Endoplasmic reticulum and death receptor. Medical search. Frequent questions

The apoptosis that follows is believed to be caused by unfolded protein response in the endoplasmic reticulum. (wikipedia.org)
Our contributions to elucidating the mechanisms of apoptosis led to clinical investigation of a novel class of molecules called Pro-Apoptotic Receptor Agonists, and aided in the advancement of apoptosis-promoting cancer medicines such as venclexta. (gene.com)
The death receptor and endoplasmic reticulum (ER) are closely related to cell apoptosis, and it is worth studying whether the apoptosis pathways mediated by them are involved in liver regeneration. (geneticsmr.com)
To understand the mechanism underlying death receptor- and ER-mediated apoptosis during rat liver regeneration, we used the Rat Genome 230 2.0 Array to determine the changes in gene expression. (geneticsmr.com)
We then searched the gene ontology (GO) and NCBI databases for genes associated with cell apoptosis mediated by the death receptor and ER. (geneticsmr.com)
Hepatocyte cell death can occur via either apoptosis or necrosis (or intermediate forms). (rug.nl)
We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
Cell death, particularly apoptosis, is probably one of the most widely-studied subjects among cell biologists. (biomedcentral.com)
Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. (uni-muenster.de)
α-TEA induces apoptosis via activation of extrinsic death receptors Fas (CD95) and DR5, JNK/p73/Noxa pathways, and suppression of anti-apoptotic mediators Akt, ERK, c-FLIP and survivin in breast, ovarian and prostate cancer cells. (biomedcentral.com)
Prevention of raft reorganization into larger platforms by inactivation of acid sphingomyelinase (ASMase), renders cells resistant to Fas clustering and apoptosis [ 9 ], indicating that ASMase/ceramide plays an important role in death receptor-mediated apoptosis. (biomedcentral.com)
Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to cause apoptosis in several types of malignant tumor cells through its interaction with the death domain-containing receptor, death receptor 5 (DR5). (nih.gov)
In the present study, we showed that co-treatment with troglitazone (TGZ), a synthetic ligand of peroxisome proliferator-activated receptor γ (PPARγ), and TRAIL synergistically induced apoptosis through DR5 upregulation in human colon cancer DLD-1 cells. (nih.gov)
Many studies on the cancer-killing activity of 125 I seeds radiation mainly focused on its ability to trigger apoptosis, which is the most well-known and dominant type of cell death induced by radiation. (hindawi.com)
This form of cell death is fundamentally different from apoptosis and lacks some distinct characteristics of apoptosis such as DNA fragmentation, pyknosis, or caspase activation and cleavage [ 14 ]. (hindawi.com)
His Immunogenic cell death study is associated with Apoptosis. (research.com)
Due to the increased drug and radiation tolerance, it is urgent to develop novel anticancer agent that triggers nonapoptotic cell death to compensate for apoptosis resistance. (oncotarget.com)

They may activate death receptors, stimulate apoptotic pathways, or initiate cellular stress response in the endoplasmic reticulum. (wikipedia.org)
Signal transduction pathways in hepatocyte cell death. (rug.nl)
This thesis describes that hepatocyte death and survival are regulated at the cross-roads of intracellular organelles (e.g., mitochondria and endoplasmic reticulum), membrane-bound receptors (such as GPCRs and EGFR) and cell survival signaling pathways (such as ERK, PI3K and PKC). (rug.nl)
Prolonged chronical UPR may activate apoptotic pathways and cause cell death. (eurekaselect.com)
For instance, CSC maintenance in glioblastoma, colon cancer, gastric cancer, and prostate cancer is regulated by CD133-mediated AKT, leucine-rich G-protein-coupled receptor 5 (LGR5)-mediated Wnt/β-catenin and speckle-type POZ protein (SPOP)-mediated Nanog pathways [ 4 - 8 ] . (oaepublish.com)
In contrast, regulation of breast cancer CSCs (BCSCs) occurs by CD44 standard splice isoform (CD44s)-activated platelet-derived growth factor receptor b (PDGFRb)/signal transducer and activator of transcription 3 (STAT3), forkhead box C1 (FOXC1)-activated sonic hedgehog (SHH), and sphingosine-1-phosphate (S1P)/S1PR3-activated NOTCH pathways [ 10 - 13 ] . (oaepublish.com)

