Endothelial cancer. Medical search. Frequent questions

VEGF: Vascular endothelial growth factor. (wjgnet.com)
In this study, we aimed to elucidate if increased CFC is associated with low-grade inflammation and/or vascular endothelial growth factor-c (VEGF-C) signaling. (nih.gov)
Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. (hotzehwc.com)
Vascular endothelial growth factor (VEGF), acting via the receptors VEGFR-1 and VEGFR-2, is a key mediator of tumour angiogenesis. (monash.edu)
In this study we show that oestradiol decreased secreted sVEGFR-1, increased secreted VEGF, and decreased the ratio of sVEGFR-1/VEGF in MCF-7 human breast cancer cells. (monash.edu)
Our results suggest that tamoxifen and oestradiol exert dual effects on the angiogenic environment in breast cancer by regulating cancer cell-secreted angiogenic ligands such as VEGF and sVEGFR-1 and by affecting VEGFR-2 expression of endothelial cells. (monash.edu)
Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. (wikipedia.org)
The role of vascular endothelial growth factor (VEGF) in differential vWF expression was investigated using cultured human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
These cells are recruited undifferentiated, in response to systemic or chemoactractive signals, such as Vascular Endothelial Growth Factor (VEGF), they lodge in the growing or lesioned tissue and ifferentiate into endothelial cells in response to local stimuli and cell-cell interactions.The extent and the significance of the EPCs contribution for the growing of most tumors, including those of the breast, are still not fully defined. (peertechzpublications.org)
van Nieuw Amerongen, G. P., Koolwijk, P., Versteilen, A. & van Hinsbergh, V. W. Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. (nature.com)
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. (nih.gov)
Previously we found that estrogen aided in this neovasculogenesis via recruitment of bone marrow derived endothelial progenitor cells (BM-EPCs), leading to increased vessel formation and vascular endothelial growth factor (VEGF) production in vivo . (biomedcentral.com)
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and as a result acts in tumor invasion. (cytgen.com)
In this study, we investigate the frequency of alleles, genotypes and haplotypes for three VEGF single nucleotide polymorphisms (SNP) in female breast cancer patients and healthy control group. (cytgen.com)
miR-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting VEGF Signaling. (ca.gov)
The increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in zebrafish and in HUVECs inhibited the angiogenic behavior of endothelial cells largely by antagonizing VEGF receptor-2 signaling. (ca.gov)
We established an important role of endothelial Pfn1 in tumor angiogenesis and further identified endothelial Pfn1-dependent regulation of several pro- ( VEGF , SERPINE1, CCL2) and anti-angiogenic factors ( platelet factor 4 ) in vivo. (bvsalud.org)
Vascular endothelial growth factor (VEGF) is a key stimulator of physiological and pathological angiogenesis. (ox.ac.uk)
VEGF signals primarily through VEGF receptor 2 (VEGFR2), a receptor tyrosine kinase whose expression is found predominantly on endothelial cells. (ox.ac.uk)
Lung cancer CM was added in combination with avastin and DME-25, before or after vascular endothelial growth factor (VEGF) depletion, to endothelial cells (HECV) and cell migration and microtubule formation were assessed in vitro. (cardiff.ac.uk)
Conclusion: DME-25 inhibits tubule formation irrespectively of the factors secreted by normoxic or hypoxic lung cancer cell CM depleted of VEGF. (cardiff.ac.uk)

