Cao participated in the discovery of angiostatin, an endogenous angiogenesis inhibitor, in Judah Folkman ́s Laboratory. (wikipedia.org)
Endogenous inhibitors of angiogenesis include thrombospondin 1 (TSP-1) and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1), and their aberrant expression may contribute to the diabetes-related dysregulation of retinal vascular homeostasis and vasculopathies ( 7 , 8 ). (spandidos-publications.com)
Lipoprotein1
To measure intravitreal low-density lipoprotein receptor-related protein 6 (LRP6) and vascular endothelial growth factor (VEGF) levels in the eyes of patients with proliferative diabetic retinopathy (PDR) and to observe their correlation with PDR activity. (molvis.org)
Vascular endoth1
Treatment with 30 mM glucose also increased the expression of vascular endothelial growth factor (VEGF) mRNA and protein, and the expression levels of VEGF mRNA and protein were suppressed by kaempferol (10 and 30 µM). (spandidos-publications.com)
Kinase1
Here, we demonstrated that CNP activates the cAMP/protein kinase A (PKA) pathway and that this activation contributed to the elongation of the hypertrophic zone in the growth plate. (tokushima-u.ac.jp)
Receptor1
RT‑qPCR and western blotting results showed that treatment with 30 mM glucose for 12, 24 and 48 h increased the expression level of estrogen‑related receptor α (ERRα) mRNA and protein. (spandidos-publications.com)
Distinct1
Adding chemical groups to the DNA backbone and modifying histone proteins impart distinct characteristics on chromatin architecture. (frontiersin.org)
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels. (bvsalud.org)
Expression1
The expression levels of various mRNAs and proteins were measured by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting, respectively. (spandidos-publications.com)
Endothelial1
This study aimed to investigate whether the recombinant mouse angiostatin gene transfected anti-angiogenic gallbladder cancer cells can express angiostatin protein with the activity of inhibiting the growth of vascular endothelial cells and the inhibitory effect on the growth of gallbladder cancer. (bvsalud.org)
Angiostatin protein2
1. The tumor-suppressing activity of angiostatin protein resides within kringles 1 to 3. (nih.gov)
2. A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer. (nih.gov)
Molecules1
[ 74 ] Subsequently, other endogenous molecules such as thrombospondin-I, plalelet factor-4, and interferon inducible protein-10 (IP-10) were discovered. (medscape.com)