AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceNamed Groups
Trans Fatty AcidsEnzyme ActivatorsPlasminogen ActivatorsMolecular Sequence DataTrans-ActivatorsTranscription FactorsBase SequenceDNA-Binding ProteinsTranscription, GeneticHydrogenationPromoter Regions, GeneticAmino Acid SequenceTranscriptional ActivationEnzyme ActivationCell LineBinding SitesSignal TransductionStereoisomerismSTAT3 Transcription FactorUrokinase-Type Plasminogen ActivatorGene Expression RegulationKineticsCells, CulturedGenetic Complementation TestPlasmidsProtein Kinase CRNA, MessengerRecombinant Fusion ProteinsReceptors, Cytoplasmic and NuclearTransfectionBacterial ProteinsPhosphorylationSorbic AcidRepressor ProteinsTetradecanoylphorbol AcetateCloning, MolecularSTAT1 Transcription FactorProtein BindingRecombinant ProteinsEscherichia coliTissue Plasminogen ActivatorSaccharomyces cerevisiaeGene Expression Regulation, BacterialPlasminogen InactivatorsPeptidylprolyl IsomeraseFatty Acids, UnsaturatedDNAHeLa CellsHerpes Simplex Virus Protein Vmw65Saccharomyces cerevisiae ProteinsDiglyceridesSequence Homology, Amino AcidPlasminogenModels, MolecularModels, BiologicalMargarineGenes, ReporterPhorbol EstersEnhancer Elements, GeneticNuclear ProteinsSTAT5 Transcription FactorDietary FatsMutagenesis, Site-DirectedFatty AcidsLinoleic Acids, ConjugatedRNA Polymerase Sigma 54Carrier ProteinsSTAT Transcription FactorsDNA PrimersDose-Response Relationship, DrugGene ExpressionFungal ProteinsGene Expression Regulation, ViralGenes, BacterialMolecular StructureGenes, RegulatorProtein ConformationCell NucleusMilk ProteinsGene Expression Regulation, FungalMutagenesisFibrinolysinEnzyme InhibitorsModels, GeneticBlotting, WesternMutationFibrinolysisTumor Cells, CulturedViral ProteinsButterSequence DeletionGene DeletionProtein Structure, TertiaryDimerizationCricetinaeMembrane ProteinsBryostatinsTime FactorsCalciumTranscription Factor TFIID
TranscriptionalGeneProteinGenesProteinsSequencesPromoterDrosophilaGeneticBindCrRNANucleicActivityMiceSequenceCellAnimalsHumanPresenceSignal transducer and activator of transcriptionTranscriptional activatorProteinsGenomeProtein encoded by this geneChromosomeRNAsBindsBiomarkersSTAT1TumorReplicationExpressionPathwayRegulationFamilyPositiveSuggestControl
Transcriptional4
  • A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1. (microbiologyresearch.org)
  • Since the repression domain can convert various kinds of transcriptional activators to dominant repressors, this suggested that MS1 functioned as a transcriptional activator. (psu.edu)
  • HTLV-1 Taxes is certainly a transcriptional transactivator of pathogen replication and induces the appearance of a Spectinomycin HCl number of mobile genes by activation from the NF-B and CREB/ATF pathways (Matsuoka and Jeang 2011). (biotech2012.org)
  • Transcriptional activator Islet-Brain 1 (IB1) is disclosed which is involved in the control of the GLUT2 and insulin genes by interacting with homologous cis-regulatory elements of the GLUT2 and insulin promoters, and to materials and methods deriving from this work. (justia.com)
Gene9
  • The Arabidopsis thaliana MALE STERILITY1 (MS1)gene encodes a nuclear protein with Leu zipper-like and PHD-finger motifs and is important for postmeiotic pollen development. (psu.edu)
  • From NCBI Gene: The protein encoded by this gene is a member of the STAT protein family. (nih.gov)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • Other genes in the trichothecene biosynthetic pathway have been cloned including the tri3 gene, encoding a 15-O-acetyltransferase, from Fusarium sporotrichioides (McCormick et al. (justia.com)
  • the tri4 gene, encoding a cytochrome P450 monooxygenase, from Fusarium sporotrichioides (Hohn et al. (justia.com)
  • the tri6 gene, encoding a zinc finger protein involved in the regulation of trichothecene biosynthesis, from Fusarium sporotrichioides (Proctor et al. (justia.com)
  • Molecular pathogenesis of Taxes The gene encodes a 353-amino acidity, 40-kDa protein, Taxes, which has a central function in HTLV-1 biology (Bangham 2018). (biotech2012.org)
  • ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. (embl.de)
  • Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)
Protein7
  • The ZEBRA (Z EBV replication activator) protein is the major transcription factor of EBV, expressed upon EBV lytic cycle activation. (mdpi.com)
  • The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. (nih.gov)
  • The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. (nih.gov)
  • In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. (nih.gov)
  • The authors injected an AAV encoding a Cre-dependent channelrhodopsin fused to enhanced yellow fluorescent protein (ChR2-EYFP) into the cortical amygdala of a transgenic mouse in which the promoter drives the manifestation of a tamoxifen-dependent Cre-recombinase (CreERT2). (researchensemble.com)
  • The IB1cDNA encodes a 714 amino acid protein with a proline-rich region and a putative basic helix-loop-helix domain (bHLH). (justia.com)
  • We show that dri encodes a nuclear protein that contains asequence-specific DNA-binding domain that bears no similarity to knownDNA-binding domains. (embl.de)
Genes5
  • In addition, shrinkage of the dentate gyrus occurs in the CaMKIIα-tTA activator line, although it is not yet known whether this is due to the expression of tTA or to the disruption of one or more endogenous mouse genes. (alzforum.org)
  • The genes encode homeodomain-containing transcription factors that control cell fates by regulating the transcription of downstream target genes. (nih.gov)
  • The changes provide powerful assays for identifying the trans -acting factors that regulate the homeotic genes and the cis -acting sequences through which they act. (nih.gov)
  • While these transgenic assays have been important in defining the structure of the cis -regulatory elements and identifying trans -acting factors that bind to them, their functions within the context of the endogenous genes remain poorly understood. (nih.gov)
  • This region is known to encode for the genes CLEC16A, DEXI, and CIITI, which are expressed in immune cells and esophageal epithelial cells. (emmes.com)
Proteins1
  • Celecoxib structure A comparative genomic evaluation involving the genome of phage eiAU and that of phage SSL 2009a unveiled that genome regions encoding many putative structural and replica tion proteins are shared by both phages. (hivprotease-signal.com)
Sequences2
  • Identification of herpes simplex virus DNA sequences which encode a trans -acting, polypeptide responsible for stimulation of immediate early transcription. (microbiologyresearch.org)
  • The present invention also relates to isolated trichodiene synthases and isolated nucleic acid sequences encoding the trichodiene synthases. (justia.com)
Promoter2
  • rTg4510 mice ("r" for regulatable) are produced by crossing the 4510 responder line, carrying a human MAPT P301L cDNA downstream of a tetracycline operon-responsive element (TRE), to an activator line expressing a tetracycline-controlled transactivator (tTA) under control of the CaMKIIα promoter. (alzforum.org)
  • promoter drives manifestation of promoter drives manifestation of the tetracycline transactivator (tTA). (researchensemble.com)
Drosophila1
  • The trans -acting factors are also conserved between Drosophila and human and have important functions, not only in development but also in stem-cell maintenance and cancer. (nih.gov)
Genetic2
  • We used the high-density Immunochip platform, encoding 200,000 genetic variants for major auto-immune disease. (emmes.com)
  • Launch Genetic information can be encoded in DNA by the precise linear series of its bases. (smartrailexpo-europe.com)
Bind1
  • GTI and GTIII have been previously shown to bind distinct, but ubiquitously expressed trans-acting factors. (justia.com)
CrRNA3
  • 1 - 3 This attribute, known as trans-cleavage, is only activated once bound to an activator (ssDNA or dsDNA) that has complementary base-pairing to the guide crRNA. (biorxiv.org)
  • Based on the crystal structure of LbCas12a/crRNA/dsDNA (PDB ID: 5XUS) 12 , we reasoned that crRNA extensions can influence the trans-cleavage activity by either activating or inhibiting the catalytic efficiency of Cas12a, allowing us to better understand crRNA design with tunable trans-cleavage activity. (biorxiv.org)
