• Genes showing reduced expression due to these RNAi treatments were short and enriched for genes encoding metabolic or enzymatic functions. (sdbonline.org)
  • PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. (sitoolsbiotech.com)
  • 120 different translocations, resulting in the generation of MLL-fusion proteins encompassing more than 75 different partner genes 5 . (nature.com)
  • More common are small, subtle changes of the DNA sequence that can alter the structure and function of the proteins encoded by genes. (healthdrugpdf.com)
  • The genes that encode proteins comprise only a tiny fraction of human DNA, even though they represent the major biological function of the genome. (healthdrugpdf.com)
  • Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. (novusbio.com)
  • ETS family members transcription factors control the appearance of oncogenes, tumor suppressor genes, and various other genes linked to vessel development, invasion, and metastasis, and expression of the elements correlates with poor survival [7C10] often. (columbiagypsy.net)
  • first patterns( progeny, class, protein lifetime, and complex anion) be depending genes: NF-kappaB is silenced via list catabolism C octanoyl, RAS has required via RasGRP cells, NF-AT creates coupled via Tumor, and AKT( PKB) methylates achieved via PDK1( involved in Shinohara and Kurosaki 2009, Stone 2006). (erik-mill.de)
  • olycomb group proteins are subunits of PcG complex 1 and 2 and other complexes and regulate the transcription of developmental regulators, which include Hox genes. (gabasignaling.com)
  • Targeting ∼7000 genes with this methodology, we discovered SAGA complex members Tada2b and Taf5l as key regulators of HSC lineage commitment. (biorxiv.org)
  • The Drosophila Polycomb group (Pc-G) genes encode transcriptional factors involved in development. (elsevierpure.com)
  • Little is known about members of the vertebrate Pc-G genes. (elsevierpure.com)
  • The human and mouse genes, which were named ENX-2 and Enx-2, encode 702 and 750 amino acids, respectively. (elsevierpure.com)
  • In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
  • Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types and, to date, the cloning of seven mammalian PKC genes encoding eight distinct isoforms has been reported. (bgu.ac.il)
  • Here we describe the molecular cloning and deduced primary structure of a cDNA encoding a novel PKC isoform, termed PKCθ, which was isolated in the course of attempts to identify PKC genes that are expressed selectively in hematopoietic cells. (bgu.ac.il)
  • Degenerate oligonucleotide primers corresponding to conserved sequence motifs, which distinguish the PKC family from other protein kinases, were employed in polymerase chain reactions (PCR) to amplify partial core sequences of putative PKC genes from a human peripheral blood lymphocyte-derived cDNA library. (bgu.ac.il)
  • The HOX family of genes plays a major role in embryogenesis and cell differentiation, including differentiation of hematopoietic cell lines. (medscape.com)
  • We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
  • Akin to the normal hematopoietic system, leukemias are sustained by a small number of leukemia stem-like cells (LSC), which can be distinct from the normal hematopoietic stem cells (HSC) but also exhibit functional characteristics of self-renewal and (abnormal or hindered) differentiation, and are often quiescent ( 2 - 4 ). (frontiersin.org)
  • When the team knocked out Ythdf2 function in a mouse model or knocked down Ythdf2 function in hUCB cells, they observed increased expression of these transcription factors and expansion of hematopoietic stem cells, which are the major type of adult stem cells in hUCB. (scitechdaily.com)
  • Since the Ythdf2 protein is present in different kinds of adult stem cells, targeting it and how it affects hematopoietic stem cells seemed a safer approach and, if it worked, broadly applicable. (scitechdaily.com)
  • His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
  • Genetic Modification of Hematopoietic Stem Cells. (swcomsvc.com)
  • WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow hematopoietic stem cells, which can manifest as an increased number of functionally normal platelets, red blood cells (RBCs). (msdmanuals.com)
  • However, because the thrombopoietin receptor is the only growth factor receptor in hematopoietic stem cells, thrombocytosis can occur before erythrocytosis. (msdmanuals.com)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (wikipedia.org)
  • Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. (antibodies-online.com)
  • Alternative splicing of this gene results in two transcript variants which encode the same protein. (origene.com)
  • Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. (origene.com)
  • Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. (sitoolsbiotech.com)
  • Y14 is part of the exon-junction complex (EJC), a set of proteins associated with transcript export, localization, and splicing, playing a critical in embryonic development. (medscape.com)
  • This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. (origene.com)
  • Expression of MLL-fusions enhances proliferation and blocks myeloid differentiation of hematopoietic progenitor cells, leading to their pathological accumulation. (nature.com)
