Endocrine tissue. Medical search. Frequent questions

Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands called the endocrine system. (medlineplus.gov)
The most common sign of multiple endocrine neoplasia type 1 is overactivity of the parathyroid glands (hyperparathyroidism). (medlineplus.gov)
Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs. (medlineplus.gov)
This unchecked cell division can lead to the formation of tumors in endocrine glands and other tissues. (medlineplus.gov)
Endocrine glands are ductless glands of the endocrine system that secrete their products, hormones, directly into the blood. (wikipedia.org)
In contrast, bioengineering of entire soft tissue organs and, in particular endocrine glands still remains a substantial challenge. (unibas.ch)
Endocrine glands release their secretions directly into the blood. (wikieducator.org)

The endocrine system includes a bunch of tissues that discharge hormones into circulation for travel to and activity on distant targets. (alliedacademies.org)
An endocrine tissue is ordinarily a ductless organ that discharges its hormones into capillaries that saturate the tissue. (alliedacademies.org)
Endocrine tissues moreover contribute imperative hormones to circulation, such as emission of atrial natriuretic peptide from the heart, erythropoietin from the kidney, insulin-like development figure from the liver, and leptin from fat. (alliedacademies.org)
Information in the endocrine system is transmitted through several small molecules, peptides and proteins that function as hormones. (tomsk.ru)
The production of hormones in the endocrine system can be regulated by the concentration of certain molecules or ions (e.g. glucose, calcium) or by the nervous system which allows for integration of external stimuli or input from higher parts of the brain. (tomsk.ru)
Some hormones produced by the pituitary directly alter the behavior of specific cells in tissues to generate physiological changes, whereas other pituitary hormones trigger cells in other organs to release hormones which change cell behavior. (tomsk.ru)
The anterior pituitary or adenohypophysis is a collection of cells that secrete hormones to control the activities of cells in other endocrine organs. (tomsk.ru)
Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. (medlineplus.gov)
Four of the six anterior pituitary hormones are tropic hormones that regulate the function of other endocrine organs. (wikipedia.org)
Thyroid tissue consists of follicles with a stored protein called colloid, containing[thyroglobulin], a precursor to other thyroid hormones, which are manufactured within the colloid. (wikipedia.org)
Endocrine tissue produces hormones such as insulin and glucagon to help the body regulate sugar. (bidmc.org)
5. Fill in the following table with the endocrine organ the hormones are produced by. (wikieducator.org)
We thought adipose tissue was simply an insulator to protect us from cold and damp, and a triglyceride storage organ, but it became clear exactly 20 years ago that adipose tissue produces hormones such as leptin and signals the energy status to the brain and other organs. (medscape.com)

Tissue-Specific Tumorigenesis in Multiple Endocrine Neoplasia Type I. (netrf.org)
The most common sign of multiple endocrine neoplasia type 2 is a form of thyroid cancer called medullary thyroid carcinoma. (medlineplus.gov)
Multiple endocrine neoplasia type 2 is divided into three subtypes: type 2A, type 2B (formerly called type 3), and familial medullary thyroid carcinoma (FMTC). (medlineplus.gov)
The signs and symptoms of multiple endocrine neoplasia type 2 are relatively consistent within any one family. (medlineplus.gov)
Multiple endocrine neoplasia type 4 appears to have signs and symptoms similar to those of type 1, although it is caused by mutations in a different gene. (medlineplus.gov)
multiple endocrine neoplasia type 2 affects an estimated 1 in 35,000 people. (medlineplus.gov)
The prevalence of multiple endocrine neoplasia type 4 is unknown, although the condition appears to be rare. (medlineplus.gov)
Mutations in the MEN1 gene cause multiple endocrine neoplasia type 1. (medlineplus.gov)
The loss of functional menin allows cells to divide too frequently, leading to the formation of tumors characteristic of multiple endocrine neoplasia type 1. (medlineplus.gov)
Mutations in the RET gene cause multiple endocrine neoplasia type 2. (medlineplus.gov)
We report a case of multiple endocrine neoplasia type 2B who presented with multiple keloids. (ispub.com)
We describe a patient with multiple endocrine neoplasia type 2B who presented with multiple keloids. (ispub.com)

