• The catalytic efficiency (i.e., the ratio between maximal velocity and Michaelis-Menten constant) of the AEA membrane transporter (AMT) is almost doubled compared with control cells, demonstrate that, among the proteins of the "endocannabinoid system," only CB1 and AMT critically depend on membrane cholesterol content, an observation that may have important implications for the role of CB1 in protecting nerve cells against (endo)cannabinoid-induced apoptosis. (wikipedia.org)
  • However, it's a little less complex in that it only has three: cannabinoid receptors, endocannabinoids, and metabolic enzymes. (chiroeco.com)
  • ECS's second component, endocannabinoids , are the cell-producing molecules found in the body which, according to Leafly, "activate cannabinoid receptors" on demand. (chiroeco.com)
  • Endocannabinoids are endogenous lipid neurotransmitters that activate cannabinoid receptors and play a role in regulating motivated behaviors, such as feeding, anxiety, drug seeking, pain, and reproduction [ 4 , 5 ]. (hindawi.com)
  • The components of the ECS, including endocannabinoids, their cognate enzymes and cannabinoid receptors, are localized in the eye, and evidence indicates that ECS modulation plays a role in ocular disease states. (frontiersin.org)
  • The ECS, whose components are widely distributed throughout the body, consists of cannabinoid receptors, endocannabinoids and the enzymes responsible for producing endocannabinoids. (naturalnews.com)
  • Endocannabinoids (eCBs) are endogenous lipid ligands that bind to cannabinoid receptors that also mediate the effects of marijuana. (degruyter.com)
  • Endocannabinoids are neurotransmitters produced by the human body that attach to cannabinoid receptors in the brain, the same receptors that are affected by the consumption of cannabis products. (bipolarnews.org)
  • They believe this hypothesis is not counteracted by the high levels of cannabinoids they found in Tourette's patients in this study, because these high levels may be accompanied by a reduced number or reduced sensitivity of the cannabinoid receptors or overactivity in the enzymes that break down endocannabinoids, such that it is difficult to maintain normal levels of these neurotransmitters. (bipolarnews.org)
  • Later on the endogenous ligands for the cannabinoid receptors were identified and the term 'endocannabinoid system' was coined to indicate the complex signaling system of cannabinoid receptors, endogenous ligands and the enzymes responsible for their biosynthesis and inactivation. (spandidos-publications.com)
  • Most work has focused on the role of endocannabinoids in regulating tumor cell growth and apoptosis and ongoing research is addressed to further dissect the precise mechanisms of cannabinoid antitumor action. (spandidos-publications.com)
  • During this time, the primary active ingredients in cannabis have been isolated, specific cannabinoid receptors have been discovered and at least five endogenous cannabinoid neurotransmitters (endocannabinoids) have been identified. (uwi.edu)
  • Cannabinoid ligands are therefore thought to display considerable therapeutic potential and the drive to develop compounds that can be targeted to specific neuronal systems at low enough doses so as to eliminate cognitive side effects remains the 'holy grail' of endocannabinoid research. (uwi.edu)
  • The findings suggest it might be possible to curb this tendency by obstructing endocannabinoid activity for example, by using drugs that "clog" cannabinoid receptors. (medicalxpress.com)
  • Monoacylglycerol lipase protects the presynaptic cannabinoid 1 receptor from desensitization by endocannabinoids after persistent inflammation. (iasp-pain.org)
  • Here we find that persistent inflammation increases endocannabinoid levels, priming presynaptic cannabinoid 1 receptors for desensitization upon subsequent addition of exogenous agonists. (iasp-pain.org)
  • Endocannabinoids readily induce cannabinoid 1 receptor desensitization if their degradation is blocked, indicating that endocannabinoid concentrations are maintained at sub-desensitizing levels and that degradation is critical for maintaining endocannabinoid regulation of presynaptic GABA release in the ventrolateral periaqueductal gray during inflammatory states. (iasp-pain.org)
  • Endocannabinoids (eCBs) are endogenous lipids that activate cannabinoid receptors. (biorxiv.org)
  • Endocannabinoids (eCBs) are endogenous neurotransmitters that appear to play a major role in generating these rewards by activating cannabinoid receptors in brain reward regions during and after exercise. (biologists.com)
