Endogenous cyclic amp dependent protein kinases. Medical search. Frequent questions

We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
5 ], inducing apoptosis through phosphorylation and downregulation of the anti-apoptotic proteins BCL-2 and BCL-XL respectively [ 6 - 9 ]. (oncotarget.com)
LPA effectively stimulated the phosphorylation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in HEK-LPA1, -LPA2, and -LPA3 cells. (bvsalud.org)
This potentiation was associated with enhanced phosphorylation of CREB and S6 ribosomal protein, two molecular targets of activated ERK1/2. (bvsalud.org)
The antidepressants also potentiated LPA-induced Gq/11-mediated phosphorylation of AMP-activated protein kinase in HEK-LPA1 and -LPA3 cells. (bvsalud.org)
In the hypothalamic lysates of ABA rats, we found a reduction in ALK receptor expression, a downregulation of Akt phosphorylation, and no change in the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) phosphorylation. (bvsalud.org)
Activators of endogenous PKA that stimulate dSlo phosphorylation, but do not produce detectable PKAc binding to dSlo, do not modulate channel function. (elsevierpure.com)
These results are consistent with the hypothesis that both binding of active PKAc to dSlo and phosphorylation of dSlo or some other protein are necessary for channel modulation. (elsevierpure.com)
Cyclic AMP increased phosphorylation of fluke protein in both fractions. (erowid.org)
Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. (adooq.com)
Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. (pp1a.com)
DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). (pp1a.com)
Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3). (pp1a.com)
The Pearse laboratory is also working on post-translational protein modifications including arginylation, transamidation and phosphorylation. (themiamiproject.org)
AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)
Using FRET-based sensors to monitor cAMP and PKA-dependent phosphorylation in the cytosol and outer mitochondrial membrane (OMM) of primary rat cardiomyocytes, we demonstrate that comparable cAMP increases in these two compartments evoke higher levels of PKA-dependent phosphorylation in the OMM. (ox.ac.uk)
We present a model that accounts for these unexpected results in which the degree of PKA-dependent phosphorylation is dictated by both the subcellular distribution of the phosphatases and the different accessibility of membrane-bound and soluble phosphorylated substrates to the cytosolic enzymes. (ox.ac.uk)

Considerably higher resistance against cyclic nucleotide phosphodiesterases compared to dibutyryl- or 8-Br-cAMP (Cat. (biolog.de)
Exploring the role of cyclic AMP-dependent phosphodiesterases in aberrant neural cell responses to injury and designing therapies that collectively target cyclic AMP and mitogen activated kinase signaling pathways for regeneration and repair. (themiamiproject.org)
Evidence supporting the heterogeneity in cAMP and PKA signaling is rapidly accumulating and has been largely attributed to the localization or activity of adenylate cyclases, phosphodiesterases, and A-kinase-anchoring proteins in different cellular subcompartments. (ox.ac.uk)
1] Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. (axonmedchem.com)

The catalytic subunit of adenosine 3',5'-cyclic monophosphate-dependent protein kinase (PKA, 200 nM, with 1 mM ATP) activates a channel with similar characteristics. (johnshopkins.edu)
Erowid.org: Erowid Reference 3068 : Adenosine Cyclic 3',5'-Monophosphate in the Liver Fluke, fasciola hepatica. (erowid.org)
In the presence of O.i mM 5HT, AC activity in the fluke particles was inhibited by 0.5 mcM LSD, and LSD also antagonized the 5HT stimulated increase in cyclic AMP levels, Adenine, adenosine, histamine (Calbiochem), adrenaline (Mann), tryptophan, dopamine, GTP (Sigma - Chem. (erowid.org)
The two well-established cyclic nucleotides are adenosine-3',5'-cyclic monophosphate (cyclic AMP) and guanine-3',5'-cyclic monophosphate (cyclic GMP). (pancreapedia.org)
remaining of IGF1( IGF-I) or IGF2( IGF-II) to the vesicular flow factors of the peptide 1 intestinal amino adenosine heterogeneity( IGF1R) is the DNA of two antimicrobial lacking kinases: the SOS-RAS-RAF-MAPK( ERK) ligand and the PI3K-PKB( AKT) phosphate( generally polyubiquitinated in Pavelic et al. (erik-mill.de)

Drosophila Slowpoke (dSlo) calcium-dependent potassium channels bind directly to the catalytic subunit of cAMP-dependent protein kinase (PKAc). (elsevierpure.com)
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. (cdc.gov)
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study. (cdc.gov)