Endocrine organs that create expanded amounts of hormone are considered hyperfunctional and may experience hypertrophy, and hyperplasia the hyperfunction may be essential, caused by a few anomaly inside the organ itself, or auxiliary caused by changes within the serum concentration of a substance that regularly controls the hormone and may in turn be regulated by the hormone. (alliedacademies.org)
All vertebrates have adrenal organ tissue, with warm blooded animals one of a kind in having it organized into layers [ 3 ]. (alliedacademies.org)
Because a great many organ systems and varieties of tissues are represented within the mediastinum, tumors that occur in this area can represent many different clinical entities and pathologic processes. (medscape.com)
The pituitary gland is the central organ of the endocrine system as it provides an interface between the nervous system and cells in several different organs and tissues. (tomsk.ru)
Sickle cell disease (SCD) is an autosomal, recessive hemoglobinopathy characterized by hemolytic anemia, intermittent occlusion of small vessels leading to acute and chronic tissue ischemia, and organ dysfunction. (medscape.com)
Endocrine dysfunction is the most common and earliest organ toxicity seen in subjects with chronic iron-induced cellular oxidative damage and can be seen in those without clinical evidence of iron overload. (medscape.com)
The predicted risks of iron overload and endocrine organ failure increase with both the duration of disease requiring transfusion therapy and the number of transfusions. (medscape.com)
Sickle cell disease (SCD) is a hereditary hemoglobino pathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small vessels, leading to acute and chronic tissue ischemia, chronic organ damage, and organ dysfunction. (medscape.com)
4 5 Adipose tissue is an active endocrine organ, heterogeneous with respect to embryonic origin, body distribution and function. (bmj.com)
We have learned during the past 10-15 years so much about adipose tissue as an active endocrine organ. (medscape.com)
It is only 20-30 g of tissue weight per body, so we are not talking about a big organ here. (medscape.com)

Along with the nervous system, the endocrine system coordinates the activities of cells in different organs and tissues to control physiological parameters or generate system-wide responses to environmental changes. (tomsk.ru)
tumors can also develop in other organs and tissues. (medlineplus.gov)

Overproduces hormone in animals by disrupted endocrine tissue. (alliedacademies.org)
Clayton M. Overproduces hormone in animals by disrupted endocrine tissue. (alliedacademies.org)
The foremost common sorts of endocrine malady are hormonal overproduction related with hyperplastic tissue fabricating intemperate sums of hormone and hormonal lack due to devastation of the endocrine tissue source, infections related with hormonal overproduction are hyperthyroidism in cats and hyperadrenocorticism in dogs. (alliedacademies.org)
Hormone receptors in the endocrine system often trigger changes in gene expression to alter the activities of key biochemical or physiological pathways. (tomsk.ru)
Somatotropic hormone or growth hormone (GH) is an anabolic hormone that stimulates the growth of all body tissues especially skeletal muscle and bone. (wikipedia.org)
He explained that endocrine disruption is a form of toxicity where the endogenous hormone system is affected by these disruptors. (biobankonline.com)
Hormone (endocrine) health. (upmc.com)

Most T4 is converted to T3 (a more active form) in the target tissues. (wikipedia.org)
Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
Wild-type (WT) AAV serotypes exhibit different tissue tropism due to different capsid protein sequences or variable regions interacting with disparate cell surface receptors, and thus can be utilized for different target tissues 3 . (nature.com)

The circadian clock regulates metabolism and energy homeostasis in peripheral tissues by mediating activity and/or expression of key metabolic enzymes and transport systems. (huji.ac.il)
In addition, key proteins play a dual role in regulating the core clock mechanism, as well as adipose tissue metabolism, and link circadian rhythms with lipogenesis and lipolysis. (huji.ac.il)
The endocrine cell population accounts for only a small part of the pancreas but is of paramount importance for the human metabolism. (snmjournals.org)
This study will be of high interest to those in the adipose tissue biology and metabolism fields. (elifesciences.org)
Vitamin A metabolism, adipose tissue as an actively secreting endocrine tissue and cerebral venous abnormalities are areas of active study regarding the pathophysiology of idiopathic intracranial hypertension. (bmj.com)

Supportive and Connective Tissues. (rincondelvago.com)

