• Genomic survey and gene expression analysis of the basic leucine zipper transcription factor family in rice , 2008, Plant Physiol. (github.io)
  • This gene encodes a basic leucine zipper (bZIP) transcription factor. (wikipedia.org)
  • Erratum: Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors (Proc. (tmu.edu.tw)
  • We have cloned and characterized the Dictyostelium discoideum repE gene, a homolog of the human xeroderma pigmentosum (XP) group E gene which encodes a UV-damaged DNA binding protein. (nih.gov)
  • Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
  • MYC associated factor X (MAX) is a gene that encodes a protein belongs to the basic helix-loop-helix leucine zipper (bHLHZ) transcription factor family. (mycancergenome.org)
  • MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. (prosci-inc.com)
  • Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. (prosci-inc.com)
  • Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene . (en-academic.com)
  • This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. (en-academic.com)
  • 1992). "A conserved retina-specific gene encodes a basic motif/leucine zipper domain" . (en-academic.com)
  • AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. (biomedcentral.com)
  • here, we describe a tcr gene transfer regimen to rapidly and reliably generate t-cells specific to ebv-encoded latent membrane protein-1 (lmp1), which is a potential target for t-cell-based immunotherapy. (liverpool.ac.uk)
  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. (zfdows.com)
  • This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. (bicnirrh.res.in)
  • Multiple transcript variants encoding different isoforms have been characterized for this gene. (bicnirrh.res.in)
  • The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. (gzsys.org.cn)
  • To describe the clinical phenotype and genetic basis of non-syndromic retinitis pigmentosa (RP) in one family and two sporadic cases with biallelic mutations in the transcription factor neural retina leucine zipper ( NRL) . (molvis.org)
  • These genes encode proteins that are required for the development and maintenance of photoreceptor structure and its matrix membranes, visual transduction, ciliary trafficking and photoreceptor outer segment shedding. (molvis.org)
  • many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. (bicnirrh.res.in)
  • Presence of a leucine zipper motif, characteristic of translation elongation factor-1 delta, was also found in the mouse TEF 1 delta. (cdc.gov)
  • AP4 (TFAP4) is a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor that exclusively forms homodimers, which bind to the E-box motif CAGCTG [ 3 ]. (biomedcentral.com)
  • We predicted the DNA-binding patterns and the dimerization properties, based on the characteristic features in the basic and hinge regions and the Leu zipper, respectively, which indicated that some highly conserved amino acid residues existed across each major group. (datadryad.org)
  • These 23 PpHDZ transcription factors all contained a homeomorphism box domain and a leucine zipper domain, were divided into 4 subfamilies(I-IV) according to the evolutionary analysis, and their promoters contained many different cis-acting elements. (biomedcentral.com)
  • Remarkably, EBV-encoded miRNAs are abundantly expressed in latently-infected cells and serve important function in viral infection and pathogenesis. (ijbs.com)
  • For example, murine gammaherpesvirus 68 (MHV-68)-encoded miRNAs are located downstream of viral tRNAs and transcribed by RNA Pol III [ 2 ]. (ijbs.com)
  • The genome of the nairoviruses consists of 3 segments of negative-sense, single-stranded RNA, small (S), medium (M), and large (L), which encode the nucleocapsid protein, glycoproteins (Gn and Gc), and viral polymerase, respectively. (cdc.gov)
  • The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. (en-academic.com)
  • Their phenotypes are similar to mutations in ABI3, which is thought to encode a 2019-12-02 · Since XIW1 affects ABI5 protein abundance, and both XIW1 and ABI5 are located in the nucleus in the presence of ABA, we wondered whether there is a direct interaction between XIW1 and ABI5. (firebaseapp.com)
  • The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. (cancerindex.org)
  • Nucleotide sequence analysis of TEF-1 delta cDNA revealed an open reading frame encoding the predicted protein of 281 amino acids and exhibited significant conservation with the corresponding protein of human, Xenopus laevis and Artemia. (cdc.gov)
  • EBV is the first human virus that has the capability to encode microRNAs (miRNAs). (ijbs.com)
  • Wang M, Yu F, Wu W, Wang Y, Ding H, Qian L. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses. (ijbs.com)
  • Additionally, an M segment-encoded nonstructural protein, NS M , was recently identified in the nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV) ( 1 ). (cdc.gov)
  • AP4 -deficient cells displayed increased expression of the long non-coding RNA MIR22HG, which encodes miR-22-3p and was directly repressed by AP4. (biomedcentral.com)
