• MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
  • MicroRNA (miRNA) belongs to the family of single-stranded noncoding RNA with approximately 22 nucleotides that negatively regulates the target genes at the posttranscriptional level, which is involved in a wide range of biological processes [ 11 ]. (hindawi.com)
  • 1,000 human miRNAs have been identified that regulate ~1/3 of the coding genes in the human genome ( 9 ). (spandidos-publications.com)
  • However, whether miR-497 regulates other target genes in HCC is unknown. (spandidos-publications.com)
  • MicroRNAs (miRNAs/miRs) are endogenous, single-stranded, small (approximately 22 nucleotides in length) noncoding RNA molecules that play an important and ubiquitous role in regulating genes expression. (spandidos-publications.com)
  • About 30% of the human protein-coding genes are negatively regulated by miRNAs which suggests that they have a major role in regulating gene expression. (usda.gov)
  • This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
  • The present findings reveal that 3 IFN-β-regulated miRs and 37 genes, which are likely their functional targets, were commonly modulated by HCV in three replicon clones. (biomedcentral.com)
  • Background: As microRNAs play important roles in cancer development and progression by regulating the expressions of oncogenes and tumor suppressor genes though interacting with the 3' untranslated region (UTR) of target genes, we aimed to evaluate the association between genetic variants of miRNAs and their binding sites and prognosis in patients with colorectal cancer (CRC). (iiarjournals.org)
  • (B) effect of miR-503 on the expression of endogenous genes. (biomedcentral.com)
  • In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
  • We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
  • MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
  • miRNA genes are transcribed by RNA polymerase II into long primary miRNA transcripts, termed pri-miRNAs that are usually several kilobases long and possess a 5' CAP and a poly(A) tail. (biomedcentral.com)
  • We observed that EGFRvIII expression alters the expression of EV-regulating genes (vesiculome) and EV properties, including their protein composition. (cancer-genetics.org)
  • MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate the expression of target genes through mRNA cleavage, translational repression and DNA methylation. (plantae.org)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • A single mRNA is regulated by multiple miRNAs, and individual miRNA targets even hundreds of mRNAs, leading to complicated regulatory networks [ 12 ]. (hindawi.com)
  • MicroRNAs (miRNAs) are short (21-24 nucleotides) sequences of RNA that reduce gene expression by promoting the breakdown of messenger RNAs (mRNAs) and by repressing translation of mRNAs into proteins. (freethoughtblogs.com)
  • MicroRNAs (miRNAs) are endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by binding to the 3′-untranslated region (UTR) of target mRNAs. (nature.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
  • MicroRNAs are endogenous, regulatory RNAs that primarily reduce protein expression by binding to the 3'-untranslated region (UTR) of target mRNAs. (grantome.com)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNAs containing 19 to 25 nucleotides that promote posttranscriptional control in regulating the expression of target gene by binding to the 3′-UTR sequences of its mRNA [ 5 ]. (hindawi.com)
  • MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs, which are single-stranded and ~21 nucleotides (~21 nt) in length. (nature.com)
  • Although they are structurally similar, plant and animal microRNAs repress gene expression through very different mechanisms. (freethoughtblogs.com)
  • We show that, similar to metazoan steady-state systems, endogenous miRNAs in Chlamydomonas can regulate gene expression both by destabilization of the mRNA and by translational repression. (freethoughtblogs.com)
  • MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs, which act as key post-transcriptional regulators of target-gene expression. (spandidos-publications.com)
  • MicroRNAs (miRNAs), a class of small, endogenous, non-coding RNAs, are able to regulate gene expression by translational repression or mRNA degradation of the target, thereby affecting critical functions in various physiological processes, ranging from cell proliferation to apoptosis ( 8 , 9 ). (iiarjournals.org)
  • Until recently, it was unknown how sexual differences in the behavior, physiology, and development of organisms are regulated by differential gene expression. (peerj.com)
  • MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that can post-transcriptionally regulate gene expression and play a critical role in gonadal differentiation as well as early development of animals. (peerj.com)
  • MicroRNAs are short RNA molecules that post-transcriptionally regulate gene expression. (biomedcentral.com)
  • MicroRNAs (miRNAs) are a novel class of endogenous, ~22 nt long RNAs that post-transcriptionally regulate gene expression [ 1 ]. (biomedcentral.com)
  • Numerous studies have demonstrated that microRNAs are powerful regulators of gene expression and play crucial roles in a wide range of disease processes including several cardiovascular and renal diseases. (grantome.com)
  • MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression in many developmental and cellular processes. (biomedcentral.com)
  • MicroRNAs (miRNAs) are an abundant class of small (approximately 22 nt) endogenous non-coding RNAs that direct post-transcriptional regulation of gene expression. (biomedcentral.com)
  • MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
  • When we explored the mechanisms underlying these effects, we found that TUG1 acts as an endogenous competing RNA (ceRNA) that 'sponges' miR-145, thereby preventing the degradation of Sirt3 mRNA and increasing expression of Sirt3 and GDH proteins. (oncotarget.com)
  • Thus, the maturing oocyte is reliant on processes such as post-transcriptional gene regulation (PTGR) to regulate the mRNA and protein repertoire. (biomedcentral.com)
  • MicroRNA (miRNA) are a class of functional small RNA that target mRNA to affect their abundance and translational efficiency. (biomedcentral.com)
  • The inability to transcribe mRNA during this stage of development and the probable necessity for post-transcriptional gene regulation (PTGR) suggests an important role for non-coding RNA in the maturing oocyte. (biomedcentral.com)
  • The single-stranded mature miRNA can then associate with an Argonaute protein, which mediates its function of mRNA regulation through direct mRNA target cleavage or interactions with associated RNA-induced silencing complex (RISC) proteins [ 24 ]. (biomedcentral.com)
  • They guide the RNA-induced silencing complex (RISC) to their mRNA targets by sequence complementarity. (biomedcentral.com)
  • MicroRNA regulation activity depends on the recognition of binding sites located on mRNA molecules. (biomedcentral.com)
  • We focused the analysis on the D. melanogaster species and updated the ComiR underlying database with the currently available releases of mRNA and microRNA sequences. (biomedcentral.com)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • Thus, we compared the expression profile of 24 selected miRs in IFN-β-treated Huh-7 cells and in three different clones of Huh-7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system). (biomedcentral.com)
  • ncRNAs are a large family of RNAs with microRNAs (miRNAs) being one kind of endogenous RNA which lack encoded proteins. (drtaheriazam.com)
  • While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. (frontiersin.org)
  • The microRNA-Medicated Hyperphosphorylation of Tau Proteins in Advertisement And a, the build up of intracellular insoluble hyperphosphorylated Tau proteins can be another pathological feature in Advertisement. (bibf1120.com)
  • MicroRNA can be linked to the phosphorylation and pathological aggregation of Tau proteins closely. (bibf1120.com)
  • Micro RNAs (MiRNAs) are endogenous, small RNA molecules that were identified in a wide range of eukaryotes. (usda.gov)
  • microRNAs (miRNAs) are important regulatory molecules in cellular processes including cell differentiation. (biomedcentral.com)
  • Here, we provide a comprehensive global analysis of the evolutionarily distant unicellular green alga Chlamydomonas reinhardtii to quantify the effects of miRNA on protein synthesis and RNA abundance. (freethoughtblogs.com)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
  • Uncoupling Protein 1 (UCP-1) in the inner membrane of brown-fat mitochondria uncouples electron transport from ATP production, allowing energy dissipation, thus helping to regulate body temperature [ 3 ]. (biomedcentral.com)
  • Similarly, the expression of miR-512 from Tau protein-rich brains of the patients with advanced AD is significantly reduced, indicating that miR-512 can negatively regulate Tau protein through targeting Fas-related death domain protein (32). (bibf1120.com)
  • This dataset was obtained by comparing the results from two different experimental approaches, i.e., inhibition, and immunoprecipitation of the AGO1 protein--a component of the microRNA induced silencing complex. (biomedcentral.com)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • The role of miR‑497 in regulating the proliferation of HCC‑derived cells was also investigated in vitro and in vivo. (spandidos-publications.com)
  • Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
  • Furthermore, we predicted and demonstrated that Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) is one of the targets of gga-miR-155, and the gga-miR-155 regulated the proliferation, cell cycle, apoptosis and invasiveness of MSB1 cells by targeting RORA. (biomedcentral.com)
  • While long noncoding RNAs (lncRNAs) are important i. (researchgate.net)
  • While long noncoding RNAs (lncRNAs) are important in cardiac development and disease, their role in physiol. (researchgate.net)
  • Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)
  • Long noncoding RNAs (lncRNAs) are important regulators in cancer progression. (oncotarget.com)
  • Marcel undertook his postdoctoral studies at the Institute for Molecular Bioscience where he studied the role of long noncoding RNAs in mammalian development and disease. (marceldinger.net)
  • Non-coding RNAs (ncRNAs) are commonly dysregulated in disease pathogenesis, and their role in cancer has been well-documented. (drtaheriazam.com)
