Encodes integral proteins. Medical search. Frequent questions

The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. (rupress.org)
This gene encodes an integral membrane protein. (wikipedia.org)
The BRAF (v-raf murine sarcoma viral oncogene homolog B) gene encodes a protein that belongs to the Raf family of serine/threonine protein kinases. (hindawi.com)
From NCBI Gene: This gene encodes a member of the claudin family. (nih.gov)
This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. (nih.gov)
This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. (dimabio.com)
The SLC30A2 gene encodes a zinc transporter, ZnT2. (medscape.com)

Duchenne and Becker muscular dystrophies are caused by mutations in the same gene encoding dystrophin. (medscape.com)
Out of 25 patients with infantile nephropathic cystinosis, 12 have two severely truncating mutations, which is consistent with a loss of functional protein, and 13 have missense or in-frame deletions, which would result in disruption of transmembrane domains and loss of protein function. (embl.de)
Eleven different mutations, all predicted to cause loss of function of the protein, were found to segregate with the disorder. (embl.de)
Heterozygous germline inactivating mutations in SDHD , SDHC , and SDHB , which encode three of the four subunits of mitochondrial complex II (succinate dehydrogenase), cause hereditary paraganglioma types 1, 3, and 4 (PGL1, PGL3, and PGL4), respectively. (bmj.com)
Because the molecular basis of the parent of origin effects in PGL1 is unknown, it is unclear whether transmissions of mutations in SDHC , the protein product of which couples with that of SDHD and forms the membrane spanning domain of mitochondrial complex II, also shows any parent of origin effects. (bmj.com)
The protein folding code can also be used to identify the biochemical consequences of mutations that cause disease. (utoronto.ca)
To investigate the emergence of compensatory mutations in the viral proteins during cell passaging, the consensus sequences of the entire polyprotein coding regions of the wild type JFH1 and three chimeric viruses were determined. (monash.edu)
Mutations in PIGA result in loss of all GPI-anchored proteins, including CD59, an important complement-regulating protein, on the surface of blood cells. (msdmanuals.com)

It is transcribed as an integral part of the mRNA encoded by the gene. (omicsonline.org)
When a cell needs to make a particular protein, it first copies the instructions from the matching gene into a molecule known as a messenger RNA (or an mRNA for short). (elifesciences.org)
The more mRNA copies it makes, the more protein it can produce. (elifesciences.org)
A simple way to control protein production is to raise or lower the number of these mRNA messages, and living cells have lots of ways to make this happen. (elifesciences.org)
The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

They are integral membrane zinc metaloprotease that cleave transmembrane domains in proteins. (tcdb.org)
Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. (embl.de)
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. (novusbio.com)
Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)
One or more ICEBs1 proteins are required for ConE's localization at the membrane, as ConE lacks predicted transmembrane segments and ConE-GFP is found dispersed throughout the cytoplasm in cells lacking ICEBs1. (bvsalud.org)

All four required genes encode predicted integral membrane proteins. (bvsalud.org)

The gene encoding human NPT1 maps to chromosome 6q21.3-p23, while the gene encoding human NPT2 maps to chromosome 5q35. (thermofisher.com)
PIGA , located on the X chromosome, encodes a protein that is integral for formation of the glycosylphosphatidylinositol (GPI) anchor for membrane proteins. (msdmanuals.com)

The recently developed HCV cell culture system, based on the JFH1 strain of HCV, has provided an opportunity to study the role of the viral proteins in the complete HCV replication cycle in human hepatoma cells. (monash.edu)
How the viral proteins functionally interact during replication of HCV in cell culture is not completely understood. (monash.edu)
Using this approach, the functional interactions of p7 and E2 with other viral proteins during HCV replication was investigated. (monash.edu)

Simeprevir inhibits HCV NS3/4A protease needed for proteolytic cleavage of the HCV-encoded polyprotein into mature forms. (medscape.com)
NS3/4A protease is needed for proteolytic cleavage of the HCV-encoded polyprotein into mature forms. (medscape.com)

Synaptogyrin 3 is a protein that in humans is encoded by the SYNGR3 gene. (wikipedia.org)
There are approximately 20,000 protein-coding genes in humans, and many of these proteins are integral to processes occurring in cells at all times. (oregonstate.edu)
We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)
Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene . (wn.com)
Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)

