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  • Ire1
  • Ribosome profiling in ER-stressed cells lacking these factors revealed that Ire1-mediated cleavage of ER-associated mRNAs results in ribosome stalling and mRNA degradation. (elifesciences.org)
  • chaperones
  • A subset of 4-PBA-modulated ER-associated degradation chaperones (GRP94, HSP84, GRP78, GRP75, and GRP58) was observed to associate with the immature B form of CFTR in ER. (mcponline.org)
  • stress
  • HLA-B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). (uclan.ac.uk)
  • The ER stress-induced protein ER degradation-enhancing α-mannosidase-like protein 1 (EDEM1) was overexpressed by transfection, and dimer levels were monitored by immunoblotting. (uclan.ac.uk)
  • Endoplasmic reticulum ( ER ) stress is a conserved mechanism in the development of fibrosis. (embopress.org)
  • and (4) to some extent alleviates osmotic stress-induced cell death probably by regulating endoplasmic reticulum (ER) stress-related gene expression, for example expression of the basic leucine zipper genes bZIP60B and bZIP60D , the binding proteins BiP1 and BiP2 , the protein disulfide isomerase PDIL8-1 , and the glucose-regulated protein GRP94 . (frontiersin.org)
  • The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a multifunctional protein with activities far beyond its well-known role in the unfolded protein response (UPR) which is activated after endoplasmic reticulum (ER) stress in the cells. (frontiersin.org)
  • EDEM
  • This is carried out by members of the EDEM (ER degradation-enhancing α-mannosidase-like protein) family (EDEM1-3) and ER mannosidase I. This mannosidase removes one mannose residue from the glycoprotein and the latter is recognized by EDEM. (wikipedia.org)
  • GRP78
  • Levels of GRP78 are maintained at relatively low levels within the cell and are increased considerably under stresses that affect the endoplasmic reticulum (ER) and calcium homeostasis. (frontiersin.org)
  • inhibited using
  • EDEM1, the UPR-associated transcription factor X-box binding protein 1 (XBP-1), the E3 ubiquitin ligase hydroxymethylglutaryl-coenzyme A reductase degradation 1 (HRD1), and the degradation-associated proteins derlin 1 and derlin 2 were inhibited using either short hairpin RNA or dominant-negative mutants. (uclan.ac.uk)