  • the CRISPR-associated nuclease Cas9 (SpCas9), a specificity-determining CRISPR RNA (crRNA), and an auxiliary trans-activating crRNA (tracrRNA) 11 . (cdc.gov)
Nucleic1
  • This phenomenon has been efficiently harnessed by SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) and DETECTR (DNA Endonuclease Targeted CRISPR Trans Reporter) to reliably detect nucleic acids. (biorxiv.org)
Activity3
  • Understanding mind function requires knowing both how neural activity encodes information and how this activity generates right responses. (researchensemble.com)
  • The activity of these XCI-activators is counterbalanced by autosomally encoded XCI-inhibitors, many of which are pluripotency factors involved in repression of Xist , providing a powerful link between loss of pluripotency and XCI initiation. (erasmusmc.nl)
  • The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
Mice1
  • T2 mice were then crossed with the CaMKIIα-tTA activator line to create bi-transgenic mice (designated rT2/T2 when homozygous for the MAPT P301L transgene). (alzforum.org)
Sequence2
  • Trichothecenes are produced by a sequence of oxygenations, isomerizations, cyclizations, and esterifications leading from trichodiene, which is produced from the cyclization of trans, trans-farnesyl pyrophosphate by the enzyme trichodiene synthase (Desjardins, Hohn, and McCormick, 1993, Microbiological Reviews 57: 595-604). (justia.com)
  • When combined with a FRET-based reporter, a fluorophore connected to a quencher via a short oligonucleotide sequence, the presence of the target activator can be confirmed. (biorxiv.org)
Cell3
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (nih.gov)
  • Our goal is to understand how linear information encoded in genomic DNA controls cell fates during development. (nih.gov)
  • The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
Animals1
  • Animals were exposed to cigarette smoke and supplemented with trans-resveratrol (6.0 mg kg-1) for two months. (bvsalud.org)
Human2
  • EBV is the first human virus that has the capability to encode microRNAs (miRNAs). (ijbs.com)
  • Our present research is aimed at identifying novel XCI-activators, elucidate the mechanisms by which they direct female exclusive XCI, and translate these findings to human. (erasmusmc.nl)
Presence2
  • Our work involving studies of tetraploid, triploid and diploid mouse ES cells revealed that initiation of XCI is a stochastic process, and indicated the presence of X-linked activators of XCI. (erasmusmc.nl)
  • The REX1-RNF12 axis provides a strong link between female specific initiation of XCI and loss of pluripotency, but our studies and studies of others also indicate the presence of more XCI-activators. (erasmusmc.nl)
Signal transducer and activator of transcription1
  • The type I IFNs (IFN-α and IFN-β), which are crucial in antiviral defense and immune regulation, signal via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway with activation of STAT1 and STAT2. (jci.org)
Transcriptional activator2
  • Acts as a transcriptional activator for SERPINB5 promoter. (nih.gov)
  • STAT1β lacks the C-terminal TAD and has been previously reported to be a weaker transcriptional activator than STAT1α, although this was strongly dependent on the target gene. (frontiersin.org)
Proteins8
  • Analyses of nuclear targeted Gli1 and Gli2 proteins suggest that both activator and dominant negative proteins are modified forms. (nih.gov)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Mitochondria have circular DNA (mitochondrial DNA, mtDNA), and mitochondrial biogenesis (mitobiogenesis) involves the replication, transcription, and translation of mtDNA-encoded genes, the interorganelle transport of phospholipids, and the import of nuclear-encoded proteins into mitochondria through the protein translocation machinery of the outer and inner membranes [ 14 ]. (biomedcentral.com)
  • Given that the majority of mitochondrial proteins are nuclear-encoded, the transcription and translation of nuclear and mitochondrial genes must be tightly coordinated to ensure the creation of new mitochondria [ 17 ]. (biomedcentral.com)
  • Proteins encoded by the REV GENES of the HUMAN IMMUNODEFICIENCY VIRUS . (nih.gov)
