Endocrine diethylhexyl phthalate. Medical search. Frequent questions

One such chemical, di-ethylhexyl phthalate - DEHP - can cause cancer. (debuglies.com)
One phthalate appeared in higher levels than the others: DEHP - the cancer-causing phthalate. (debuglies.com)
After days with preschool attendance, lower urinary concentrations of metabolites originating from DEP and phthalates that are strictly regulated within the EU REACH legislation (DEHP, DnBP, and DiBP) and higher concentrations of metabolites originating from DiNP, DPHP, and DiDP, i.e. less or non-regulated phthalates were found compared the urinary concentrations of these metabolites in weekends. (lu.se)
Di (2-ethylhexyl) phthalate (DEHP) is a neuroendocrine disruptor that can cause multi-tissue organ damage by inducing oxidative stress. (bvsalud.org)
We investigated BBB damage by di-(2-ethylhexyl) phthalate (DEHP) or its metabolite mono-(2-ethylhexyl) phthalate (MEHP) using brain endothelial cells and rat models. (bvsalud.org)
B. Braun is reviewing its entire portfolio of products and focusing on eliminating chemicals of concern, such as Diethylhexyl phthalate (DEHP) or polyvinyl chloride (PVC) plastic. (jhconline.com)
DEHP is an ortho-phthalate that's considered to be a carcinogenic, reprotoxic, and endocrine disrupting chemical (EDC), linked to a growing list of illnesses and disorders that afflict people," Kentner said. (jhconline.com)
We're assessing our products for changes in materials, especially in the case of ortho-phthalate plasticizers like DEHP. (jhconline.com)
Proposition 65 Warnings Office of Environmental Health Hazard Assessment: Di(2-ethylhexyl)phthalate (DEHP). (jhconline.com)
4) DEHP (di-2-ethyl-hexyl-phthalate) is now prohibited by the Cosmetics Ingredient Hotlist and has been classified as a probable human carcinogen by the International Agency for Research on Cancer. (sustainablog.org)
Diethylhexyl-phthalate (DEHP) is a widely used plastic additive. (greenfacts.org)
In yet another episode of 'I can't figure out a legitimate research project, so I'll pick on phthalates,' a group from Germany has concluded, based on minimal data and a host of confounding factors, that infusion systems containing the phthalate DEHP increase the risk for a certain liver disease in neonates. (shawsecologic.com)
There is sufficient evidence in rodents that phthalate exposure causes developmental and reproductive toxicity.The curated interactions between 16 phthalates and genes/proteins were obtained from Comparative Toxicogenomics Database (CTD), and a total of 445 interactions between the five most frequently curated phthalates (DEHP/MEHP and DBP/BBP/MBP) and 249 unique genes/proteins were found. (ntnu.edu.tw)
Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in polyvinyl chloride products. (biomedcentral.com)
Because cyclooxygenase-2 (COX-2) dependent prostaglandin synthesis is implicated in preterm birth, we evaluated effects of mono-2-ethylhexyl phthalate (MEHP), the active metabolite of DEHP, on prostaglandin E2 (PGE2) synthesis and COX expression in human placental macrophages (PM). In addition, responses in PM were compared to those in a human macrophage-like cell line, THP-1. (biomedcentral.com)
Following oral exposure, DEHP is quickly metabolized by gut lipases to its active metabolite, monoethylhexyl phthalate (MEHP), and excreted in the urine. (biomedcentral.com)
The 6 phthalates were dimethyl phthalate (DMP), diethyl phthalate (DEP), dibropyl phthalate (DBP), benzyl-bropyl phthalate (BBP), diethyl-hexyl phthalate (DEHP) and di-n-octyl phthalate (DnOP). (juniperpublishers.com)
Search for phthalates in bottled edible oils showed no significance, while some bottled beverages and soft drinks revealed traces of DEHP. (juniperpublishers.com)
Moreover, infants and hospitalized children are in particular more exposed to phthalates, because most of medical devices and tubing contain more than 50% DEHP which could easily leached out when using warm saline and/ or blood (Sathyanarayana, 2008). (juniperpublishers.com)

