Loading...
  • PERK
  • Cytokines and palmitate triggered ER stress in β-cells as evidenced by increased phosphorylation of PERK, EIF2α and JNK, and increased expression of ATF4 and CHOP. (diabetesjournals.org)
  • pathway
  • However, if the ER stress is not resolved during the prosurvival phase, components of the ER stress response activated at later stages, during the proapoptotic phase, initiate the programmed cell death pathway. (ahajournals.org)
  • Ghrelin might prevent endoplasmic reticulum stress activation by stimulating the Akt signaling pathway, which attenuated inflammation and ameliorated asthma in mice. (ovid.com)
  • However, we still have a limited picture of the PCD pathway components activated when ER stress is unresolved. (frontiersin.org)
  • mediates
  • Taken together, our data suggest that proteasome dysfunction mediates obesity-induced ER stress, leading to insulin resistance in the liver. (diabetesjournals.org)
  • correlates
  • The expression of the calreticulin orthologue calnexin is up-regulated in various cancer models, such as breast cancer, and this correlates with enhanced resistance to stress ( 7 ). (aacrjournals.org)
  • chronic
  • In particular, inflammation caused by chronic overnutrition/unhealthy diet has been proposed to be an inducer of ER stress ( 3 - 5 ). (diabetesjournals.org)
  • Chronic ER stress is emerging as a trigger that imbalances a number of systemic and arterial-wall factors and promote atherosclerosis. (hindawi.com)
  • Recent studies have suggested that chronic ER stress originating from glucolipotoxicity is one of the major culprits that can very well explain the underlying causes of both insulin resistance and β -cell dysfunction [ 4 - 7 ]. (hindawi.com)
  • Chronic endoplasmic reticulum (ER) stress is a major contributor to obesity-induced insulin resistance in the liver. (diabetesjournals.org)
  • physiological
  • Significantly, ER stress plays an important role in numerous physiological and pathological conditions, including degenerative diseases and cancer. (suny.edu)
  • activation
  • This SCCA1-mediated cell death in response to ER stress is carried out by intracellular aggregation and subsequent activation of caspase-8. (suny.edu)
  • The DCCs exhibited an endoplasmic reticulum (ER) stress response but, paradoxically lacked both inositol-requiring enzyme 1α activation and expression of the spliced form of transcription factor XBP1 (XBP1s). (sciencemag.org)
  • This review covers what is known about caspase-like enzymatic activities during plant ER stress-induced PCD and discusses possible regulation pathways leading to the activation of relevant proteases in plants. (frontiersin.org)
  • Here we demonstrate that sustained activation of PPARα in ACOX1(-/-) mouse liver by these ACOX1 substrates results in endoplasmic reticulum (ER) stress. (nih.gov)
  • Conversely, prolonged or severe ER stress can lead to the activation of apoptotic cell death. (hindawi.com)