  • It is a heterogeneous disease, cellularly and molecularly, with an overarching theme of ectopic self-renewal and arrested differentiation potential at multiple levels of the hematopoietic tree ( 1 ). (frontiersin.org)
  • Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide, a 515 aa extracellular domain with 10 potential N-linked glycosylation sites, a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain. (rndsystems.com)
  • The human PD-1 gene is located on chromosome 2 at band q37, and the full length PD-1 cDNA is 2,106 nucleotides long and encodes a predicted protein of 288 amino acid residues. (biomedcentral.com)
  • In this study, we have isolated a cDNA encoding a human Pc-G protein and the mouse equivalent. (elsevierpure.com)
  • Included within this ~2.7-kilobase pair cDNA is an open reading frame of 2,118 nucleotides encoding a putative 82-kDa protein. (bgu.ac.il)
  • The PD-1 gene is a CD28 family member that is a member of the immunoglobulin gene superfamily. (biomedcentral.com)
  • Receptors for the Fc region of IgG (Fc gamma Rs) are members of the Ig superfamily that function in the activation or inhibition of immune responses such as degranulation, phagocytosis, ADCC (antibody-dependent cellular toxicity), cytokine release, and B cell proliferation (1‑3). (novusbio.com)
  • The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. (utsouthwestern.edu)
  • The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. (utsouthwestern.edu)
  • Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
  • Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), as known as OX40 or CD134 is expressed primarily on activated T cells [ 12 ]. (biomedcentral.com)
  • C/EBPβ is encoded by a single mRNA, yet translation of this mRNA results in the synthesis of three C/EBPβ isoforms based on alternative translation initiation sites [ 3 , 4 ]. (biomedcentral.com)
  • it reduces after delivery apart from thymus nevertheless, hematopoietic progenitor cells, and basal buy Oxcarbazepine epithelial cells from the digestive tract [1]. (buyresearchchemicalss.net)
  • Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
  • There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)
  • on chromosome 11 to produce a chimeric transcription aspect that will require the DNA binding domains encoded by for change. (columbiagypsy.net)
  • 3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
  • Most cases are X-linked and caused by mutations in a gene on the X chromosome that encodes a protein (CD154, or CD40 ligand) on the surfaces of activated helper T cells. (msdmanuals.com)
  • Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. (origene.com)
  • Flt-3 expression has been detected in various tissues, including placenta, gonads, and tissues of nervous and hematopoietic origin. (rndsystems.com)
  • Expression of the protein has been observed in various human cancer cell lines established from malignant tumors. (utsouthwestern.edu)
  • The expression of TC10 was increased in v-Rel-transformed chicken embryonic fibroblasts (CEFs) 3 to 6-fold relative to control cells at both the RNA and protein levels. (grunebaumfoundation.org)
  • Additionally, the cytokine protein also regulates the activities of both NF - κB and mitogen-activated protein kinase (MAPK), which can stimulate the expression of IL6 and cyclooxygenase 2 (PTGS2/COX-2) and enhance the production of nitric oxide (NO). (cyagen.com)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • SAGA complex member expression is significantly reduced in aged HSCs and upregulated with heterochronic parabiosis, suggesting a novel mechanism of age-associated hematopoietic decline and rejuvenation. (biorxiv.org)
  • ENX-2/Enx-2 protein exhibits a high homology (53-55% identity) to Drosophila Enhancer of zeste [E(z)] protein belonging to the Pc-G. The expression of Enx-2 was observed in mouse kidney, adrenal gland, testis and brain at high levels by Northern blot analysis. (elsevierpure.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • High Throughput Protein Expression and Purification. (swcomsvc.com)
  • Thus, PKCθ represents an additional member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells. (bgu.ac.il)
  • Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in hematopoietic cells but rather in radioresistant stromal cells needed for the development of secondary lymphoid organs. (rupress.org)
  • Acute myeloid leukemia (AML) is a heterogenous and hematologic malignant disease which is characterized by infiltration of the bone marrow, blood, and other tissues by proliferative, clonal, abnormally differentiated, and occasionally poorly differentiated cells of the hematopoietic system [ 1 ]. (biomedcentral.com)
  • RNase protection assays and semiquantitative PCR analysis indicated that, although PKCθ transcripts are expressed ubiquitously, the highest levels are found in hematopoietic tissues and cell lines, including T cells and thymocytes. (bgu.ac.il)
  • Donor lymphocyte infusion (DLI) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been widely used in preventing post-transplant relapse. (bvsalud.org)
  • The pathogenesis of donor cell leukemia (DCL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is unclear and likely multifactorial. (bvsalud.org)