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. (gene.com)
Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
Endoplasmic reticulum stress (ERS) is a state induced by increased synthesis of intracellular proteins, accumulation of mal-folded proteins, changes in cytosolic calcium levels, or imbalances in endoplasmic reticulum (ER) redox homeostasis [ 8 ]. (biomedcentral.com)
However, if the stress on the ER is chronic or severe and quality control of protein folding cannot be met, ER activates its stress receptor, the unfolded protein response, which triggers programmed cell death [ 9 ]. (biomedcentral.com)
Three models of hepatocyte cell death were studied: glycochenodeoxycholic acid (GCDCA)-induced cell death as a model for bile acid toxicity, tumor necrosis factor α (TNFα)/ actinomycin D (ActD, an inhibitor of transcription) as a model for cytokine-induced toxicity and menadione-induced cell death (menadione is a superoxide anion donor) as a model for oxidative stress-induced toxicity. (rug.nl)
Accumulation of PAEL receptor in the endoplasmic reticulum causes endoplasmic reticulum stress and apoptotic cell death. (rasagiline.com)
We found evidence to indicate accumulation of PAEL receptor and the presence of endoplasmic reticulum stress in a patient with AR-JP (Park2). (rasagiline.com)
Background: Widespread protein aggregation occurs in the living system under stress or during aging, owing to disturbance of endoplasmic reticulum (ER) proteostasis. (eurekaselect.com)
Mechanistically, the deficiency of Oxtr impaired MAPK/ERK-CREB signaling, which exaggerated the endoplasmic reticulum stress response and ultimately increased the death of beta cells in pancreatic islets under stressed conditions. (elsevierpure.com)
These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target. (elsevierpure.com)
Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). (nih.gov)
Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress. (shengsci.com)
Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress. (research.com)
Recently, single-residue mutations in the cardiac RyR (RyR2) have been identified in families that exhibit CPVT (catecholaminergic polymorphic ventricular tachycardia), a condition in which physical or emotional stress can trigger severe tachyarrhythmias that can lead to sudden cardiac death. (silverchair.com)
Mechanistic investigations revealed that through increasing the levels of intracellular reactive oxygen species (ROS), Gyp-L triggered protein ubiquitination and endoplasm reticulum (ER) stress response, leading to Ca 2+ release from ER inositol trisphosphate receptor (IP 3 R)-operated stores and finally cell death. (oncotarget.com)
Interestingly, there existed a reciprocal positive-regulatory loop between Ca 2+ release and ER stress in response to Gyp-L. In addition, protein synthesis was critical for Gyp-L-mediated ER stress and cell death. (oncotarget.com)

In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a member of the TRAF family and an important multifunctional intracellular adaptin of the tumor necrosis factor superfamily and toll/IL-1 receptor (TIR) superfamily. (shengsci.com)
These include production of homologues of mammalian tumor necrosis factor receptor, interleukin-1beta receptor, interleukin 18-binding protein, interferon-alpha/beta receptor, and interferon-gamma receptor, as well as a complement-binding protein and a caspase inhibitor. (medscape.com)

Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
What is the precise role of intracellular and extracellular galectins in the control of cell death programs? (nature.com)
ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state. (shengsci.com)
The study incorporates disciplines such as Extracellular, Programmed cell death and Adenosine triphosphate in addition to Immune system. (research.com)

Ultra structure of prokaryotic and eukaryotic cells, organelles structure marker and function, Endoplasmic reticulum, Golgi complex, Types of vesicles - transport and their functions, Lysosomes. (amrita.edu)
Regardless of their effect on rod viability, all of the mutants primarily localized to the outer segment and Golgi and showed little or no endoplasmic reticulum accumulation. (jneurosci.org)

