• Endothelial cells from the vein of the umbilical cord which are usually termed as HUVEC are also of interest to researchers as it can be manipulated in vitro to study endothelial cells behaviour and vascular-associated diseases. (elsevier.com)
  • Immunophenotyping for positive and negative markers of mesenchymal stem cells was performed on HUVEC and compared to the closest stem cells that were isolated from the umbilical cord matrix which is termed as HUCMSC in this study. (elsevier.com)
  • abstract = "Mesenchymal stem cells population has been successfully isolated from the matrix and characterised for its stemness properties. (elsevier.com)
  • The results showed that HUVEC strongly expressed hematopoietic and mesenchymal stem cells markers (CD31, CD34, CD9, CD44, CD73 and CD90) while HUCMSC possess mesenchymal stem cells properties with strong expression of CD9, CD44, CD73 and CD90. (elsevier.com)
  • In a new study published in Developmental Cell , a research team led by experts from Osaka University investigated the mechanism underlying endothelial cell resistance to TNFα-induced apoptosis, an important mechanism of cell death in inflammatory conditions. (eurekalert.org)
  • In addition to providing a clear understanding of endothelial cell survival during inflammation, this study has revealed a potential pathway for other cell types to avoid the onset of apoptosis, and may be important in future regenerative medicine therapies. (eurekalert.org)
  • Focal adhesion kinase and endothelial cell apoptosis. (nih.gov)
  • Growing evidence indicates that FAK is important in maintenance of normal cell survival and that disruption of FAK signaling results in loss of substrate adhesion and anoikis (apoptosis) of anchorage-dependent cells, such as endothelial cells. (nih.gov)
  • This review summarizes the signaling pathways of FAK in prevention of apoptosis and the role of FAK in mediating adenosine and homocysteine-induced endothelial cell apoptosis and in cardiovascular diseases. (nih.gov)
  • At 24h after transfection, cells were incubated in buffer alone (HBS, vehicle) or with 1 mM adenosine (Ado) or 100 μM adenosine plus 100 μM homocysteine (Ado/HC) for additional 16 h and then apoptosis was assessed by Hoechst staining. (nih.gov)
  • Apoptosis was presented as the ratio of apoptotic HA− or CD2 cells to total HA or CD2 expressing cells. (nih.gov)
  • Dramatic changes of pressure in the local circulation flow field would lead to alterations in biorheological characteristics of Endothelial cells(ECs), and futher resulted in the apoptosis induced by loss of anchorage, a form of cell death known as anoikis. (scirp.org)
  • Flusberg, D.A., Numaguchi, Y. and Ingber, D.E. (2001) Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. (scirp.org)
  • Background and Purpose -Our recent study showed that oxyhemoglobin (OxyHb) induces apoptosis in cultured endothelial cells. (ahajournals.org)
  • This study was undertaken to investigate the effect of 2 caspase inhibitors, Z-VDVAD-FMK and Z-DEVD-FMK, in the protection of endothelial cells from OxyHb-induced apoptosis. (ahajournals.org)
  • 9 10 11 12 We previously reported that OxyHb induced apoptosis in cultured endothelial cells in a time- and concentration-dependent manner. (ahajournals.org)
  • In this study we investigated the effect of OxyHb on the activities of caspase-2 and -3 and the prophylaxis effect of caspase inhibitors on OxyHb-induced apoptosis in bovine brain microvessel endothelial cells. (ahajournals.org)
  • Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity. (thefreedictionary.com)
  • To investigate whether Ox-LDL regulates OX40L expression through an oxidized LDL-1 receptor (LOX-1)-mediated mechanism, we investigated the effect of different concentrations of Ox-LDL (50, 100, 150 µg/mL) on endothelial cell proliferation and apoptosis. (scielo.br)
  • Previous studies have suggested a role for an increased apoptosis of the endothelial cells in the pulmonary capillaries of the alveolar septa in the pathogenesis of human pulmonary emphysema. (bmj.com)
  • Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. (uniprot.org)
  • During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. (uniprot.org)
  • The amounts of connective tissue and smooth muscle in the vessel wall vary according to the vessel's diameter and function, but the endothelial lining is always present. (nih.gov)
  • Once a vessel has matured, signals from the endothelial cells to the surrounding connective tissue and smooth muscle continue to play a crucial part in regulating the vessel's function and structure. (nih.gov)