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • MLL-fusion proteins are found in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) and are often associated with adverse prognosis, particularly in pediatric patients 3 . (nature.com)
  • It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. (antibodypedia.com)
  • Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood. (frontiersin.org)
  • This cytokine stimulates non-hematopoietic cells and promotes the production of chemokines, thereby recruiting myeloid cells to the site of inflammation. (cyagen.com)
  • Citation: Chickarmane V, Enver T, Peterson C (2009) Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility. (lu.se)
  • In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
  • Fli-1, a known person in the ETS transcription aspect family members, is also the mark of insertional activation by Friend murine leukemia trojan (F-MuLV) and it is preferentially portrayed in vascular endothelial cells and hematopoietic tissue [6]. (columbiagypsy.net)
  • The protein encoded by IL-17A is a proinflammatory cytokine that not only plays a key role in inducing innate immune defense, but also has important effects on host defense, cell transport, immune regulation, and tissue repair. (cyagen.com)
  • This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. (antibodypedia.com)
  • strong course="kwd-title" Keywords: Survivin, Prolactinoma, Microprolactinoma, Macroprolactinoma, Pituitary neoplasms Intro Survivin, an associate from the inhibitors from the apoptosis (IAPs) proteins family, is definitely encoded by BIRC5 gene located 17q25 in the human being sequence. (buyresearchchemicalss.net)
  • It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. (wikipedia.org)
  • It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. (biolegend.com)
  • inhibiting of download to the translesion is cell of cartilage dependent PLP members( ITAMs) in the Standard cells of Ig-alpha and Ig-beta by Src phophorylate energy pathways, missing LYN, FYN, and BLK( Nel et al. (erik-mill.de)
  • v-Rel is the oncogenic member of the Rel/NF-kappaB family of transcription factors and transforms hematopoietic cells and fibroblasts. (grunebaumfoundation.org)
  • In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. (utsouthwestern.edu)
  • The protein encoded by IL-17A is a pro-inflammatory cytokine produced by activated T cells. (cyagen.com)
  • 1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
  • Widely expressed in hematopoietic cells but not in other cell types. (affbiotech.cn)
  • The protein, called Ythdf2, recognizes a particular type of modification on a group of mRNAs encoding key transcription factors for hematopoietic stem cell self-renewal and promotes the decay of these mRNAs within cells. (scitechdaily.com)
  • Targeted gene deletion and radiation chimera analyses have provided insights into the molecular machinery underlying the development of secondary lymphoid organs, emphasizing the importance of crosstalk between hematopoietic and nonhematopoietic cells. (rupress.org)
  • There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
  • The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. (antibodypedia.com)
  • IL-17A mediates downstream pathways involved in the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. (cyagen.com)
  • In the study, published online on July 31, 2018, in Cell Research, researchers zeroed in on a protein that affects multiple targets and pathways involved in hematopoietic stem cell self-renewal, a broader approach than other studies that focus on a single target or pathway in the process. (scitechdaily.com)
  • with us one can be cytosol proteins, " badenova( 2009) is four primary photoreceptors, the most non-crossover-generating of which chloroplasts release, phosphorylated, and ready ataxia bacterial to a cascade of challenging glycoprotein GTPases. (evakoch.com)
  • Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
  • This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. (antibodies-online.com)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • It has therefore been proposed that the oncogenic activity of MLL-fusion proteins depends on chromatin targeting functions exerted by the MLL N-terminus in combination with other functional properties encoded by the fusion partners 6 . (nature.com)
  • Epigenetic regulation refers to the multiple chemical modifications of DNA or DNA-associated proteins that alter chromatin structure and DNA accessibility in a heritable manner, without changing DNA sequence. (frontiersin.org)
  • A yeast open reading frame sharing homology with the two known yeast Rab GTPase-activating proteins (GAPs), Gyp6p and Gyp7p, was found in a data base search. (embl.de)
  • The finding that yeast Rab GAPs share homology with proteins in other species, such as Caenorhabditis elegans and human, suggests the existence of a conserved Rab GAP family. (embl.de)
  • The insulin receptor (IR) and JAK1 tyrosine kinases and STAT3 can serve as direct substrates for the T-cell protein tyrosine phosphatase (TCPTP). (diabetesjournals.org)
  • The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. (antibodypedia.com)
  • The Flt-3 ( fms- like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. (rndsystems.com)
  • IL-17A (also known as CTLA8, IL17) is a member of the IL-17 receptor family. (cyagen.com)
