Endocrine agents. Medical search. Frequent questions

Moore agreed, explaining that although the strategy of switching endocrine therapy or the CDK4/6 inhibitor is often employed, there are very little data guiding those decisions. (medpagetoday.com)

According to the NIEHS , there is limited research to show how endocrine disruptors affect humans, but some research has found they can harm animals. (medicalnewstoday.com)
An in vitro model system (immortalised Sertoli cells) will be used to verify the possible link of hormonal regulation of connexins with endocrine disruptors. (cefic-lri.org)
Endocrine disruptors (EDs) are exogenous compounds that act like hormones in the endocrine system and disrupt the physiologic function of endogenous hormones. (mdpi.com)
Evidence that certain man-made chemicals have the ability to disrupt the endocrine systems, by mimicking endogenous hormones, sparked intense international scientific discussion and debate some fifteen years ago, culminating in language in legislation that reauthorized the Safe Drinking Water Act and authorized the 1996 Food Quality Protection Act, mandating that the Environmental Protection Agency (EPA) develop a screening program for endocrine disruptors. (mdpi.com)

The development and improvement of innovative proteomic technologies is also encouraged through their application to relevant biological questions related to the pathophysiology of endocrine glands, gastrointestinal tract, liver and kidney, bladder and prostate. (nih.gov)
Overview of Adrenal Function The adrenal glands, located on the cephalad portion of each kidney (see figure ), consist of a Cortex Medulla The adrenal cortex and adrenal medulla each have separate endocrine functions. (msdmanuals.com)
Polyglandular Deficiency Syndromes Polyglandular deficiency syndromes are characterized by sequential or concurrent deficiencies in the function of several endocrine glands that have a common cause. (msdmanuals.com)
However, older thalassaemics may have to contend with multiple conditions including early osteoporosis, cardiac disease, pulmonary hypertension and diabetes, some of which result from increased iron deposition in the endocrine glands and myocardial cells. (who.int)

Dr. Williams specializes in developmental and reproductive toxicology, endocrine disruption, carcinogenicity mode-of-action assessments, and general toxicology related to exposure to chemical substances and physical agents. (exponent.com)
For Volume 124, the scope of the system- cancer in humans and cancer in experimental atic review encompassed a comprehensive animals formed the basis of the Working Group's search of the literature, focusing on an agent evaluation of "shift work that involves circadian name reflecting variations on "night shift work", disruption" as Group 2A. (who.int)

Most patients with hormone receptor (HR)-positive metastatic breast cancer should receive up to three lines of endocrine therapy as part of guideline-recommended care before starting chemotherapy, said Hope S. Rugo, MD, director of Breast Oncology and Clinical Trials Education at the Helen Diller Family Comprehensive Cancer Center of the University of California San Francisco. (medpagetoday.com)
Almost every patient will acquire resistance to endocrine therapy over time," Rugo told MedPage Today . (medpagetoday.com)
Some patients will develop resistance in the first year of treatment -- sometimes within months -- and some can stay on their first-line endocrine therapy for 7 to 10 years. (medpagetoday.com)
There are a variety of mechanisms believed to be responsible for acquired resistance to endocrine therapy, which is what can make it a challenge to select second-line therapy. (medpagetoday.com)
CDK4/6 inhibitors are designed to overcome resistance to endocrine therapy by interfering with cyclin-dependent kinases, which are involved with one of the cell pathways that lead to cell division. (medpagetoday.com)
All three drugs were initially approved in combination with endocrine therapy for treatment of patients who had disease progression on endocrine therapy. (medpagetoday.com)
Despite that, clinicians may still encounter women with long-term responses to endocrine therapy who have not yet been exposed to a CDK4/6 inhibitor and can thus receive these agents as second-line therapy. (medpagetoday.com)
What we don't understand now is whether all patients whose cancer progresses on a first-line CDK4/6 inhibitor combined with endocrine therapy has developed resistance to the endocrine therapy alone or also to the CDK4/6 inhibitor," Rugo said. (medpagetoday.com)
There are currently studies evaluating the use of a CDK4/6 inhibitor after progression on a CKD4/6 inhibitor combined with an alternative endocrine therapy. (medpagetoday.com)
If a patient progressed on a CDK4/6 inhibitor in combination with endocrine therapy, the next decision is based on the availability of a clinical trial, the presence of a PIK3CA mutation, and in some cases, the presence of ESR1 mutations. (medpagetoday.com)
Treatment options for breast cancer include endocrine therapy. (cochrane.org)
Endocrine therapy can also be used to prevent breast cancer for women who have not been diagnosed with breast cancer. (cochrane.org)
It would help doctors and their patients to understand whether some patients are likely to have greater benefit from endocrine therapy than others. (cochrane.org)
The structure of the breast is likely to change following endocrine therapy. (cochrane.org)
We wanted to find out whether reductions in breast density after endocrine therapy can help to determine how well endocrine therapy works. (cochrane.org)
We assessed whether a reduction in breast density after receiving endocrine therapy was associated with better outcomes. (cochrane.org)
We included studies of adult women with breast cancer if the women's breast cancer had been diagnosed at an early stage and could be treated with endocrine therapy (hormone receptor-positive breast cancer). (cochrane.org)
Most studies reported a reduced risk of breast cancer after endocrine therapy for women who had a breast density reduction compared with women who did not have a reduction. (cochrane.org)
EOP is a sub-study within the main I-SPY-2 clinical trial utilizing neoadjuvant endocrine therapy in patients whose tumors are predicted to be sensitive to endocrine therapy but for whom chemotherapy is expected to provide little or no benefit. (biospace.com)
Women need better and more tolerable options for extended endocrine therapy. (biospace.com)
Neoadjuvant endocrine therapy is an alternative to chemotherapy, but it has not shown high levels of efficacy for high-risk breast cancer, explained Gavilá. (aacr.org)
Previous studies showed that combining endocrine therapy with CDK4/6 inhibitors, drugs designed to prevent cancer cells from dividing, resulted in similar response rates to chemotherapy for metastatic breast cancers. (aacr.org)
We already knew that the combination of endocrine therapy with CDK4/6 inhibitors was efficacious in advanced breast cancers, so we were interested in investigating the efficacy of this combination for high-risk, early-stage breast cancer," explained Gavilá. (aacr.org)
Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. (kegg.jp)
The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SERMs, e.g. tamoxifen), estrogen synthesis inhibitors (e.g. aromatase inhibitors (AIs) such as anastrozole, letrozole, and exemestane), and selective estrogen receptor down-regulators (SERDs, e.g. fulvestrant). (kegg.jp)

The Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand calcium and phosphate metabolism. (massgeneral.org)
There is an unmet medical need for novel agents in life-threatening diseases and this research is vital to advancing patient outcomes. (biospace.com)
This group comprises preparations used in the treatment of neoplastic diseases, and immunomodulating agents. (whocc.no)

Invasive lobular carcinoma (ILC) of the breast typically presents with clinical biomarkers consistent with a favorable response to endocrine therapies, and over 90 % of ILC cases express the estrogen receptor (ER). (nih.gov)
Many of the agents under clinical development at the time, such as cetuximab (Erbitux) or sorafenib (Nexavar), were causing. (ascopost.com)
Our results indicate that neoadjuvant treatment with a combination of ribociclib and letrozole has similar clinical benefits as standard multi-agent chemotherapy, and with less toxicity," said Gavilá. (aacr.org)
However, resistance to these agents has become a major clinical obstacle. (kegg.jp)

To assess these mechanisms in the context of endocrine resistance, we developed novel ILC endocrine-resistant long-term estrogen-deprived (ILC-LTED) models. (nih.gov)
Fat mobilisation with insulin sensitising agents: what clues to mechanisms? (endocrine-abstracts.org)
Mechanisms of endocrine resistance include loss of ER-alpha expression, altered expression of coactivators or coregulators that play a critical role in ER-mediated gene transcription, ligand-independent growth factor signaling cascades that activate kinases and ER-phosphorylation, altered availability of active tamoxifen metabolites regulated by drug-metabolizing enzymes, such as CYP2D6, and deregulation of the cell cycle and apoptotic machinery. (kegg.jp)
The cumulative data and knowledge on the endocrine system, the mechanisms of endocrine disrupting, the impact on the public health of EDs and the regulatory responses to EDs will certain improve our understanding and predicting potential EDs and, thus, protect the public health. (mdpi.com)

Indeed, glyphosate is a powerful endocrine disrupter. (activistpost.com)
Apparently "endocrine disrupter" sounds too ominous. (grist.org)

BPA is an endocrine disruptor . (medicalnewstoday.com)

Using ILC cell lines, we previously demonstrated that ER regulates a distinct gene expression program in ILC cells, and we hypothesized that these ER-driven pathways modulate the endocrine response in ILC. (nih.gov)
WNT4 signaling may represent a novel target to modulate endocrine response specifically for patients with ILC. (nih.gov)
From endocrine-mimics that modulate nuclear receptor driven gene expression to indirectly altering homeostatic regulation of lipoprotein metabolism, transcription factor pharmacotherapy is a current reality and will increasingly contribute to the treatment of human disease. (eurekaselect.com)

Additionally, Dr. Williams has lectured on principles of basic toxicology and worked on programs related to chemical and biological warfare agents for the Department of Defense and the development of predictive toxicity measures for chemicals of concern for the Department of Homeland Security. (exponent.com)
Currently there are three iron chelating agents available for continuous use in patients with thalassemia on regular transfusions (desferrioxamine, deferiprone, and deferasirox) providing good results in reducing cardiac, hepatic and endocrine toxicity. (scielo.br)

