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  • oxidative stress
  • Recent studies have shown that hydrogen sulfide (H 2 S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. (hindawi.com)
  • Myoglobin is the major heme-iron protein in the mammal skeletal muscle and its activation by hydrogen peroxide generate reactive hypervalent heme-iron species, perferrylmyoglobin and ferrylmyoglobin, which may induce oxidative stress conditions. (usp.br)
  • pathways
  • The different persulfide patterns observed in wild-type, GR-null, and TR/GR-null livers suggest distinct roles for the Trx and GSH systems in regulating subsets of protein persulfides and thereby fine-tuning sulfide signaling pathways. (sciencemag.org)
  • pulmonary
  • This entry presents the methods that we used to determine the levels of myeloperoxidase activity, chemokines and adhesion molecules protein, substance P and hydrogen sulfide (main interests of our laboratory), and pulmonary microvascular permeability. (pancreapedia.org)
  • molecules
  • Scientists discovered in the past decade that cells in the human body generate small quantities of H 2 S molecules, which in turn deliver information to proteins. (smu.edu)
  • neurons
  • Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of neurons and glia, and generate signals proportionate to physical, chemical, and/or electrical changes in these cells. (frontiersin.org)
  • protects
  • These results provide evidence that CSE-produced hydrogen sulfide protects beta-cells from glucotoxicity via regulation of TBP-2 expression levels and thus prevents the onset/development of type 2 diabetes. (jove.com)
  • increases
  • Purpose: The purpose of this study was to investigate the increases in intraosseous temperature generated by a modern ultrasonic device for bone surgery (UDBS) and the influences of working pressure and cooling irrigation on this temperature. (biomedsearch.com)
  • expression
  • Additionally, in WT mice, there was a greater level of pancreatic CSE expression and sulfide-synthesizing activity in caerulein-induced pancreatitis compared with the saline control. (jove.com)
  • molecular
  • We made a molecular probe that, when it reacts with hydrogen sulfide, forms a fluorescent compound that can be visualized using fluorescence microscopy," Lippert said. (smu.edu)
  • First, H 2 S is a small gas with the simple molecular structure of two hydrogen atoms and one sulfide atom. (hindawi.com)
  • cells
  • In the new study, chemists developed a chemical probe that reacts and lights up when live human cells generate hydrogen sulfide, says chemist Alexander R. Lippert , Southern Methodist University, Dallas. (smu.edu)
  • Previously, scientists couldn't observe H 2 S being generated in live cells. (smu.edu)
  • Once the cells start generating H 2 S, they behave like squiggly fluorescent green worms. (smu.edu)
  • As the cells initiated blood vessel formation, H 2 S was generated. (smu.edu)