As children are particularly vulnerable to the effects from exposure to endocrine disrupting chemicals (EDCs), it is essential to monitor exposure to EDCs such as phthalates and non-phthalate plasticizers in indoor environments intended for use by children. (lu.se)
The aim of this peer reviewed comparison is to put in perspective the potential dangers and risks of four phthalates used mainly as plasticizers in PVC applications and help the non specialist reader to make its opinion in these matters. (greenfacts.org)
Phthalates are widely used as plasticizers to soften and increase the flexibility in polyvinyl chloride plastics, but they can leach into the surrounding environment. (ntnu.edu.tw)
Plastic bottles and packaging food containers contained up to 60% by weight of plasticizers, most commonly phthalate esters. (juniperpublishers.com)
BACKGROUND: Some phthalates are endocrine disrupting chemicals used as plasticizers in consumer products, and have been associated with obesity in cross-sectional studies, yet prospective evaluations of weight change are lacking. (cdc.gov)

Some of these proposed pathways include inappropriate modulation of nuclear receptor function which therefore allows the compounds to be classified as endocrine disrupting chemicals that act to mimic hormones in the body, altering the normal homeostasis maintained by the endocrine system. (wikipedia.org)
Obesogens have been detected in the body both as a result of intentional administration of obesogenic chemicals in the form of pharmaceutical drugs such as diethylstilbestrol, selective serotonin reuptake inhibitors, and thiazolidinedione and as a result of unintentional exposure to environmental obesogens such as tributyltin, bisphenol A, diethylhexylphthalate, and perfluorooctanoate. (wikipedia.org)
The study, published online in the journal Environmental Sciences: Process Impacts , is the first of its kind to show that microbes can break down these chemicals, called phthalates. (debuglies.com)
The term covers an entire group of chemicals, and studies have shown that they can affect the human endocrine system, which includes human reproductive organs. (debuglies.com)
Triclosan has also been linked with endocrine and thyroid function disorders and, in 2015, the European Chemicals Agency recommended its use be phased out across the continent due to the recognized risk of repeated use. (newwaytoclean.com)
So, it's a huge relief to know I can trust that Norwex skincare products are free of SLS, SLES, parabens, phthalates, mineral oil, propylene glycol, synthetic dyes and other questionable chemicals. (newwaytoclean.com)
Several plasticizing chemicals induce endocrine disrupting effects in humans, and the indoor environment is suggested to be a source of exposure. (lu.se)
Phthalates in contaminated foods and personal care products are one of the most frequently exposed chemicals with a public health concern. (bvsalud.org)
Phthalates are chemicals used to make products more pliable and to increase the performance of synthetic fragrances to make them last longer. (naturiabeauty.com)
That was the discovery that fetal rats exposed to phthalates 18 to 21 days after mating were more likely to be born with malformed genitals, but the ones that were exposed to those endocrine-disrupting chemicals before or after that window didn't have the problem, right? (theintercept.com)
In 2000, a colleague from the Centers for Disease Control and Prevention told me they were able to measure lots of chemicals, including phthalates, at low doses for little cost in lots of people. (theintercept.com)
Our work has shown that chemicals, including the diethylhexyl phthalate , shorten the AGD in males. (theintercept.com)
Anyway, tell me about the relationship between endocrine disrupting chemicals and how children play? (theintercept.com)
A growing body of evidence shows that Americans receiving care in hospitals and other settings can be exposed to dangerous levels of phthalates, a family of industrial chemicals used to soften PVC. (jhconline.com)
Endocrine disruptors are chemicals that can influence the functioning of the system of hormones and receptors that regulate the body. (greenfacts.org)
While there are many endocrine disrupting chemicals, xenoestrogens are one of the most important. (archetypeltd.co.nz)
PhD studentship (with the Salmon and Trout Association) - Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors. (exeter.ac.uk)
Agay‐Shay K, Martinez D, Valvi D, Garcia‐Esteban R, Basagana X, Robinson O, Casas M, Sunyer J, Vrijheid M. Exposure to endocrine‐disrupting chemicals during pregnancy and weight at 7 years of age: A multi‐pollutant approach. (comprehensivephysiology.com)
an ambiguous term where many toxic chemicals are hidden under, fragrance oils are synthetically produced using petroleum or coal tar, containing phthalates - a plasticizing material used in polyvinyl chloride PVC which can mess with the endocrine system. (sunsaraspa.com)