Glycogen synthase is also regulated by protein phosphatase 1 (PP1), which activates glycogen synthase via dephosphorylation. (wikipedia.org)
After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)
The clustering of DAB1 activates SRC family tyrosine kinases (SFKs), then Reelin-activated SFKs phosphorylate the NMDAR on NR2 subunits, resulting in the potentiation of NMDAR-mediated Ca 2+ influx. (biomedcentral.com)

Chloride channels at the apical membrane of intestinal epithelial cells are involved in the excessive fluid secretion in diarrhea and diminished secretion in cystic fibrosis (CF). Diarrhea induced by heat-stable toxin from Escherichia coli is associated with elevated guanosine 3',5'-cyclic monophosphate (cGMP) in intestinal epithelial cells, but it is unknown whether chloride secretion is regulated by cGMP directly or via cGMP- dependent protein kinase (PKG). (johnshopkins.edu)
Single-channel recordings (inside-out excised patches) from the apical membrane of T84 cells reveal a 10-pS chloride channel with a linear current-voltage relationship, which is opened when an endogenous membrane-bound PKG is activated with ATP (1 mM) and cGMP (100 μM). (johnshopkins.edu)
Addition of nonhydrolyzable forms of ATP (AMP-PNP, 1 mM) or a combination of ATP, cGMP, plus H-8 (5 μM), an inhibitor of PKG, also does not stimulate the channel. (johnshopkins.edu)
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM). (adooq.com)
cGMP Dependent Kinase Inhibitor Peptid is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. (adooq.com)
On the horizon, novel insights into metabolism and energy homeostasis reveal guanosine 3′,5′-cyclic monophosphate (cGMP) signaling circuits as emerging targets for antiobesity pharmacotherapy. (eddoctor24h.com)

The increase in 36Cl- permeability is diminished by protein kinase A inhibitors and is not mediated by an increase in intracellular calcium concentrations. (nih.gov)
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. (adooq.com)
Due to the fact TRII is usually a constitutively lively kinase and TGF signaling usually requires TRI ALK activation, ALK is the principle target for designing tiny molecule inhibitors that block TGF signaling. (hifsignaling.com)
This stimulation of cAMP was not Ca 2+ -sensitive and was unaffected by a range of protein kinase inhibitors. (jneurosci.org)

Furthermore, we find that extracellular signal-regulated kinase (ERK)-mediated retrograde signalling is required for PCAF-dependent regenerative gene reprogramming. (nature.com)
In addition, we observed that extracellular signal-regulated kinase (ERK) axonal retrograde signalling is required for PCAF-dependent acetylation at these promoters and for their enhancement in gene expression. (nature.com)
TLR ligands include high-mobility group B1 (HMGB1), heat shock proteins (HSP60, HSP70), endotoxins, and extracellular matrix components [ 23 ]. (hindawi.com)
One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)
The biological download of SMAD2 and SMAD3 is known by SMURF type membranes, which consist acids for I. In turbine, Apaf-1 R-SMAD: ligand Hepatocyte is leader of extracellular humans( projections), including a applicable kinase-inhibitor turnover. (erik-mill.de)

Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)

Many heterologously expressed mutants of the cystic fibrosis transmembrane conductance regulator (CFTR) exhibit residual chloride channel activity that can be stimulated by agonists of the adenylate cyclase/protein kinase A pathway. (nih.gov)
Fasciola hepatica were collected from fresh beef livers and particulate fractions of whole flukes, 'tails' or 'heads' (anterior ends) assayed for adenylate cyclase (AC) activity and cyclic AMP concentration using a protein binding assay. (erowid.org)
Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)
whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. (adooq.com)
H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase. (adooq.com)
NH125 is a selective eEF-2 kinase inhibitor. (adooq.com)
PKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor. (adooq.com)
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family. (adooq.com)
Rp-cAMPS is a cell-permeable and reversible inhibitor of PKA (protein kinase A) (Ki = 11 uM). (adooq.com)
PKI 14-22 amide, myristoylated is a useful heat stable cAMP-dependent protein kinase inhibitor. (adooq.com)
HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50 = 8, 12, and 4 μM, respectively). (adooq.com)
Other authors have shown attenuated germ cell apoptosis SB-742457 kinase inhibitor following antioxidant therapy. (hifsignaling.com)
Furthermore, inhibition of endogenous PKA by the heat-stable PKA inhibitor is sufficient to stimulate MAPK activity in these extracts in the absence of protein synthesis and without dependence on a functional Ras protein. (ox.ac.uk)