To be able to present knowledge to assist reply this query, we, subsequently, investigated the consequences of endurance coaching on the degrees of host proteins concerned in SARS-CoV-2 an infection in mice. (aidstar-one.com)
Taken collectively, endurance coaching altered the degrees of host proteins concerned in SARS-CoV-2 cell entry in an organ-dependent method. (aidstar-one.com)
Most NLRs guard host proteins that are the direct targets of pathogen effectors. (ubc.ca)

They are frequently encoded in gene clusters with lantibiotic biosynthetic enzymes and ABC transporters. (tcdb.org)

Helix Capping Propensities in Peptides Parallel Those Found in Proteins. (utoronto.ca)

The selected candidate will become an integral part of a research project focused on exploring the non-canonical functions of two complement proteins, C3 and CD59, in the pathophysiology of pancreatic β-cells, particularly in their connection to diabetes development. (lu.se)

A small protein of 63 amino acids, p7 is encoded at the junction of the structural and non-strucutural region. (monash.edu)

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. (genetex.com)
The gene SLC39A4 was found to encode a solute carrier protein called human zinc/iron-regulated transporterlike protein (hZIP4). (medscape.com)

The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. (thermofisher.com)
For example, alkaline vacuole/lysosome are deficient in autophagy, Golgi pH regulates its ability to glycosylate proteins and failure to maintain endosomal pH perturbs with its ability to recycle receptors to the Plasma membrane or, the trans-Golgi. (upstate.edu)
[ 3 ] This protein controls zinc uptake across the plasma membrane of various cell types, including the intestine. (medscape.com)

Researchers from the University of Sheffield found that while the proteins varied, there were structurally similar portions that interacted with the machinery. (diamond.ac.uk)

SUSA2 encodes an F-box protein Actin-Related Protein 8 (ARP8) and SUSA3 encodes the chaperone protein HSP90.3. (ubc.ca)

The Wistar team demonstrated how TERRA mediates and partially stabilizes interactions between telomeric proteins that play essential roles in DNA replication. (news-medical.net)
As the assembly was carried out in the absence of ATP, this suggests that formation of the holoenzyme from the individual subcomplexes is solely driven by protein-protein interactions at the interface. (upstate.edu)
Interestingly, functionally redundant SNIPER1 and SNIPER2 can control the protein levels of diverse sNLRs and the interactions between SNIPER1 and sNLRs appear to be through the common nucleotide-binding (NB) domains of sNLRs. (ubc.ca)
In summary, this thesis demonstrates the importance of functional interactions between HCV proteins during virus morphogenesis and infectivity. (monash.edu)
These encompass cutting-edge techniques such as advanced flow cytometry, confocal microscopy, molecular methodologies, including CRISPR/Cas-9 gene editing, investigations into protein interactions, and specialized assays tailored for β-cell research. (lu.se)

In cell cultures, through RNA affinity purification, a process that isolates a single type of protein from a complex mixture, the team identified telomeric proteins (Shelterin components TRF1 and TRF2, and origin recognition complex subunits ORC1, ORC2, and ORC4) that bound to a TERRA oligonucleotide sequence but not to control oligonucleotides. (news-medical.net)
The mechanism by which a particular protein folds into its 3D structure is encoded in its amino acid sequence. (utoronto.ca)
From its sequence we foresaw that the enzyme could be an integral membrane protein, therefore difficult to isolate and handle. (europa.eu)
These sequences represent the protein coding region of the KCNJ14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)
Peptide with sequence C-TELEYLGPDEND, from the C Terminus of the protein sequence according to NP_001033.1. (genetex.com)
Toc12 shares a high degree of sequence similarity with Arabidopsis (Arabidopsis thaliana) DnaJ-J8, which has been suggested to be a soluble protein of the chloroplast stroma. (ncku.edu.tw)

1] "A Synechococcus gene encoding a putative pore-forming intrinsic membrane protein. (tcdb.org)

It was shown to be an integral outer membrane protein localizing in the intermembrane space of the chloroplast envelope. (ncku.edu.tw)