In preclinical studies, vepdegestrant demonstrated up to 97% ER degradation in tumor cells, induced tumor shrinkage when dosed as a single agent in multiple ER-driven xenograft models, and showed increased anti-tumor activity when compared to a standard of care agent, fulvestrant, both as a single agent and in combination with a CDK4/6 inhibitor. (biospace.com)
SAN ANTONIO - Neoadjuvant treatment with the CDK4/6 inhibitor ribociclib (Kisqali) and the aromatase inhibitor letrozole (Femara) produced response rates similar to multi-agent chemotherapy in patients with high-risk luminal B breast cancer, according to results from the SOLTI-1402/CORALLEEN trial presented at the San Antonio Breast Cancer Symposium , held Dec. 10-14. (aacr.org)

Committees and members of The Endocrine Society, The European Society of Endocrinology, and The Pituitary Society reviewed and commented on preliminary drafts of these guidelines. (nih.gov)

EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents? (cefic-lri.org)
1994. Threshold limit values for chemical substances and physical agents and biological exposure indices (1994-1995). (cdc.gov)
Marks KJ , Howards P, Smarr M, Flanders WD, Northstone K, Daniel J , Sjödin A, Calafat A, Hartman T. Prenatal Exposure to Mixtures of Persistent Endocrine-disrupting Chemicals and Birth Size in a Population-based Cohort of British Girls . (cdc.gov)
new agent name encompasses workers in fixed locations (e.g. hospital, call centre, or factory) as well as those involved in transmeridian air travel Exposure assessment quality (e.g. aircrew). (who.int)

Gloria G. Guerrero Manriquez , " Frontiers in Anti-infective Agents ", Bentham Science Publishers (2020). (benthamscience.com)
Anti-infective agents are secondary metabolites produced and obtained from a different sources (plants, bacteria, virus, fungi, and marine oceans) with antibacterial or antiviral properties. (benthamscience.com)
Anti-infective agents (antibacterial or antiviral) possess either a bactericidal/virucidal or bacteriostatic /virustatic ability against microbes and viruses. (benthamscience.com)
Therefore, the aim of the present chapter is to outline the world of anti- infective agents, along with their mechanism of action. (benthamscience.com)

The pancreas is a heterocrine gland as it functions both as an endocrine and as an exocrine gland. (wikipedia.org)
Chronic relapsing pancreatitis with progressive loss of both exocrine and endocrine cells and their replacement by fibrous connective tissue results in diabetes mellitus. (merckvetmanual.com)

Auto-immunity may occur in all endocrine tissues, with a particular prevalence in thyroid and pancreatic islets. (karger.com)

The pituitary gland (or hypophysis) is an endocrine gland about the size of a pea and weighing 0.5 grams (0.018 oz) in humans. (wikipedia.org)

The study enrolled 106 patients, who were randomly assigned 1:1 to receive either the ribociclib and letrozole combination or multi-agent chemotherapy as neoadjuvant treatment. (aacr.org)

In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload. (scielo.br)
however, hepatic and endocrine complications also occur. (scielo.br)

WNT4 drives a novel signaling pathway in ILC cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. (nih.gov)

Education about adrenal insufficiency among patients as well as non-endocrine medical personnel were regarded as highly important. (bvsalud.org)

However, a subset of ILC cases may be resistant to endocrine therapies, suggesting that ER biology is unique in ILC. (nih.gov)
If patients have exhausted other endocrine therapies and perhaps been on palbociclib or ribociclib, one could try abemaciclib in later-line settings. (medpagetoday.com)

In rare cases, promotility agents can be prescribed, though the risks and benefits must carefully be discussed with the patients before the drugs are started. (medscape.com)
Diabetes mellitus is a common endocrine disease in dogs and cats, occurring in about 1 of every 300 patients. (merckvetmanual.com)
Finding an effective alternative to multi-agent chemotherapy for patients with high-risk breast cancer is a priority," he added. (aacr.org)
Transfusion-dependent patients with thalassemia major(TM) develop iron overload which leads to damage of the liver, heart, and endocrine organs and related morbidity and mortality ( 1 1. (scielo.br)
For the current Regulation with respect to cancer evaluation, the Working Group elected to change patients the agent name to "night shift work" in order to better reflect the main evidence base for the Regulations on shift work are in place in studies of cancer in humans, and to avoid mixing many countries. (who.int)

Take, for example, the current controversy about endocrine disrupters, the class of chemicals that mimic or block the action of the body's hormones. (grist.org)
These disrupters include many pesticides, PCBs, dioxins, ingredients in plastics, cleaning agents, and other chemicals that you and I encounter every day. (grist.org)

Further, WNT4 was required for endocrine response in ILC cells, as WNT4 knockdown blocked estrogen-induced proliferation. (nih.gov)