  • by signaling this information to the surrounding cells, they enable the blood vessel to adapt its diameter and wall thickness to suit the blood flow. (nih.gov)
  • Human vascular endothelial cells are important for developing engineered vessels for treatment of vascular disease ( 1 ) and also may be useful for augmenting vessel growth to areas of ischemic tissue or after implantation ( 2 ). (pnas.org)
  • Early endothelial progenitor cells isolated from differentiating mouse embryonic stem cells were shown to give rise to three blood vessel cell components, hematopoietic, endothelial, and smooth muscle cells ( 5 ). (pnas.org)
  • A dense network of arteries, capillaries and veins leaves every cell of the body within less than one tenth of a millimeter of the nearest blood vessel. (dkfz.de)
  • The newly emerging concepts of 'angiocrine signaling' - the notion that endothelial cells are active drivers and not just passive responders - will transform our conceptual understanding of vascular function and may in the long run pave the way towards the development of novel therapeutic strategies aimed at interfering with vessel and organ diseases. (dkfz.de)
  • Remodelling, due to neoplastic-like alterations in smooth muscle and endothelial cells of the vessel wall, is arguably the most important and, to date, the least treated factor in this pathogenetic triad. (eurekalert.org)
  • VEGFs exert their function by binding to the three known VEGFRs, VEGFR-1, VEGFR-2 or VEGFR-3, which are expressed by blood vessel endothelial cells (BECs) in case of VEGFR-1 and -2, and lymphatic vessel endothelial cells (LECs) in case of VEGFR-2 and -3. (nature.com)
  • Endothelial colony forming cells represent a distinct population that has been found to have the potential to differentiate and promote vessel repair. (wikipedia.org)
  • Development of a nanofibrous bioactive vascular graft that wo uld direct appropriate cell adhesion and growth would have a significant impact on small vessel repair and replacement. (sbir.gov)
  • In response, the endothelial cells embark on a multistep process that results in new blood vessel formation. (aacrjournals.org)
  • The lumen of each blood vessel is surrounded by a thin layer of endothelial cells (ECs) supported by a basement membrane and mural cells (pericytes and smooth muscle cells). (stemcell.com)
  • We conclude that vasculogenic endothelial cells and nascent vessels are critical for the earliest stages of organogenesis, prior to blood vessel function. (sciencemag.org)
  • Transmission electron microscopy (TEM) imaging has unequivocally shown that CECs sorted according to our latest protocol are in large part nucleated necrotic cells, most likely derived from vessel wall turnover. (aacrjournals.org)
  • Understanding the endothelial cell migration on micropatterned polymers, as well as the cell orientation is a critical issue in tissue engineering, since it is the preliminary step towards cell polarization and that possibly leads to the blood vessel formation. (aimsciences.org)
  • Our aim is to identify novel targets in endothelial cells for cardiovascular diseases. (helsinki.fi)
  • It is hoped that by blocking the formation of new blood vessels through drugs that act on endothelial cells, it may be possible to block the growth of tumors (discussed in Chapter 23). (nih.gov)
  • In particular, bevacizumab has activity in one of the deadliest tumors, glioblastoma multiforme (GBM), which is a very vascular tumor and also a tumor type in which the cancer stem cell fraction is thought to drive tumor growth. (sciencemag.org)
  • Groups led by Tabar and De Maria independently observed that a high proportion (up to 90%) of endothelial cells in human GBM tumors carried the same abnormal genomes as the malignant GBM cells, suggesting that endothelial cells are derived from the tumor cells rather than from normal surrounding vessels. (sciencemag.org)
  • When these tumor-derived endothelial cells were ablated in the tumors transplanted into mice, the tumors demonstrated profound regression, suggesting that these cells are crucial for tumor growth. (sciencemag.org)
  • 4 Interestingly, the gene expression profile of EPC more closely resembled that of freshly isolated endothelial cells from tumors rather than that of cultured endothelial cells. (haematologica.org)
  • 2011) Human solid tumors contain high endothelial venules (HEV): association with T and B lymphocyte infiltration and favourable prognosis in breast cancer. (ipbs.fr)
  • Pulmonary artery endothelial cells (PAECs) were incubated in HEPES buffer in the absence (vehicle) or presence of 100 μM adenosine plus 100 μM homocysteine (Ado/HC) for 4 h. (nih.gov)