12]. Systemic lupus erythematosus (SLE) the prototypic systemic autoimmune disease is definitely characterized by autoantibodies to nuclear and cytoplasmic parts immune complex-mediated glomerulonephritis (GN) and early death [16]. (biobender.com)
Paraptosis is a kind of caspase-independent programmed cell death and is characterized by distinct cytoplasmic vacuolization derived from swelling endoplasmic reticulum and/or mitochondria. (hindawi.com)

Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
In addition, we found two additional candidate proteins, i.e., alpha-synuclein 22 and PAEL receptor, with the collaboration of Professor Denis Selkoe of Harvard Medical School and Dr. Ryosuke Takahashi of RIKEN, respectively. (rasagiline.com)
The receptor has a plethora of interacting client proteins. (eurekaselect.com)

These data suggest that there may be subtypes of the PGE1 receptor in this clone: a high-affinity receptor mediating cyclic AMP formation, and a low-affinity receptor mediating IP accumulation, cyclic GMP formation, and intracellular calcium mobilization. (shengsci.com)
Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors. (shengsci.com)

another ER chaperone), and becomes available to regulate inositol trisphosphate (IP3) receptor-mediated Ca 2+ release to maintain mitochondrial Ca 2+ homeostasis. (molvis.org)
These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. (rochester.edu)
An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca sensitivity. (rochester.edu)
Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis. (rochester.edu)

Epidermal Growth factor receptor ,EGFR) is the prototype member of the type 1 receptor tyrosine kinases. (insulin-receptor.info)

Toll-like receptors (TLRs) play a key role in innate immune responses and inflammation. (diabetesjournals.org)

Lipotoxicity is a metabolic syndrome that results from the accumulation of lipid intermediates in non-adipose tissue, leading to cellular dysfunction and death. (wikipedia.org)

The constant region at the carboxyl-terminal end of the heavy chain, called the Fc region, binds to the Fc receptors of neutrophils, eosinophils, macrophages, dendritic cells, B cells, and the natural killer (NK) cells. (medscape.com)

Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons. (rochester.edu)

Importantly, overexpression of PAD4 promotes neuroinflammation and neuronal death via the IRE1α/ASK1/JNK signaling pathway after TBI. (biomedcentral.com)
We found that 125 I seeds radiation activated PI3K/AKT signaling pathway and could trigger paraptosis-like cell death. (hindawi.com)
Moreover, inhibitor of PI3K/AKT signaling pathway could inhibit paraptosis-like cell death induced by 125 I seeds radiation. (hindawi.com)
Our data suggest that 125 I seeds radiation can induce paraptosis-like cell death via PI3K/AKT signaling pathway. (hindawi.com)

High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, and nuclear factor-κB (NF-κB) p65-dependent activation in THP-1 cells. (diabetesjournals.org)

These abnormalities can trigger apoptotic cell death. (rasagiline.com)

The sigma-1 receptor (σR1), a ligand-operated chaperone, has been inferred to be neuroprotective in previous studies using σR1 ligands. (molvis.org)
The apoptotic response of cells can be induced by the intrinsic and the extrinsic pathway, the former being mediated by the mitochondria and the latter activated by ligand stimulation of death receptors at the cell surface [ 1 ]. (biomedcentral.com)

In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)

When the storage capacity of non-adipose cells is exceeded, cellular dysfunction and/or death result. (wikipedia.org)
Under prolonged cellular stresses, the σR1 translocates to the extended ER network, whereby it interacts with and regulates the function of a variety of ion channels, receptors, or kinases. (molvis.org)
Knowledge about the cellular mechanisms regulating death and survival of liver cells is of clinical and scientific interest for developing new therapeutic strategies. (rug.nl)
[ 11 ] which controls actin dynamics and leads to a loss of cellular detachments and cell death. (medscape.com)
Usually several hours are required from the initiation of cell death to the final cellular fragmentation. (biomedcentral.com)