Glioblastoma is considered the most aggressive tumour initiated in the brain, whereas breast cancer is the most common metastatic cancer in the brain, both types of cancer are known as high infiltrated cancer and their invasiveness due to their capability to release factors that can alter the neighbouring cells to facilitate their progression. (uwc.ac.za)
Angiogenesis is a result of the interplay between cancer and endothelial cells, and sex steroids may exert effects on both cell types. (monash.edu)
Moreover, human umbilical vein endothelial cells (HUVEC) incubated with supernatants from oestradiol-treated MCF-7 cells exhibited higher VEGFR-2 levels than controls. (monash.edu)
It acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration. (wikipedia.org)
Hematopoietic stem cells emerge from endothelial cells in blood vessels during embryogenesis through the endothelial to hematopoietic transition. (biorxiv.org)
Here, we used single-cell transcriptomics analysis to compare embryonic and post-natal endothelial cells to investigate the potential of adult vasculature to be reprogrammed in hematopoietic stem cells. (biorxiv.org)
Although transcriptional similarities have been found between embryonic and adult endothelial cells, we found some key differences in term of transcription factors expression. (biorxiv.org)
There is a deficit of expression of Runx1, Tal1, Lyl1 and Cbfb in adult endothelial cells compared to their embryonic counterparts. (biorxiv.org)
Using a combination of gene expression profiling and gene regulatory network analysis, we found that endothelial cells from the pancreas, brain, kidney and liver appear to be the most suitable targets for cellular reprogramming into hematopoietic stem cells. (biorxiv.org)
Cultured human arterial endothelial cells (HAECs) were exposed to hypoxia/deoxygenation (H/R). Cells were also treated with baicalin at serially diluted concentrations. (medscimonit.com)
UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
vWF is produced exclusively by endothelial cells and megakaryocytes. (biomedcentral.com)
The aim of the present study was to identify whether P. gingivalis heat‑shock protein 60 (HSP60) induced the dysfunction of human umbilical vein endothelial cells (HUVECs) in vitro. (spandidos-publications.com)
Certain studies show that P. gingivalis lipopolysaccharide (LPS) could induce the expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human umbilical vein endothelial cells (HUVECs) ( 13 , 14 ), which significantly enhances trans-endothelial migration of inflammatory cells. (spandidos-publications.com)
We investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells. (plos.org)
En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
However, the action of PDCD4 in endothelial cells is unclear. (plos.org)
Vascular endothelial cells, as a monolayer in direct contact with the flowing blood, bear the most of the wall shear stresses and have important homeostatic functions in response to stress [16] . (plos.org)
Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
Recent evidences demonstrated the importance of bone marrow derived Endothelial rogenitor Cells (EPC), in the contribution to postnatal physiological and pathological neovascularization, and in tumor growth and angiogenesis. (peertechzpublications.org)
Here, we use single-cell metabolic imaging to measure glycolysis in individual endothelial cells with genetically encoded biosensors capable of deciphering metabolic heterogeneity at subcellular resolution. (nature.com)
Fig. 5: RhoA induces glucose transporter SLC2A3 translocation which drives subcellular glycolysis in thrombin-stimulated contractile endothelial cells. (nature.com)
Tumor endothelial cells (TEC) play an indispensible role in tumor growth and metastasis although much of the detailed mechanism still remains elusive. (tmu.edu.tw)
Endothelial cells play a central role in controlling vascular function and maintaining vascular integrity. (nii.ac.jp)
We identified a set of microRNAs (miRNAs) expressed in vascular endothelial cells, which regulate vascular malfunction. (nii.ac.jp)
We focused on several miRNAs expressed in endothelial cells. (nii.ac.jp)
2) miR-424/503 changes the phenotype of endothelial cells. (nii.ac.jp)
Journal Article] Upregulation of non-β Cell-derived Vascular Endothelial Growth FactorA Increases Small Clusters of Insulin producing Cells in the Pancreas. (nii.ac.jp)
Experiments with endothelial cells fortified with the isolated fraction from native honey enriched in antioxidants, exposed to peroxyl radicals from 1,1-diphenyl-2-picrylhydrazyl (AAPH, 10 mM) and to hydrogen peroxide (H2O2, 50-100 microM), indicated that phenolic acids and flavonoids were the main causes of the protective effect. (researchgate.net)
We found that bone marrow endothelial cells from patients with MM express high levels of EGFR and HB-EGF, compared with cells from patients with monoclonal gammopathy of undetermined significance, and that overexpressed HB-EGF stimulates EGFR expression in an autocrine loop. (uni-wuerzburg.de)
Moreover, blockade of HB-EGF-EGFR signaling, by an anti-HB-EGF neutralizing antibody or the EGFR inhibitor erlotinib, limited the angiogenic potential of bone marrow endothelial cells and hampered tumor growth in an MM xenograft mouse model. (uni-wuerzburg.de)
Therefore, a better understanding of the effects of antiangiogenic treatments on endothelial cells is necessary. (johnshopkins.edu)
In this study, we evaluate the changes in cell surface vascular endothelial growth factor receptor (VEGFR) expression on endothelial cells in culture treated with the antiangiogenic tyrosine kinase inhibitor drug sunitinib, using quantitative flow cytometry. (johnshopkins.edu)
Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)
Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
We invite investigators to submit original research as well as review articles addressing recent advancements in our understanding of stem cells in cancer. (hindawi.com)
Correlations of observations of the GCX with a number of EC functions were sought with an emphasis on studies of trans-endothelial barrier integrity against vessel wall infiltration of cells and molecules from the circulation. (iospress.com)
Endothelial cells lining blood vessels help keep what belongs in and what doesn't belong out. (asbmb.org)
Estrogen modulation of HIF-1 and subsequent effects on endothelial cells is dependent on the Akt/PI3K pathway and protein synthesis as validated by the use of the inhibitors wortmannin and cycloheximide which abrogated estrogen's effects respectively. (biomedcentral.com)
Soluble factors in conditioned media from E 2 treated breast cancer cells also lead to migration and tube formation of human umbilical vein endothelial cells (HUVEC) in vitro . (biomedcentral.com)
Objectives: To detect the relation between the circulating endothelial progenitor cells (CEPCs) and stages of breast cancer patients. (journalcra.com)
Immunocytochemistry and RT-PCR have been widely used for the detection of circulating endothelial progenitor cells (CEPCs) in patients with breast cancer but their specificity is limited. (journalcra.com)
Various signaling pathways control the behavior of endothelial cells-the cells that line the interior surface of blood vessels. (ca.gov)
We show that a microRNA called miR-10 regulates the behavior of endothelial cells during blood vessel formation by encouraging signals that promote blood vessel growth. (ca.gov)
Genetic experiments in zebrafish revealed that miR-10 functions, in part, by directly regulating the level of a protein called FLT1, which inhibits the behavior of endothelial cells that promotes new blood vessel growth. (ca.gov)
Various signaling pathways control the behavior of endothelial cells, but their post-transcriptional dose-titration by miRNAs is poorly understood. (ca.gov)
Methods and Results: We show that the highly conserved microRNA family encoding miR-10 regulates the behavior of endothelial cells during angiogenesis by positively titrating pro-angiogenic signaling. (ca.gov)
Knockdown of miR-10 led to premature truncation of intersegmental vessel growth (ISV) in the trunk of zebrafish larvae, while overexpression of miR-10 promoted angiogenic behavior in zebrafish and cultured human umbilical venous endothelial cells (HUVECs). (ca.gov)
In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
Standard chemotherapy works by killings cancer cells and some normal cells, targeted treatment zeroes in on specific targets (molecules) in or on cancer cells. (medlineplus.gov)
These targets play a role in how cancer cells grow and survive. (medlineplus.gov)
Using these targets, the drug disables the cancer cells so they cannot spread. (medlineplus.gov)
People with the same type of cancer may have different targets in their cancer cells. (medlineplus.gov)
Cancer cells can become resistant to these drugs. (medlineplus.gov)
Do KT, Kummar S. Therapeutic targeting of cancer cells: era of molecularly targeted agents. (medlineplus.gov)
To study the contributions of vascular β-adrenergic receptor signaling in the tumor microenvironment, we utilized the Cdh5(PAC)-CreERT2 mouse to conditionally delete Adrb2 in endothelial cells. (taconic.com)
By intercrossing Adrb2-floxed mice to stromal Cre-expressing lines, including the endothelial-specific Cdh5(PAC)-CreERT2 mouse , Ali found that Conditional Adrb2 deletion in endothelial cells (ECs), but not myeloid cells or pericytes, inhibited angiogenesis and reduced disease progression throughout all histopathological cancer stages. (taconic.com)
Furthermore, we showed that endothelial cells are adrenergic stromal targets, and that conditional endothelial Adrb2 deletion inhibits the angiogenic switch and prostate cancer progression by increasing endothelial aerobic metabolism. (taconic.com)
We previously reported that Pfn1 is predominantly overexpressed in tumor -associated vascular endothelial cells in human clear cell renal carcinoma . (bvsalud.org)
In this study, we combined in vivo strategies involving endothelial cell -specific depletion and overexpression of Pfn1 to demonstrate a role of vascular endothelial Pfn1 in promoting tumorigenicity and enabling progressive growth and metastasis of renal carcinoma cells in a syngeneic orthotopic mouse model of kidney cancer . (bvsalud.org)
Endothelial Pfn1 overexpression increases tumor infiltration by macrophages and concomitantly diminishes tumor infiltration by T cells including CD8+ T cells in vivo, correlating with the pattern of endothelial Pfn1-dependent changes in tumor abundance of several prominent immunomodulatory cytokines . (bvsalud.org)
Our hypothesis is that inhibition of AQP1 will reduce migration and invasiveness of colon cancer cells, and the migration and tube-forming capacity of endothelial cells in vitro . (biomedcentral.com)
Effect of YangZheng XiaoJi Extract, DME-25, on endothelial cells and their response to Avastin. (cardiff.ac.uk)
However, over the course of anti-angiogenic therapies, cancer cells acquire resistance to these therapies after an initial period of success. (cardiff.ac.uk)
Transcript expression of several influential angiogenic markers in lung cancer cells were assessed following hypoxic/normoxic conditions. (cardiff.ac.uk)
We present a rate equation model for the TGF-b pathway in endothelial cells together with novel measurements. (lu.se)
Specifically, molecular interactions between cancer-associated fibroblasts, pericytes and endothelial cells are explored with a special focus on novel anti-cancer strategies. (lu.se)
The role of inflammatory lipid mediators on colon cancer initiating cells (CICs). (lu.se)
Crosstalk between colorectal cancer cells and tumour-associated macrophages. (lu.se)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