  • Subfamily I HKT genes ( HKT1s ) encode Na + -selective transporters, which are mostly located at the plasma membrane in xylem parenchyma cells. (springeropen.com)
  • All HD-ZIP superclass proteins possess HD and leucine-zipper (LZ) domains. (frontiersin.org)
  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. (caslab.com)
  • These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
  • As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (nih.gov)
  • The core abscisic acid (ABA) signaling pathway consists of receptors, phosphatases, kinases and transcription factors, among them ABA INSENSITIVE 5 (ABI5) and ABRE BINDING FACTORs/ABRE-BINDING PROTEINs (ABFs/AREBs), which belong to the BASIC LEUCINE ZIPPER (bZIP) family and control expression of stress-responsive genes. (mdpi.com)
  • It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. (gzsys.org.cn)
  • While deep sequencing and qPCR analysis have shown that L1 copy number is much higher in certain parts of the human brain, direct in vivo studies regarding detection of L1-encoded proteins is lacking due to ineffective reagents. (biomedcentral.com)
  • Immediate early and delayed early genes each comprised an estimated several dozen genes encoding a diverse set of proteins (4-6). (nih.gov)
  • The largest class of immediate early response genes encoded transcription factors, including members of the AP1 basic-leucine zipper family (c-Jun, JunB, c-Fos, Fra-1 FosB), the Egr1/Zif268 family of zinc finger proteins (8,9), c-Myc, and Id proteins. (nih.gov)
  • Results Env-enriched VLPs showed high levels of Env content and retained their physical and functional properties Modified Env gene constructs were generated by replacing the original transmission peptide encoding sequences with the honeybee melittin sequence and adding a trimeric form of leucine zipper sequence, GCN4pii to the C-termini of Env cytoplasmic sequences to increase Env glycoprotein production and to express conformation-stabilized trimeric Env proteins, respectively (Fig. (rawveronica.com)
  • Both of these genes encode secreted proteins implicated in the modulation cell growth and differentiation, and IGFBP-3 was shown previously to have tumor suppressing activity. (nih.gov)
  • However, most transcribed sequences do not encode proteins, and little is known about the functional relevance of noncoding (nc) transcriptome in neuronal subtypes. (nih.gov)
  • In addition to these HD-ZIP proteins, leucine zippers can be found in the plant-specific WRKY factors as well as in basic leucine zippers, which are present in all three eukaryotic kingdoms. (biomedcentral.com)
  • As the authors point out, the function of approximately 40-50% of the proteins encoded by each genome cannot be determined on the basis of similarities to proteins of known function. (biomedcentral.com)
  • The alignment of the deduced mandarinfish Mx protein amino acid sequence with that of other species shows that the Mx protein of mandarinfish contains a triparitite guanosine-5'-triphosphate (GTP)-binding motif (GXXXSGKS/T, DXXG, T/NKXD), a signature of the dynamin family (LPRGS/ KGIVTR), and a highly conserved leucine zipper motif in the C-terminal region of the protein, which are conserved in all IFN-induced Mx proteins of vertebrates. (virosin.org)
  • Genetically-encoded reporter constructs that are derived from fluorescent proteins are leading a revolution in the real-time visualization and tracking of various cellular events. (nature.com)
  • The FGFR2 gene encodes a tyrosine kinase receptor with 3 immunoglobulin domains, a signal sequence, an acidic region in the extracellular ligand binding site, and 2 tyrosine kinase domains localized intracellularly. (medscape.com)
  • The KIT gene encodes a plasma membrane receptor with a ligand-binding domain containing 5 immunoglobulinlike regions and 2 tyrosine kinase domains in the cytoplasm. (medscape.com)
  • In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 ( LZTR1 ) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. (nih.gov)
  • One of the most frequently amplified genes residing on chromosome 3 is MAP3K13, which encodes the Leucine Zipper-bearing Kinase (LZK). (nih.gov)
  • The protein encoded by this gene is a member of the serine/threonine kinase family. (nih.gov)
  • Description: Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. (cd-34.com)
  • This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. (cd-34.com)
  • Mutations in the gene that encode this kinase are associated with X-LINKED AGAMMAGLOBULINEMIA. (nih.gov)
  • The PAX3 gene encodes a transcription factor with a paired box domain, an octapeptide domain, and a homeobox domain essential for survival of melanocytes during development. (medscape.com)
  • RCO arose through gene duplication and encodes a class I homeobox-leucine zipper protein. (mpg.de)
  • The EDNRB gene encodes a G protein-coupled plasma membrane receptor with 7 transmembrane domains and 2 autophosphorylation sites. (medscape.com)
