com)
T lymphocytes originate via lymphoid stem cells that migrate to the thymus and differentiate under the influence of the thymic hormones thymopoietin and thymosin. (medscape.com)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
LMO2 protein expression has been noted in diffuse large B-cell lymphoma, the most common adult non-Hodgkin's lymphoma, as well as follicular lymphoma, a neoplasm derived from germinal center B-cells that accounts for a number of cases of non-Hodgkin's lymphomas. (genomeme.ca)
Further studies in mice by Cumano and colleagues sought to address the issue of an anatomical origin of the long-term (LT) reconstituting hematopoietic stem cell (HSC) found in adult animals [ 10 ]. (biomedcentral.com)
This is because of a higher degree of complications after transplant, which is also limited by having enough numbers of stem cells to reconstitute the hematopoietic system in an adult. (cheapgenericsonline.com)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
In an adult, roughly half of the bone marrow is still red. (medscape.com)

Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells. (biomedcentral.com)
Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
Embryonic stem cells isolation primarily requires the consent of donors and can include the killing of fertilized eggs. (techscience.com)

The bone marrow niche includes cells belonging to the stroma, which includes mesenchymal stromal cells , adipocytes (fat cells), nerve cells, connective tissue cells, and cells involved in bone formation and remodeling. (medicalnewstoday.com)
Mesenchymal stromal cells can divide and differentiate into a number of cell types, including bone, cartilage, and adipocytes. (medicalnewstoday.com)
The present study found that aged mice showed a decrease in the population of mesenchymal stromal cells and osteoprogenitor cells that are involved in bone formation in the endosteum. (medicalnewstoday.com)
In contrast, there was an increase in the number of mesenchymal stromal cells in the central marrow of aged mice. (medicalnewstoday.com)

The company's Haematokine is an investigational Vascular Adhesion Protein 1 (VAP-1) inhibitor which blocks VAP-1 enzymatic activity to supports the expansion of human hematopoietic stem cells. (pharmaceutical-technology.com)

In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)

Bone marrow failure syndrome (BMFS) is a group of disorders that may manifest as single cytopenia (eg, erythroid, myeloid, or megakaryocytic) or as pancytopenia. (medscape.com)

It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf & Nicola). (stemcell.com)
Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. (umbc.edu)

It may also act as a homotypic adhesion molecule by interacting with PECAM-1 on bone marrow stromal macrophage-like cells and endothelial cells or on endothelial cells during stem/progenitor cell migration. (ox.ac.uk)
Cells were then analyzed by flow cytometry for expression of myeloid marker CD11b, monocyte/macrophage marker CD14, and M2 macrophage activation marker CD163 and CD206. (jci.org)
Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
Because it is such a diverse population of cells, a fundamental question is whether they have a common precursor or whether each macrophage population develops from a different precursor. (frontiersin.org)

The aim of this study was to identify early diabetes-related changes in the expression of genes that have been reported to be closely involved in endothelial progenitor cell migration and function. (biomedcentral.com)
Based on review of current literature, this study examined the expression level of 35 genes that are known to be involved in endothelial progenitor cell migration and function in magnetically sorted Lin - /VEGF-R2 + endothelial progenitor cells obtained from the bone marrow of Akita mice in the early stages of diabetes (18 weeks) using RT-PCR and Western blotting. (biomedcentral.com)

(B) Subset of cell surface markers used in the characterization of this developmental process. (biomedcentral.com)
Similarly to the bone marrow stroma, ECs express several surface markers that may allow cell-to-cell contact between them and CLL cells (e.g. (ovgu.de)
We will employ different methods for metabolic profiling using an in vitro co-culture model (cooperation with Project 2 ) including single-cell RNA sequencing (cooperation with Project 12 ), targeted metabolomics, and flow cytometry-based analyses of metabolic markers/parameters as well as intracellular signaling components (focus on NF-κB signaling in cooperation with Project 1 ). (ovgu.de)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the regeneration of the endothelial lining of blood vessels. (wikipedia.org)
They discovered that blood vessel cells actively sustain nearby stem cells and guide organ regeneration. (cheapgenericsonline.com)
Faron's receptors involved in regulation of immune response in oncology, organ damage and bone marrow regeneration as a current pipeline. (pharmaceutical-technology.com)
The use of cell therapy for vascular regeneration offers an exciting new prospect in regenerative medicine. (biomedcentral.com)