Although vascular endothelial growth factor (VEGFA-165) is primarily known for its role in angiogenesis, it also plays important neurotrophic and neuroprotective roles for spinal motor neurons. (jneurosci.org)
inhibition of angiogenesis is a promising new approach in cancer therapy. (karger.com)
Epidermal growth factor receptor (EGFR) and its ligand heparin-binding EGF-like growth factor (HB-EGF) sustain endothelial cell proliferation and angiogenesis in solid tumors, but little is known about the role of HB-EGF-EGFR signaling in bone marrow angiogenesis and multiple myeloma (MM) progression. (uni-wuerzburg.de)
Angiogenesis, the formation of new blood vessels, is an essential step for cancer progression, but antiangiogenic therapies have shown limited success. (johnshopkins.edu)
Conclusion: CEPC elevation in the blood of breast cancer patients established as a useful marker of tumor angiogenesis and progression. (journalcra.com)
We showed that there was an increase in angiogenesis (an angiogenic switch), structurally patterned by adrenergic nerves, during progression from the pre-neoplastic low-grade prostatic intraepithelial neoplasia (PIN) to the cancer-committed high-grade PIN," Ali said. (taconic.com)
AQP1 knockout mouse models of human cancers showed marked inhibition of tumor-induced angiogenesis, and in pre-clinical studies of colon adenocarcinomas, forced over-expression of AQP1 was shown to increase angiogenesis, invasion and metastasis. (biomedcentral.com)
The effect of AqB013 on angiogenesis was tested using an endothelial cell tube-formation assay. (biomedcentral.com)
Specific classes of AQP channels have been implicated in enhanced migration, angiogenesis and metastasis in a variety of cancer types [ 8 , 9 ], prompting the suggestion that inhibitors of AQP channels might provide new tools for cancer therapy [ 8 ]. (biomedcentral.com)
ackground: Angiogenesis is a cellular process that has been identified as a key target for therapy in solid cancer. (cardiff.ac.uk)
COX-2/sEH dual pharmacological inhibitors also potently suppress primary tumor growth and metastasis by inhibiting tumor angiogenesis via selective inhibition of endothelial cell proliferation. (cdc.gov)