  • Alternate splicing of this gene results in two transcript variants encoding different isoforms. (antibodies-online.com)
  • Two transcript variants encoding the same protein have been found for this gene. (nih.gov)
  • Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. (nih.gov)
  • These variants encode at least five different isoforms. (cd-34.com)
  • Two such genes are PTCH1 and GLI1 (encoding the Shh receptor and a transcriptional activator, respectively), exemplifying the feedback and fine-tuning of the Shh pathway. (biorxiv.org)
  • Four promoters are involved, two of which depend on the transcriptional activator GvpE that resembles a leucine-zipper protein. (tu-darmstadt.de)
  • Our genetic screens uncovered a basic helix-loop-helix leucine zipper transcription factor called TFAP4 as a potential regulator of WNT signaling. (nih.gov)
  • The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. (nih.gov)
  • The MITF gene encodes a transcription factor containing a basic-helix-loop-helix-leucine zipper. (medscape.com)
  • A pool of alpha-helix encoding sequences was designed and selected for interference with the coiled coil domain (CC) of a melanoma-associated basic-helix-loop-helix-leucine-zipper (bHLHLZ) protein, the microphthalmia associated transcription factor (MITF). (uni-bielefeld.de)
  • We have begun to address these questions by studying WNT signaling, a fundamental pathway that encodes positional information in animals, orchestrates patterning and morphogenesis during embryonic development, and promotes tissue renewal and regeneration in adults. (nih.gov)
  • The mouse gene, tsg101, appears to suppress malignant cell growth, and the putative protein encoded by tsg 101 has the sequence characteristics of a transcription factor. (davidson.edu)
  • In addition, a small open reading frame encoding a 21-aa peptide is found in 5'-UTR D , and the role of this putative peptide in gene regulation or in the formation of the gas vesicle structure is addressed. (tu-darmstadt.de)
  • Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A. LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients. (medlineplus.gov)
  • Encodes an auxin efflux carrier that is similar to bacterial membrane transporters. (or.jp)
  • NEEDLE1 encodes an ATP-dependent metalloprotease which alters endogenous auxin levels. (adenosine-kinase.com)
  • 13. An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. (nih.gov)
  • Nucleotide sequence analysis of TEF-1 delta cDNA revealed an open reading frame encoding the predicted protein of 281 amino acids and exhibited significant conservation with the corresponding protein of human, Xenopus laevis and Artemia. (cdc.gov)
  • An open reading frame of 1140 nucleotides found in the cDNA sequence was predicted to encode a 380 amino acid protein with a mass of 42.841 kDa. (davidson.edu)
  • The result of sequence analysis indicates that the 2.4kb mandarinfish Mx cDNA contains an open reading frame (ORF) of 1881nt encoding a 627 amino acid protein whose deduced protein molecular weight is 71.5kDa. (virosin.org)
  • This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. (nih.gov)
  • The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. (medlineplus.gov)
  • A novel rat gene encoding a Humicein‐like peptide endowed with broad neuroprotective activity"​1​ 1. (researchpeptides.net)
  • Delta sleep‐inducing peptide and glucocorticoid‐induced leucine zipper: potential links between circadian mechanisms and obesity? (researchpeptides.net)
  • One point mutation at a splice junction site results in transcripts that encode a truncated protein lacking the fork head homology domain. (nih.gov)
  • Within the Arabidopsis genome, 1,533 genes were found to encode members of known transcription factor families, 45% of which are from families specific for plants. (biomedcentral.com)
  • The EDN3 gene encodes a ligand called endothelin-3 for the endothelin-B receptor. (medscape.com)
  • The Env, a virally encoded protein which hides conserved CD4 and co-receptor binding sites with an evolving shield of glycans, variable immunodominant loops, and conformational masks, is the only target for antibodies to neutralize7. (rawveronica.com)
  • Nucleotide-binding site and leucine-rich repeat (NBS-LRR) genes are the largest class of disease resistance genes cloned from plant with highly conserved domains, which can be used to facilitate the isolation of candidate genes associated with downy mildew resistance in IL5211S. (biomedcentral.com)
  • The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. (gzsys.org.cn)
  • We show that the leucine-zipper protein LUZP1 localizes to the pericentriolar material and actin cytoskeleton. (biorxiv.org)
  • The gene, encoding a leucine zipper type transcription aspect, can be rod-specific (and rod-promoting) in mammals (Hennig et al. (bioxorio.com)
  • On the other hand, the ubiquitously expressed transcription factor GAGA , which is encoded by the Trithorax-like (Trl) gene was previously demonstrated to be important for Drosophila oogenesis. (sdbonline.org)