We observed a significant increase in the number of Lin - /VEGF-R2 + endothelial progenitor cells within the bone marrow in diabetic mice compared with non-diabetic mice. (biomedcentral.com)
Led by Dr. Jason Butler and Dr. Michael Poulos, the research isolated blood vessel cells from young or old mice and grew them in petri dishes with blood stem cells. (cheapgenericsonline.com)
The team found out that the rejuvenated old cells were able to create a healthy blood system when transplanted back into mice. (cheapgenericsonline.com)
The group then gave mice a strong dose of whole body radiation, similar to what patients undergo prior to bone marrow transplant. (cheapgenericsonline.com)
A recent study in mice shows that aging is linked to the inflammation of cells in the bone marrow. (medicalnewstoday.com)
A recent study conducted in mice shows that blocking the receptor for the proinflammatory protein IL-1 using the FDA-approved rheumatoid arthritis drug Anakinra may attenuate the deficits in the functioning of hematopoietic stem cells due to aging. (medicalnewstoday.com)
In the present study, the researchers performed several analysis in the hindlimb, forelimb, and pelvic bones from young and old mice to examine the impact of aging on the interaction between the bone marrow niche and hematopoietic cells. (medicalnewstoday.com)
Studies in our knockout mice reveal that deficiency of HOXB4 leads to a hypocellularity in hematopoietic organs and impaired proliferative capacity. (dissertations.se)
Transplanting young blood vessel cells into older mice can make their aged stem cells take on the characteristics of young stem cells, leading to healthier blood systems and promoting better recovery from cancer treatment side effects, according to new research from Weill Cornell Medicine. (cornell.edu)
When transplanted back into mice, these stem cells grew and functioned better and created healthy blood systems. (cornell.edu)
The investigators then transplanted young blood vessel endothelial cells into mice that had been given a strong dose of whole body radiation. (cornell.edu)
They noted that the blood systems in the mice recovered quickly, indicating that the young endothelial cells boosted the function of the blood stem cells. (cornell.edu)
In another experiment, mice received radiation therapy, similar to what patients undergo prior to bone marrow transplant. (cornell.edu)
Dr. Butler's team then transplanted very low numbers of bone marrow cells into mice, some of which also received young endothelial cells. (cornell.edu)
We found that when we transplant endothelial cells with this limited number of bone marrow cells the mice survived and recovered faster," said lead author Dr. Michael Poulos , an instructor of regenerative medicine at Weill Cornell Medicine. (cornell.edu)

Bidirectional interaction between CLL cells and the surrounding non-transformed stromal compartment (especially in the bone marrow) and extracellular matrix components extend CLL survival and protect from chemotherapeutics. (ovgu.de)
All these cells, along with blood vessels and the extracellular matrix, form the bone marrow niche . (medicalnewstoday.com)

Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. (techscience.com)
Hematopoietic stem cells differentiate into multipotent progenitor cells. (differencebetween.com)

Primitive and definitive hematopoietic development. (biomedcentral.com)
Distinct anatomical regions of primitive and definitive hematopoietic development in both the mouse and human. (biomedcentral.com)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)

Endothelial cells (ECs) also represent a component of the tumor stroma and previous data suggest an involvement in CLL pathobiology. (ovgu.de)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)

Mesenchymal, endothelial and myeloid population were characterized by flow cytometry. (elsevierpure.com)

The only stimulant that enhanced PAC paracrine angiogenic activity was atorvastatin, which also had ability to stabilize endothelial tubes in vitro . (hindawi.com)
Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
These cells are phenotypically similar to endothelial cells and have been shown to create vessel-like structures in vitro and in vivo. (wikipedia.org)
Hemangioblasts (or their in vitro counterpart, blast-colony forming cells) are cells believed to give rise to both the endothelial and hematopoietic systems during early development. (wikipedia.org)
Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)

Older patients are also frequently not good candidates for bone marrow transplant, the cure for many blood disorders. (cheapgenericsonline.com)
Therefore, strategies to support blood stem cell recovery are needed to expand the pool of possible bone marrow transplant recipients. (cheapgenericsonline.com)
Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)

The drug candidate is a humanized monoclonal IgG4 antibody targeting cells expressing CLEVER-1 (Common lymphatic endothelial and vascular endothelial receptor-1). (pharmaceutical-technology.com)
Mature B-cell-derived cells progressively accumulate in the patients' peripheral blood, lymphatic tissues, and bone marrow. (ovgu.de)
Bone marrow is also an important part of the lymphatic system. (medscape.com)

The induction of CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) is an important immune-evading mechanism used by tumors. (ashpublications.org)
Additionally, we described further CLL-related immune escape mechanisms that include the induction of myeloid derived suppressor cells (MDSCs) or an enhanced expression of the immune checkpoint molecule PD‑L1. (ovgu.de)

