Amyloid Precursor Protein SecretasesAmyloid beta-Protein PrecursorAspartic Acid EndopeptidasesAmyloid beta-PeptidesAlzheimer DiseaseEndopeptidasesAmyloidPresenilin-1Plaque, AmyloidNeprilysinProtein PrecursorsMice, TransgenicProtease NexinsPeptide FragmentsSerum Amyloid A ProteinBrainPresenilin-2Molecular Sequence DataProtein Processing, Post-TranslationalAmino Acid SequenceNeuronsAmyloidosisCerebral Amyloid AngiopathyPresenilinsSerine EndopeptidasesProtease InhibitorsProtein Structure, TertiaryMembrane Proteinstau ProteinsMutationNerve Tissue ProteinsDisease Models, AnimalThiorphanAmyloidogenic ProteinsCell LineAmyloid NeuropathiesHippocampusCells, CulturedIslet Amyloid PolypeptideCerebral CortexProtein BindingMice, Inbred C57BLLDL-Receptor Related ProteinsProtein TransportPHEX Phosphate Regulating Neutral EndopeptidaseTransfectionMetalloendopeptidasesProteolysisBase SequenceCysteine EndopeptidasesImmunohistochemistryMaze LearningBlotting, WesternCHO CellsRecombinant ProteinsDipeptidesSubstrate SpecificityCricetinaeNeurofibrillary TanglesAxonal TransportPC12 CellsADAM ProteinsPeptidesNerve DegenerationMice, KnockoutKineticsHydrolysisGene Expression RegulationCell MembraneRNA, MessengerConvolvulusSerum Amyloid P-ComponentBinding SitesPrionsNeuroblastomaAgingEnzyme-Linked Immunosorbent AssayInsulysinReceptors, NotchNeuritesBrain ChemistryCongo RedCathepsin BCricetulusAxonsRecombinant Fusion ProteinsEnzyme PrecursorsCloning, MolecularEndosomesGene ExpressionCell Line, TumorModels, BiologicalMemory DisordersCOS CellsGliosisImmunoprecipitationMicrogliaAstrocytesSignal TransductionHEK293 Cells