  • Panel a: Bovine pulmonary artery endothelial cells (PAECs) were transfected with wild type FAK (pHA-FAK) or central kinase inactive FAK mutants (pHA-FAK Y397F and pHA-FAK D395A ). (nih.gov)
  • In the context of pulmonary hypertension, miRNAs have been shown to control the expression of the bone morphogenetic protein receptor type II (BMPR2), which is one of the master regulators in endothelial and smooth muscle cells. (eurekalert.org)
  • The BPAE cell line was initiated in January 1979 from the main stem of a pulmonary artery belonging to a young cow ( Bos taurus ). (microscopyu.com)
  • We found that the H5N1 virus, but not common seasonal influenza viruses, can target human pulmonary endothelial cells. (infectioncontroltoday.com)
  • There, the viruses replicate rapidly, creating an overwhelming inflammatory cytokine response, essentially causing an immune response so powerful that it kills the pulmonary endothelial cells, results which Tumpey says correlate with the H5N1-induced acute respiratory distress syndrome that is observed in humans where the production of cytokines, immune system compounds, has been detected in lung endothelial cells. (infectioncontroltoday.com)
  • Although the mechanism of H5N1 pathogenesis is not entirely known, our research identified one virulent factor, the cleavage site of the viral surface glycoprotein hemagglutinin, which we found to be critical for the production of infectious progeny H5N1 virus in pulmonary endothelial cells," says Tumpey. (infectioncontroltoday.com)
  • The culture of bovine pulmonary artery endothelial cells appearing in the digital image above was stained with MitoTracker Red CMXRos, vividly labeling the intracellular mitochondrial network. (fsu.edu)
  • View a larger image of the bovine pulmonary artery endothelial (BPAE) cells. (fsu.edu)
  • 2 However, it is unknown if a decrease in the blood of these stem cells contributes to the pathogenesis of pulmonary emphysema in humans. (bmj.com)
  • No significant correlation was found between total and endothelial stem cell numbers and HRCT score of pulmonary emphysema ( figure 1 ), lung function data or smoking status (current vs ex-smokers). (bmj.com)
  • These data indicate that the number of circulating endothelial stem cells is not related to the presence and/or severity of the pulmonary emphysema or the presence or absence of COPD. (bmj.com)
  • Correlation between number of circulating endothelial stem cells (ESC) expressed as a percentage of the total number (CD34+) of circulating stem cells, and high-resolution CT scan of the chest score of pulmonary emphysema. (bmj.com)
  • In bovine pulmonary artery endothelial cells, aspirin at low antithrombotic concentrations (0.03 to 0.3 mmol/L) induced the synthesis of ferritin protein in a time- and concentration-dependent fashion up to 5-fold over basal levels, whereas ferritin H (heavy chain) mRNA remained unaltered. (ahajournals.org)
  • Bovine pulmonary artery endothelial cells (ATCC CCL 209) were obtained from the American Type Culture Collection. (ahajournals.org)
  • EPO also appears to have direct biologic effects on endothelial cells. (bloodjournal.org)
  • Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. (wikipedia.org)
  • 10 They build fenestrated and discontinuous cell formations to aid cellular trafficking (bone marrow) or absorption (intestinal villi), as well as continuous layers that operate as a barrier between compartments (brain). (ahajournals.org)
  • They build continuous, fenestrated, or discontinuous cell layers to, for example, regulate cell barrier function in the brain, trafficking in bone marrow or absorption in the intestine. (ahajournals.org)
  • Ablation of the endothelial progenitor cells in the bone marrow lead to a significant decrease in tumour growth and vasculature development. (wikipedia.org)
  • The bone marrow (BM) microenvironment, consisting of the vascular endothelial cell (EC) and perivascular stromal niches, normally provides paracrine signals to support HSC maintenance and function. (sciencemag.org)
  • 4 Further studies in mice revealed that bone marrow-derived cells naturally participate in the formation of new blood vessels in ischemic limb. (haematologica.org)
  • 6 - 8 Functional evidence for the bone marrow component of circulating EPC was originally based on mice models of hematopoietic stem cell transplantation, in which EPC of the recipient were shown to originate from donor stem cells by clonal analysis. (haematologica.org)
  • 10 While CD34 positive cells comprise only about 0.1% of the total circulating white blood cell population, hematopoietic or angiogenic growth factors induce significant release of these cells from the bone marrow into the peripheral blood circulation. (haematologica.org)
  • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. (semanticscholar.org)
  • The other is the quality and activity of the hematopoietic stem cell population in the bone marrow, where immune cells are created. (fightaging.org)
  • It is characteristic of hematopoietic stem cells, as well as muscle stem cells. (wikipedia.org)
  • Hematopoietic stem cells can of course undergo self-renewal, and are multipotent cells that give rise to erythrocytes (red blood cells), megakaryocytes/platelets, mast cells, T-lymphocytes, B-lymphocytes, dendritic cells, natural killer cells, monocyte/macrophage, and granulocytes. (wikipedia.org)
  • Aging is associated with changes in the hematopoietic system, including cell-intrinsic alterations of hematopoietic stem cells (HSCs), leading to a decline in HSC self-renewal, immune system dysregulation, and predisposition to myeloid neoplasms. (sciencemag.org)
  • Although VEGFR-1 and VEGFR-2 are expressed in vascular endothelial cells, monocytes, macrophages, and hematopoietic stem cells, the expression of VEGFR-3 is largely restricted to lymphatic endothelial cells consistent with a role of this receptor in lymphangiogenesis ( 4 ). (aacrjournals.org)
  • It gives rise to the body's connective tissues, blood cells, and blood vessels, as well as muscle, kidney, and many other structures and cell types. (nih.gov)
  • Almost all tissues depend on a blood supply, and the blood supply depends on endothelial cells , which form the linings of the blood vessels. (nih.gov)
  • Here, the researchers used a unique type of mouse, in which TAK1 could be deleted in specific tissues, to show that TAK1 is an essential component in ensuring survival of endothelial cells during inflammation and injury. (eurekalert.org)
  • Thus, the presence of TAK1 safeguarded the survival of endothelial cells in these tissues. (eurekalert.org)
  • More recently, mesoangioblasts have been theorized as a cell giving rise to multiple mesodermal tissues. (wikipedia.org)
  • Senescence of endothelial cells (ECs) impaired vascular functions, leading to aging of tissues and organ [ 4 ]. (mdpi.com)
  • NK cells accumulate rapidly in tissues under certain conditions, including viral infections, administration of biologic response modifiers, and transplantation of allografts or xenografts ( 16 , 18 ). (jimmunol.org)
  • In many cases, solutions of fluorophores or cell suspensions can be deoxygenated, but this is not feasible for living cells and tissues. (fsu.edu)
  • ECs form the physical interface between the blood and surrounding solid tissues, and as such, regulate physiological events including vasodilatation and vasoconstriction, blood coagulation, nutrient delivery, gas exchange, and the homing of regulatory cells. (stemcell.com)
  • Our team is among the world leaders for the characterization of high endothelial venules (HEVs), portals of entry for lymphocytes into lymphoid organs, inflamed and tumor tissues (~ 25 years expertise), and for the study of IL-33, a nuclear cytokine from the IL-1 family that we discovered in 2003, which plays crucial roles in innate immunity and allergic inflammation. (ipbs.fr)
  • The early stages of visceral organ development serve as a model for changes in cells and tissues that occur in various biological contexts. (sciencemag.org)
  • During the embryonic specification of tissues such as the liver, endodermal epithelial cells receive stimuli from mesodermal cells that cause changes in gene expression and cell division. (sciencemag.org)
  • Vascular cells regulate the inflammatory process through the expression of adhesion molecules, cytokines, chemokines and growth factors. (biomedsearch.com)
  • MitoAKAPs (mitochondrial A kinase anchoring proteins), encoded by the Akap1 gene, regulate multiple cellular processes governing mitochondrial homeostasis and cell viability. (ovid.com)
  • In endothelial cells, there is no colocalization with WPBs, and the number, size, and morphology of these organelles is not influenced by STXBP5. (jci.org)
  • They found no significant difference in cell loss or morphology compared to 42 control eyes that had not undergone either procedure. (aao.org)
  • Interestingly there was an improvement in endothelial morphology in patients who underwent PRK, presumably due to the cessation of contact lens wear. (aao.org)
  • ECFCs are isolated by plating peripheral blood mononuclear fraction on collagen-coated plates, removing non-adherent cells, and culturing for weeks until the emergence of colonies with a distinctive cobblestone morphology. (wikipedia.org)
  • in 1997 as a population of postnatal blood cells that formed an adherent layer of cells of endothelial morphology after 7 days of culture in endothelial growth medium. (haematologica.org)