The non-canonical cyclic nucleotides include the purines inosine-3',5'-cyclic monophosphate (cyclic IMP), xanthosine-3',5'-cyclic monophosphate (cyclic XMP) and the pyrimidines cytidine-3',5'-cyclic monophosphate (cyclic cCMP), uridine-3',5'-cyclic monophosphate (cyclic UMP), and thymidine-3',5'-cyclic monophosphate (cTMP) (145). (pancreapedia.org)

The search for the molecular mechanisms underlying the effects of dimethyltryptamines showed that N,N-DMT & 5-MeO-DMT, two closely related metabolic products, can act as systemic endogenous regulators of inflammation and immune homeostasis through both 5-hydroxytryptamine receptors (5-HTRs) & sigma-1 receptors (σ-1Rs)13,14. (baoninhsunrise.com)
5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. (aspetjournals.org)
Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11. (aspetjournals.org)
Endocannabinoids (eCBs) are endogenous lipid ligands that bind to cannabinoid receptors that also mediate the effects of marijuana. (degruyter.com)
Both CB 1 and CB 2 receptors, which share a low level (44%) of sequence homology [6], are G protein-coupled receptors that mainly signal via G i /G o proteins, even though they may also activate G s , G q/11 , and G protein-independent signaling pathways [ 7 ]. (degruyter.com)
The existence of specific receptors for plant-derived molecules in mammalian cells initiated a search for specific endogenous ligands. (degruyter.com)
Enhancement of GABA release through endogenous activation of axonal GABA(A) receptors in juvenile cerebellum. (sppin.fr)
Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)
Neuromodulatory transmitters engage G-protein coupled receptors (GPCRs), activating intracellular signaling cascades that then can directly activate or modify the properties of ion channels. (frontiersin.org)
Binding of Reelin to the receptors induces feed-forward activation of DAB1, an adaptor protein that interacts with NPxY motifs in both receptor tails [ 20 ]. (biomedcentral.com)

2007). These proteins are important for the regulation of intracellular pH (pH i ) and play crucial roles in the epithelial absorption of HCO 3 - (e.g., in the renal proximal tubule) and secretion of HCO 3 - (e.g., in the pancreatic duct). (tcdb.org)
Notably, the cAMP and transcriptional signaling steps are subject to discrete RBM12-dependent regulation. (sciety.org)
Regulation of mitogen-activated protein kinase activation by protein kinases A and C in a cell-free system. (ox.ac.uk)

It regulates the PKA dependent signaling pathways. (adooq.com)
These results suggest that independent pp60v-src and PKC pathways converge at Ras and that PKA acts to block MAPK activation by both Ras-dependent and -independent signals. (ox.ac.uk)
inhibiting of download to the translesion is cell of cartilage dependent PLP members( ITAMs) in the Standard cells of Ig-alpha and Ig-beta by Src phophorylate energy pathways, missing LYN, FYN, and BLK( Nel et al. (erik-mill.de)

Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. (ox.ac.uk)
Furthermore, we show that the activity of soluble phosphatases attenuates PKA-driven activation of the cAMP response element-binding protein while concurrently enhancing PKA-dependent mitochondrial elongation. (ox.ac.uk)

Understanding the role of ATE1 and protein arginylation in neuronal cell death and abortive axon regeneration in CNS injury and disease. (themiamiproject.org)

The proximal events of TLR-mediated intracellular signaling are initiated by interactions with cytosolic adapters, mainly myeloid differentiation primary response protein 88 (MyD88) [ 25 ]. (hindawi.com)
Elevated intracellular Ca 2+ can activate the transcription factor cyclic AMP response element binding protein (CREB), thereby potentially initiating the expression of genes that are important for synaptic plasticity, neurite growth and dendritic spine development [ 20 - 22 ]. (biomedcentral.com)

Dopamine and cyclic-AMP activated Mr32kDa phosphoprotein (DARPP-32) is a central signaling proteins in neurotransmission. (pp1a.com)
Use knockout HEK293 cells to verify that RBM12 is novel repressor of the GPCR/cAMP pathway that extends to multiple GPCRs coupled to the stimulatory G protein (e.g. dopamine 1 receptor, beta-2 adrenergic receptor). (sciety.org)

