• MicroRNAs (miRs) little noncoding 18- to 24-nucleotide RNAs are forecasted to regulate appearance in excess of 90% of proteins encoding genes thus affecting diverse mobile and molecular procedures [2]. (biongenex.com)
  • MicroRNAs (miRNAs/miRs) are endogenous, single-stranded, small (approximately 22 nucleotides in length) noncoding RNA molecules that play an important and ubiquitous role in regulating genes expression. (spandidos-publications.com)
  • However, miRNA-122 also regulates cholesterol (HDL) and the activity of tumor-suppressor genes (oncogenes).This means that not only will knocking out the microRNA-122 reduce the HCV infection, but it will also reduce the activity of tumor suppressor genes, potentially leading to liver cancer. (wikipedia.org)
  • Prediction of target genes of 3 miRs, confirmed in all HCV clones, was performed by means of miRGator program. (biomedcentral.com)
  • Microarray analysis revealed that 37 out of 1981 genes, predicted targets of the 3 miRs, showed an inverse expression relationship with the corresponding miR in HCV clones, as expected for true targets. (biomedcentral.com)
  • The present findings reveal that 3 IFN-β-regulated miRs and 37 genes, which are likely their functional targets, were commonly modulated by HCV in three replicon clones. (biomedcentral.com)
  • CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
  • Among the various targets and verified regulated genes identified by microarray, we confirmed the downregulation of Integrin a5 in vitro and in vivo. (uni-frankfurt.de)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
  • MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)
  • More than 700 miRs have been identified and registered in humans, with each individual miR predicted to target multiple genes based on the seed sequence matches in their 3'-untranslated regions (UTRs) [ 6 ]. (biomedcentral.com)
  • miRNAs (miRs) are 18- to 25-nucleotide long noncoding RNAs that regulate pathophysiological functions via expression of target genes at the posttranscriptional level. (biomedcentral.com)
  • MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • Antagomirs, also known as anti-miRs, are a class of chemically engineered oligonucleotides designed to silence endogenous microRNAs (also known as miRNAs or miRs). (wikipedia.org)
  • MicroRNAs (miRNAs or miRs) refer to a group of small noncoding RNA molecules, typically 18~25 nucleotides in length, that function in RNA silencing and post-transcriptional regulation of gene expression [ 9 ]. (ijbs.com)
  • MicroRNAs (miRs) are small, non-coding RNAs that negatively regulate gene expression via translational repression or messenger RNA degradation. (biomedcentral.com)
  • They are spliced together to become a MESSENGER RNA or other functional RNA. (lookformedical.com)
  • MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression. (edu.hk)
  • MicroRNAs (miRs) are endogenous non-coding RNAs of ∼ 23-mer, which have important roles in regulation of gene expression. (nature.com)
  • Mature form of miRs silence gene expression by binding to the 3′-UTR of target mRNAs and initiate translational repression or cleavage of cognate mRNAs. (nature.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • These single-stranded non-coding RNAs drive the post-transcriptional repression of gene expression ( 9 ) and can be released to the extracellular environment either as circulating cell-free molecules or encapsulated within extracellular vesicles (EVs). (frontiersin.org)
  • MicroRNA (miR) is a small, non-coding RNA that negatively regulates gene expression mainly via translational repression. (biomedcentral.com)
  • MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
  • MiRs modulate mRNA amounts and translation through canonical bottom pairing between your seed sequence from the miRNA (nucleotides 2-8 on (-)-Catechin gallate the 5′end) as well as the complementary seed match sequences of focus on mRNAs which are usually situated in the 3′ untranslated area (UTR) [3]. (biongenex.com)
  • Due to the promiscuity of microRNAs, each of which regulate multiple mRNAs, antagomirs can potentially affect the expression of many different mRNA molecules besides the desired target. (wikipedia.org)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • Despite the evolutionary conservation of miRs, a single miR can target thousands of mRNAs, resulting in a lack of clarity about their true function or place in pathophysiologic events, including those that are central to the development of PF. (biomedcentral.com)
  • Through this mechanism, a single microRNA can alter the function of multiple mRNAs. (archivesofmedicalscience.com)
  • MicroRNAs (miRs) are small endogenous non-coding RNAs that regulate the balance and/or translation of complementary mRNA goals. (biongenex.com)
  • MicroRNAs silence their cognate goals by mRNA cleavage translational repression mRNA destabilization or a combined mix of these systems [4]. (biongenex.com)
  • Our study reveals an unprecedented mechanism through which the RNA structure switch modulates EGFR-TKI resistance by controlling YRDC mRNA translation in an ELAVL1-dependent manner. (bvsalud.org)