Our data provide evidence that estrogen signaling mediates the tumor vasculogenic process required for breast cancer progression and involves a key regulator of the hypoxia signaling pathway. (biomedcentral.com)
Taken together with the fact that 60-70% of human breast cancers are estrogen receptor-alpha positive[ 7 ], the evidence suggests an etiological significance of estrogen in breast cancer initiation and progression. (biomedcentral.com)
In addition to its normal physiological roles, estrogen is also implicated in breast cancer initiation and progression. (biomedcentral.com)
Interestingly, estrogen is also capable of contributing to breast cancer progression by a novel role, via modulation of proteins involved in hypoxia signaling, namely hypoxia inducible factor 1 (HIF-1). (biomedcentral.com)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
For his work investigating mechanisms connecting SNS-mediated microenvironmental effects to prostate cancer progression, Ali Zahalka was awarded Taconic Biosciences' American Association for Cancer Research (AACR) 2017 Annual Meeting Travel Award. (taconic.com)
Our lab is interested in identifying factors that promote early-stage cancer progression," Ali told Taconic, "with the aim of developing novel therapeutic interventions. (taconic.com)
An MD/PhD candidate in the lab of Dr. Paul S. Frenette at Albert Einstein College of Medicine, Ali Zahalka presented preliminary work on these investigations at AACR 2017, which identified mechanisms through which loss of βARs may inhibit prostate cancer progression. (taconic.com)
Previous research, spearheaded by Ali's PhD mentor, Dr. Frenette, identified an essential role for adrenergic nerves is early stage prostate cancer progression. (taconic.com)
Building on this previous work, Ali "aimed to identify the stromal targets of adrenergic signals and the mechanisms by which loss of these signals inhibit prostate cancer progression. (taconic.com)
Taken together, our data suggests that adrenergic nerves mediate a pro-angiogenic switch during the early stages of prostate carcinogenesis, and abrogation of β-adrenergic signaling inhibits the angio-metabolic switch and delays cancer progression. (taconic.com)
Ali next measured prostate cancer progression in the transgenic HI-myc prostate cancer model after conditional beta-2 adrenergic receptor (Adrb2) deletion in stromal populations. (taconic.com)
Vascular endothelial profilin-1 drives a protumorigenic tumor microenvironment and tumor progression in renal cancer. (bvsalud.org)
In conclusion, this study demonstrates for the first time a direct causal relationship between vascular endothelial Pfn1 dysregulation, immunosuppressive tumor microenvironment , and disease progression with mechanistic insights in kidney cancer . (bvsalud.org)
Role of β-catenin and leukotriene in colon cancer progression. (lu.se)