  • If we view cannabinoid receptors as the lock, then endocannabinoids are the key. (royalqueenseeds.com)
  • This endocannabinoid also binds to both major cannabinoid receptors, and plays a key role in the body [2] . (royalqueenseeds.com)
  • Data reported so far clearly indicate the presence of a dysregulation in the endocannabinoid system (both in term of cannabinoid receptors and endocannabinoid ligands) in animal models of psychosis as well as in schizophrenic patients. (eurekaselect.com)
  • The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (lu.se)
  • The endocannabinoids (anandamide, AEA, and 2-arachidonoylglycerol, 2-AG) on the other hand, are non-charged lipids that readily cross lipid membranes. (wikipedia.org)
  • The primary endocannabinoids are anandamide (AEA, N-arachidonoylethanolamine) and 2-arachidonoyl glycerol. (nih.gov)
  • According to a study published in the British Journal of Sports Medicine , moderate-intensity exercise dramatically increases blood plasma levels of the endocannabinoid anandamide . (naturalnews.com)
  • The study, released as a preprint on Research Square before peer review, suggests that simvastatin, a widely used medication, affects enzymes in the endocannabinoidome, the expanded endocannabinoid system encompassing several endogenous fatty acid compounds in addition to anandamide and 2-AG (the two most prominent endocannabinoids). (projectcbd.org)
  • Exposure to the statin-based medication ultimately increased cellular endocannabinoid expression, meaning it boosted the levels of anandamide and 2-AG. (projectcbd.org)
  • The endocannabinoid metabolism inhibitors, URB597 or JZL184 (which increase the levels of anandamide and 2-arachidonoylglycerol, respectively) were administered intraperitoneally before or after extinction training depending on the paradigm. (nottingham.ac.uk)
  • We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. (biomedcentral.com)
  • Both of these receptors also respond to naturally synthesized cannabinoids, namely anandamide (AEA) and 2-arachidonyl-glycerol (2-AG), so-called endocannabinoids. (biomedcentral.com)
  • OBJECTIVE: In rheumatoid arthritis (RA) synovial fluid, levels of the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol are elevated. (uni-regensburg.de)
  • Treatment of zebrafish larvae with endocannabinoids , such as 2-arachidonoylglycerol (2-AG) and anandamide (AEA), altered larvae movement , and the expression of genes that regulate their metabolism was affected by phytocannabinoid treatment , highlighting the possibility that changes to endocannabinoid levels may represent one facet of the anticonvulsant effect of phytocannabinoids. (bvsalud.org)
  • Endocannabinoids are arachidonic acid-derived endogenous lipids that activate the endocannabinoid system which plays a major role in health and disease. (nih.gov)
  • The endocannabinoid system (ECS) is a unique and ubiquitous cell-signaling system that is just beginning to be understood. (medscape.com)
  • When Mechoulam and colleagues isolated THC in 1964, they made it possible to further understand the complex nature of the endocannabinoid system. (medscape.com)
  • The endocannabinoid system - a target for the treatment of LUTS? (nature.com)
  • Currently, the endocannabinoid system is considered as a potential drug target for pharmacological management of LUTS, with a more favourable adverse event profile than antimuscarinic agents. (nature.com)
  • Figure 1: Functional organization of the endocannabinoid system during normal micturition. (nature.com)
  • Figure 2: Functional organization of the endocannabinoid system during bladder dysfunction. (nature.com)
  • It is the endocannabinoid system. (chiroeco.com)
  • According to Leafly , one of the top online cannabis information providers today, "the body's endocannabinoid system (ECS) is a vital molecular system for helping maintain homeostasis. (chiroeco.com)
  • The final key component of the endocannabinoid system is metabolic enzymes. (chiroeco.com)
  • Hemp oil rich in phytocannibinoids can provide a unique way to support the body's healthy regulation of the endocannabinoid system. (chiroeco.com)
  • VANCOUVER , Jan. 30, 2017 /PRNewswire/ - Alternate Health Corp. (CSE:AHG) (the "Company") is pleased to announce the first continuing medical education course on the "Endocannabinoid System and Cannabidiol. (prnewswire.com)