  • Antagomirs are microRNA inhibitors that bind miRNAs and prevent them from binding to a target mRNA molecule, and the consequent degradation of that mRNA via the RNA-induced silencing complex (RISC). (wikipedia.org)
  • Blockmirs are similarly engineered molecules which, on the other hand, are designed to have a sequence that is complementary to an mRNA sequence that is targeted by a microRNA. (wikipedia.org)
  • Upon binding to an untranslated region of an mRNA, blockmirs sterically block microRNAs from binding to the same site. (wikipedia.org)
  • MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
  • Micro-RNAs are 18-22 nucleotide non-coding RNAs that can bind to the mRNA, mediating translational repression either by inhibiting the binding to either 60 s or 40 s ribosomal subunits or by activation of the RNA-induced silencing complex (RISC complex). (biomedcentral.com)
  • A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)
  • Our results have laid down a solid foundation in exploration of novel CRC mechanisms, and identification of miRNA roles as oncomirs or tumor suppressor mirs in CRC. (edu.hk)
  • The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). (biorxiv.org)
  • Total RNA was extracted from tissues of 78 patients with epithelial ovarian cancer, 17 normal ovarian epithelium tissues and two ovarian cancer cell lines. (scite.ai)
  • Total RNA was extracted from ESCC cell lines, OE21 and TE10, and a non-malignant human esophageal squamous cell line, Het-1A, and subjected to microarray analysis. (biomedcentral.com)
  • Total RNA was extracted in the C2C12 cells using TRIzol? (colinsbraincancer.com)
  • Circular RNAs (circRNAs) are a series of endogenous non-coding RNAs with a covalently closed loop structure ( 9 ). (spandidos-publications.com)
  • METHODS Using high-throughput RNA sequencing (RNA-Seq), we conducted an in-depth bioinformatic analysis of noncoding RNAs (ncRNAs) in human cell-free saliva (CFS) from healthy individuals, with a focus on microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and circular RNAs (circRNAs). (scite.ai)
  • Recently, METTL3 was also found to affect the m6A modification in non-coding RNAs including miRNAs, lincRNAs and circRNAs. (biomedcentral.com)
  • While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits (Cell Rep 2:1697-1709, 2012), most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy. (biomedcentral.com)
  • BACKGROUND Extracellular RNAs (exRNAs) in human body fluids are emerging as effective biomarkers for detection of diseases. (scite.ai)
  • Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
  • Pre-miRNA is exported to the cytoplasm by exportin-5 and cleaved by Dicer (an RNA degrading enzyme) and produces approximately 22 nucleotide RNA duplexes. (archivesofmedicalscience.com)
  • METHODS: The correlation between RNA m5C methylation, m5C writer NOP2/Sun RNA methyltransferase family member 2 (NSUN2) and EGFR-TKIs resistance was determined in non-small-cell lung cancer (NSCLC) cell lines and patient samples. (bvsalud.org)
  • Because aberrant microRNA (miR) promoter methylation contributes to cancer development, we investigated whether altered miR-30a-5p expression associates with DNA promoter methylation and evaluated the usefulness as clear cell RCC (ccRCC) diagnostic and prognostic markers. (biomedcentral.com)
  • In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy. (biomedcentral.com)
  • Because MMP-13 and its regulatory networks are suitable targets for the development of effective early treatment strategies for OA, we discuss the specific targets of MMP-13, including upstream regulatory proteins, DNA methylation, non-coding RNAs, and autophagy-related proteins of MMP-13, and their therapeutic potential to inhibit the development of OA. (biomedcentral.com)
  • Among them, N6-methyladenosine (m6A) RNA methylation is one of the most common modifications, accounting for about 50% of total methylated ribonucleotides and 0.1-0.4% of all adenosines in total cellular RNAs [ 8 , 9 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs, miRs) are a class of small, non-coding, endogenous and functional RNAs. (biomedcentral.com)
  • In a previous study using a microRNA (miRNA/miR) microarray assay, we demonstrated that miR-133b-5p was upregulated in response to hypoxic preconditioning (HPC). (spandidos-publications.com)
  • Among these miRNAs, we focused on miRNA-31 (miR-31) because miR-31 was the only miR that has been reported to regulate tumor phenotype, an anti-metastatic effect in breast cancer. (nature.com)
  • Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • However, the relationship between BDNF and microRNA (miRNA) in cardiomyocytes are unclear. (ijbs.com)
  • After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
  • In conclusion, the present study indicated that propofol inhibited the proliferation and invasion, but enhanced the apoptosis of GC cells by regulating the circ‑PVT1/miR‑195‑5p/ETS1 axis. (spandidos-publications.com)
  • Peng and Zhang ( 8 ) indicated that propofol inhibited proliferation, but induced apoptosis of SGC-7901 cells by regulating matrix metalloproteinase (MMP)2 ( 8 ). (spandidos-publications.com)
  • MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate cellular proliferation, differentiation, and apoptosis, through regulating BCL6. (biomedcentral.com)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
  • The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. (biorxiv.org)
  • Additionally, the effects of transfection with circ‑PVT1 small interfering RNA (si‑circ‑PVT1) on HGC‑27 and AGS cells could be reversed by treatment with miR‑195‑5p inhibitor. (spandidos-publications.com)
  • Recently, it has been proposed that also microRNAs (miRs), a class of small non-coding regulatory RNAs, are involved in the antiviral pathway induced by IFN-β treatment. (biomedcentral.com)
  • microRNAs (miRs) are endogenous small noncoding RNAs that are aberrantly expressed in various carcinomas. (scite.ai)
  • Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
  • MicroRNAs (miRNAs) are small and highly conserved RNA molecules that serve as key post-transcriptional regul. (biomedcentral.com)
  • Hier de conclusie van deze review en daaronder een studie abstract met ranpirnasse uit 2002 met bijzonder goede resultaten op de mediane overlevingstijd. (kanker-actueel.nl)
  • Hang P, Sun C, Guo J, Zhao J, Du Z. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats. (ijbs.com)
  • By comparative analysis of >90 RNA-Seq data sets of different origins, we observed that piRNAs were surprisingly abundant in CFS compared with other body fluid or intracellular samples, with expression levels in CFS comparable to those found in embryonic stem cells and skin cells. (scite.ai)
  • PIWI-interacting RNAs (piRNAs) are responsible for preventing the movement of transposable elements in germ cells and protect the integrity of germline genomes. (biomedcentral.com)
  • The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • RNA immunoprecipitation (RIP), co-immunoprecipitations and RNA m6A dot blot assays were conducted to confirm that METTL3 interacted with the microprocessor protein DGCR8 and modulated the pri-miR221/222 process in an m6A-dependent manner. (biomedcentral.com)
  • We investigated the mechanism of chemoresistance by analysis of microRNAs using the ovarian cancer cell line KFr13 and its PTX-resistant derivative (KFr13Tx). (nature.com)
  • However, only a few systematic reviews emphasize the most relevant miRs able to contribute to the establishment of new prognostic biomarkers in CRC patients. (biorxiv.org)
  • Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
  • BACKGROUND: RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. (bvsalud.org)
  • The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors. (bvsalud.org)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • The aberrant expression of circulating microRNAs (miRNAs/miRs) is reported in many tumors and can provide insights into the pathogenesis of tumor development and progression. (frontiersin.org)
  • Accumulating evidence indicates that deregulation of miRs is associated with human malignancies and suggests a causal role of miRs in tumor initiation and progression, since they can function as oncogenes or tumor suppressors [ 10 ]. (biomedcentral.com)
  • Atherosclerosis initiation and progression are driven by many pro-inflammatory and pro-thrombotic microRNAs. (archivesofmedicalscience.com)
  • MicroRNAs are powerful modulators of plaque progression and transformation into a vulnerable state, which can eventually lead to plaque rupture. (archivesofmedicalscience.com)
  • Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis over welke aanpak bij mesothelioma eventueel zou kunnen werken. (kanker-actueel.nl)
  • Furthermore, reverse transcription‑quantitative PCR was used to examine the expression levels of circular RNA‑PVT1 (circ‑PVT1), micoRNA‑195‑5p (miR‑195‑5p) and ETS1 in GC tissues and cells. (spandidos-publications.com)
  • To date, the effect produced by HCV on the expression of microRNAs (miRs) involved in the interferon-β (IFN-β) antiviral pathway has not been explored in details. (biomedcentral.com)
  • Thus, we compared the expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in three different clones of Huh-7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system). (biomedcentral.com)
  • The expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in HCV replicon 21-5 clone with respect to Huh-7 parental cells was analysed by real-time PCR. (biomedcentral.com)
  • The expression profile revealed that 16 out of 24 miRs were modulated in HCV replicon clone 21-5. (biomedcentral.com)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • EpCAM + AFP + HepCSCs have an activated Wnt/β-catenin signaling with a parallel increased expression of all four microRNA-181 family members. (biomedcentral.com)
  • Using both western blot and quantitative reverse transcriptase-PCR analyses, we found that the expression of all four microRNA-181 family members was positively correlated with β-catenin expression in HCC cell lines. (biomedcentral.com)
  • MicroRNA-181 expression could be directly induced upon an activation of Wnt/β-catenin signaling, which includes Wnt10B overexpression, inhibition of GSK3β signaling by LiCl, or forced expression of β-catenin/Tcf4. (biomedcentral.com)