Programmed cell death 4 (PDCD4) is an important tumor suppressor in the development of various human cancers [1] and inhibits translation rather than transcription. (plos.org)
Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. (nature.com)

Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
Wnt-5a signaling in breast cancer metastasis. (lu.se)

This study aimed to explore if DME-25 on its own and in combination with avastin affected endothelial cell behaviour in vitro in the presence of hypoxic lung cancer-conditioned medium (CM). Materials and Methods: Two lung cancer cell lines, A549 and SK-MES-1, were exposed to hypoxic conditions (O2 ≤1%) for 4 h, after which CM, and RNA were collected. (cardiff.ac.uk)

Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but the mechanisms remain elusive. (mdpi.com)
Mechanical activation of hypoxia-inducible factor 1α drives endothelial dysfunction at atheroprone sites. (nature.com)

The therapeutic properties of honey, once considered a form of folk or preventive medicine, are acquiring importance for the treatment of acute and chronic free radical-mediated diseases (atherosclerosis, diabetes and cancer). (researchgate.net)

The levels of vascular endothelial (VE)‑cadherin, endothelial nitric oxide synthase (eNOS) and cysteinyl aspartate‑specific protease‑3 (caspase‑3) were measured using western blot analysis. (spandidos-publications.com)

The aim of this work was to study the protective activity of a honey of multifloral origin, standardized for total antioxidant power and analytically profiled (HPLC-MS) in antioxidants, in a cultured endothelial cell line (EA.hy926) subjected to oxidative stress. (researchgate.net)

The majority of breast cancers are oestrogen dependent, but it is not fully understood how oestrogen and the antioestrogen, tamoxifen, affect the balance of angiogenic factors. (monash.edu)

p38 MAPK Signalling in Endothelial Apoptosis. (lu.se)

LIPG endothelial lipase and breast cancer risk by subtypes. (harvard.edu)

To demonstrate the importance of GCX as a regulator of trans-endothelial infiltration, assays were performed using ECs with an intact GCX and compared to assays of ECs with an experimentally degraded GCX. (iospress.com)