Bone marrow loss and a high proclivity to leukemic progression are the characteristics of myelodysplastic syndrome (MDS). (techscience.com)

There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. (umbc.edu)

As we age, blood stem cells become less able to perform at the best of their capability. (cheapgenericsonline.com)
In the marrow, blood stem cells are found in close contact with blood vessels cells, which provide many types of substances, such as KIT ligand that stem cells need to keep performing at their best. (cheapgenericsonline.com)
A recent study from Weill Cornell Medical College shows that older blood vessel cells made young blood stem cells act old. (cheapgenericsonline.com)
The young blood stem cells bias showed a tendency toward producing more of one type of immune cells, myeloid cells, which is a hallmark of aging. (cheapgenericsonline.com)
His pioneering work spans discoveries in basic biology of blood stem cells and leukemia to first-in-human clinical trials for people with cancer and heart diseases, alongside shaping innovative policies in state health and healthcare financing. (ufl.edu)
In his early career Dr. Cogle discovered that blood stem cells make blood vessels and used that biology to invent new therapeutics and diagnostics for people with cancer and heart disease. (ufl.edu)
Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots when dysregulated. (ca.gov)
Dr. Jason Butler and his team discovered that aged blood vessels strongly influence the functional characteristics of blood stem cells. (cornell.edu)
In addition, their aged blood stem cells make it hard for them to recover after cancer treatments like chemotherapy and radiation therapy that destroy blood cells. (cornell.edu)
We're trying to figure out how we can rejuvenate blood stem cells in order to help people recover faster from these treatment regimens. (cornell.edu)
In a study published online on Oct. 16 and appearing in the November issue of The Journal of Clinical Investigation, Dr. Butler and his colleagues report that the age of blood vessel cells in the bone marrow strongly influences the function of blood stem cells. (cornell.edu)
Additionally, they found a way to harness cells from young mouse blood vessels to rejuvenate old blood stem cells and restore their function. (cornell.edu)

Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Last, we will interfere with the identified (metabolic) mechanisms in vivo using a preclinical model and evaluate the impact on the CLL cell metabolism, T cell compartment, and response to therapies. (ovgu.de)
Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)

Endothelial colony forming cells represent a distinct population that has been found to have the potential to differentiate and promote vessel repair. (wikipedia.org)
While ER Clark first reported the observation of vascular generation in tadpoles in 1909, and Stockard described blood-vessel development and coined the term angioblast in fish embryos in 1915, it was not until 1920 that F Sabin described the formation of blood cells through the angioblast 'liquefying' within the aorta [ 1 - 3 ]. (biomedcentral.com)
Aged blood vessel cells, shown in red and green, with blue nuclei, with an age-associated defect. (cheapgenericsonline.com)
Blood vessel cells, or endothelial cells, are a particular cell type that lines the inside of blood vessels. (cheapgenericsonline.com)
So, instead of a pipe system, we can think of blood vessel cells more like active supporters lined up along a cyclist's race. (cheapgenericsonline.com)
Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)
This image shows a blood-vessel defect that occurs as a result of aging: the increased presence of reactive oxygen species (magenta) in aged bone marrow-derived blood vessels (depicted in red and green with blue nuclei). (cornell.edu)

ABSTRACTBackgroundAcute myeloid leukemia (AML) is a life-threatening disease whose treatment is made difficult by a number of mutations or receptor overexpression in the proliferating cellular clones. (journaltocs.ac.uk)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)

They have the ability to give rise to all types of blood cells, including white blood cells, red blood cells, and platelets. (differencebetween.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
White blood cells last anywhere from a few hours to a few days, platelets for about 10 days, and red blood cells for about 120 days. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)

MSCs have a lower ability to differentiate into osteoblasts but a higher ability to differentiate into adipocytes, which could be linked to myeloid malignancies ( Woods and Guezguez, 2021 ). (techscience.com)
MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. (techscience.com)
The Mesenchymal and Tissue Stem Cell Committee, which belongs to the International Society for Cellular Therapy, stated that plastic-adherent properties are the minimum criteria for determining MSCs. (techscience.com)