Anaplastic lymphoma kinase (ALK) receptor is a protein-tyrosine kinase mainly known as a key oncogenic driver. (bvsalud.org)
By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. (pp1a.com)
Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
We utilize two complementary models, HEK293 cells and human iPSC-derived neurons, and delineate RBM12 as a novel repressor of the G protein-coupled receptor/cyclic AMP/protein kinase A (GPCR/cAMP/PKA) signaling axis. (sciety.org)
In agreement with its activity as an RNA-binding protein, loss of RBM12 leads to altered gene expression, including that of multiple effectors of established significance within the receptor pathway. (sciety.org)
The cannabinoid receptor-stimulated accumulation of cAMP was blocked in a concentration-dependent manner by SR141716A, suggesting that the response was regulated through the CB1 receptor. (jneurosci.org)
Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
Moreover, neuromodulators control the activity of these proteins through G-protein coupled receptor signaling cascades. (frontiersin.org)

The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. (adooq.com)
Altogether, we are the first to demonstrate that NETs inhibition with Cl-amidine ameliorated neuroinflammation, neuronal apoptosis, and neurological deficits via STING-dependent IRE1α/ASK1/JNK signaling pathway after TBI. (biomedcentral.com)

Cyclic nucleotides, like other nucleotides, are composed of three functional groups: a ribose sugar, a nitrogenous base, and a single phosphate group. (pancreapedia.org)
A cyclic nucleotide, unlike other nucleotides, has a cyclic bond arrangement between the ribose sugar and the phosphate group. (pancreapedia.org)
There are two main groups of cyclic nucleotides: the canonical or well-established and the non-canonical or unknown-function cyclic nucleotides. (pancreapedia.org)
An overview of the non-canonical cyclic nucleotides is provided in Section V. (pancreapedia.org)
Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)
This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)

The release of mouse from the conversion in kinase shows STIM1 to confer with ORAI and TRPC1 levels in the hydrolase binding, depending in an Expression of due complex antagonists( Muik et al. (erik-mill.de)

Glycogen synthase is directly regulated by glycogen synthase kinase 3 (GSK-3), AMPK, protein kinase A (PKA), and casein kinase 2 (CK2). (wikipedia.org)

Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. (nature.com)
We found that p300/CBP-associated factor (PCAF)-dependent acetylation of histone 3 lysine 9 (H3K9ac), paralleled by a reduction in methylation of H3K9 (H3K9me2), occurred at the promoters of select genes only after PNS axonal injury. (nature.com)

5HT (Calbiochem) caused a marked concentration-dependent accumulation of cyclic AMP especially in 'heads', maximal activation of AC occurring at i mM, and an accompanying increase in motility of the isolated fluke head. (erowid.org)
Maxi-mum accumulation of cyclic AMP occurred in 5-10 min. (erowid.org)

Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. (adooq.com)
Dibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. (adooq.com)

RBM12 knockdown yielded hyperactive upregulation of NR4A1 and FOS mRNAs, two known CREB-dependent immediate early genes induced by neuronal activity. (sciety.org)

Protein kinase activity was 2-5 times greater in the 'head' than in the posterior end of the fluke and in both particulate and supernatant fractions half-maximal activation was obtained at 0.1-0.4 mcM cyclic AMP. (erowid.org)
The degree of activation by cyclic AMP was inversely correlated with endogenous cyclic AMP and 5HT concentration. (erowid.org)
Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. (cipsm.de)

The activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates several forms of synaptic plasticity and has been linked to neuropsychiatric illness. (bvsalud.org)
This study found an increase in excess GR transcriptional activity of protein phosphatase 1 alpha (PP1α) in HEK-293 cells and a decrease in the expression levels of GR-responsive gene knockdown following PP1α model A549 cells endogenously . (pp1a.com)
Research work conducted by Dr. Pearse's group have shown that the reparative efficacy of Schwann cells can be enhanced when they are used in conjunction with other glial cells such as olfactory ensheathing cells, are accompanied by the elevation of cyclic AMP, employed with biomaterials and matrices, modified with gene therapeutic delivery of growth factors or polysialic acid, among other combinatory strategies. (themiamiproject.org)

Calcium-dependent docking of synaptic vesicles. (sppin.fr)

These data demonstrate the role of DARPP-32 and related kinase signaling as a prognostic marker in ovarian cancer clinical utility. (pp1a.com)
We demonstrate that this disparity depends on differences in the rates of phosphatase-dependent dephosphorylation of PKA targets in the two compartments. (ox.ac.uk)

Both cyclic AMP and cyclic GMP are second messengers. (pancreapedia.org)

Here we show that protein kinase C (PKC) is also able to stimulate MAPK in a Ras-dependent manner, but PKC is not necessary for signaling by pp60v-src. (ox.ac.uk)

The enhanced levels of cyclic AMP were preserved by both caffeine and papaverine, and NaF up to 5 mM caused a specific stimulation of AC. (erowid.org)
In addition, preincubation of extracts with cAMP-dependent protein kinase (PKA) blocks stimulation of MAPK by cyclin, p21V12ras, PKC, or pp60v-src, by at least 50%, but stimulation by c-Mos is unaffected. (ox.ac.uk)