By employing single-cell transcriptomics, endothelial fate mapping, and functional multiplex immune profiling, we demonstrate that antiangiogenic immune-modulating therapies evoke transdifferentiation of postcapillary venules into inflamed high-endothelial venules (HEVs) via lymphotoxin/lymphotoxin beta receptor (LT/LTβR) signaling. (utu.fi)

Absence of Lymphangiogenesis and Intratumoural Lymph Vessels in Human Metastatic Breast Cancer," The Journal of Pathology, Vol. 200, 2003, pp. 195-206. (scirp.org)
From existing research data, it is apparent that CEPCs monitoring is efficient, specific and reproducible as early predictors of metastatic potential in breast cancer patients with sensitivity 100 and specificity 100% at 52850 /5x106 PBMC as a cutoff point. (journalcra.com)
The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
Blocking VEGFA-induced disassembly of endothelial junctions, thereby suppressing tumour oedema and metastatic spread, may be preferable to full vascular suppression in the treatment of certain cancer forms. (lu.se)
Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer. (lu.se)

do Espírito Santo GF, Galera BB, Duarte EC, Chen ES, Azis L, Damazo AS, Saba GT, de Sousa Gehrke F, Guerreiro da Silva IDC, Waisberg J. Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients. (wjgnet.com)
T genetic polymorphism genotypes in colorectal cancer patients. (wjgnet.com)
Several risk factors and pathologies, including ageing, smoking, obesity and diabetes have been associated with poor prognosis in colorectal cancer patients. (frontiersin.org)

We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)
Glioblastoma and breast cancer are the most aggressive solid tumour. (uwc.ac.za)
Vascular endothelial growth factor directly stimulates tumour cell proliferation in non-small cell lung cancer. (ox.ac.uk)

As described in his AACR 2017 abstract , Ali used an orthotopic prostate cancer xenograft model to confirm his lab's previous findings by illustrating that genetic deletion of the SNS βAR neural receptors in the microenvironment inhibited tumor growth. (taconic.com)

M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)

Abnormal endothelial cell migration is seen in various diseases, including rheumatoid arthritis, cancer and macular degeneration. (asbmb.org)
Results: HECV cell migration was reduced in the presence of avastin, although less efficiently in the presence of lung cancer CM. A combination of DME-25 and avastin with lung cancer CM significantly reduced HECV cell migration irrespective of culture under hypoxia or normoxia. (cardiff.ac.uk)

Yet, the expression pattern of vWF in human gastric cancer (GC) tissues and its relation to clinicopathological features of these cases remains unknown. (biomedcentral.com)
The effect of varying concentrations of the AQP1 inhibitor AqB013 was tested on human colon cancer cell lines expressing high versus low levels of AQP1, using wound closure (migration) assays, matrigel invasion assays, and proliferation assays. (biomedcentral.com)
2. Find values for the kinetic parameters from experimental b pathway have been detected in several human diseases, estimates or by fitting the model to experimental kinetic most notably in many forms of cancer, and in fibrotic diseases data. (lu.se)
Asynchronous DNA Replication of Biallelically Expressed Genes in Human Peripheral Blood Lymphocytes as a Prognostic Sign of Cancer. (cdc.gov)

We show that cellular glycolysis fuels endothelial activation, migration and contraction and that sites of high lactate production colocalize with active cytoskeletal remodelling within an endothelial cell. (nature.com)
Role of DARPP-32 in Breast Cancer Cell Signalling and Migration. (lu.se)

Fig. 2: Endothelial LPR in response to shear stress is heterogeneous. (nature.com)

H- ras was one of the oncogenes that first caught the attention of molecular biologists interested in cell signaling, cell growth control, and cancer. (medscape.com)

This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. (nih.gov)
Overexpression of actin-binding protein profilin-1 (Pfn1) correlates with advanced disease features and adverse clinical outcome of patients with clear cell renal carcinoma , the most prevalent form of renal cancer . (bvsalud.org)

These results demonstrate a critical interaction of these two lipid metabolism pathways on tumorigenesis and suggest dual inhibition of COX-2 and sEH as a potential therapeutic strategy for cancer therapy. (cdc.gov)

Guided by Upstream Regulator Analysis of tumor transcriptome data, we further established endothelial Pfn1-induced Hif1α elevation and suppression of STAT1 activation. (bvsalud.org)

Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. (cdc.gov)
Customized diets for cancer prevention according to genetic polymorphisms: are we ready yet? (medscape.com)