Compared to previous Swedish and international studies performed during approximately the same time period, high urinary concentrations of monobenzyl phthalate (MBzP), a metabolite from the strictly regulated BBzP, were measured in this study (median 17 ng/mL). (lu.se)
Overall, high urinary phthalate metabolite concentrations were observed in this study compared to the US CDC-NHANES from the same time period and similar age-group. (lu.se)

Edebere okwu endocrine disruptor na 1991 na Wingspread Conference Center na Wisconsin. (wikipedia.org)
other chemical compounds accept normal hazards: Phthalates, for example, which are often found in artificial fragrances , are a class of hormone disruptor which may also be affiliated to birth defects, agent harm, infertility, and the feminization of child boys, for example. (platinumdelux.com)

na nyocha ahụike mmadụ "iji tinye kemịkalụ na-akpaghasị endocrine (EDCs) dị ka ihe na-emetụta ahụike ọha. (wikipedia.org)

A simple and reliable method of analysis using GC-MS was validated and applied to detect the most common phthalate esters used in manufacturing of different sizes of bottles and/or packaging food containers. (juniperpublishers.com)
An applied method showed a detection limit of 25ng/ul with recovery percentages ranged between 90.6±6.9 depending upon the kind and type of the 6 studied phthalate esters. (juniperpublishers.com)
So, the short alkyl chain phthalate esters were not detected, only long alkyl chain phthalates were released to the inner drinking water. (juniperpublishers.com)
This article focuses more particularly on heavy metals, polycyclic aromatic hydrocarbons, mineral oils, phthalates and 3-MCPD or glycidyl esters. (ocl-journal.org)

New research even shows that exposure to phthalates has been linked to disorders such as reduced semen quality (5), reduced angogenital distance (6) as well as testicular cancer (7). (sustainablog.org)
Yet our intrepid team thinks that exposure to phthalates could be the key. (shawsecologic.com)

and di-ethyl phthalate, DEP) and one non-phthalate plasticizer (di-isononyl cyclohexane 1,2-dicarboxylate, DiNCH) were measured in 206 urine samples collected at four occasions, i.e. twice during the winter and twice during the spring from 54 children (mean 5.1 years, SD 0.94) enrolled at eight preschools in Sweden. (lu.se)
lubricant leak during the process may contaminate the oil and contact with plastic material may lead to plasticizer migration such as phthalates. (ocl-journal.org)

They have been found to have endocrine disruption effects, and have been linked with endometriosis and early puberty in girls, and reproductive organ abnormalities and reduced fertility in males. (brooklantree.com.au)
Grün and Blumber's study titled, " Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling ," confirmed that the calories-in-calories-out model might not be the full story. (connersclinic.com)
There is an association between phthalates and endocrine disruption leading to development of breast cancer Lopez-Carillo [ 5 ]. (juniperpublishers.com)

Parabens have been reported as likely endocrine disruptors, meaning they have the potential to alter the body's hormone functions. (naturiabeauty.com)
Three of the most common xenoestrogens are the bisphenol A, phthalates and parabens. (archetypeltd.co.nz)
Unlike some of the substances and products that we readily associate with adverse effects on our health and well being - pesticides, dioxins, heavy metals, etc. - parabens, bisphenol A and phthalates are found in everyday items: our food and food containers, plastics, cosmetics and personal care products, toys. (archetypeltd.co.nz)