  • The field of non-coding RNA (ncRNA) has made significant progress in understanding the pathogenesis of diseases and has broadened our knowledge towards their targeting, especially in cancer therapy. (drtaheriazam.com)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • However, the functional role of most microRNAs in the development of systemic hypertension and hypertensive tissue injury remains unknown. (grantome.com)
  • For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
  • Recently, an increasing number of studies have revealed that microRNA-497 (miR-497) levels are decreased in tumors, and that it functions as a tumor suppressor in a number of types of human cancer, including colorectal, gastric, cervical and breast cancers, adrenocortical carcinoma and melanoma ( 12 - 20 ). (spandidos-publications.com)
  • Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
  • It has been demonstrated that non-coding RNAs, more specifically, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play essential roles in tumor progression [ 9 , 10 ]. (aging-us.com)
  • MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. (biomedcentral.com)
  • Extracellular small non-coding RNAs (exRNAs) have been associated with cardiac inflammation and fibrosis and we hypothesized that they are associated with post-MI LVRm phenotypes. (researchgate.net)
  • Recently, it has been proposed that also microRNAs (miRs), a class of small non-coding regulatory RNAs, are involved in the antiviral pathway induced by IFN-β treatment. (biomedcentral.com)
  • In the current study, we sequenced two small non-coding RNA libraries made from the gonads of adult male and female budgerigars using Illumina paired-end sequencing technology. (peerj.com)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • MicroRNA are small non-coding RNAs that post-transcriptionally regulate the expression levels of messenger RNAs. (biomedcentral.com)
  • In this study, by data mining of the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC and normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p and miR-455-5p. (nature.com)
  • The seven microRNAs that were common and differentially expressed of when all the smoking and vaping groups were compared with non-smokers (NS) are hsa-let-7a-5p, hsa-miR-21-5p, hsa-miR-29b-3p, hsa-let-7f-5p, hsa-miR-143-3p, hsa-miR-30a-5p and hsa-let-7i-5p. (researchsquare.com)
  • The e-cig vs. NS group has differentially expressed 5 microRNAs (hsa-miR-224-5p, hsa-miR-193b-3p, hsa-miR-30e-5p, hsa-miR-423-3p, hsa-miR-365a-3p, and hsa-miR-365b-3p) that is specific for this group and are not expressed in other three groups. (researchsquare.com)
  • We have only known that microRNAs even existed since the early 1990's, and their importance in gene regulation and development wasn't appreciated until the 2000's. (freethoughtblogs.com)
  • MicroRNAs (miRNAs) are all non-coding RNAs that play vital role in post-transcriptional regulation of various animals and plants ( Bartel, 2009 ). (peerj.com)
  • Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • The ncRNAs regulate various molecular pathways and mechanisms in cancer that can lead to induction/inhibition of carcinogenesis. (drtaheriazam.com)
  • Nevertheless, a lack of knowledge relating to the mechanisms regulating their differentiation has limited their clinical application. (biomedcentral.com)
  • The goal of the current project is to investigate the role of microRNA miR-29 in the development of hypertension and renal injury and understand the mechanisms involved. (grantome.com)
  • However, it remains unknown whether the insufficiency of renal miR-29 contributes to the development of hypertension and renal injury in the SS rat, whether renal miR-29 protects SS.13BN rats from developing hypertension, what mechanisms mediate any effect of miR-29 on hypertension, and how the expression of miR-29 is regulated in the kidneys of SS rats. (grantome.com)
  • To date, the effect produced by HCV on the expression of microRNAs (miRs) involved in the interferon-β (IFN-β) antiviral pathway has not been explored in details. (biomedcentral.com)
  • Accumulating studies have revealed that miRNAs that participate in the myocardial fibrotic program, such as miR-18a-5p, attenuate cardiac fibrosis via regulating the Notch2 pathway [ 13 ], and miR-24-3p alleviates myocardial fibrosis through PHB2 [ 14 ]. (hindawi.com)
  • Although HCV activates the endogenous IFN-α/β pathway it conversely shows an impressive ability to induce persistent infections. (biomedcentral.com)
  • Gene set enrichment analysis of microRNAs showed significant changes in the top six enriched functions that consisted of biological pathway, biological process, molecular function, cellular component, site of expression and transcription factor in all the groups. (researchsquare.com)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • ComiR is a web tool realized to predict the targets of a set of microRNAs, starting from their expression profile. (biomedcentral.com)
  • ComiR was trained with the information regarding binding sites in the 3'utr region, by using a reliable dataset containing the targets of endogenously expressed microRNA in D. melanogaster S2 cells. (biomedcentral.com)
  • In this work, we tested whether including coding region binding sites in ComiR algorithm improves the performance of the tool in predicting microRNA targets. (biomedcentral.com)
  • As a result, we find that ComiR algorithm trained with the information related to the coding regions is more efficient in predicting the microRNA targets, with respect to the algorithm trained with 3'utr information. (biomedcentral.com)
