• The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. (thermofisher.com)
  • There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. (thermofisher.com)
  • Ten genes encode an alpha subunit in mammals, and of these, four are expressed in the cerebellum: Nav1.1, Nav1.2, Nav1.3 and Nav1.6. (nih.gov)
  • Three genes encode beta subunits (Nabeta1-3), and all three are expressed in the cerebellum. (nih.gov)
  • The gene encoding the Ov-phy-1 open reading frame contained 11 introns, similar in structure to the gene encoding human prolyl 4-hydroxylase isoform I. Genomic Southern blot, EST and genomic PCR studies demonstrated that the O. volvulus genome contained between three and eight genes closely related to Ov-phy-1. (embl.de)
  • Abstract: Fungal strains isolated from ixodid ticks in the Republic of Moldova were geneticallycharacterized using the ribosomal RNA operon internal transcribed spacer (ITS) regions togetherwith the 5.8S rRNA gene as well as the nuclear genes ef1α encoding the alpha subunit ofeukaryotic translation elongation factor 1α as phylogenetic markers. (iobc-wprs.org)
  • Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B which are expressed in a tissue-specific manner. (lu.se)
  • Sodium channels are heteromultimeric membrane proteins, consisting of a large alpha subunit that forms the pore, and one or more beta subunits. (nih.gov)
  • Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7. (medscape.com)
  • Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. (medscape.com)
  • This gene encodes one member of the sodium channel alpha subunit gene family. (nih.gov)
  • Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene. (wikipedia.org)
  • Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. (drugbank.com)
  • A cDNA encoding the human gamma-aminobutyric acidA (GABAA) receptor alpha 6 subunit has been cloned and sequenced. (drugbank.com)
  • Recombinant human alpha 6 beta gamma 2S GABAA receptors have been expressed in both stably transfected cells and Xenopus oocytes, and the pharmacology of the benzodiazepine binding site has been determined. (drugbank.com)
  • A number of compounds that bind to the benzodiazepine site potentiated the GABA response of alpha 6 beta 2 gamma 2 receptors. (drugbank.com)
  • The AMPK enzyme complex consists of one catalytic (alpha) and two regulatory (beta and gamma) subunits. (usda.gov)
  • Previously, we found that chickens expressed three gamma subunits (gamma 1-3), each encoded by a different gene. (usda.gov)
  • The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. (thermofisher.com)
  • This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. (nih.gov)
  • The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. (avivasysbio.com)
  • Exists as a hetero-oligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. (lu.se)
  • Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. (wikipedia.org)
  • The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. (wikipedia.org)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • EC 3.2.1.52), the beta subunits of Hex A (EC 3.2.1.52), and the G M2 activator protein. (medscape.com)
  • Hex A is a dimer and has the structure alpha-beta. (medscape.com)
  • the beta subunit is encoded by the HEXB gene at band 5q13. (medscape.com)
  • A site on the alpha subunit acts against negatively charged sulfated substrates, while a site on the beta subunit acts against neutral water-soluble substrates. (medscape.com)
  • This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). (thermofisher.com)
  • Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. (semanticscholar.org)
  • The primary structure of the alpha and beta subunits. (wikipedia.org)
  • The alpha subunit and beta subunit. (wikipedia.org)
  • Molecular cloning of the human thyrotropin-beta subunit gene. (wikipedia.org)
  • In sandwich immunoassays, less than 0.15% cross-reactivity or interference was observed with recombinant human (rh) IGF-I, rhIGF‑II, rhIL‑3 R alpha, rhIL‑9 R, and rhTGF‑ beta RII. (rndsystems.com)
  • Insulin-like growth factor I receptor (IGF-I R) is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. (rndsystems.com)
  • Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. (rndsystems.com)
  • The alpha subunit of IGF-I R is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. (rndsystems.com)
  • Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
  • This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. (ucsc.edu)
  • Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable). (ucsc.edu)
  • Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
  • Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. (novusbio.com)
  • Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. (nih.gov)
  • Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
  • Studies link a gene cluster encoding for alpha 3 beta 4 alpha 5-D398N nicotinic acetylcholine receptors to lung cancer risk as well as link a second mutation in this cluster to an increased risk for nicotine dependence. (rti.org)
  • However, there are currently no recognized drugs for discriminating alpha 3 beta 4 alpha 5 signaling. (rti.org)
  • In this study, we describe the development of homogeneous HEK-293 cell clones of alpha 3 beta 4 and alpha 3 beta 4 alpha 5 receptors appropriate for drug screening and characterizing biochemical and pharmacological properties of incorporated alpha 5 subunits. (rti.org)
  • We demonstrated an incorporation of two alpha 3 subunits in approximately 98% of plasma membrane receptor pentamers, indicating a 2/3 subunit expression ratio of alpha 3 to beta 4 alone or to coexpressed beta 4 and alpha 5. (rti.org)
  • Hit compounds from both libraries suggest the alpha 5 and alpha 5-D398N subunits allosterically modify the behavior of nicotine at the parent alpha 3 beta 4 nicotinic acetylcholine receptor. (rti.org)
  • The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. (nih.gov)
  • The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. (nih.gov)
  • Sodium channel subunit beta-2 or Navbeta2 Na+ channel is encoded by SCN2B. (antibodiesinc.com)
  • Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. (antibodiesinc.com)
  • Direct sequencing of PRAKCB encoding for the catalytic subunit beta (C^. (endocrine-abstracts.org)
  • Tay-Sachs disease (TSD) and its variants are caused by absence or defects of the alpha subunit of Hex A. (medscape.com)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (thermofisher.com)
  • Exons containing variants were sequenced directly by the standard dideoxy method using [alpha- 32 P]dCTP as label and the fmol sequencing kit ( Promega , Madison,WI). (molvis.org)