Here we report on DNA variants in MINAR2 , encoding membrane integral NOTCH2-associated receptor 2, in four families underlying autosomal recessive nonsyndromic deafness. (nih.gov)
This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. (antibodies-online.com)
In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)

This protein is thought to be part of a family of integral Golgi membrane proteins. (novusbio.com)

A fusion of ConE to green fluorescent protein (GFP) localizes to the membrane preferentially at the cell poles. (bvsalud.org)

In this thesis, a chimeric JFH1 genome that encodes the p7 protein of genotype (GT) 1b strain J4 was generated. (monash.edu)

It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. (wn.com)
Oxr1p belongs to the group of TLDc domain containing proteins that are highly conserved in higher eukaryotes. (upstate.edu)

The protein folding code will aid in interpreting genomic sequences by providing information which can be used to infer function for new genes. (utoronto.ca)
Known as "destabilising motifs", these sequences attract the attention of a group of proteins called Ccr4-Not. (elifesciences.org)
However, unlike the other components of the harpoon, there are distinct variants of the TssA protein that contain radically different amino acid sequences at one end of the protein. (diamond.ac.uk)

Further characterization showed that susa2-2 only suppresses the autoimmunity mediated by either CHS1-SOC3 or TN2-SOC3 paired NLR proteins, indicating that SUSA2 is specifically involved in NLR protein SOC3-mediated immunity. (ubc.ca)
Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

This entry represents the extracellular repeated domains found in cadherins and related proteins. (embl.de)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)

Journal cover: V-ATPase is regulated by disassembly into soluble V 1 (shown in cyan) and membrane integral V o (shown in gold) subcomplexes. (upstate.edu)

Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)

The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. (nih.gov)
The M50 Peptidase (S2P-M50) family includes proteins frequently of 700-800 aas in length with six N-terminal or centrally located TMSs. (tcdb.org)
It is a potential target for ubiquitination by the Nedd4 family of proteins. (novusbio.com)
However, proteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. (embl.de)
p7 is a highly hydrophobic, integral membrane protein and is classified in the viroporin family. (monash.edu)
Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)

G (His81Gln) mutation in the MPZ gene, which encodes the major integral membrane protein of the peripheral nerve system. (nih.gov)
They consist of two types, peripheral and integral proteins. (curehunter.com)

Protein concentration was measured by BCA protein assay kit.This product is manufactured by and sold under license from OriGene Technologies and its use is limited solely for research purposes. (novusbio.com)

In a study published on-line on August 27 in Molecular Cell, the Wistar scientists, led by Lieberman, describe how they discovered the telomere proteins that interact with TERRA and the processes by which they do so. (news-medical.net)

Real-time quantitative PCR (RT-qPCR) analysis and sfGFP (superfolder green fluorescent protein) analysis reveal that AmtR directly and negatively regulates the transcription and expression of crn A, cre T, csh A, and hyu B. A growth test shows that C. glutamicum ATCC 14067 can use creatine or creatinine as a sole nitrogen source. (frontiersin.org)
Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. (harvard.edu)

[ 4 ] Protein hZIP4 transports zinc ions from the cell exterior or lumen of intracellular organelles into the cytoplasm, where it is available to other newly synthesized proteins. (medscape.com)

The fragment encoding HAI-tagged EYFP was fused with the C-terminus of glycerol-phosphate dehydrogenase, an integral protein of the inner mitochondrial membrane. (harvard.edu)

We show that Per8p is an integral membrane protein of the peroxisome and that it is concentrated in the membranes of newly formed organelles. (rupress.org)
Proteins which are found in membranes including cellular and intracellular membranes. (curehunter.com)

The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. (wikipedia.org)
For example, Streptomyces griseus encodes in the following order: an ABC-2 type transporter, an ABC-type ATPase (see TC#3.A.1.105.11), a S2P-M50 peptidase with a CBS domain (see 9.B.149.1.1), a lantibiotic synthesis protein and a lantibiotic dehydratase. (tcdb.org)
however, homology to other proteins suggests that it may be an integral membrane transporter. (antibodypedia.com)

Two transcript variants encoding the same protein have been found for this gene. (thermofisher.com)
Multiple transcript variants encoding different isoforms have been found for this gene. (antibodies-online.com)
Alternatively spliced transcript variants encoding different isoforms have been identified. (antibodypedia.com)