  • Furthermore, we observed that the lists of targets obtained by analyzing data from one experimental approach only, that is, inhibition or immunoprecipitation of AGO1, are not reliable enough to test the performance of our microRNA target prediction algorithm. (biomedcentral.com)
  • The ability of predicting the targets of the endogenous miRNAs is then crucial to understand the processes they are involved in. (biomedcentral.com)
  • Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)
  • However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
  • It has been suggested that adipogenesis is regulated by PPARβ/δ followed by PPARγ and C/EBPα promoting differentiation into mature adipocytes [ 12 ]. (biomedcentral.com)
  • This systematic review aims to provide a panel of miRNAs that regulate the differentiation of hDP-MSCs including hDPSCs and SHEDs. (biomedcentral.com)
  • The findings of this systematic review support the potential application of the specific miRNAs to regulate the directed differentiation of hDP-MSCs in the field of regenerative therapies. (biomedcentral.com)
  • MicroRNAs (miRNAs) regulate many physiological processes including body growth. (nature.com)
  • The miRNAs regulate root elongation, lateral root (LR) formation and adventitious root (AR) development in response to hormone signaling, nutrient uptake and biotic/abiotic stress. (chinaagrisci.com)
  • Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
  • Since the insulin and growth phenotypes are rescued by expression of sNPFR1, we propose that the conserved miR-9a/miR-9 regulates body growth by modulating insulin signalling through its conserved sNPFR1/NPY2R target in both Drosophila and mammals. (nature.com)
  • RAB18 was upregulated in HCC tissues and cell lines, and the expression of RAB18 was regulated by miR-455. (hindawi.com)
  • A comprehensive differential expression analysis of microRNAs, tRNAs and piRNAs showed significant changes across different pairwise comparisons. (researchsquare.com)
  • Plasma exosomes of cigarette smokers, waterpipe smokers, e-cig users and dual smokers have common differential expression of microRNAs which may serve to distinguish smoking and vaping subjects from NS. (researchsquare.com)
  • The expression of 10 adipogenesis-regulated miRNAs were studied using real-time qPCR and then we selected 5 miRNAs, that showed robust expression, were profiled in subcutaneous adipose tissue obtained from 20 humans with a range of body mass indices (BMI, range = 21-48, and all samples have U133+2 Affymetrix profiles provided). (biomedcentral.com)
  • Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
  • When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • Circulating extracellular RNAs (ex-RNAs) are an emerging class of biomarkers with target-organ epigenetic effects. (researchgate.net)
  • Moreover, miR-15a can target extracellular Rabbit Polyclonal to MC5R signal-regulated kinase BMS-790052 kinase activity assay 1 (ERK1) for the involvement of Tau hyperphosphorylation (9). (bibf1120.com)
  • The overexpression of miR-195 in N2a/APP695 cells presents the reduced A known level, as the inhibition of miR-195 network marketing leads to the boost of A. The decreased appearance of the microRNAs may bring about the raised appearance and function of BACE1, therefore causing aberrant A production as the characteristics of the brains from humans and mice with AD. (bibf1120.com)
  • MicroRNAs are critical in many important biological processes, and are important markers for many diseases. (biomedcentral.com)
  • It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (cancer-genetics.org)
  • The aim of the present review is to evaluate the role of ncRNAs in regulating autophagy in gastrointestinal tumors. (drtaheriazam.com)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • Next Generation Sequencing (NGS) was used to identify microRNAs (miRNAs) at the molecular response in CML adult patients receiving TKIs treatment. (biomedcentral.com)
  • 48 h after transfection with the indicated RNA duplex, cells were subjected to Western blot analysis. (biomedcentral.com)
  • (C) signaling pathways that regulate the cell cycle control in HCC involving miR-503. (biomedcentral.com)
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)
  • microRNAs are present in higher concentration in exosomes that play a major role in various physiological and pathological functions. (researchsquare.com)
  • In conclusion, we provide a preliminary analysis of miRNAs associated with primary cell in vitro adipogenesis and demonstrate that the inflammation-associated miRNA, mir-21 is up-regulated in subcutaneous adipose tissue in human obesity. (biomedcentral.com)
  • Of particular importance is miRNA-21 (MIR21) due to its role in regulating programmed cell death 4 (PDCD4). (biomedcentral.com)
  • Of particular interest is understanding the role of non-coding RNA in regulating meiotic checkpoints in the oocyte, particularly that of microRNA-21 (MIR21). (biomedcentral.com)
  • In a previous study using a microRNA (miRNA/miR) microarray assay, we demonstrated that miR-133b-5p was upregulated in response to hypoxic preconditioning (HPC). (spandidos-publications.com)
  • We hypothesized that the non-coding RNAs transcript may serve as susceptibility to disease biomarkers by smoking and vaping. (researchsquare.com)