Notably, recent studies suggest that the accumulation of sphingolipids, namely ceramides and it's metabolites, play essential roles in the development of insulin resistance in tissues such as skeletal muscle, liver and, adipose tissue in obese rodents, and humans ( 6 - 20 ). (frontiersin.org)
Moreover, we hypothesized that these mice would have accumulation of TGs in other tissues, such as the liver or skeletal muscle, resulting in lipotoxicity and metabolic derangements, such as insulin resistance or fatty liver disease. (elifesciences.org)

Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)

We demonstrated that AAV9 capsid modified with N -ethyl Maleimide (NEM) increased its tropism more towards murine bone marrow (osteoblast lineage ) while decreased transduction of liver tissue compared to the unmodified capsid. (nature.com)
GH is needed to stimulate growth of bone and other tissues. (uhhospitals.org)

What is an endocrine disruptor? (biobankonline.com)
It also shows a high unintended biological activity as a potent inhibitor of the soluble epoxide hydrolase (sEH) and may be an endocrine disruptor. (cdc.gov)

What tissues make up the endocrine system? (tomsk.ru)
These alterations can be in the form of agonistic or antagonistic effects or by disrupting the endocrine system balance. (biobankonline.com)
It is now under intense investigation as an experimental tool to test cellular 3D auto-assembly of thyroid tissue and its related vascular system up to the ex situ generation of a 3D macroscopic thyroid gland. (unibas.ch)
Here, we describe a 3D culture system that supports the expansion of adult human pancreatic tissue and the generation of a cell subpopulation with progenitor characteristics. (prinsesmaximacentrum.nl)
The PET tracer 11 C-5-HTP can be used for quantitative imaging of the serotonergic system in the endocrine pancreas. (snmjournals.org)
Detailed information on the endocrine system, its anatomy and function, including a full-color, labeled illustration. (uhhospitals.org)

Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
The adipose tissue participates in numerous endocrine functions via the secretion of bioactive molecules, such as adipokines [ 10 ]. (plos.org)
Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. (wjgnet.com)
Conclusion Rheumatoid AAT is highly reactive tissue which upon stimulation secretes considerable amounts of proinflammatory (IL-6, IL-8, TNF) and anti-inflammatory (IL-1Ra) cytokines and classical adipokines. (bmj.com)
Recently, adipose tissue has been shown to synthesise and release highly bioactive substances: classical adipokines (eg, leptin, adiponectin) and various proinflammatory factors such as cytokines, chemokines, growth factors and complement components. (bmj.com)

A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
5 , - , 9 This loose connective tissue is composed of extracellular matrix and various types of cells: fat cells-named adipocytes, and the non-fat cells of the stromal vascular fraction that contains preadipocytes, capillary endothelial cells, infiltrating leucocytes and multipotent stem cells. (bmj.com)
The physical substance of the human organism, composed of living cells and extracellular materials and organized into tissues, organs, and systems. (rincondelvago.com)

Lymphomas, primary or ectopic endocrine tumors, and a wide variety of mesenchymal tumors can occur in the mediastinum. (medscape.com)
In obesity the inherent capacity of adipose tissue to store and sense nutrients is compromised, causing spillover of the intermediate lipid metabolites into circulation and resulting in their ectopic deposition in tissues not suitable for lipid storage, a phenomenon known as lipotoxicity. (frontiersin.org)

Conversely, insufficient TG storage such as occurs in lipodystrophy is usually associated with adipocyte endocrine deficiency and similar metabolic derangements. (elifesciences.org)

The major forms of multiple endocrine neoplasia are called type 1, type 2, and type 4. (medlineplus.gov)
Many different types of tumors are associated with multiple endocrine neoplasia. (medlineplus.gov)
Mutations in the MEN1 , RET , and CDKN1B genes can cause multiple endocrine neoplasia. (medlineplus.gov)
The association of multiple endocrine neoplasia (MEN) and keloids has not been described. (ispub.com)
A 31-year-old white Caucasian with a history of prophylactic total thyroidectomy at the age 8 after her mother was diagnosed in her 30's with multiple endocrine neoplasia (MEN) 2B (metastatic medullary thyroid carcinoma and pheochromocytoma). (ispub.com)
Multiple endocrine neoplasia (MEN) syndromes consist of rare, autosomal dominant mutations in genes regulating cell growth. (ispub.com)