Lipotoxicity affects the pancreas when excess free fatty acids are found in beta cells, causing their dysfunction and death. (wikipedia.org)
Immunolabeling detected this receptor in cells of both the ganglion cell layer and the photoreceptor cell layer in wild-type retinas. (molvis.org)
In cancer, there is a loss of balance between cell division and cell death and cells that should have died did not receive the signals to do so. (biomedcentral.com)
In acinar cells the distribution of these receptors is tightly localized to an area associated with the actin cytoskeleton in the apical secretory pole of the cell. (rochester.edu)
Here, we report that Oxt signaling attenuates the death of pancreatic beta cells in islets exposed to cytotoxic stresses. (elsevierpure.com)
MUC16 expression was down-regulated by stably expressing an anti-MUC16 single-chain antibody (scFv) targeted to the endoplasmic reticulum (ER), which prevents cell surface localization of MUC16 in OVCAR3 cells. (biomedcentral.com)
Immunogenic death of colon cancer cells treated with oxaliplatin. (research.com)
Nevertheless, if the PCSK9 molecule is normally obstructed, LDL receptors are recycled, came back to the top of cells, and remove even more LDL contaminants from flow. (researchensemble.com)
In this study, we show that treatment with gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum , induced nonapoptotic, lysosome-associated cell death in human esophageal cancer cells. (oncotarget.com)
As Dörner emphasized, these cells are not under the command of the B-cell receptor and are independent of the cytokine BAFF (B-cell activating factor). (medscape.com)
Viral particles bind to plasma membrane receptors on host cells and then enter into the cytoplasm, where the viral genome is replicated and viral progeny are assembled. (medscape.com)

The sigma-2 receptor (σR2) subtype has been identified pharmacologically [ 7 ], but has yet to be cloned. (molvis.org)

Mycolactone also inhibits the function of the Sec61 translocation, which is responsible for protein translocation into the endoplasmic reticulum. (medscape.com)
Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. (nih.gov)
Rhodopsin protein loss occurred as soon as photoreceptors developed, preceding photoreceptor cell death. (nih.gov)
Likely target for the cowpox virus CRMA death inhibitory protein. (lu.se)
Several mutations in the N terminus of the G-protein-coupled receptor rhodopsin disrupt NXS/T consensus sequences for N-linked glycosylation (located at N2 and N15) and cause sector retinitis pigmentosa in which the inferior retina preferentially degenerates. (jneurosci.org)
Mutations affecting glycosylation of the heptahelical G-protein-coupled receptor rhodopsin are associated with retinitis pigmentosa (RP), a disease characterized by progressive degeneration of photoreceptors. (jneurosci.org)

Binding to the adapter molecule fadd recruits it to either receptor. (lu.se)

In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied. (rochester.edu)

Homozygotes for targeted mutations show variably abnormalities that may include growth retardation, death after weaning unless given hydrated food, nonresponsiveness to dopamine D1 receptor agonists and antagonists, and normal to hyperactive locomotor activity. (jax.org)

Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
However, therapeutic options for posttraumatic neuroinflammation and ongoing neuronal death remain limited and are often ineffective, indicating a lack of understanding of the pathophysiological mechanism of secondary brain injury post-TBI and targeted treatment approaches. (biomedcentral.com)
A review on therapeutic targeting of cancer via death receptors dissects this topic comprehensively and is therefore subtly discussed in this minireview which focuses on ROS cancer therapeutics [ 22 ]. (degruyter.com)
Taken together, this work suggested a novel therapeutic option by Gyp-L through the induction of an unconventional ROS-ER-Ca 2+ -mediated cell death in human esophageal cancer. (oncotarget.com)

Interestingly, expression of similar bovine rhodopsin mutants did not cause rod cell death, possibly attributable to greater stability of bovine rhodopsin. (jneurosci.org)

glutamate receptor, ionotropic, NMDA1. (wikigenes.org)

Here, decreasing stimulation via the B-cell receptor by aging T-lymphocytes makes a difference. (medscape.com)

As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. (nature.com)

The aim of this study was to observe the proliferation of, and cell-cycle changes in, the human lens epithelial cell line HLEC after Toll-like receptor 4 ( TLR4 ) gene silencing. (geneticsmr.com)