  • Transcription from the human immunodeficiency computer virus (HIV)-1 is controlled by the cooperation of virally encoded and host regulatory proteins. (immune-source.com)
  • Proteins of the cytohesin/Arno/Grp1 family of Arf activators are positive regulators of the insulin-signaling pathway and control various remodeling events at the plasma membrane. (omicsdi.org)
  • Expression or transient expression of cell cycle arresting genes is described for "metabolic engineering", i.e. regulating expression of desirable proteins, and it is mentioned that a transcriptional "squelching" effect by the VP16 transactivator domain may be lethal for the host cell, even at moderate expression levels (Berger et al. (allindianpatents.com)
Genome3
  • Thus, the SFV-1 genome encodes a transactivator that functions on the LTR at the transcriptional level. (nih.gov)
  • 10. The 3' region of bovine leukemia virus genome encodes a trans-activator protein. (nih.gov)
  • The provirus integrated in the host genome may remain in a quiescent state in the resting lymphocytes until basal transcription produces a threshold level of the viral trans-activator protein, Tat. (biomedcentral.com)
Protein encoded by this gene2
  • From NCBI Gene: The protein encoded by this gene is a member of the STAT protein family. (nih.gov)
  • The protein encoded by this gene belongs to the ETS family of transcription factors. (nih.gov)
Chromosome1
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
RNAs1
  • Examples of cis- or trans-encoded antisense RNAs are discussed, and their properties compared. (cnrs.fr)
Binds1
  • The encoded protein binds DNA and is expressed in cells of the B lineage, but not in cell populations representing T lymphocytes or myeloid cells. (ox.ac.uk)
Biomarkers2
  • Fig. 1: Engineering DNA-encoded synthetic urine biomarkers with CRISPR-Cas-mediated disease detection. (nature.com)
  • DNA-encoded synthetic urine biomarkers are comprised of a nanocarrier (synthetic or biological) functionalized with protease-activated short peptides barcoded with oligonucleotides (1). (nature.com)
STAT11
  • In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. (nih.gov)
Tumor1
  • A CAG/CAA repeat length polymorphism encodes a stretch of 17 to 29 glutamines in the HR-interacting carboxyl-terminal region of the protein which is somatically unstable in tumor tissues and cell lines. (nih.gov)
Replication1
  • These data suggest a key role of IRF-1 in the early phase of viral replication and/or during viral reactivation from latency when viral transactivators are absent or present at very low levels and suggest that the interplay between IRF-1 and IRF-8 may play a key role in computer virus latency. (immune-source.com)
Expression2
  • The progeny viruses expressed from the activated viral gene expression are assembled on and budded through the host cell membrane after being processed by the viral encoded enzyme protease [ 7 ]. (biomedcentral.com)
  • Since the tTA gene is encoded on the multicistronic expression unit itself, little or no tTA is expressed under repressive conditions. (allindianpatents.com)
Pathway1
  • The mRNAs encoding three enzymes of the melatonin synthesis pathway (tryptophan hydroxylase (TPH), arylalkylamine-N-acetyltransferase (AANAT) and hydroxyindole-O-methyl-transferase (HIOMT)) are expressed with a day/night rhythm in the chicken pineal gland and retina. (nih.gov)
Regulation1
  • The DDIT4 gene, encoding the DNA-damage-inducible transcript 4, associated with regulation and development of DNA processes after damage by ionizing radiation and in p53 mediated apoptotic processes, is up-regulated. (ijpsr.com)
Family1
  • In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (nih.gov)
Positive1
  • Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop. (omicsdi.org)
Suggest1
  • Our data suggest that DNA-encoded nanosensors can non-invasively detect and differentiate disease states in transplanted and autochthonous murine cancer models. (nature.com)
Control1
  • The C14orf4 gene ( IRF2BPL ) suggests a bifunctional role in transcription control as a promotor's activator as well as a repressor. (ijpsr.com)