The encoded protein is thought to undergo O-linked glycosylation. (thermofisher.com)

Dystrophin protein is integral to the structural stability of the myofiber. (medscape.com)
The make-up and complexity of these molecular machines present perfect problems for structural biology and many of the protein components of these machines have been examined using X-ray crystallography or cryo-Electron Microscopy. (diamond.ac.uk)

The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. (wn.com)

BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)

As a positive regulator of plant immunity, E3 ligase SAUL1 is guarded by NLR protein SOC3. (ubc.ca)

Mice with loss of function of the Minar2 protein ( Minar2 tm1b/tm1b ) present with rapidly progressive sensorineural HL associated with a reduction in outer hair cell stereocilia in the shortest row and degeneration of hair cells at a later age. (nih.gov)
Then, the C/EBP 3â UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. (omicsonline.org)
Each vial of cell lysate contains 100ug of total protein (at 1 mg/ml). (novusbio.com)
Each vial of cell lysate contains 100ug of total protein which should be sufficient for 20-50 reactions. (novusbio.com)
The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. (antibodies-online.com)
Characterized components of the ICEBs1 T4SS include the conserved VirB4-like ATPase ConE, the bifunctional cell wall hydrolase CwlT, and the presumed VirD4-like coupling protein ConQ. (bvsalud.org)
Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. (genetex.com)

NS5A is integral for HCV RNA viral replication. (medscape.com)
Ledipasvir inhibits HCV NS5A protein, which is required for viral replication. (medscape.com)

We propose a model in which the ICEBs1 conjugation machinery is composed of ConB, ConC, ConD, ConE, ConG, CwlT, ConQ, and possibly other ICEBs1 proteins, and that ConB interacts with ConE, helping to recruit and/or maintain ConE at the membrane. (bvsalud.org)

This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. (nih.gov)
Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

Together these proteins shorten the end of the mRNAs, preparing the molecules for degradation. (elifesciences.org)
MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)

Daclatasvir inhibits NS5A, a nonstructural protein encoded by HCV. (medscape.com)

Classically, the 3â untranslated region (3â UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. (omicsonline.org)

In both adults and children, a first-morning urine protein/creatinine ratio of 2-3 mg/mg or more indicates nephrotic-range proteinuria. (medscape.com)

This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. (nih.gov)
The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)

They found that despite these differences, there was a very specific conserved region at the other end of the protein. (diamond.ac.uk)
Here, we isolated genes encoding DnaJ-J8 from pea and found that Toc12 is a truncated clone of one of the pea DnaJ-J8s. (ncku.edu.tw)

The cryo-EM analysis also revealed a population of free V 1 bound to Oxidation Resistance 1 (Oxr1p), a poorly characterized protein that has been implicated in protecting cells from oxidative stress. (upstate.edu)
shown in red), a poorly characterized protein implicated in oxidative stress response. (upstate.edu)

It is an integral part of numerous metallo-enzymes and transcription factors and is an important intracellular mediator, similar to calcium. (medscape.com)

Anatomy28

Organisms9

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes51

Disciplines and Occupations3

Technology, Industry, Agriculture5

Information Science7

Health Care2

Gene encodes7

Mutations8

MRNA6

Transmembrane5

Genes encode1

Chromosome2

Viral proteins3

Polyprotein2

Humans6

Host proteins3

Clusters1

Peptides1

CD591

Amino Acids1

Solute2

Plasma membrane3

Structurally1

Actin1

Interactions5

Sequence7

Putative1

Outer membrane protein1

Receptor3

Golgi1

Preferentially1

Genome1

Belongs2

Sequences3

Characterization2

Extracellular3

Membrane integral1

Nucleotide1

Family6

Peripheral2

Assay1

Interact1

Green fluores2

Zinc1

Inner mitochon1

Membranes2

Transporter3

Transcript3

Glycosylation1

Structural2

Synaptic1

Kinases1

Immunity1

Cell7

Replication2

Interacts1

Heparan2

Molecular weight1

Degradation2

NS5A1

Eukaryotic1

Creatinine1

Roles2

Found2

Oxidative2

Intracellular1