His Immunology study integrates concerns from other disciplines, such as Interleukin 21, IL-2 receptor, CD40 and Antigen-presenting cell. (research.com)

Isoform 9 interacts at the endoplasmic reticulum with a complex containing bcap31, bap29, bcl2 and/or bcl2l1. (lu.se)

Retinal ganglion cell death was induced by acute optic nerve crush in wild-type and Sigmar1 −/− mice. (molvis.org)
Our data indicated faster retinal ganglion cell death in Sigmar1 −/− than in wild-type mice under the stresses caused by optic nerve crush, providing direct evidence for a role of the σR1 in alleviating retinal degeneration. (molvis.org)

Generation of the subunits requires association with the death-inducing signaling complex (disc), whereas additional processing is likely due to the autocatalytic activity of the activated protease. (lu.se)

MUC16 decreases TRAIL receptor R2 (DR5) expression and inhibits pro-caspase-8 activation at the death-inducing signaling complex (DISC). (biomedcentral.com)

In addition, insulin-like growth factor I receptor- (IGFIR-) induced paraptosis has been reported to be inhibited by MEK-2-specific inhibitors and by antisense oligonucleotides directed against JNK-1 [ 15 ]. (hindawi.com)

The mechanism by which lipotoxicity causes death and dysfunction is not well understood. (wikipedia.org)
Less serious' effects are those that are not expected to cause significant dysfunction or death, or those whose significance to the organism is not entirely clear. (cdc.gov)

Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)

The protective effect of Oxt was diminished in islets isolated from oxytocin receptor knockout (Oxtr -/- ) mice. (elsevierpure.com)

This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. (rochester.edu)

In addition, Cl-amidine exerted neuroprotective effects by attenuating BBB disruption, inhibiting immune cell infiltration, and alleviating neuronal death after TBI. (biomedcentral.com)

Gyp-L-induced cell death was associated with lysosomal swelling and autophagic flux inhibition. (oncotarget.com)

According to WHO, 13% of world deaths accounted in 2005 is a result of cancer. (researchsquare.com)
Colorectal cancer remains one of the most common causes of cancer-related deaths worldwide [ 1 ]. (hindawi.com)
Mickaël Michaud mainly focuses on Immunology, Cancer research, Immunogenic cell death, Immune system and Autophagy. (research.com)
Mickaël Michaud interconnects Endoplasmic reticulum, Calreticulin, Immunosurveillance, Cancer cell and Carcinogenesis in the investigation of issues within Cancer research. (research.com)
Mickaël Michaud spends much of his time researching Cell biology, Cancer research, Autophagy, Programmed cell death and Immunogenic cell death. (research.com)
Esophageal cancer is the fifth leading cause of cancer death for male and eighth for female in developing countries [ 1 ]. (oncotarget.com)

The aim of this thesis is to elucidate the mechanisms of cell death in hepatocytes, in order to develop strategies to protect hepatocytes and prevent liver injury. (rug.nl)
Approximately 75% of the idiosyncratic drug reactions result in liver transplantation or death. (medscape.com)
Of the adults, 12 deaths and 5 liver transplants occurred, and among the pediatric patients, 1 death and 6 liver transplants occurred. (medscape.com)

Anatomy36

Organisms10

Diseases7

Chemicals and Drugs128

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes49

Disciplines and Occupations1

Information Science4

Health Care1

Apoptosis18

Pathways6

Stress16

Tumor3

Extracellular4

Golgi2

Cytoplasmic2

Proteins5

Intracellular2

Inositol4

EGFR1

TLRs1

Accumulation1

Binds1

Neurons1

Signaling pathway4

Kinase1

Trigger1

Ligand2

Decoy1

Cellular5

Cells11

Sigma-2 recept1

Protein6

FADD1

Phosphorylation1

Agonists1

Therapeutic4

Rhodopsin1

Glutamate1

Cell receptor1

Regulation1

Gene1

Interleukin1

Isoform1

Ganglion2

Subunits1

TRAIL1

Insulin1

Dysfunction2

Molecules1

Mice1

Spatial1

Neuronal death1

Inhibition1

Cancer6

Liver3