Palmer and colleagues present a computational model of drug additivity that can predict clinical efficacy for the majority of combination therapy trials in advanced cancer that led to US Food and Drug Administration approvals between 1995-2020. (nature.com)
Cancer, 2020 Aug 1. (nih.gov)
Cancers (2020) 12:1, 173. (uni-wuerzburg.de)

We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
Further, hypoxia and estrogen are interchangeable as both similarly modulate epithelial-endothelial cell interaction. (biomedcentral.com)

High LYVE-1-Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer," Clinical Cancer Research, Vol. 10, No. 21, 2004, pp. 7144-7149. (scirp.org)
Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)

External validation verified some of these ECM-associated genes are not only generally overexpressed in various cancer tissues but also specifically overexpressed in colorectal cancer ECs and lymphoma ECs. (tmu.edu.tw)
In conclusion, our data demonstrated that ECM-associated genes play pivotal roles in breast cancer EC biology and some of them could serve as potential TEC biomarkers for various cancers. (tmu.edu.tw)
Variants in motilin, somatostatin and their receptor genes and risk of biliary tract cancers and stones in Shanghai, China. (cdc.gov)

IL-33 overexpression in gallbladder cancers associated with pancreatobiliary maljunction. (cdc.gov)

However, the functional interactions of these two pathways in cancer are unknown. (cdc.gov)

BMC cancer 2021 11 21 (1): 1245. (cdc.gov)

BACKGROUND:The onset of many disease processes depends on the function of the endothelial cell (EC) glycocalyx (GCX) which acts as a flow-dependent barrier to cellular infiltration and molecular transport across the blood vessel wall. (iospress.com)

These data provide good evidence for further testing of the inhibitor as a therapeutic agent in colon cancer. (biomedcentral.com)

Given a potential, predictive and therapeutic value of EPCs in breast cancer, level of CEPCs in breast cancer would correlate with extent of the disease. (journalcra.com)
Our study also provides a conceptual basis for targeting Pfn1 for therapeutic benefit in kidney cancer . (bvsalud.org)
The dilemma is finding a balance between the benefit of therapy, which may be incremental, and risk of harm, and to that end discovery of new therapeutic targets and pharmacological agents is a continuing goal for improving adjuvant cancer therapy. (biomedcentral.com)
Role of novel tumor suppressors in colon cancer : Mechanisms and therapeutic opportunities. (lu.se)

This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. (lu.se)

The ability to regulate blood vessel growth is important for treating many diseases, including cancer. (ca.gov)

Cancer Discov (2017) 7 (12): 1404-1419. (aacrjournals.org)

Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adherens junctions and a block in molecular extravasation. (lu.se)

Not all therapies work for all people with cancer. (medlineplus.gov)
Targeted therapies can treat most types of cancers. (medlineplus.gov)
Your provider will decide whether targeted therapies may be an option for your type of cancer. (medlineplus.gov)
Doctors thought that targeted therapies might have fewer side effects than other cancer treatments. (medlineplus.gov)

RhoA activation triggers a glycolytic burst through the translocation of the glucose transporter SLC2A3/GLUT3 to fuel the cellular contractile machinery, as demonstrated across multiple endothelial cell types. (nature.com)

Anatomy12

Organisms3

Diseases57

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Psychiatry and Psychology1

Phenomena and Processes50

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science7

Named Groups2

Health Care31

Geographicals4

VEGF21

Cells76

Angiogenesis11

Progression15

Inhibits2

Metastasis2

Vitro1

Dysfunction2

Atherosclerosis1

Nitric oxide sy1

Cultured endothelial cell1

Angiogenic1

Apoptosis1

Lipase1

Trans-endothelial1

Single-cell transcriptomics1

Metastatic5

Colorectal cancer patients3

Tumour3

Tumor growth1

Lymphangiogenesis1

Cell migration2

Human4

Migration2

Shear stress1

Signaling1

Protein2

Inhibition1

Transcriptome1

Polymorphisms2

20203

Hypoxia2

Lymphatic2

Genes3

Overexpression1

Pathways1

20211

Infiltration1

Inhibitor1

Therapeutic4

Intracellular1

Vessel1

20171

VEGFR21

Therapies4

Activation1