  • The course is accredited through the University of Louisville in accordance with the American Medical Association (AMA) and the American Board of Medical Specialties (ABMS) educational requirements, and provides a comprehensive overview of the endocannabinoid system (ECS), and the vital role it plays in various physiological functions of the human body. (prnewswire.com)
  • The endocannabinoid system (ECS) has emerged as an important regulator of both physiological and pathological processes. (frontiersin.org)
  • Learn about the opportunity for non-CBD alternatives that can act upon the body's endocannabinoid system, and specifically about a branded form of PEA to support managing discomfort, stress, inflammation and immune response. (naturalproductsinsider.com)
  • This has provided an opportunity for non-CBD alternatives, including substances that can act upon the body's endocannabinoid system. (naturalproductsinsider.com)
  • We'll also take a closer look at PEA's potential from the perspective of an endocannabinoid system expert. (naturalproductsinsider.com)
  • Learn about the importance of the endocannabinoid system and the role CBD and PEA play within this system. (naturalproductsinsider.com)
  • Researchers define the human endocannabinoid system (ECS) as a complex cell-signaling system that plays an important role in the development of the central nervous system (CNS), synaptic plasticity -- a characteristic of neurons in the brain -- and the body's response to internal and external insults or stressors. (naturalnews.com)
  • Recently, researchers set out to determine whether concentrations of endocannabinoids in the cerebrospinal system are related to Tourette syndrome. (bipolarnews.org)
  • The 'endocannabinoid system' is involved in a broad range of functions and in a growing number of pathological conditions. (spandidos-publications.com)
  • However, endocannabinoids are now emerging as suppressors of angiogenesis and tumor spreading since they have been reported to inhibit angiogenesis, cell migration and metastasis in different types of cancer, pointing to a potential role of the endocannabinoid system as a target for a therapeutic approach of such malignant diseases. (spandidos-publications.com)
  • The endocannabinoid system, including endogenous cannabinoids and their corresponding receptors, has received extensive attention in the last few years for their neuroprotective effect in the central nervous system. (uwaterloo.ca)
  • Together, these form the framework of a complex endocannabinoid signalling system that has widespread distribution in the body and plays a role in regulating numerous physiological processes within the body. (uwi.edu)
  • The endocannabinoid system is involved in extinction learning. (nottingham.ac.uk)
  • Cannabis action is mediated by the endocannabinoid system (ECS), which expression is well established in the brain but unknown in the developing testis. (biomedcentral.com)
  • In addition to the endocannabinoids and their receptors, this endocannabinoid system (thereafter called ECS) comprises synthesis and degradation enzymes and transporters [ 14 ]. (biomedcentral.com)
  • They co ntacted Comodo Screen looking for help to create a video explaining how endocannabinoid system works. (comodoscreen.com)
  • The endocannabinoid system is one of the great unknowns of the biology of our organism. (comodoscreen.com)
  • The endocannabinoid system serves as a universal regulator of nearly all systems within the body. (royalqueenseeds.com)
  • Below, discover everything you need to know about this system, how it works in the body, and what happens when we become deficient in endocannabinoids. (royalqueenseeds.com)
  • Then, find out how you can modulate your endocannabinoid system through exercise, diet, and herbs to maintain optimal health. (royalqueenseeds.com)
  • The endocannabinoid system serves as a universal regulator within the human body, helping to keep other biological systems in balance. (royalqueenseeds.com)
  • the endocannabinoid system ensures things don't stray too high or low from baseline. (royalqueenseeds.com)
  • We can view the endocannabinoid system as a set of traffic lights within the body. (royalqueenseeds.com)
  • The endocannabinoid system is composed of three major parts. (royalqueenseeds.com)
  • Cannabis derivatives produce their CNS effect through activation of the endocannabinoid system, a recently discovered signalling system comprising specific receptors, their intrinsic lipid ligands and the associated enzymatic machinery (transporters, biosynthetic and degradative enzymes). (eurekaselect.com)
