Platelet AggregationReceptorProstacyclinProstaglandinsSynthesisCyclooxygenaseAngiotensinNitric oxidePotentInhibitorPlateletsSubstancesRelationshipBiochemicalProductionGreaterBloodResearchEicosanoidsTXA2ArachidonicMetabolitePrecursorsReceptorsInhibitProinflammatoryCardiacGeneProteinBeneficialExpressionFormationControlAgentPatientsRole
Platelet Aggregation1
- The antiplatelet effect of Mg may be related to the finding that Mg inhibits the synthesis of thromboxane A2 and 12-hydroxyeicosatetraenoic acid, eicosanoids thought to be involved in platelet aggregation. (mg12.info)
Receptor7
- The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid receptor cloned. (wikipedia.org)
- The TP receptor derives its name from its preferred endogenous ligand thromboxane A2. (wikipedia.org)
- The gene responsible for directing the synthesis of the thromboxane receptor, TBXA2R, is located on human chromosome 19 at position p13.3, spans 15 kilobases, and contains 5 exons. (wikipedia.org)
- Exposure of isolated bovine coronary arteries to high glucose (30 mmol/l d -glucose) but not to osmotic control mannitol (30 mmol/l) switched angiotensin II-stimulated prostacyclin (PGI 2 )-dependent relaxation into a persistent vasoconstriction that was sensitive to either indomethacin, a cyclooxygenase inhibitor, or SQ29548, a selective thromboxane receptor antagonist. (diabetesjournals.org)
- Interplay between cyclic GMP- and thromboxane receptor-mediated mechanisms in the rat middle cerebral artery (MCA). (otka-palyazat.hu)
- Testosterone increase human platelet thromboxane A2 receptor density and aggregation responses. (stfconstruction.com)
- Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. (csnpharm.com)
Prostacyclin3
- There is an overwhelming mass of evidence demonstrating the development of endothelial dysfunction in animal models of diabetes and in human blood vessels from diabetic patients, as evidenced by increased release of reactive oxygen species, decreased nitric oxide (NO) bioactivity, decreased release of prostacyclin (PGI 2 ), and enhanced endothelial production of vasoconstrictor thromboxane (Tx)A 2 /prostaglandin (PG)H 2 in early stages of diabetes ( 1 - 3 ). (diabetesjournals.org)
- Biochemical evidence includes an imbalance in the prostacyclin:thromboxane ratio and high circulating concentrations of von Willebrand factor, endothelin, and cellular fibronectin. (health.am)
- This is primarily accomplished by timely and balanced production and release of endothelial relaxing factors, namely, nitric oxide, prostacyclin, or endothelium-derived hyperpolarizing factor [2C4], as well as endothelium-derived contracting autacoids, such as endothelin-1, thromboxane A2, angiotensin II, or superoxide anion. (mundial-brasil2014.net)
Prostaglandins2
- Thus, the term ' prostanoids ' relates to the products of the cyclooxygenase pathway ( prostaglandins , prostacyclins , and thromboxanes ) but to compounds produced by free radical-catalyzed mechanism ( Isoprotanes, phytoprostanes, neuroprostanes ). (gerli.com)
- This term includes prostaglandins, prostacyclins, thromboxanes, and related substances, but 'prostaglandins' is often used loosely to include all prostanoids. (gerli.com)
Synthesis2
- Our studies have shown that endogenous carbon monoxide (CO) has a dual influence on the cerebral circulation: on one hand it induces prostanoid-mediated vasodilation but on the other hand reduces the blood flow by inhibition of nitric oxide (NO) synthesis. (otka-palyazat.hu)
- Furthermore, with this pathological procedure endothelial cells are influenced by oxidative tension, boost of endogenous nitric oxide synthesis inhibitors, swelling, increased adipocytokines, improved launch of aldosterone, or depletion of tetrahydrobiopterin [9]. (mundial-brasil2014.net)
Cyclooxygenase1
- We assessed arteriolar function via perivascular nerve stimulation and active hyperemia with or without inhibitors for endogenous NO production or cyclooxygenase (COX) products. (cdc.gov)
Angiotensin1
- AA is released from cell membrane(endogenous AA) by several agonists such as histamine, bradykinins, angiotensin, cytokines and growth factors, including shear stress. (tci-thaijo.org)
Nitric oxide2
- The role of endogenous carbon monoxide (CO) and its interaction with nitric oxide (NO) in the cerebral circulation. (otka-palyazat.hu)
- Nitric oxide synthase blockade sensitizes the cerebrocortical circulation to thromboxane-induced CBF oscillations. (otka-palyazat.hu)
Potent1
- Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. (csnpharm.com)
Inhibitor1
- Ozagrel Sodium, also known as KCT-0809 and Cataclot, is a thromboxane A2 synthase inhibitor used to treat cerebrovascular diseases. (csnpharm.com)
Platelets1
- Normal platelets will further respond by releasing endogenous ADP from their granules. (biodatacorp.com)
Substances1
- To characterize endogenous substances and activities from the Golgi organic, protein in transit were 99% cleared from rat hepatocytes through the use of cycloheximide (CHX) treatment. (bioinf.org)
Relationship2
- Relationship between endogenous intercourse hormone levels, lipoproteins and coronary atherosclerosis in men present process coronary angiography. (stfconstruction.com)
- Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in males undergoing coronary angiography. (akdenizsaglikvakfi.org)
Biochemical1