The etiology of bone marrow failure (BMF) includes defective stem/progenitor cells and/or stroma/accessory cells/growth factors, as well as deficient nonspecific nutrients or, as in the case of acquired aplastic anemia, immune-mediated abnormalities. (medscape.com)
Over the course of a person's life, these cells will continuously supply all types of blood cells that we need, including different types of immune cells. (cheapgenericsonline.com)
The drug candidate is devoid of T cell epitopes which limits mounting of immune reaction against FP-1304. (pharmaceutical-technology.com)
We found this is at least partly mediated via bioenergetic reprogramming and formation of immune escape variants, both of which are of particular importance for drug sensitivity and immunotherapeutic concepts including among others monoclonal antibodies or genetically engineered CAR T-cells. (ovgu.de)
enhance the CLL cells' ability to suppress immune responses by e.g., substrate depletion and/or production of bioactive metabolites and it could (2. (ovgu.de)
A team at Children's Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. (ca.gov)
The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)

Her innovative research has already led to several discoveries, such as a novel strategy to protect normal Haematopoietic Stem Cells from chemotherapy or radiation damage. (edu.au)
Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)
Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)

A better comprehension of cellular hierarchies, epigenetic effects, clonal evolution, and their impact on gene regulation might help to understand disease progression, stratify patient risk, and help to improve the treatment of hematopoietic malignancies in the future. (uni-heidelberg.de)

Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor (BCR), leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. (umbc.edu)

First, we will analyze the metabolic phenotype and the underlying signaling pathways of human/murine CLL cells in response to their interaction with ECs. (ovgu.de)
The correct cell must be chosen for its phenotype, cell characteristics and biological functions. (biomedcentral.com)

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell (HSC) disease. (medscape.com)

Analysis from scRNA and scATAC V showed different FLT3 activity/chromatin signatures within clusters of leukemic cells in the relapse that could be explained by midostaurin resistance and the emergence of distinct subclones as detected by scDNA-seq. (uni-heidelberg.de)
Interestingly, both MO-MDSCs and PMN-MDSCs suppressed antigen-specific T-cell responses, albeit using distinct effector molecules and signaling pathways. (ashpublications.org)

In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
The biology and therapeutic application of mesenchymal cells. (edu.au)
Recently, there has been growing interest in the therapeutic potential of using a cell-based approach to treat vasodegenerative disorders. (biomedcentral.com)
In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)
There is a therapeutic window in which to deliver the cells, to avoid extensive tissue damage, fibrosis and necrosis. (biomedcentral.com)

Inherited bone marrow failure syndromes (IBMFS) are usually the result of intrinsic stem cell/progenitor defects. (medscape.com)

The number and function of proangiogenic cells are impaired in patients with diabetes or cardiovascular diseases. (hindawi.com)
Analyses of single-cell RNA sequencing data show that co-expression of ACE2 and TMPRSS2 is elevated in absorptive enterocytes from the inflamed ileal tissues of Crohn disease patients compared to uninflamed tissues, revealing shared pathobiology between COVID-19 and inflammatory bowel disease. (bvsalud.org)
Integrative analyses of metabolomics and transcriptomics (bulk and single-cell) data from asthma patients indicate that COVID-19 shares an intermediate inflammatory molecular profile with asthma (including IRAK3 and ADRB2). (bvsalud.org)
Impact By targeting blood cancer stem cells, these compounds can be used to treat and prevent recurrence of cancer in patients. (ca.gov)
Research Objective We will use integrated gene editing techniques to develop a new CAR-T cell therapy for multiple myeloma treatment Impact Develop an improved CAR-T cell therapy for patients with refractory multiple myeloma and a new manufacturing strategy that circumvents the costs and inefficiencies of viral production. (ca.gov)

Anatomy53

Organisms16

Diseases27

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes52

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Named Groups1

Health Care1

Acute16

Hematopoiesis14

Progenitors16

Monocytes8

Transplantation14

Differentiation17

Macrophages6

Proliferation4

Stromal cell3

Peripheral blood and bone marrow3

Precursors5

HSCs14

Mobilization of hematopoietic stem1

Populations6

Microenvironment3

Lineages3

CD346

EPCs6

Subsets2

Lymphoid6

Adult6

Embryonic3

Mesenchymal stromal cells4

Human Hematopoietic Stem1

Lymphocytes1

Erythroid1

Neutrophils3

Macrophage4

Progenitor cell migration2

Markers3

Regeneration5

Mice15

Extracellular matrix2

Multipotent2

Primitive3

Tumor2

Characterized by flow cytometry1

Vitro5

Transplant3

Lymphatic3

Suppressor cells2

Myelodysplastic1

Maturation3

Blood stem cells12

Angiogenic cells1

Therapies3

Vessel7

Leukemia2

Platelets4

MSCs3

Immune7

Chemotherapy4

Malignancies1

Receptor2

Phenotype2

Clonal1

Distinct2

Therapeutic6

Failure syndromes1

Patients5