  • Based on these observations, the pharmacological modulation of the endocannabinoid system has been taken into account as a new therapeutic possibility for psychotic disorders. (eurekaselect.com)
  • Another important aspect in studying the relationship between the endocannabinoid system and schizophrenia is the impact of Cannabis consumption on psychotic disorders, especially when this occurs at vulnerable ages such as adolescence. (eurekaselect.com)
  • Since AEA levels are regulated by COX-2 and FAAH, inhibition of both enzymes along with low-dose glucocorticoids may provide a therapeutic option to maximally boost the endocannabinoid system in RA, with possible beneficial effects. (uni-regensburg.de)
  • Here, we'll explore the science behind delta 8 gummies and how they can affect your endocannabinoid system. (shopbrianlichtenberg.com)
  • Delta 8 gummies work by interacting with our bodies' natural endocannabinoid system-a network of receptors throughout our brain and central nervous system responsible for regulating mood, sleep patterns, appetite, and overall wellbeing. (shopbrianlichtenberg.com)
  • Taking delta-8 gummies has a range of potential benefits due to their interaction with our bodies' own natural endocannabinoid system. (shopbrianlichtenberg.com)
  • Chronic pain in Alzheimer's disease: Endocannabinoid system. (qxmd.com)
  • This review summarizes the role of the endocannabinoid system in pain, its potential role in chronic pain in AD, and addresses gaps and future directions. (qxmd.com)
  • In the 21st century, new discoveries of other endocannabinoids, their site distributions, and roles are deepening our understanding of the endocannabinoid system. (medscape.com)
  • Exercise activates the endocannabinoid system. (bvsalud.org)
  • The lipidome, however, consists of endocannabinoids and endocannabinoid-like neurotransmitters. (projectcbd.org)
  • However, that has not yet been determined, and it is also possible that the endocannabinoids are a reaction to dysfunction involving other neurotransmitters, are incidental to the syndrome, or in the best case that they are a direct cause of the syndrome. (bipolarnews.org)
  • Humans and animals alike naturally synthesize endocannabinoids, chemical compounds that activate the same receptors as delta-9-tetrahydrocannabinol (THC), the active component of marijuana ( Cannabis sativa ). (medscape.com)
  • Levels of endocannabinoid ligands (AEA, NAGly, and 2-AG) change significantly in rodent brain with the estrous cycle and show sex differences, suggesting a preparatory role for mating [ 10 ]. (hindawi.com)
  • In vitro experiments, including cell studies using two cell lines (HTT22 and CB1-CHO), ThT based kinetic assay, and TEM studies were used to determine the effects of above mentioned five endocannabinoids, arachidonic acid, and a CB1 antagonist to understand the role of endocannabinoid ligands and pathways involved in Aβ-induced neurotoxicity. (uwaterloo.ca)
  • The cholesterol-cutting drug altered genes responsible for endocannabinoid creation and degradation. (projectcbd.org)
  • Müller-Vahl and colleagues suggest that based on the effectiveness of cannabis in treating Tourette's, it may turn out that the syndrome is a sort of endocannabinoid deficiency. (bipolarnews.org)
  • Cannabis helps counteract the symptoms of endocannabinoid deficiency from PTSD. (medicalmarijuana411.com)
  • View this poster to discover how we investigated the relationship between cannabis use and phyto-/endocannabinoid levels in plasma samples from young adults diagnosed with cannabis use disorder (CUD) and how we developed a novel targeted UPLC-MS/MS method-based metabolomic panel to concurrently measure endocannabinoids, phytocannabinoids, and their metabolites from a single sample. (metabolon.com)
  • Therefore the continuum and interdependence of endocannabinoid actions during the formation and function of synapses together with dynamic changes in focal and circulating endocannabinoid levels upon maternal nutritional imbalance suggest that endocannabinoids can execute the 'reprogramming' of specific neuronal networks. (nih.gov)
  • However, the quantification of endocannabinoids, the signaling molecules in this pathway, has been challenging due to their low abundance and structural variability. (metabolon.com)
  • While their biosynthesis and metabolism have been studied in detail, it remains unclear how endocannabinoids are transported across the cell membrane. (nih.gov)
  • Scientific evidence suggests that endocannabinoids have a role in inflammation, insulin sensitivity, and fat and energy metabolism. (medscape.com)