  • Moreover, microRNA-181 expression was inhibited upon an inactivation of Wnt/β-catenin signaling by an induction of adenomatosis polyposis coli (APC) expression or silencing β-catenin via RNA interference. (biomedcentral.com)
  • Regulating microRNA expression: At the heart of diabetes mellitus and the mitochondrion. (wvu.edu)
  • Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. (biorxiv.org)
  • The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. (biorxiv.org)
  • Based on the miR microarray analysis, there were 14 miRs that showed significant differences (more than 2-fold) in expression between the 2 ESCC cells and non-malignant Het-1A. (biomedcentral.com)
  • Among the significantly altered miRs, miR-205 expression levels were exclusively higher in 5 ESCC cell lines examined than any other types of malignant cell lines and Het-1A. (biomedcentral.com)
  • The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. (biorxiv.org)
  • Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
  • To choose differentially portrayed miRNAs between your two groupings, the regularity of miRNAs was normalized to compute the proportion of 0.125 Hz extended 1034616-18-6 IC50 cells to Mouse monoclonal to IgM Isotype Control.This can be used as a mouse IgM isotype control in flow cytometry and other applications regulate cells. (colinsbraincancer.com)
  • However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear. (bvsalud.org)
  • RNA structures have widespread and crucial functions in many biological regulations, however, the functions of RNA structures in regulating cancer drug resistance remain unclear. (bvsalud.org)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
  • Hepatocellular carcinoma (HCC) is a malignant cancer with an observable heterogeneity and microRNAs are functionally associated with the tumorigenesis of HCC. (biomedcentral.com)
  • Here, we used RNAseq to identify a novel class of cardiac lncRNAs that are dynamically regulated by exercise. (researchgate.net)
  • miR-195 level was dynamically regulated in response to MI and significantly increased in ischemic regions 24 h post-MI as well as in hypoxic or H 2 O 2 -treated cardiomyocytes. (ijbs.com)
  • However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
  • Genome-wide methylome and RNA sequencing data from a set of ccRCC and normal tissue samples from The Cancer Genome Atlas (TCGA) database were integrated to identify candidate CpG loci involved in cancer onset. (biomedcentral.com)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • A potential cancer therapy strategy is provided by using antisense oligonucleotide (ASO) to perturb the interaction between RNA and protein. (bvsalud.org)
  • Integrated RNA-seq and m5C-BisSeq analyses identified quiescin sulfhydryl oxidase 1 (QSOX1) as a potential target of aberrant m5C modification. (bvsalud.org)
  • CONCLUSIONS: Our study reveals a critical function of aberrant RNA m5C modification via the NSUN2-YBX1-QSOX1 axis in mediating intrinsic resistance to gefitinib in EGFR-mutant NSCLC. (bvsalud.org)
  • Moreover, it could affect the internal m6A modification of lincRNA1281 and mediate a competing endogenous RNA (ceRNA) model to regulate mouse embryonic stem cell differentiation [ 30 ].Alarcon et al found that METTL3 could promote the maturation of miRNAs (let-7e, miR221/222, miR4485, miR25, miR93, miR126 and miR335 et al) by interact with the microprocessor protein DGCR8 [ 24 ]. (biomedcentral.com)
  • RNA structure formation in YRDC 3' UTR suppresses embryonic lethal abnormal vision-like 1 (ELAVL1) binding, leading to EGFR-TKI sensitivity by impairing YRDC translation. (bvsalud.org)
  • Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important role in the host response to infection and the development of disease. (biomedcentral.com)
  • Our results show RNA structural regions are enriched in untranslation regions (UTRs) and correlate with translation efficiency (TE). (bvsalud.org)
  • RNA modification affects many biological processes and physiological diseases. (bvsalud.org)
  • Multiple components of biological fluids are being investigated as potential disease-related markers, including microRNAs (miRs, miRNAs) ( 8 ). (frontiersin.org)
  • Phosphorylation of HSP27 not only regulates its structural organization, but also affects its biological functions [ 13 ]. (biomedcentral.com)
  • This discrepancy might be partially due to the involvement of Dicer in other cellular processes like heterochromatin formation and to the fact that Dicer and Drosha target mainly different subsets of microRNAs. (uni-frankfurt.de)
  • Furthermore, individual variability of these salivary RNA species was highly similar to those in other body fluids or cellular samples, despite the direct exposure of saliva to environmental impacts. (scite.ai)
  • Dicer and Drosha are the major enzymes involved in microRNA processing. (uni-frankfurt.de)
  • Using siRNA targeting Dicer and Drosha, thereby downregulating a substantial number of microRNAs in EC, we demonstrate a crucial role of both enzymes in angiogenic processes. (uni-frankfurt.de)
  • Micro-RNAs are short RNA transcripts that demonstrate specific regulatory capabilities depending on the cell's physiology as well as micro-environment. (biomedcentral.com)