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  • endogenous
  • Here we report on the endogenous production of a previously unknown class of ω-3 PUFA-derived lipid metabolites that originate from the crosstalk between endocannabinoid and cytochrome P450 (CYP) epoxygenase metabolic pathways. (pnas.org)
  • Despite the fact that most of the studies on this field have been performed using in vitro models, endocannabinoid-mediated plasticity might be considered as a plausible candidate underlying some of the diverse physiological functions of the endogenous cannabinoid system, including developmental, affective and cognitive processes. (hindawi.com)
  • Conclusions- We conclude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing the CB 1 -mediated cardiodepressor and vasodilator effects of endogenous anandamide by blocking its hydrolysis can normalize blood pressure. (ahajournals.org)
  • obesity
  • The bingeing literature may not have the same focus and may not be as important to the overall state of obesity as the straight-up obesity literature - but with respect to "munchies" and endocannabinoids, I think it is a fair backdrop. (blogspot.com)
  • rats
  • Levels of the endocannabinoids 2-AG and anadamide were increased in the jejunum (the middle part of the small intestine) of rats fed the corn oil or mixed liquid diet, but not in rats fed the protein or sugar solutions. (blogspot.com)
  • molecules
  • Endocannabinoids are lipid signalling molecules with pivotal role in a plethora of physiological and pathophysiological states, including anxiety, fear, learning and memory, pain etc . (els.net)
  • We are now at a point where you have to understand how [endocannabinoids] can be so relevant in so many areas-literally everywhere in the body," says Mauro Maccarrone , head of biochemistry and molecular biology at Campus Bio-Medico University of Rome, Italy, who has studied the molecules since 1995. (the-scientist.com)
  • reward
  • Endocannabinoids interact with multiple hypothalamic circuits and transmitter systems to stimulate food intake in general, and they also act in reward areas of the brain to selectively enhance intake of palatable foods. (springer.com)