  • CACs are further characterized by their morphology, adhesion to fibronectin, and cell surface protein expression. (stemcell.com)
  • High endothelial cells from HEVs (green) are characterized by a plump morphology and express high levels of the nuclear cytokine IL-33 (red). (ipbs.fr)
  • The novel procedure described in our article enumerates a population of circulating cells with endothelial phenotype, morphology, and molecular characteristics that differ in number from the population described in previous articles from our laboratories. (aacrjournals.org)
  • Depletion of GIT1 with antisense GIT1 oligonucleotides had no effect on basal cell morphology, but increased cell rounding and contraction of HUVECs, increased FA formation, and increased FAK tyrosine phosphorylation in response to thrombin, concomitant with increased endothelial hyperpermeability. (ahajournals.org)
  • Human coronary artery endothelial cells (HCAECs), purchased from Clonetics, were cultured in EGM-2 media (Clonetics) and used at passages 2 to 3. (ahajournals.org)
  • We found that, in tumor in which TNFα is expressed abundantly, localized deletion of TAK1 resulted endothelial cell death and thereby tumor regression, suggesting that TAK1 may be a useful target in anti-angiogenic therapy. (eurekalert.org)
  • Increasing evidence indicates that tumor endothelial cells (TEC) differ from normal endothelial cells (NEC). (plos.org)
  • Recent studies have shown that TMV contain numerous types of bioactive molecules and affect normal stromal cells in the tumor microenvironment. (plos.org)
  • Here we showed that TMV isolated from tumor cells were taken up by NEC through endocytosis. (plos.org)
  • These findings offer new insights into cancer therapies and the crosstalk between tumor and endothelial cells mediated by TMV in the tumor microenvironment. (plos.org)
  • Tumor blood vessels provide nutrition and oxygen, promote tumor progression, and serve as gatekeepers for tumor cells to metastasize to other organs. (plos.org)
  • Furthermore, there are many differences at the molecular and functional levels between tumor endothelial cells (TEC) and normal EC (NEC) , . (plos.org)
  • Recent studies report that crosstalk between tumor cells and stromal cells are important for tumor progression or acceleration of tumor malignancy by secreting microvesicles (MVs) , . (plos.org)
  • Although tumor cells continuously mutate to evade chemotherapy, blood vessels were thought to be genetically stable and thus more easily targeted. (sciencemag.org)
  • Treatment with the vascular endothelial growth factor antibody bevacizumab reduced formation of these new tumor-derived endothelial cells. (sciencemag.org)
  • Cancer stem cells in glioblastoma multiforme give rise to a subset of tumor blood vessels. (sciencemag.org)
  • This is a complex process that requires multiple growth factors, 1 such as acidic and basic fibroblast growth factors, interleukin-8, transforming growth factors-α and -β, hepatocyte growth factor, tumor necrosis factor-α, epidermal growth factor, angiogenin, angiopoietin-1, platelet-derived growth factor and vascular endothelial growth factor. (haematologica.org)
  • In cancer, angiogenic factors can be produced by the tumor cells themselves but also by surrounding hematopoietic cells in the tumor microenvironment, including monocytes, lymphocytes, dendritic cells, neutrophils and mast cells. (haematologica.org)
  • For example, recent reports demonstrated that a population of circulating EPC may carry identical genetic abnormalities as the primary tumor cells in patients with multiple myeloma 15 or myeloproliferative disorders, 16 suggesting that both EPC and the tumor cells may have originated from the same multipotent hemangioblast precursor cell. (haematologica.org)
  • 15 , 16 The precise mechanism underlying recruitment of EPC to tumor sites remains poorly understood, but recent reports suggested the involvement of c-Kit ligand expression by endothelial cells. (haematologica.org)
  • Moreover, activation of endothelial cells by tumor cell-derived growth signals results in elevated galectin-1 expression ( 2 , 6 , 7 ) and translocation of the protein to the endothelial cell surface ( 2 , 8 ). (aacrjournals.org)
  • Knockdown of galectin-1 expression in glioblastoma tumor cells reduced the number of tumor vessels following injection of the cells in mice ( 10 ). (aacrjournals.org)
  • We show that tumor endothelial cells in gal-1 −/− mice take up galectin-1 from galectin-1-secreting tumor cells. (aacrjournals.org)