Science says: Numerous studies have tied phthalates to reproductive and endocrine disorders. (newwaytoclean.com)

Thus, the top 34 genes/proteins may serve as molecular biomarkers of phthalate toxicity.The top three phthalate toxicity categories were found to be cardiotoxicity, hepatotoxicity and nephrotoxicity, and the top 20 diseases included cardiovascular, liver, urologic, endocrine and genital diseases. (ntnu.edu.tw)

Our objective was to evaluate associations between phthalate biomarker concentrations and weight and weight change among postmenopausal women. (cdc.gov)

This study may provide novel insights into enhancing phthalate toxicity in susceptible populations, such as diabetic patients. (bvsalud.org)

Since the Grün and Blumberg study, the term "obesogen" has begun to appear in the scientific literature and, today, many other toxins have joined the ranks of obesogens, such as tributyltin, diethylhexylphthalate and perfluorooctanoate, with more research surfacing. (connersclinic.com)

We measured 13 phthalate metabolites and creatinine in spot urine samples provided at baseline. (cdc.gov)

The biggest concern with phthalates is they are linked to bioaccumulation, which means they absorb at a rate faster than our body can expel them so they build up and become trapped in the body forever! (brooklantree.com.au)

The findings from this study are the first to demonstrate phthalate-stimulated PGE2 synthesis in PM and warrant future studies into COX-2-dependent prostaglandin synthesis as a mechanism of toxicant-associated preterm birth. (biomedcentral.com)

They found microbes, of course, and phthalates. (debuglies.com)
Phthalates are used as plasticisers and solvents, and can be found in fragrances, hair products, skin lotions, nail polish and nail hardeners. (brooklantree.com.au)
Yes, we found a relationship between women's phthalate levels and their sexual satisfaction. (theintercept.com)

There's plenty of evidence to suggest carcinogenicity and likely toxic to the endocrine system (hormone disruptors). (naturiabeauty.com)
A consumer advocate displays toys that contain high amounts of lead and toxic phthalates at a news conference in Seattle, Wash., on Nov. 25, 2008. (theintercept.com)

Ụfọdụ ndị na-akpaghasị usoro endocrine achọpụtala ma wepụ ya n'ahịa (dịka ọmụmaatụ, ọgwụ a na-akpọ diethylstilbestrol), mana ejighị n'aka ma ụfọdụ ndị na-akpaghasị usoro endocrine n'ahịa na-emerụ mmadụ na anụ ọhịa n'ezie na doses nke anụ ọhịa na ụmụ mmadụ na-ekpughere. (wikipedia.org)
It is worth noting that virtually all attempts to match rodent responses to phthalates (typically at high doses) to what happens in human exposure to these compounds have failed. (shawsecologic.com)

Endocrine disruptors or xenohormones are exogenous substances - substances from outside the body that can bind with or block hormone receptors, disrupting or mimicking the production or action of our own hormones. (archetypeltd.co.nz)

Phthalates are most commonly used to make plastics and vinyl. (debuglies.com)

Phthalate exposure is related to cardiovascular diseases, including diabetic vascular complications and cerebrovascular diseases, yet the mechanism is still unclear. (bvsalud.org)

What if I could see those in humans and link them to phthalates? (theintercept.com)
However, the intake of phthalates contained in the food is still the most significant route of exposure for humans. (juniperpublishers.com)

When we help customers develop people-friendly spaces, we want to ensure indoor air quality, health, and well-being with phthalate-free design solutions as well as products having low and/or non-detectable Volatile Organic Compounds (VOCs) emissions. (allergystandards.com)
Portable RoHS analyzers, also known as X-ray fluorescence or XRF metal analyzers, are used to screen and verify restricted metals, with the advent of RoHS 3 and the four phthalates, different tests are required to determine these The content of compounds that are extracted with a solvent. (kingfordpcb.com)