Serotonergic biosynthesis in the endocrine pancreas, of which the islets of Langerhans is the major constituent, has been implicated in insulin release and β cell proliferation. (snmjournals.org)

Clocks similar to the one located in the SCN are found in peripheral tissues, such as the kidney, liver, and adipose tissue. (huji.ac.il)
CB1 antagonism may have potential in the metabolic syndrome, with effects mediated through central orexigenic mechanisms and via peripheral action on white adipose tissue (WAT). (endocrine-abstracts.org)
Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipogenesis, lipolysis, and oxidation of fatty acids. (wjgnet.com)

Symptomatic patients might have any of the characteristic manifestations of systemic iron overload: liver disease with the eventual development of cirrhosis and hepatocellular carcinoma, arthropathy, increased skin pigmentation, cardiomyopathy, diabetes mellitus, gonadal insufficiency and other endocrine disorders. (medscape.com)
Exceeding the capacity to store TG in adipocytes occurs in obesity and is often accompanied by deposition of TG in other tissues and metabolic diseases, such as diabetes mellitus or non-alcoholic fatty liver disease. (elifesciences.org)

This article describes the endocrine and metabolic disorders reported in patients with SCD, discusses their management, and identifies gaps in current knowledge and opportunities for future research. (medscape.com)
Endocrine disorders. (differencebetween.net)

Equivalent studies in brown adipose tissue (BAT) are lacking.ObjectiveWe aimed to compare CB1 and CB2 receptor expression during WAT and BAT adipogenesis and to investi. (endocrine-abstracts.org)
How Much Brown Adipose Tissue Do We Have? (medscape.com)
Is it brown adipose tissue? (medscape.com)
One of the emerging research fields in understanding adipose tissue biology is to investigate brown adipose tissue. (medscape.com)
We know that brown adipose tissue may protect rodents (such as mice and rats) from the cold in winter. (medscape.com)
They have a lot of brown adipose tissue in the interscapular region-the neck region-because brown adipose tissue produces heat. (medscape.com)
We thought that brown adipose tissue was something that we wouldn't find in adult humans. (medscape.com)
We know that newborns have a lot of brown adipose tissue because they cannot produce heat by muscle shivering. (medscape.com)
So newborn humans also have brown adipose tissue, but it is lost rapidly during the first 1-2 years of life. (medscape.com)
Recently, it was discovered that even adult humans may have brown adipose tissue. (medscape.com)
Absolutely, and it is difficult to quantify with any of the measurement scales that we have, so we need sophisticated methods such as PET-CT to discover brown adipose tissue. (medscape.com)
One talk in the session was about the seasonal expression of brown adipose tissue. (medscape.com)

More rarely, the masses found are associated with aberrant parathyroid or thyroid tissue. (medscape.com)
Studies performed on rats and on thyroid tissue samples suggest that PABA may disrupt thyroid activity. (safecosmetics.org)
The structural specificity of sulfanilamide-like compounds as inhibitors of the invitro conversion of inorganic iodide to thyroxine and diiodotyrosine by thyroid tissue. (safecosmetics.org)

Tumors originating from lymphatic, vascular, or mesenchymal tissues can also be found in this compartment. (medscape.com)
It is unclear why these tumors preferentially affect endocrine tissues. (medlineplus.gov)

Endocrine lineage markers were detected upon in vitro differentiation. (prinsesmaximacentrum.nl)
We conclude that adult human pancreatic tissue has potential for expansion into 3D structures harboring progenitor cells with endocrine differentiation potential. (prinsesmaximacentrum.nl)
Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
Recently, the role of the circadian clock in regulating the differentiation into the different adipose tissues has been investigated. (huji.ac.il)
In this review, the role of clock proteins and the downstream signaling pathways in white, brown, and brite adipose tissue function and differentiation will be reviewed. (huji.ac.il)

The histology was atypical with pronounced proliferation of endocrine cells comprising >70% of the pancreatic tissue and a small pancreatoblastoma. (lu.se)

The islets of Langerhans are the major constituent of the neuroendocrine pancreas, and neuronal tissue makes up the remaining part. (snmjournals.org)
Uptake of 11 C-5-HTP in the normal human pancreas is generally high, but this has not previously been systematically investigated despite the fact that islets and some neuronal tissue constitute the only amine precursor uptake and decarboxylase tissue within the pancreas. (snmjournals.org)