  • E-selectin expression is found only on endothelial cells after activation of proinflammatory cytokines (interleukin-1, tumor necrosis factor) or endotoxin. (thefreedictionary.com)
  • SU11248 inhibits VEGFRs, PDGFR, c-kit, and Flt-3 and has efficacy in imatinib-resistant gastrointestinal stromal tumor ( 8 ) and renal cell carcinoma. (aacrjournals.org)
  • In addition to tumor cells, stromal cells are thought to be a source of various proangiogenic factors. (aacrjournals.org)
  • Tumor-associated fibroblasts (TAF) are an important source of stromal-derived factor 1, leading to the recruitment of endothelial progenitor cells or myeloid cells into the tumor microenvironment ( 10 ). (aacrjournals.org)
  • The identification and quantification of circulating endothelial cells (CEC) have been developed as a novel marker of endothelial function. (hindawi.com)
  • Flow mediated dilation (FMD) by ultrasound of the brachial artery on the contralateral arm will be used as an additional marker of endothelial function. (utsouthwestern.edu)
  • While STXBP5 facilitates granule release from platelets, it inhibits secretion from the Weibel-Palade bodies (WPBs) of endothelial cells. (jci.org)
  • A ) STXBP5 inhibits regulated exocytosis from endothelial cells, but promotes granule secretion from platelets. (jci.org)
  • Together, these studies demonstrate that STXBP5 differentially regulates exocytosis in these two cell types. (jci.org)
  • Together with other cell-types such as astrocytes or pericytes, they form the neurovascular unit (NVU), which specifically regulates the interchange of fluids, molecules and cells between the peripheral blood and the CNS. (jove.com)
  • Regulates endothelial chemotaxis and tube formation (By similarity). (uniprot.org)
  • Endothelial cells, the inner lining of blood vessels, do not just respond passively to exogenous stimuli. (dkfz.de)
  • Endothelial cells are widely considered as a rather passive, barrier-forming cell population that at best responds to exogenous stimuli. (dkfz.de)
  • Recent work is casting a very different view of endothelial cells: Instead of just serving as passive responder to exogenous stimuli, endothelial cells themselves control surrounding cells quite actively. (dkfz.de)
  • In response to different stimuli, ECs secrete a set of proteins, which can act on the various neighbouring cell types. (helsinki.fi)
  • Comparing CAGE and microarray data sets, we furthermore identified a small number of genes that showed a receptor-dependent response in LECs, demonstrating that these receptors, despite activating very similar signaling pathways, fulfill overlapping but not identical functions within the same cell type (LECs). (nature.com)
  • Therefore, a possible mechanism might be the induction of genes that protect cells from damage by reactive oxygen species. (ahajournals.org)
  • This revealed that there were 149 genes upregulated in HUVEC cells and 317 upregulated in ocular microvascular ECs. (arvojournals.org)
  • Using SAM analysis, 1804 genes were differentially expressed between proliferating human retinal and choroidal endothelial cells while 76 genes were differentially expressed between unpassaged proliferating human iris and choroidal endothelial cells. (arvojournals.org)
  • 4 These cells expressed several markers in common with endothelial cells such as CD34, CD31, VEGFR2 (KDR), and Tie2. (haematologica.org)
  • Despite the fact these two antigens have continued to be used as markers for circulating cells with vascular reparative properties, it was not demonstrated that the infused cells directly formed new blood vessels. (stemcell.com)
  • However, due to a lack of early endothelial cell markers and genetic mutations that eliminate endothelial cell lineages, previous studies did not rigorously assess the potential contribution of angioblasts or early endothelial cells to the morphogenetic induction of the liver or other endoderm-derived organs. (sciencemag.org)
  • The embryonic role of endothelial cells and nascent vessels in promoting organogenesis, prior to vascular function, is unclear. (sciencemag.org)
  • In the present study, we use such tools and a liver bud culture system to assess the role of endothelial cells in the morphogenetic phase of organ development. (sciencemag.org)
  • Furthermore, a polyclonal antibody raised against KLK12′s proteolytic cleavage site on fibronectin prevented the KLK12-dependent inhibition of fibronectin polymerization and the KLK12-mediated pro-migratory effect on endothelial cells. (nature.com)
  • Upon partial hepatectomy, Ang2 production in endothelial cells is rapidly downregulated. (dkfz.de)
  • Junctional communication is induced in migrating capillary endothelial cells. (rupress.org)