17.10 Organs with Secondary Endocrine Functions. (wikipedia.org)
As a result of multiple transfusions over the years, various organs become severely overloaded with iron, and, in order to avoid death in adolescence, regular subcutaneous infusion of an iron-chelating agent is essential. (who.int)

The European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended the use of special regulatory processes to facilitate licensure of two medications that address unmet needs for two rare pediatric endocrine disorders. (medscape.com)
Cite this: EU Gives Okay to Two Drugs for Rare Pediatric Endocrine Disorders - Medscape - Dec 18, 2017. (medscape.com)

Light Activated Compounds as Patented Antimicrobial Agents, Frontiers in Anti-Infective Drug Discovery (2010) 1: 17. (benthamscience.com)

Indications and side effects of therapeutic agents for treating prolactinomas are also presented. (nih.gov)
The discovery of an endocrine incidentaloma in the inpatient setting warrants a systematic approach that includes both diagnostic and potentially therapeutic management. (the-hospitalist.org)

They can be new anti-TB drugs or agents for HDT. (benthamscience.com)
2 In this survey, the most prescribed classes of prescription drugs included analgesics, anti-hyperlipidemic agents, and dermatologic agents, including steroid creams. (ndnr.com)
and (3) respiratory agents, including anti-asthma drugs. (gao.gov)

NEW HAVEN, Conn. and SAN FRANCISCO , May 2, 2023 /PRNewswire/ -- Arvinas Inc. , (Nasdaq: ARVN) and Quantum Leap Healthcare Collaborative™ today announced that Arvinas' vepdegestrant (ARV-471), a novel PROTAC® estrogen receptor (ER) protein degrader being co-developed with Pfizer Inc. will be evaluated in the ongoing I-SPY TRIAL endocrine program sponsored by Quantum Leap. (biospace.com)
Many targets, such as estrogen and androgen receptors, related to the endocrine disrupting, have been studied. (mdpi.com)

What Is the Best Approach for the Evaluation and Management of Endocrine Incidentalomas? (the-hospitalist.org)
Recently, the Endocrine Society released consensus recommendations to guide the evaluation and treatment of pituitary incidentalomas, which are included in the approach outlined below. (the-hospitalist.org)

However, the committee did include several scientists who are worried about endocrine disrupters and who brought a mountain of compelling evidence to the table. (grist.org)

1 Unfortunately, regardless of the intent of use, many of these medications have profound effects on the endocrine system. (ndnr.com)
3 In the endocrine system, opioids have been shown to induce hypogonadism in both men and women. (ndnr.com)
The recent findings on the close relations between the immune system and the central nervous system lead to conceive an actual psychoneuro-endocrine-immune axis. (karger.com)

It is an alpha1- and alpha2-adrenergic blocking agent that blocks circulating epinephrine and norepinephrine action, reducing hypertension that results from catecholamine effects on alpha receptors. (medscape.com)
At the recent American Academy of Dermatology Annual Meeting in Miami, researchers presented interesting findings regarding melanoma and other skin cancers, as well as dermatologic effects of cancer agents. (ascopost.com)
As recently as 2004 , glyphosate was revealed to exhibit endocrine-disruptive and embryotoxic effects, indicating that it may contribute to birth defects and abnormal fetal development. (activistpost.com)
Misoprostol may augment the effects oxytocic agents, especially when given less than 4 hours before initiating oxytocin. (medscape.com)

With reference to recent patents, we then illustrate uses of PACT agents, including: 5-aminolevulinic acid, phenothiazinium based compounds, psoralens and organorhodium complexes. (benthamscience.com)

2019 ). to evaluate melatonin as part of the agent name in relation to cancer risk in humans. (who.int)

When treatment combining transfusion and iron-chelating agent is started early and maintained, the patient's quality of life can be very good and the prognosis is optimistic. (who.int)

The I-SPY-2 Endocrine Optimization Platform (EOP) study (NCT01042379) will include a vepdegestrant monotherapy arm and a vepdegestrant in combination with letrozole arm. (biospace.com)

Anatomy23

Diseases40

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes10

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Health Care2

Switching endocrine therapy1

Disruptors4

Glands4

Disruption2

Therapy25

Diseases3

Clinical4

Mechanisms4

Disrupter2

Disruptor1

Modulate3

Toxicity2

CDK42

Endocrinology1

Exposure4

Anti-Infective Agents4

Exocrine2

Tissues1

Pituitary gland1

Neoadjuvant1

Complications2

Resistance1

Adrenal1

Therapies2

Patients5

Chemicals2

Cells1

Organs2

Pediatric2

Frontiers1

Therapeutic2

Drugs3

Estrogen2

Evaluation2

Committee1

System3

Effects4

Recent patents1

20191

Treatment1

Include1