Exocrine tissue produces digestive juices (or enzymes) to help digest food. (bidmc.org)

Trauma, foreign-body reactions, infections, and endocrine dysfunction have all been proposed as precipitating factors. (ispub.com)

Interestingly, gene expression profiling revealed that ALDH hi cells are closer to human fetal pancreatic tissue compared with adult pancreatic tissue. (prinsesmaximacentrum.nl)
In the context of β cell replacement therapy for diabetes, de Koning and colleagues describe a 3D culture platform that supports ex vivo expansion of human pancreatic tissue as organoids. (prinsesmaximacentrum.nl)
70% of the pancreatic tissue and a small pancreatoblastoma. (lu.se)
Routine genetic analysis for CHI was normal in the blood and resected pancreatic tissue. (lu.se)
A next generation sequencing panel with 303 SNPs on 21 chromosomes showed pUPD in both blood and pancreatic tissue. (lu.se)

The favorable metabolic phenotype resulted from activation of energy expenditure, in part via BAT activation and beiging of white adipose tissue. (elifesciences.org)

Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. (hindawi.com)

She was diagnosed with recurrent pheochromocytoma and then underwent a left cortical sparing adrenalectomy with implantation of adrenal tissue in the left forearm. (ispub.com)

The LC-MS/MS analysis of water and tissues provided bioconcentration of TCC and its metabolites in fish body and rapid excretion into culture water. (cdc.gov)

But with an autoimmune disease, it makes antibodies that attack the body's own tissues. (uhhospitals.org)

In addition, NPY and a structurally related peptide, peptide YY (PYY), containing endocrine cells have been identified in the periphery. (nih.gov)
Current technical options for reconstruction of endocrine viscera include either biocompatible 3D reticular scaffolds lacking any organomorphic geometry, or allogenic/xenogenic acellular 3D matrices derived from a gland similar to that to be bioengineered, eventually recellularized by autologous/heterologous cells. (unibas.ch)
These organoids harbor a subpopulation of ALDH hi cells that display proliferative capacity and can differentiate to an endocrine fate. (prinsesmaximacentrum.nl)
For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
In vitro tracer uptake in endocrine cells (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellular conversion into serotonin. (snmjournals.org)

Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)

Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)

Keloids are benign fibrous growths that result from an abnormal connective tissue response in certain predisposed individuals. (ispub.com)

In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)

Because energy sources are not always available from the environment, many metazoan organisms have evolved the ability to store large amounts of metabolic energy as triglycerides (TG) in adipose tissue. (elifesciences.org)

An Endocrine Disruptors Testing and Assessment Advisory Group (EDTA AG) has been established for 20 years and has been working on both in vitro and in vivo validation along with new approach methods (NAMs). (biobankonline.com)

Despite the fast pace of success for AAV vectors, unresolved challenges still exist such as limited tropism, poor transduction efficacy in certain tissues, pre-existing neutralizing antibodies (NAbs), and high vector dosage 2 . (nature.com)

Endocrine 66 (2), 405-415 (2019). (springer.com)

Alison's previous wet-lab research interests lie in adipose tissue regulation, obesity and developmental origins of health and disease. (nottingham.ac.uk)

Anatomy14

Diseases22

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes3

Disciplines and Occupations2

Information Science2

Glands7

Hormones13

Multiple endocrine neop12

Organ11

Organs and tissues2

Hormone7

Target tissues3

Metabolism5

Connective tissues1

Skeletal2

Tumor2

Bone2

Disruptor2

System6

Adipokines5

Extracellular3

Ectopic2

Adipocyte1

Neoplasia6

Insulin1

Peripheral3

Liver2

Disorders2

Brown adipos12

Thyroid tissue3

Tumors2

Differentiation5

Histology1

Neuronal2

Digestive1

Dysfunction1

Pancreatic tissue5

White Adipos1

Physiological1

Adrenal Tissue1

Excretion1

Body's1

Cells5

Degradation2

Secretion1

Growths1

Metabolic diseases1

Triglycerides1

Vitro1

Antibodies1

20191

Obesity1