They are essential regulators of cyclic nucleotide signaling with diverse physiological functions. (axonmedchem.com)

Although the C-terminal domain comprises a small percentage of the total protein, this domain in some cases (i) has PSD-95/Discs Large/ZO-1-binding motifs that may be important for protein-protein interactions (e.g. (tcdb.org)

The genome of E. coli MG1655 is 4,641,642 bp, corresponding to 4702 genes encoding 4328 proteins. (encyclopedia.pub)
The genome size of E. coli strain K-12 MG1655 is 4,641,652 bp, corresponding to 4702 genes encoding 4328 proteins, 228 RNA genes, and 146 pseudogenes. (encyclopedia.pub)
first patterns( progeny, class, protein lifetime, and complex anion) be depending genes: NF-kappaB is silenced via list catabolism C octanoyl, RAS has required via RasGRP cells, NF-AT creates coupled via Tumor, and AKT( PKB) methylates achieved via PDK1( involved in Shinohara and Kurosaki 2009, Stone 2006). (erik-mill.de)

Glycogen synthase can be classified in two general protein families. (wikipedia.org)
Each of these protein kinases leads to phosphorylated and catalytically inactive glycogen synthase. (wikipedia.org)
For enzymes in the GT3 family, these regulatory kinases inactivate glycogen synthase by phosphorylating it at the N-terminal of the 25th residue and the C-terminal of the 120th residue. (wikipedia.org)

This discovery formed the basis of a powerful technique used nowadays to study brain activity: blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI). (frontiersin.org)
Incubation of fluke heads for 5 min with 1 mM 5HT increased protein kinase activity of both fractions in the absence of added cyclic AMP, but with 5 mcM cyclic AMP protein kinase activity was increased inthe particulate and decreased in the super-natant fraction. (erowid.org)
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. (cipsm.de)

CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. (adooq.com)

It inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. (adooq.com)
In this study, we report the development and characterization of an in vitro system for studies of replication of the endogenous plasmids from the unicellular cyanobacterium Synechocystis 6803. (upenn.edu)

Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
Multidrug resistance, generally, results from over expression of ATP-dependent efflux pumps [5]. (savedelicious.com)

This difference is most evident for small, physiological increases of cAMP levels and with both OMM-located probes and endogenous OMM proteins. (ox.ac.uk)

These data indicate that endogenous levels of deltaF508 protein can be stimulated to increase 36Cl- permeability in airway epithelial cells. (nih.gov)
both strongly stimulated motility but had no effect on cyclic AMP levels. (erowid.org)
glucagon (Lilly) and noradrenaline (Winthrop) had no effect on motility or cyclic AMP levels. (erowid.org)

In humans, the AE family (also called the SLC4 family) is composed of 10 paralogous members, among which are the proteins that perform Na + -independent Cl-HCO 3 - exchange (e.g. (tcdb.org)

Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)

Previously pp60v-src, cyclin A, p39mos, and maturation-promoting factor (composed of Cdc2 and cyclin B) have been shown to activate mitogen-activated protein kinase (MAPK) and MAPK kinase (MEK) in cell-free extracts of Xenopus oocytes. (ox.ac.uk)

TLRs are membrane-anchored proteins present in several cell types ranging from macrophages and T and B cells to nonimmune cells such as cardiomyocytes [ 20 , 21 ]. (hindawi.com)
Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. (tcdb.org)
All AE proteins are hypothesized to share a similar topology in the cell membrane. (tcdb.org)

Anatomy19

Organisms13

Chemicals and Drugs165

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes43

Information Science3

Phosphorylation18

Phosphodiesterases4

Adenosine5

Catalytic subunit3

Activates3

CGMP6

Inhibitors4

Extracellular7

Subunit1

Adenylate5

Inhibitor10

Monophosphate1

Receptors10

Regulation3

Pathways3

Phosphatases3

Neuronal cell1

Intracellular2

Dopamine2

Receptor8

Inhibition2

Nucleotides6

Antagonists1

Casein1

Axonal2

Accumulation2

Activator3

CREB1

Activation3

Gene3

Calcium1

Demonstrate2

Second messengers1

Stimulate1

Stimulation2

Regulators1

Interactions1

Genes3

Glycogen3

Activity3

Closely related1

Vitro2

Expression2

Increases1

Levels3

Humans1

Ovarian1

Activate1

Cell3