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  • COMT
  • The researchers got the idea for testing the effectiveness of EGCG as a COMT inhibitor as part of Parkinson's disease therapy from the fact that catechol-containing bioflavonoids and tea catechins have been identified as good substrates for COMT. (life-enhancement.com)
  • In addition, these compounds have also been found to be strong inhibitors of liver COMT-mediated O-methylation of endogenous catechol estrogens. (life-enhancement.com)
  • Cytochrome P-450 1A1 (CYP1A1), Cytochrome P-450 1B1 (CYP1B1), Catechol-O-methyl transferase (COMT) and Nicotinamide adenine dinucleotide phosphate-quinone oxidoreductase 1 (NQO1). (jcancer.org)
  • Our previous studies suggested that both catechol O -methyl transferase (COMT) and glutathione S-transferase (GST) M1 and T1 genotypes are associated with breast cancer risk. (springer.com)
  • mediate
  • The authors suggested that 2-hydroxylated estrogens may mediate the action of the hormone parent, having properties distinct but relevant to the physiology or pathophysiology of a target organ. (aacrjournals.org)
  • Testosterone
  • All of the different forms of estrogen are synthesized from androgens, specifically testosterone and androstenedione, by the enzyme aromatase. (wikipedia.org)
  • tumor
  • These results, complemented by other data, strongly support the hypothesis that CE-3,4-Q are endogenous tumor initiators. (pnas.org)
  • reactive
  • 2-Hydroxyestradiol, as well as 2-hydroxyestrone and 4-hydroxyestradiol, can undergo metabolic redox cycling to generate free radicals like superoxide and reactive estrogen semiquinone/quinone intermediates. (wikipedia.org)
  • tumors
  • Estrogens induce tumors in laboratory animals and have been associated with breast and uterine cancers in humans. (semanticscholar.org)
  • The implication of estrogens in development of tumors at various organ sites of both animals and humans has been universally recognized over the last 70 years. (aacrjournals.org)
  • breast cancer
  • In this study we investigated the effect of TNF-α on the estrogen metabolic pathway in MCF-7, a breast cancer cell line. (jcancer.org)
  • However, there is conceivable evidence that estrogen induced breast cancer can also occur by a non ER-alpha mediated mechanism involving the estrogen metabolic pathway [ 5 ]. (jcancer.org)
  • Catechol-O-methyltransferase and breast cancer risk. (semanticscholar.org)
  • An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer. (semanticscholar.org)
  • It is widely recognized that estrogens play a primary role in development and growth of human breast cancer. (aacrjournals.org)
  • DNA damage induced by estrogen and stress is an important factor in the pathogenesis and development of breast cancer and is now recognized as a critical provision for chemoprevention of breast cancer. (biomedcentral.com)
  • In this review, we summarize the relationships between estrogen- and stress-induced DNA damage with regard to the pathogenesis and development of breast cancer. (biomedcentral.com)
  • Estrogen replacement therapy and breast cancer: analysis of age of onset and tumour characteristics. (fixwomenshealth.com)
  • significantly
  • Conversely, ratio values of 4:2 hydroxy+methoxy estrogens was significantly lower ( P = 0.006) in deceased patients. (aacrjournals.org)
  • While estrogen levels are significantly lower in males compared to females, estrogens nevertheless also have important physiological roles in males. (wikipedia.org)
  • While estrogens are present in both men and women, they are usually present at significantly higher levels in women of reproductive age. (wikipedia.org)