- Among the biochemical markers currently under investigation is the endogenous opioid system and its implication in mediating the reinforcing effects of ethanol. (mg12.info)
Production1
- Hence, the compensatory mechanism for the NO deficit appears to be COX mediated, through enhanced sensitivity and possibly increased endogenous production. (cdc.gov)
Greater2
- Suffusion of the muscle with U46619 (1-100 nM), a thromboxane A2 mimetic, led to a significantly greater vasoconstriction in exposed animals compared to control (max % of control -22 +/- 3.4% sham, -31 +/- 4.0% exposed). (cdc.gov)
- Our data indicate that the self induced basal contraction of Dupuytrens cells was caused by greater endogenous TGF b like Smad signal ling, which enhanced a SMA expression and promoted collagen contraction. (checkpointinhibitor.com)
Blood1
- In the absence of NO the cerebral vessels become vulnerable to thromboxane A2-induced vasomotion which may lead to cerebrocortical blood flow oscillations and vasospasm in certain pathophysiological states. (otka-palyazat.hu)
Research1
- subunit as well as for determining that it's necessary for the discussion with eIF2 [35], which gives an answer towards the discrepancy in the outcomes obtained in prior research using endogenous phosphorylated eIF2B [35C37]. (bioinf.org)
Eicosanoids1
- Thromboxane is a member of the family of lipids known as eicosanoids . (wikimili.com)
TXA22
- Cardiotoxicity of the endogenous arachidonic acid metabolite thromboxane A2 (TXA2) is presumed to arise indirectly from its induction of vasoconstriction and platelet aggregation. (cdc.gov)
- Ketorolac unleashed anticancer T cell immunity that was augmented by immune checkpoint blockade, negated by adjuvant chemotherapy, and dependent on inhibition of the COX-1/thromboxane A2 (TXA2) pathway. (nih.gov)
Arachidonic2
- Thromboxane-A synthase , an enzyme found in platelets , converts the arachidonic acid derivative prostaglandin H 2 to thromboxane. (wikimili.com)
- Arachidonic acid can be synthesized from endogenous precursors, particularly linoleic acid or LA or 18:2n-6, the main PUFA in the Western diet. (tuscany-diet.net)
Metabolite2
- 1-methylnicotinamide (1-MNA), an endogenous metabolite of nicotinamide, has recently gained interest due to its anti-inflammatory and anti-thrombotic activities linked to the COX-2/PGI 2 pathway. (biomedcentral.com)
- 1-methylnicotinamide (1-MNA), an endogenous metabolite of nicotinamide (NA), is synthetized in the reaction of nicotinamide N-methyltransferase (NNMT), an enzyme expressed predominantly in the liver, where it plays a pivotal role in the N-methylation of NA and possibly other pyridine compounds [ 1 ]. (biomedcentral.com)
Precursors1
- The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. (wikimili.com)
Receptors1
- Discovery and development of several highly potent and selective antagonists to platelet-activating factor receptors facilitated experimental studies underscoring the role of this factor as an endogenous mediator in cerebral disorders, particularly cerebral ischemia and trauma. (nih.gov)
Inhibit1
- Endogenous opioids are key mediators in the descending inhibitory pathways and can inhibit pain signal transmission. (nih.gov)
Proinflammatory2
- Platelet-activating factor, an endogenous phospholipid of proinflammatory, hemostatic, and vasoactive properties, is synthesized by neurons and in injured brain. (nih.gov)
- Thus, simultaneously blocking the ensuing proinflammatory response and activating endogenous resolution programs before surgery may eliminate micrometastases and reduce tumor recurrence. (nih.gov)
Cardiac1
- The thromboxane A2 mimic U46619 increases calcium transients in rat cardiac myocytes. (cdc.gov)
Gene2
- The R406 (freebase) gene showing the least variance in expression between the genotypes was (gene encoding polymerase (RNA) II (DNA directed) polypeptide A) and it was selected as the endogenous control gene for this experiment. (bioinf.org)
- were purchased from Applied Biosystems Assays on Demand (Applied Biosystems Foster City CA). RT-PCR was performed around the Applied Biosystems 7900HT system (Applied Biosystems Foster City CA). dCT values were calculated by subtracting the CT of the target gene from your CT of the endogenous control gene for each sample. (bioinf.org)
Protein1
- 4. Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism. (nih.gov)
Beneficial1
- Vitamins are prominent among natural or endogenous compounds considered to be beneficial to human health. (biomedcentral.com)
Expression1
- Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells. (kyoto-u.ac.jp)
Formation1
- Thromboxane is named for its role in blood clot formation ( thrombosis ). (wikimili.com)
Control1
- RNA was extracted by the TRIzol method (Invitrogen Carlsbad CA) and reverse transcribed with the High Capacity RNA-to-cDNA kit (Applied Biosystems Foster City CA). Before running samples a mouse endogenous control plate (Applied Biosystems Foster City CA) was utilized to determine the ideal endogenous control. (bioinf.org)
Agent1
- Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation. (wikimili.com)
Patients1
- People with asthma tend to have increased thromboxane production, and analogs of thromboxane act as bronchoconstrictors in patients with asthma. (wikimili.com)
Role1
- It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's angina . (wikimili.com)