  • The biochemistry of endocannabinoid synthesis, metabolism, and bioactivity has been difficult to study in the past. (medscape.com)
  • In the present paper, we review molecular evidence suggesting that maternal nutrition and metabolism during pregnancy can affect the formation and function of the hippocampus and hypothalamus by altering endocannabinoid signalling such that neuropsychiatric diseases and obesity respectively ensue in affected offspring. (nih.gov)
  • New research published today in the journal Cell Metabolism indicates that endocannabinoids might enable organisms to stay thin without the need for exercise or diets. (scitechdaily.com)
  • Previous research has shown that endocannabinoids play an important role in regulating energy metabolism. (scitechdaily.com)
  • However, research regarding endocannabinoid metabolism inhibition in extinction impairment and fear relapse is lacking. (nottingham.ac.uk)
  • These results suggest that endocannabinoid metabolism inhibition may not affect fear relapse and extinction impairment within the current paradigms. (nottingham.ac.uk)
  • Future research should address these potential confounds to assess the potential benefit of endocannabinoid metabolism inhibition in fear relapse and impaired extinction. (nottingham.ac.uk)
  • With scientific evidence suggesting their role in inflammation, insulin sensitivity, and fat and energy metabolism, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)
  • Endocannabinoids, a family of signal lipids derived from polyunsaturated fatty acids, have been implicated in neuronal fate determination, the control of axonal growth, synaptogenesis and synaptic neurotransmission. (nih.gov)
  • The present study demonstrated that endocannabinoid signaling is altered in canine CEs, and that CE subtypes showed distinct profiles of 2-AG, PEA and OEA plasma levels, suggesting that these circulating bioactive lipids might have the potential to become candidate biomarkers for canine CEs. (frontiersin.org)
  • The purpose of this study was to determine whether endocannabinoids are involved in the descending modulation of dural and/or cutaneous facial trigeminovascular nociceptive responses, from the brainstem ventrolateral periaqueductal gray (vlPAG). (jneurosci.org)
  • These findings demonstrate for the first time that brainstem endocannabinoids provide descending modulation of both basal trigeminovascular neuronal tone and Aδ-fiber dural-nociceptive responses, which differs from the way the brainstem modulates spinal nociceptive transmission. (jneurosci.org)
  • This webinar will examine how PEA specifically influences similar endocannabinoid pathways without any of the challenges that are seen with CBD. (naturalproductsinsider.com)
  • Therefore, we hypothesized that endocannabinoids might reduce amyloid β-protein deposition and inhibit neuronal cell death through CB1 or other possible pathways. (uwaterloo.ca)
  • 2) Define the role of hormone-sensitive lipase in endocannabinoid signaling and thereby regulation of energy homeostasis and 3) define the role of bile acids as regulators of glucose homeostasis. (lu.se)
  • Sometimes, our bodies produce low levels of endocannabinoids, leading to a deficiency associated with numerous health conditions. (royalqueenseeds.com)
  • Find out what causes endocannabinoid deficiency, and how you can combat it with foods, herbs, exercise, and more. (royalqueenseeds.com)
  • Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
  • Como parte de las terapias alternativas para el control de síntomas refractarios en enfermedades avanzadas destaca el uso de cannabidiol. (bvsalud.org)
  • 40 % de los pacientes, quienes han demostrado disminución en la frecuencia de convulsiones con el uso concomitante de cannabidiol y antiepilépticos convencionales, con efectos secundarios leves, como diarrea y somnolencia. (bvsalud.org)
  • de determinar el uso del cannabidiol para el control de síntomas neurológicos refractarios en pacientes con síndromes convulsivos y enfermedades neurodegenerativas, se realizó una búsqueda bibliográfica en Pubmed, Scopus y Embase. (bvsalud.org)
  • Los efectos del cannabidiol lo convierten en una alternativa, of the title and research adicional a la terapéutica convencional, para el control de síntomas en trastornos neurológicos, disminuyendo de forma objectives, exhaustive sostenida el número total de episodios con un perfil de seguridad aceptable. (bvsalud.org)