  • All six members of this family exhibit a high sequence similarity in their C-terminal DNA binding domain and a more diverge regulatory N-terminus [ 1 , 2 ]. (biomedcentral.com)
  • The deduced primary structure contains consensus sequences characteristic of protein kinase catalytic domains and, based on its amino acid sequence and domain structure, is a member of the PKC family. (bgu.ac.il)
  • Sequence analysis of the complete merozoite surface protein 1 gene of P. knowlesi from 10 human and 5 macaque blood samples showed considerable genetic diversity among isolates. (cdc.gov)
  • IP3 has proteins on the ER binding and stimulates incorporation of hydrolysis files from the bis(monoacylglycerol into the development. (erik-mill.de)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
  • The ~200 amino acid TBC/rab GTPase-activating protein (GAP) domain is well conserved across species and has been found in a wide range of different proteins from plant adhesion molecules to mammalian oncogenes. (embl.de)
  • EX2 (360 bp) encodes a short hydrophilic-region (6 aa) and an extracellular V-like domain (120 aa) and is separated from EX3 (156 bp) by an intron of 267 bp that encodes a connecting-region (23 aa), transmembrane-region (24 aa) and a portion of the C-like-domain (5 aa). (biomedcentral.com)
  • PD-1 is a 50-55 kDa type I transmembrane protein with a single IgV domain in the extracellular region. (biomedcentral.com)
  • The active full-length CRYAA protein corresponding to amino acids 1-173 of CRYAA was recombined. (molvis.org)
  • The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
  • This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. (sitoolsbiotech.com)
  • RNA data sourced from Human Protein Atlas . (antibodypedia.com)
  • The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. (utsouthwestern.edu)
  • To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
  • A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
  • One-hundred and twenty-seven of 17,225 human full-length proteins were identified that interact with CRYAA. (molvis.org)
  • CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)
  • Acute myelogenous leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
  • This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. (utsouthwestern.edu)
  • Scmh1 encodes a protein with quite a few characteristic domains, including the malignant brain tumor domains, the professional line, glutamine, serine, and threonine rich domains, the N terminal and C terminal putative nuclear localization sig nals, as well as Scm polyhomeotic l mbt domain, also designated as the SAM domain. (gabasignaling.com)
  • Scmh1 encodes a protein with many characteristic domains, as well as the malignant brain tumor domains, the pro line, glutamine, serine, and threonine wealthy domains, the N terminal and C terminal putative nuclear localization sig nals, plus the Scm polyhomeotic l mbt domain, also designated since the SAM domain. (gabasignaling.com)
  • Families of related leukemia fusion proteins that share genomic and biological properties represent unique opportunities to study how the combination of distinct functional protein modules can drive oncogenic transformation. (nature.com)
  • However, it is unclear whether these molecular mechanisms pertain to the entire family of MLL-fusions or if they specifically affect the leukemogenicity of isolated MLL-fusion proteins. (nature.com)
  • We previously demon strated that Scmh1 mediates a molecular interaction of PcG com plex one with geminin and that PcG complex one acts as an selleck chemicals E3 ubiquitin ligase for geminin to sustain the hematopoietic stem cell exercise. (gabasignaling.com)
  • molecular Applications of Green Fluorescent Protein. (swcomsvc.com)
  • Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene. (wikipedia.org)
  • only the adeno-associated parvoviruses (members of the dependovirus genus) and B19 are known to infect humans. (cdc.gov)
  • Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. (antibodies-online.com)
  • To date, most of our understanding of epigenetic regulation and its participation in leukemogenesis is based on the enzymatic activities and protein-protein interactions of histone and DNA modifiers. (frontiersin.org)
  • There are 36093 TBC domains in 36071 proteins in SMART's nrdb database. (embl.de)
  • Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. (origene.com)
  • CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
  • Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
  • The HuProt microarray results showed that the signals of 343 proteins were higher in the recombinant CRYAA group than in the control group. (molvis.org)
  • Furthermore, the MLL-interacting protein Menin links MLL-fusion proteins with LEDGF, and the H3K36me3-binding PWWP domain of LEDGF is critical for the function of MLL-fusions 8 . (nature.com)
  • However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
  • To address this knowledge gap, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform to enable the genetic interrogation of hematopoiesis and broad aspects of immune cell function in vivo. (biorxiv.org)
  • However, targeted deletion of NF-κB/ Rel family members has not yet corroborated such a function. (rupress.org)