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  • opiate
  • Opiate receptor antagonism by L-prolyl-L-leucyl-glycinamide, MIF-I". Peptides. (wikipedia.org)
  • By the mid-1960s, it had become apparent from pharmacologic studies that opiate drugs were likely to exert their actions at specific receptor sites, and that there were likely to be multiple such sites. (wikipedia.org)
  • Pathway
  • this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. (genecards.org)
  • In animal studies, the N/OFQ-NOP receptor pathway has also been found to play both positive and negative roles in both learning and memory. (wikipedia.org)
  • As such, the receptor pathway maintains homeostatic responses to fear and stressful situations. (wikipedia.org)
  • Activation of NOP's canonical β-arrestin pathway causes receptor phosphorylation, internalization, and eventual downregulation and recycling. (wikipedia.org)
  • The receptor cannot activate the PKC but it can still activate the ERK1/2 pathway although it is a little bit slower. (wikipedia.org)
  • homologous
  • There have been studies done on specific amino acids on the urotensin II receptor especially the ones that are homologous to the other members of the rhodopsin family. (wikipedia.org)
  • Activation
  • Rawls et al (2010) 5-HT 1A -like receptor activation inhibits abstinence-induced metha. (tocris.com)
  • These results suggest that endomorphin-1 but not endomorphin-2 impairs learning and memory resulting from cholinergic dysfunction, and from activation of mu(1)-opioid receptors. (nii.ac.jp)
  • However, in clinical practice drugs applied intravenously that are agonists of α 2 {\displaystyle \alpha _{2}} receptors (clonidine) lead to powerful vasodilation, which causes a decrease in blood pressure by presynaptic activation of α 2 {\displaystyle \alpha _{2}} receptors in the sympathetic ganglia. (wikipedia.org)
  • Agonism of β 2 {\displaystyle \beta _{2}} receptors causes vasodilation and low blood pressure (i.e. the effect is opposite of the one resulting from activation of α 1 {\displaystyle \alpha _{1}} and α 2 {\displaystyle \alpha _{2}} receptors in the vascular smooth muscle cells). (wikipedia.org)
  • NOP activation also causes indirect inhibition of opioid receptors MOP and KOP, resulting in anti-opioid activity in certain tissues. (wikipedia.org)
  • When the urotensin II receptor is activated through an intracerebroventricular (icv) injection of urotensin II it causes an increase of corticotropin releasing factor through the activation of the hypothalamic paraventricular neurons (PVN) which lead to increased plasma levels of adrencorticotropic hormones. (wikipedia.org)
  • The stimulation of the PVN by the activation of urotensin II receptor means that it directly affects the hypothalamus pituitary axis (HPA) which is important in the regulation of many important body functions. (wikipedia.org)
  • Wakefulness and slow wave sleep were not affected by the activation of the urotensin II receptor. (wikipedia.org)
  • Short term effects of the activation of the urotensin II receptor is the burst intercellular calcium in the aorta which causes vasoconstriction of the vessel. (wikipedia.org)
  • There is also evidence that there are long term effects of the activation of the urotensin II receptor which could play a role in cardiomyocitic hypertrophy. (wikipedia.org)