  • Existe limitada información respecto al uso de search of information in cannabidiol en enfermedades neurodegenerativas, por lo que no se ha evidenciado su efectividad. (bvsalud.org)
  • In an article published in the journal Neuropsychopharmacology in 2020, researcher Kirsten R. Müller-Vahl and colleagues report that endocannabinoid concentrations were significantly higher in the cerebrospinal fluid of 20 people with Tourette's syndrome than in 19 control participants without Tourette's. (bipolarnews.org)
  • It is possible that higher concentrations of endocannabinoids are present in the syndrome because they compensate for the overactive influence of dopamine. (bipolarnews.org)
  • This review provides the latest preclinical and clinical breakthroughs on the endocannabinoid system's role in psychotic disorders such as schizophrenia. (eurekaselect.com)
  • Phytocannabinoids Reduce Seizures in Larval Zebrafish and Affect Endocannabinoid Gene Expression. (bvsalud.org)
  • Emerging and exciting areas of research and novel methodological approaches, including genome-wide gene expression studies, immune, endocannabinoid, oxytocin, and glutamatergic systems, are explored to help delineate innovative mechanisms that may contribute to resilience. (cdc.gov)
  • In this review, we critically discuss the different models of endocannabinoid trafficking, focusing on AEA cellular uptake which is best studied. (nih.gov)
  • Since synovial fibroblasts (SFs) possess all of the enzymes necessary for endocannabinoid synthesis, it is likely that these cells contribute significantly to elevated endocannabinoid levels. (uni-regensburg.de)
  • While glucocorticoids initiate endocannabinoid synthesis in neurons, this study was undertaken to test whether cortisol also regulates endocannabinoid levels in mesenchymal cells such as SFs, and whether this interferes with integrin-mediated adhesion. (uni-regensburg.de)
  • Endocannabinoids regulate how quickly the human body burns fat. (scitechdaily.com)
  • Consequently, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)
  • This is the first demonstration that endocannabinoid signaling in the gut plays an important role in regulating fat intake," added the Louise Turner Arnold Chair in the Neurosciences and professor of pharmacology. (medicalxpress.com)
  • Furthermore, our data demonstrate a novel interaction between serotonergic and endocannabinoid systems in the processing of somatosensory nociceptive information, suggesting that some of the therapeutic action of triptans may be via endocannabinoid containing neurons in the vlPAG. (jneurosci.org)
  • According to Watkins, one of the reasons exercise is linked to good overall health and well-being is because it induces endocannabinoid production in the brain . (naturalnews.com)
  • Moreover, we propose that the placenta, fetal adipose and nervous tissues interact via endocannabinoid signals. (nih.gov)
  • While both compounds interact with our endocannabinoid systems, delta-8 has less psychoactive effects than its counterpart. (shopbrianlichtenberg.com)
  • The use of delta-8 THC has been gaining traction in recent years due to its ability to provide mild psychoactive effects without overwhelming the user as typical THC products might do - making it well suited for those looking to naturally supplement their own endocannabinoid systems without experiencing unpleasant side effects! (shopbrianlichtenberg.com)
  • The researchers found elevations in the endocannabinoids AEA and 2-AG, the endocannabinoid-like ligand PEA, and the metabolite AA in the participants with Tourette's syndrome. (bipolarnews.org)
  • Director of the UCI School of Medicine's Center for Drug Discovery & Development, Piomelli is one of the world's leading researchers on endocannabinoids. (medicalxpress.com)
  • The results of this study on HT22 cells showed that some, but not all of the endocannabinoids were able to exhibit neuroprotective effects against Aβ-induced toxicity. (uwaterloo.ca)
  • On the other hand, AM251 was able to inhibit the protective effects of some, but not all, of the endocannabinoids in CB1-CHO cells. (uwaterloo.ca)
  • In their study, the Piomelli team discovered that when rats tasted something fatty, cells in their upper gut started producing endocannabinoids. (medicalxpress.com)
  • This can be problematic because excessive endocannabinoid activity "is associated with a plethora of pathological conditions affecting both the brain and peripheral organs and tissues," the preprint authors explain, citing examples such as "type 2 diabetes, liver and kidney dysfunctions. (projectcbd.org)