Scientists generally recommend that children and pregnant women avoid phthalate exposure. (newwaytoclean.com)
What is even worse is the fact a pregnant mother's phthalate levels (look at how many are continually drinking from plastic water bottles, etc., thinking that it's something healthful) hugely influence not only the development of the child's brain and glands, but even future fertility and cancers in their unborn children, not to mention, of course, obesity. (holisticthyroidcare.net)

Ndị na-akpaghasị ọrịa endocrine, mgbe ụfọdụ a na-akpọkwa ya dị ka ndị na-arụ ọrụ nke homonụ, endocrine na-akpaghasị kemịkalụ, ma ọ bụ endocrin na-akpaghasị ogige bụ kemịkalụ nwere ike igbochi usoro endocrine (ma ọ bụ hormonal). (wikipedia.org)
Have endocrine disruptors affected wild life and our hormonal system? (greenfacts.org)

In light of these concerns, several phthalates have been banned for use in cosmetics in Australia: dibutylphthalate, diethylhexylphthalate, diisobutylphthalate and di(methyloxyhexyl)phthalate. (brooklantree.com.au)
Diethyl phthalate, which is used as a binding agent in some fragrances and cosmetics. (conklelaw.com)

synthetic fragrances, which often comprise phthalates, can additionally trigger allergy symptoms and different health complications. (platinumdelux.com)

Also, women may be at high risk for potential adverse health effects of phthalates due to increased and excessive cosmetic usage. (juniperpublishers.com)
The cumulative effects of phthalates have similar mechanisms of action to other anti-androgens. (juniperpublishers.com)

Nervous system, endocrine system. (h2odistributors.com)
The human endocrine system is made up of a variety of glands that secrete hormones (the pituitary, thyroid, ovaries, testes, adrenals, etc.) and receptor cells which detect and react to those hormones. (archetypeltd.co.nz)

Phthalates are the highest pollutant in the body being over 10,000 times higher than any of the thousands of other environmental toxins. (holisticthyroidcare.net)
The bottom line is many people will never lose weight or solve their medical problems because they have not gotten rid of the phthalates and other environmental pollutants that have damaged their chemistry and genetics. (holisticthyroidcare.net)

Ogige ndị na-akpaghasị Endocrine gụnyere klaasị kemịkalụ dị iche iche, gụnyere ọgwụ, ọgwụ pesticides, ogige ndị a na-eji na ụlọ ọrụ rọba na ngwaahịa ndị ahịa, ngwaahịa sitere na ụlọ ọrụ mmepụta ihe na mmetọ, na ọbụna ụfọdụ kemịkalụ botanical emepụtara. (wikipedia.org)

Then, they stored the pieces of carpet at varying levels of humidity to see how the microbes and phthalates might interact. (debuglies.com)

He said I should study phthalates. (theintercept.com)

Such traces of phthalates reached its maximum with low pH beverages "orange juice" of small size bottles ≤1 liter after 3 months of packaging. (juniperpublishers.com)

All of that was on the researchers' minds when they started looking into ways phthalates might break down indoors. (debuglies.com)

The ovaries are responsible for regulating reproduction and endocrine function. (mdpi.com)

However, this work mentions 'phthalate' once, and this referred only to rodent studies, as drawn from a textbook published in 1998. (shawsecologic.com)

Anatomy2

Diseases2

Chemicals and Drugs5

DEHP19

Plasticizers5

Chemicals19

Metabolite2

Disruptor2

EDCs1

Esters4

Exposure to phthalates2

Plasticizer2

Disruption3

Parabens3

Reproductive1

Biomarkers1

Concentrations1

Toxicity1

Obesogens1

Metabolites1

Concern1

Synthesis1

Found3

Toxic2

Doses2

Exogenous1

Commonly1

Cardiovascular1

Humans2

Compounds2

Pregnant2

Hormonal2

Cosmetics2

Synthetic1

Effects2

System2

Environmental2

Pesticides1

Levels1

Study1

Bottles1

Researchers1

Function1

Work1