  • Alternative splicing results in many transcript variants encoding different proteins. (thermofisher.com)
  • Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. (ucsc.edu)
  • Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. (novusbio.com)
  • Two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). (nih.gov)
  • Introduction: Alterations of the cAMP signaling pathway are described in adrenal tumors causing Cushing syndrome, specifically mutations in the gene coding for the protein kinase A (PKA) catalytic subunit alpha (PRAKCA) in cortisol producing adenomas (CPA) with overt Cushing syndrome.Materiel and Methods: Eight CPAs without PRKACA mutations were analyzed by whole exome sequencing. (endocrine-abstracts.org)
  • This gene encodes an enzyme responsible for this post-translational modification. (antikoerper-online.de)
  • Encodes the alpha-subunit of a glucosidase II enzyme. (or.jp)
  • The hyperkalemic form is due to mutations in the gene that encodes the alpha-subunit of the skeletal muscle sodium channel ( SCN4A ). (msdmanuals.com)
  • Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
  • Navß2 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. (antibodiesinc.com)
  • The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. (thermofisher.com)
  • Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. (ucsc.edu)
  • The deduced amino acid sequence of this cDNA shows 91.4% identity with the published rat alpha 6 subunit. (drugbank.com)
  • Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. (wikipedia.org)
  • A full-length cDNA (Ov-phy-1) encoding a catalytically active alpha-subunit of Onchocerca volvulus prolyl 4-hydroxylase was isolated and characterized. (embl.de)
  • At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. (antikoerper-online.de)
  • The derived amino acid sequence of Ov-phy-1 encoded a peptide that was most similar to the two Caenorhabditis elegans prolyl 4-hydroxylase homologues and to the isoform II enzymes of vertebrates. (embl.de)
  • This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)
  • Forms heteromultimeric complex with alpha subunits. (ucsc.edu)
  • The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones. (wikipedia.org)
  • Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. (nih.gov)
  • The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. (nih.gov)
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • cDNAs encoding functional maxi KCa channel alpha-subunits (hslo) were cloned from human myometrium. (semanticscholar.org)
  • The isoform alpha-1F gives rise to L-type calcium currents. (hmdb.ca)
  • The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2.1 and Kv2.2, mediate the bulk of the neuronal delayed rectifier K + current in many mammalian central neurons. (jneurosci.org)
  • This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
  • In situ hybridization histochemistry reveals the alpha 6 mRNA to be located within the granule cell layer of the human cerebellar cortex. (drugbank.com)
  • Dryja TP, Hahn LB, Reboul T, Arnaud B. Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. (medlineplus.gov)
  • Around 80% of affected patients with DS carry a mutation in the alpha-1 subunit of the sodium channel of the SCN1A gene localized in 2q24.3, encoding a voltage-gated sodium channel essential for the excitability of neurons. (hindawi.com)
  • In the hypokalemic form, 70% of affected people have a mutation in the alpha-subunit of the voltage-sensitive muscle calcium channel gene on chromosome 1q (HypoPP type I). In some families, the mutation is in the alpha-subunit of the sodium channel gene on chromosome 17 (HypoPP type II). (msdmanuals.com)
  • The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. (novusbio.com)
  • CNTFR encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. (novusbio.com)
  • With prolonged nicotine exposure, the plasma membrane expression of receptors with and without incorporated alpha 5 increased. (rti.org)
  • Whereas alpha 5 subunit expression decreased the cell calcium response to nicotine and reduced plasma membrane receptor number, it partially protected receptors from nicotine mediated desensitization. (rti.org)
  • For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
  • Spiller B. O., Blackbourne, D., Mark L, Proctor D. and * Blom A. M. , (2003) Functional activity of the complement regulator encoded by Kaposi's sarcoma associated herpesvirus. (lu.se)
  • a plastid-encoded bacterial-type RNA polymerase (PEP) and a nuclear-encoded phage-type RNA polymerase (NEP), which recognize distinct types of promoters. (frontiersin.org)
  • Much less is known of the highly related Kv2.2 subunit, especially in forebrain neurons. (jneurosci.org)
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. (thermofisher.com)
  • The protein encoded by this gene represents the alpha subunit. (nih.gov)
  • Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. (wikipedia.org)
  • Linear amino acid sequence of the alpha subunit. (wikipedia.org)
  • Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). (wikipedia.org)
  • The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. (thermofisher.com)
  • CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. (thermofisher.com)
  • This protein is one part (the alpha subunit) of a protein complex called transducin. (medlineplus.gov)
  • This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
  • In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. (prosci-inc.com)
  • Both subunit precursors acquire the mannose 6-phosphate marker for recognition by lysosomes. (medscape.com)
  • Genomic DNAs were amplified by PCR in the presence of [alpha- 32 P]dCTP, electrophoresed in 7% acrylamide denaturing gels along with a size marker, and exposed to X-ray film as described previously (12). (molvis.org)
  • In summary, the present data suggest that deficits of BDNF levels and signaling through ERK1/2 and alpha-CaMKII might contribute to cognitive and neuroplastic defects associated with prenatal exposure to cannabinoids. (researchgate.net)
  • and CNCG , encoding the alpha-subunit of the rod cGMP-gated channel, 3/173 patients (7). (molvis.org)
  • This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (ucsc.edu)
  • The restricted pattern of Kv2.2 expression persists in Kv2.1-KO mice, suggesting distinct cell- and layer-specific functions for these two highly related Kv2 subunits. (jneurosci.org)
  • These studies identify pharmacological tools from two distinct classes of drugs, antagonists and modifiers that are alpha 5 and alpha 5-D398N subtype selective that provide a means to characterize the role of the CHRNAS/A3/B4 gene cluster in smoking and cancer. (rti.org)